The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Changes in Abundance of Oral Microbiota Associated with Oral Cancer
Open accessAbstract
Individual bacteria and shifts in the composition of the microbiome have been associated with human diseases including cancer. To investigate changes in the microbiome associated with oral cancers, we profiled cancers and anatomically matched contralateral normal tissue from the same patient by sequencing 16S rDNA hypervariable region amplicons. In cancer samples from both a discovery and a subsequent confirmation cohort, abundance of Firmicutes (especially Streptococcus) and Actinobacteria (especially Rothia) was significantly decreased relative to contralateral normal samples from the same patient. Significant decreases in abundance of these phyla were observed for pre-cancers, but not when comparing samples from contralateral sites (tongue and floor of mouth) from healthy individuals. Weighted UniFrac principal coordinates analysis based on 12 taxa separated most cancers from other samples with greatest separation of node positive cases. These studies begin to develop a framework for exploiting the oral microbiome for monitoring oral cancer development, progression and recurrence.
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Cites
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Self-citationvegan: Community Ecology Package
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Cited by
The oral microbiota in colorectal cancer is distinctive and predictive
Flemer, B., Warren, R. D., Barrett, M. P., Cisek, K., Das, A., Jeffery, I. B., Hurley, E., O‘Riordain, M., Shanahan, F., & O‘Toole, P. W. (2018) · Gut · doi:10.1136/gutjnl-2017-314814 · Cited by 646
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Anticancer effects of the microbiome and its products
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Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer
Chattopadhyay, I., Verma, M., & Panda, M. (2019) · Technology in Cancer Research & Treatment · doi:10.1177/1533033819867354 · Cited by 407
“The bacterial taxa Veillonella, Fusobacterium, Prevotella, Porphyromonas, Actinomyces, and Clostridium belonging anaerobes, and Haemophilus, Enterobacteriaceae, and Streptococcus subspecies belonging to aerobes were highly abundant in tumor sites of patients with OSCC.(43,58) Capnocytophaga, Pseudomonas, and Atopobium…”
BackgroundOral Microbiota Community Dynamics Associated With Oral Squamous Cell Carcinoma Staging
Yang, C.-Y., Yeh, Y.-M., Yu, H.-Y., Chin, C.-Y., Hsu, C.-W., Liu, H., Huang, P.-J., Hu, S.-N., Liao, C.-T., Chang, K.-P., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00862 · Cited by 369
Metadata
- Authors
- Schmidt, B. L., Kuczynski, J., Bhattacharya, A., Huey, B., Corby, P. M., Queiroz, E. L. S., Nightingale, K., Kerr, A. R., DeLacure, M. D., Veeramachaneni, R., Olshen, A. B., Albertson, D. G., & Teh, M.-T.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-06-02
- Volume
- 9
- Issue
- 6
- Pages
- e98741
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2120335773
- Cited by
- 375
- References
- 56
- FWCI
- 25.39
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-08-15)
- Open access
- gold
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- Schmidt, B. L., Kuczynski, J., Bhattacharya, A., Huey, B., Corby, P. M., Queiroz, E. L. S., Nightingale, K., Kerr, A. R., DeLacure, M. D., Veeramachaneni, R., Olshen, A. B., Albertson, D. G., & Teh, M.-T. (2014). Changes in Abundance of Oral Microbiota Associated with Oral Cancer. PLoS ONE. https://doi.org/10.1371/journal.pone.0098741
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
