The Remedial Efficacy of Spirulina platensis versus Chromium-Induced Nephrotoxicity in Male Sprague-Dawley Rats
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This study was conducted to investigate the possible protective effect of Spirulina platensis against chromium-induced nephrotoxicity. A total of 36 adult male Sprague-Dawley rats were divided into 4 equal groups (Gps). Gp1 served as control, rats of Gps 2, 3, and 4 were exposed to Spirulina platensis (300 mg/kg b.wt per os) and sodium dichromate dihydrate (SDD) via drinking water at concentration of 520 mg /l respectively. Chromium administration caused alterations in the renal function markers as evidenced by significant increase of blood urea and creatinine levels accompanied with significant increase in kidney's chromium residues and MDA level as well as decreased catalase activity and glutathion content in kidney tissue. Histologically, Cr provoked deleterious changes including: vascular congestion, wide spread tubular epithelium necrobiotic changes, atrophy of glomerular tuft and proliferative hyperplasia. The latter was accompanied with positive PCNA expression in kidney tissues as well as DNA ploidy interpretation of major cellular population of degenerated cells, appearance of tetraploid cells, high proliferation index and high DNA index. Morphometrical measurements revealed marked glomerular and tubular lumen alterations. On contrary, spirulina co-treatment with Cr significantly restored the histopathological changes, antioxidants and renal function markers and all the previously mentioned changes as well.
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Antioxidant activity accounts for the protective role of Spirulina against toxicity induced by carbon tetrachloride, metals, deltamethrin, and drugs in animal models.
“It has been suggested that the antioxidant activity accounts for the protective role of Spirulina against the toxicity induced by carbon tetrachloride (CCl4) [40], by metals (arsenic, mercuric chloride, chromium, cadmium, and fluoride) [34, 41–44], by the insecticide deltamethrin in mice [39] and rats [45]”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [43]
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- Authors
- Elshazly, M. O., Abd El-Rahman, S. S., Morgan, A. M., & Ali, M. E.
- Affiliations
- Cairo University (EG)
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-06-01
- Volume
- 10
- Issue
- 6
- Pages
- e0126780
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4450866
- OpenAlex
- W2166914636
- Cited by
- 31
- References
- 43
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chromium effects and bioremediation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Keywords
- Spirulina platensis, sodium dichromate, renal protection, oxidative stress, antioxidant enzymes, catalase, glutathione, malondialdehyde, DNA ploidy, PCNA, kidney histopathology, glomerular atrophy, tubular necrosis, renal function markers
- MeSH terms
- Animals, Body Weight, Catalase, Chromium, DNA, Glutathione, Immunohistochemistry, Kidney, Kidney Diseases, Male, Malondialdehyde, Organ Size, Ploidies, Biomarkers, Rats, Sprague-Dawley, Oxidative Stress, Proliferating Cell Nuclear Antigen, Protective Agents, Spirulina
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