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Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML

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NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome

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CRISPR/Cas9-based genome editing and functional analysis of SlHyPRP1 and SlDEA1 genes of Solanum lycopersicum L. in imparting genetic tolerance to multiple stress factors

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Technologies and Computational Analysis Strategies for CRISPR Applications

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Prime Editing Guide RNA Design Automation Using PINE-CONE

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Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods

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Genetic Engineering in Bacteria, Fungi, and Oomycetes, Taking Advantage of CRISPR

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Efficient CRISPR/Cas9-Mediated Versatile, Predictable, and Donor-Free Gene Knockout in Human Pluripotent Stem Cells

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Targeted knock-in of an scFv-Fc antibody gene into the hprt locus of Chinese hamster ovary cells using CRISPR/Cas9 and CRIS-PITCh systems

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A deletion in the STA1 promoter determines maltotriose and starch utilization in STA1+ Saccharomyces cerevisiae strains

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Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy

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CRISPR-Based Genome Editing: Advancements and Opportunities for Rice Improvement

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GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity

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Template-independent genome editing in the Pcdh15 mouse, a model of human DFNB23 nonsyndromic deafness

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Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F

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A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity

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Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT

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Identification of a tomato UDP-arabinosyltransferase for airborne volatile reception

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CRISPR/Cas12a Mediated Genome Editing Enhances Bombyx mori Resistance to BmNPV

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multicrispr: gRNA design for prime editing and parallel targeting of thousands of targets

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CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy

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Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells

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T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds

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Unlocking Fungal Potential: The CRISPR-Cas System as a Strategy for Secondary Metabolite Discovery

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CRISPR/Cas-Mediated Site-Specific Mutagenesis in Arabidopsis thaliana Using Cas9 Nucleases and Paired Nickases

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Targeted in vivo epigenome editing of H3K27me3

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The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

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FCHO controls AP2’s initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch

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CRISPR/Cas9-Mediated Mutation in XSP10 and SlSAMT Genes Impart Genetic Tolerance to Fusarium Wilt Disease of Tomato (Solanum lycopersicum L.)

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Synergizing CRISPR/Cas9 off-target predictions for ensemble insights and practical applications

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The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma

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Investigating Host and Parasitic Plant Interaction by Tissue-Specific Gene Analyses on Tomato and Cuscuta campestris Interface at Three Haustorial Developmental Stages

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An Efficient Hairy Root System for Validation of Plant Transformation Vector and CRISPR/Cas Construct Activities in Cucumber (Cucumis sativus L.)

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An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization

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Creating saponin‐free yellow pea seeds by CRISPR/Cas9‐enabled mutagenesis on β‐amyrin synthase

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Review of applications of artificial intelligence (AI) methods in crop research

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CRISPR-M: Predicting sgRNA off-target effect using a multi-view deep learning network

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No off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophy

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Cxcl9l and Cxcr3.2 regulate recruitment of osteoclast progenitors to bone matrix in a medaka osteoporosis model

Phan, Q. T., Tan, W. H., Liu, R., Sundaram, S., Buettner, A., Kneitz, S., Cheong, B., Vyas, H., Mathavan, S., Schartl, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006093117 · Cited by 37

Turning Up the Temperature on CRISPR: Increased Temperature Can Improve the Editing Efficiency of Wheat Using CRISPR/Cas9

Milner, M. J., Craze, M. S., Hope, M. S., & Wallington, E. J. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.583374 · Cited by 36

An Efficient Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-Associated Protein 9 Mutagenesis System for Oil Palm (Elaeis guineensis)

Yeap, W., Khan, N. C. M., Jamalludin, N., Muad, M. R., Appleton, D. R., & Kulaveerasingam, H. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.773656 · Cited by 37

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

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Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure

Lehne, F., Pokrant, T., Parbin, S., Salinas, G., Großhans, J., Rust, K., Faix, J., & Bogdan, S. (2022) · Nature Communications · doi:10.1038/s41467-022-30167-0 · Cited by 35

Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility

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Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

Murray, A., Gough, G., Cindrić, A., Vučković, F., Koschut, D., Borelli, V., Petrović, D. J., Bekavac, A., Plećaš, A., Hribljan, V., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104692 · Cited by 38

Noninvasive In Toto Imaging of the Thymus Reveals Heterogeneous Migratory Behavior of Developing T Cells

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High-throughput CRISPR Vector Construction and Characterization of DNA Modifications by Generation of Tomato Hairy Roots

Jacobs, T. B., & Martin, G. B. (2016) · Journal of Visualized Experiments · doi:10.3791/53843 · Cited by 35

Functional interrogation of non-coding DNA through CRISPR genome editing

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An efficient system for homology-dependent targeted gene integration in medaka (Oryzias latipes)

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Efficient genome editing using CRISPR/Cas9 ribonucleoprotein approach in cultured medaka fish cells

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CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses

Isken, O., Postel, A., Bruhn, B., Lattwein, E., Becher, P., & Tautz, N. (2018) · Journal of Virology · doi:10.1128/jvi.01714-18 · Cited by 36

Control of Adipogenic Differentiation in Mesenchymal Stem Cells via Endogenous Gene Activation Using CRISPR-Cas9

Furuhata, Y., Nihongaki, Y., Sato, M., & Yoshimoto, K. (2017) · ACS Synthetic Biology · doi:10.1021/acssynbio.7b00246 · Cited by 35

CRISPR–Cas9/CRISPRi tools for cell factory construction in E. coli

Hashemi, A. (2020) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-020-02872-9 · Cited by 34

The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors

Harland, L. T. G., Simon, C. S., Senft, A. D., Costello, I., Greder, L. V., Imaz-Rosshandler, I., Göttgens, B., Marioni, J. C., Bikoff, E. K., Porcher, C., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-020-00611-8 · Cited by 30

Comparative Study in Zebrafish and Medaka Unravels the Mechanisms of Tissue Regeneration

Chowdhury, K., Lin, S., & Lai, S.-L. (2022) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2022.783818 · Cited by 37

Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish

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