The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22
Open accessAbstract
Mesenchymal stem cells (MSCs) have potential application for the treatment of ischemic heart diseases. Besides differentiation properties, MSCs protect ischemic cardiomyocytes by secretion of paracrine factors. In this study, we found exosomes enriched with miR-22 were secreted by MSCs following ischemic preconditioning (Exo(IPC)) and mobilized to cardiomyocytes where they reduced their apoptosis due to ischemia. Interestingly, by time-lapse imaging, we for the first time captured the dynamic shedding of miR-22 loaded exosomes from cytosol to extracellular space. Furthermore, the anti-apoptotic effect of miR-22 was mediated by direct targeting of methyl CpG binding protein 2 (Mecp2). In vivo data showed that delivery of Exo(IPC) significantly reduced cardiac fibrosis. Our data identified a significant benefit of Exo(IPC) for the treatment of cardiac diseases by targeting Mecp2 via miR-22.
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Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
Mittelbrunn, M., Gutiérrez-Vázquez, C., Villarroya-Beltri, C., González, S., Sánchez-Cabo, F., González, M. Á., Bernad, A., & Sánchez-Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,769
Gnecchi, M., He, H., Liang, O. D., Melo, L. G., Morello, F., Mu, H., Noiseux, N., Zhang, L., Pratt, R. E., Ingwall, J. S., et al. (2005) · Nature Medicine · doi:10.1038/nm0405-367 · Cited by 1,677
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
Hergenreider, E., Heydt, S., Tréguer, K., Boettger, T., Horrevoets, A. J. G., Zeiher, A. M., Scheffer, M. P., Frangakis, A. S., Yin, X., Mayr, M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2441 · Cited by 1,305
Kroh, E. M., Parkin, R. K., Mitchell, P. S., & Tewari, M. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.032 · Cited by 1,175
Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
Ranganath, S. H., Levy, O., Inamdar, M. S., & Karp, J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.02.005 · Cited by 809
BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression
Roccaro, A. M., Sacco, A., Maiso, P., Azab, A. K., Tai, Y.-T., Reagan, M., Azab, F., Flores, L. M., Campigotto, F., Weller, E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66517 · Cited by 794
Uemura, R., Xu, M., Ahmad, N., & Ashraf, M. (2006) · Circulation Research · doi:10.1161/01.res.0000225952.61196.39 · Cited by 621
Self-citationWon Kim, H., Haider, H. K., Jiang, S., & Ashraf, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020925 · Cited by 370
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The biology , function , and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770
Concise review: MSC-derived exosomes for cell-free therapy
Phinney, D. G., & Pittenger, M. F. (2017) · Stem Cells · doi:10.1002/stem.2575 · Cited by 1,834
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491
Harrell, C. R., Jovicic, N., Djonov, V., Arsenijevic, N., & Volarevic, V. (2019) · Cells · doi:10.3390/cells8121605 · Cited by 795
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Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737
Metadata
- Authors
- Feng, Y., Huang, W., Wani, M., Yu, X., & Ashraf, M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-02-18
- Volume
- 9
- Issue
- 2
- Pages
- e88685
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1981571777
- Cited by
- 477
- References
- 19
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Feng, Y., Huang, W., Wani, M., Yu, X., & Ashraf, M. (2014). Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22. PLoS ONE. https://doi.org/10.1371/journal.pone.0088685
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