Cited by 234Autophagy in Disease and TherapyCellular transport and secretionCalcium signaling and nucleotide metabolism

Regulation of autophagy by phosphatidylinositol 3‐phosphate

Burman, Chloe, Ktistakis, Nicholas T.·2010·FEBS Letters

Abstract

The simple phosphoinositide phosphatidylinositol 3‐phosphate (PI(3)P) has been known to have important functions in endocytic and phagocytic traffic, and to be required for the autophagic pathway. In all of these settings, PI(3)P appears to create platforms that serve to recruit specific effectors for membrane trafficking events. In autophagy, PI(3)P may form the platform for autophagosome biogenesis.

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Crossref · 10.1016/j.febslet.2010.01.011

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115 of 115 references verified0 citation errors · 0 not checkable

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  • Nucleation of the nascent phagophore is orchestrated by a class III phosphatidylinositol 3-kinase complex containing BECN1, PIK3C3/VPS34, PIK3R4/p150, NRBF2 and either ATG14 or UVRAG.

    “Next, nucleation of the nascent phagophore is orchestrated by a class III phosphatidylinositol 3-kinase (PtdIns3K) complex containing BECN1, PIK3C3/VPS34, PIK3R4/p150, NRBF2 and either ATG14 or UVRAG [38,39].”

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Authors
Burman, C., & Ktistakis, N. T.
Affiliations
Babraham Institute (GB)
Corresponding author
Ktistakis, Nicholas T.
Venue
FEBS Letters
Publisher
Wiley
Published
2010-01-13
Volume
584
Issue
7
Pages
1302-1312
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2031697171
Cited by
234
References
115
Citations by year
2026: 10 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 14 · 2021: 17 · 2020: 14 · 2019: 23 · 2018: 9 · 2017: 21 · 2016: 28 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 16
FWCI
1.45
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Biotechnology and Biological Sciences Research Council (BBS/E/B/00001221)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
autophagy, phosphatidylinositol 3-phosphate, autophagosome formation, membrane trafficking, endocytosis, phagocytosis, phosphoinositide signaling
MeSH terms
Animals, Autophagy, Humans, Phagocytosis, Signal Transduction, Protein Structure, Tertiary, Phosphatidylinositol Phosphates, Phosphatidylinositol 3-Kinases

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