Regulation of autophagy by phosphatidylinositol 3‐phosphate
Abstract
The simple phosphoinositide phosphatidylinositol 3‐phosphate (PI(3)P) has been known to have important functions in endocytic and phagocytic traffic, and to be required for the autophagic pathway. In all of these settings, PI(3)P appears to create platforms that serve to recruit specific effectors for membrane trafficking events. In autophagy, PI(3)P may form the platform for autophagosome biogenesis.
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Nucleation of the nascent phagophore is orchestrated by a class III phosphatidylinositol 3-kinase complex containing BECN1, PIK3C3/VPS34, PIK3R4/p150, NRBF2 and either ATG14 or UVRAG.
“Next, nucleation of the nascent phagophore is orchestrated by a class III phosphatidylinositol 3-kinase (PtdIns3K) complex containing BECN1, PIK3C3/VPS34, PIK3R4/p150, NRBF2 and either ATG14 or UVRAG [38,39].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [38]
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Jayabalasingham, B., Voss, C., Ehrenman, K., Romano, J. D., Smith, M. E., Fidock, D. A., Bosch, J., & Coppens, I. (2013) · Autophagy · doi:10.4161/auto.27166 · Cited by 43 · see citing works
Autophagy-Dependent Secretion: Contribution to Tumor Progression
Keulers, T. G., Schaaf, M. B. E., & Rouschop, K. M. A. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00251 · Cited by 43 · see citing works
The interplay between oxidative stress and autophagy in chronic obstructive pulmonary disease
Zhao, X., Zhang, Q., & Zheng, R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1004275 · Cited by 46 · see citing works
The Autophagic Machinery in Enterovirus Infection
Lai, J. W., Sam, I., & Chan, Y. F. (2016) · Viruses · doi:10.3390/v8020032 · Cited by 42 · see citing works
Grasso, G., Santoro, A. M., Lanza, V., Sbardella, D., Tundo, G. R., Ciaccio, C., Marini, S., Coletta, M., & Milardi, D. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.06.004 · Cited by 42 · see citing works
Pib2 and the EGO complex are both required for activation of TORC1
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Role and mechanisms of autophagy in alcohol-induced liver injury
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Calcium Dyshomeostasis and Lysosomal Ca2+ Dysfunction in Amyotrophic Lateral Sclerosis
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Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods
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Char, R., & Pierre, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00779 · Cited by 38 · see citing works
Dual role of autophagy/mitophagy in chronic obstructive pulmonary disease
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Ubiquitin pathways regulate the pathogenesis of chronic liver disease
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Targeting autophagy in liver cancer
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Protein Kinase C Isozymes and Autophagy during Neurodegenerative Disease Progression
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The many paths to artemisinin resistance in Plasmodium falciparum
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- Authors
- Burman, C., & Ktistakis, N. T.
- Affiliations
- Babraham Institute (GB)
- Corresponding author
- Ktistakis, Nicholas T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-01-13
- Volume
- 584
- Issue
- 7
- Pages
- 1302-1312
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2031697171
- Cited by
- 234
- References
- 115
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 14 · 2021: 17 · 2020: 14 · 2019: 23 · 2018: 9 · 2017: 21 · 2016: 28 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 16
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BBS/E/B/00001221)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, phosphatidylinositol 3-phosphate, autophagosome formation, membrane trafficking, endocytosis, phagocytosis, phosphoinositide signaling
- MeSH terms
- Animals, Autophagy, Humans, Phagocytosis, Signal Transduction, Protein Structure, Tertiary, Phosphatidylinositol Phosphates, Phosphatidylinositol 3-Kinases
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