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Physical Activity and Cardiorespiratory Fitness Are Beneficial for White Matter in Low-Fit Older Adults
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Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.
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“Cardiorespiratory fitness and aerobic exercise have been positively associated with fronto-parietal and medial temporal lobe white matter tracts including the fornix, cingulum bundle and superior longitudinal fasciculus”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [99]
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- MW Voss, 2013, The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention, Hum Brain Mapp, 34, 2972, 10.1002/hbm.22119 · DOI · Paper page
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White Matter Plasticity in the Adult Brain
Sampaio‐Baptista, C., & Johansen‐Berg, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.026 · Cited by 432
Physical activity, brain, and cognition
Erickson, K. I., Hillman, C. H., & Kramer, A. F. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.01.005 · Cited by 406
Self-citationMediators of Physical Activity on Neurocognitive Function: A Review at Multiple Levels of Analysis
Stillman, C. M., Cohen, J., Lehman, M. E., & Erickson, K. I. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00626 · Cited by 421
Exercise-Induced Neuroplasticity: A Mechanistic Model and Prospects for Promoting Plasticity
El‐Sayes, J., Harasym, D., Turco, C. V., Locke, M. B., & Nelson, A. J. (2018) · The Neuroscientist · doi:10.1177/1073858418771538 · Cited by 335
Sexton, C. E., Betts, J. F., Demnitz, N., Dawes, H., Ebmeier, K. P., & Johansen‐Berg, H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.071 · Cited by 278
Metadata
- Authors
- Burzynska, A. Z., Chaddock-Heyman, L., Voss, M. W., Wong, C. N., Gothe, N. P., Olson, E. A., Knecht, A., Lewis, A., Monti, J. M., Cooke, G. E., Wojcicki, T. R., Fanning, J., Chung, H. D., Awick, E., McAuley, E., & Kramer, A. F.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- University of Iowa (US)
- Corresponding author
- Burzynska, Agnieszka Zofia
- Voss, Michelle W.
- Wong, Chelsea N.
- Gothe, Neha P.
- Olson, Erin A.
- Knecht, Anya
- Lewis, Andrew
- Monti, Jim M.
- Cooke, Gillian E.
- Fanning, Jason
- Chung, Hyondo David
- Awick, Elisabeth
- McAuley, Edward
- Kramer, Arthur F.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-09-17
- Volume
- 9
- Issue
- 9
- Pages
- e107413
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4167864
- OpenAlex
- W2074572113
- Cited by
- 161
- References
- 92
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 18 · 2020: 18 · 2019: 20 · 2018: 10 · 2017: 14 · 2016: 12 · 2015: 19 · 2014: 1
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Robert Bosch Stiftung
- University of Illinois at Urbana-Champaign
- National Institute on Aging (AG025667, R37AG025667)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- physical activity, cardiorespiratory fitness, white matter integrity, older adults, sedentary behavior, moderate-to-vigorous physical activity, white matter lesions, diffusion tensor imaging
- MeSH terms
- Age Factors, Aged, Cognition, Female, Humans, Life Style, Male, Middle Aged, Motor Activity, Physical Fitness, Sex Factors, Diffusion Tensor Imaging, Sedentary Behavior, White Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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