Stress-associated immune dysregulation and its importance for human health: a personal history of psychoneuroimmunology
Abstract
Historically, clinicians have suspected that both major and minor stressful events can have health implications. Observations and case reports link severely stressful life events with a sudden onset or worsening of a variety of illnesses. The immune system was quickly implicated as a means to help explain how stressful life events could produce this relationship. The field of psychoneuroimmunology (PNI) is a field of research that deals with the complex interactions between the central nervous system, endocrine and immune systems, and how behavior/stress can modify these interactions. In this review, I have selected some of our papers that represent our efforts to study the effects of stress on the immune response and also include selected papers that describe how our PNI program at The Ohio State University Medical Center has evolved; virtually all of this research has been performed in collaboration with Janice Kiecolt-Glaser and others in our research group.
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Mental arithmetic was used as an acute and reliable laboratory stressor.
“Mental arithmetic was used as an acute and reliable laboratory stressor shown in research”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Glaser, 2005
A power analysis with a medium to large effect size (f = 0.32) for repeated measures ANOVA yielded a total sample size of 18 for two groups to achieve at least 80% power.
“we conducted a power analysis with a medium to large effect size (f = 0.32) for repeated measures of aNOVa, yielding a total sample size of 18 for two groups to achieve at least 80% power.”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Glaser, 2005
The S-IgA decrease was significantly correlated with the cortisol increase during the 20 minutes after stress.
“found that the siga decrease was significantly correlated with the cortisol increase during the 20 minutes after stress (Glaser, 2005).”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Glaser, 2005
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- Authors
- Glaser, R.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Glaser, Ronald
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 19
- Issue
- 1
- Pages
- 3-11
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2010121952
- Cited by
- 158
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 11 · 2012: 11
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- psychoneuroimmunology, stress, immune dysregulation, stress and immune response, life events
- MeSH terms
- Adult, Bacterial Vaccines, DNA Repair, Female, Herpesviridae Infections, Humans, Immunization, Male, Psychoneuroimmunology, Reference Values, Stress, Psychological, Viral Vaccines, Wound Healing, Neuroimmunomodulation, Virus Latency, Epstein-Barr Virus Infections
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