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Perinatal Exposure of Mice to the Pesticide DDT Impairs Energy Expenditure and Metabolism in Adult Female Offspring
Open accessAbstract
Dichlorodiphenyltrichloroethane (DDT) has been used extensively to control malaria, typhus, body lice and bubonic plague worldwide, until countries began restricting its use in the 1970s. Its use in malaria control continues in some countries according to recommendation by the World Health Organization. Individuals exposed to elevated levels of DDT and its metabolite dichlorodiphenyldichloroethylene (DDE) have an increased prevalence of diabetes and insulin resistance. Here we hypothesize that perinatal exposure to DDT disrupts metabolic programming leading to impaired metabolism in adult offspring. To test this, we administered DDT to C57BL/6J mice from gestational day 11.5 to postnatal day 5 and studied their metabolic phenotype at several ages up to nine months. Perinatal DDT exposure reduced core body temperature, impaired cold tolerance, decreased energy expenditure, and produced a transient early-life increase in body fat in female offspring. When challenged with a high fat diet for 12 weeks in adulthood, female offspring perinatally exposed to DDT developed glucose intolerance, hyperinsulinemia, dyslipidemia, and altered bile acid metabolism. Perinatal DDT exposure combined with high fat feeding in adulthood further impaired thermogenesis as evidenced by reductions in core temperature and in the expression of numerous RNA that promote thermogenesis and substrate utilization in the brown adipose tissue of adult female mice. These observations suggest that perinatal DDT exposure impairs thermogenesis and the metabolism of carbohydrates and lipids which may increase susceptibility to the metabolic syndrome in adult female offspring.
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Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
Developmental origins of metabolic diseases
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Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action
Mohajer, N., Du, C. Y., Checkcinco, C., & Blumberg, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.780888 · Cited by 72
Güil-Oumrait, N., Valvi, D., Garcia-Esteban, R., Guxens, M., Sunyer, J., Torrent, M., Casas, M., & Vrijheid, M. (2021) · Environment International · doi:10.1016/j.envint.2021.106469 · Cited by 57
Metadata
- Authors
- La Merrill, M., Karey, E., Moshier, E., Lindtner, C., La Frano, M. R., Newman, J. W., & Buettner, C.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-07-30
- Volume
- 9
- Issue
- 7
- Pages
- e103337
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2145746529
- Cited by
- 176
- References
- 10
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- La Merrill, M., Karey, E., Moshier, E., Lindtner, C., La Frano, M. R., Newman, J. W., & Buettner, C. (2014). Perinatal Exposure of Mice to the Pesticide DDT Impairs Energy Expenditure and Metabolism in Adult Female Offspring. PLoS ONE. https://doi.org/10.1371/journal.pone.0103337
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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