Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis
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OBJECTIVE: We aimed to review the literature regarding epidemiology of functional abdominal pain disorders in children and to assess its geographic, gender and age distribution including associated risk factors of developing functional abdominal pain. METHODS: The Cochrane Library, MEDLINE, EMBASE, CINAHL and PsychInfo databases were systematically searched up to February 2014. Study selection criteria included: (1) studies of birth cohort, school based or general population samples (2) containing data concerning epidemiology, prevalence or incidence (3) of children aged 4-18 years (4) suffering from functional abdominal pain. Quality of studies was rated by a self-made assessment tool. A random-effect meta-analysis model was used to estimate the prevalence of functional abdominal pain in childhood. RESULTS: A total of 58 articles, including 196,472 children were included. Worldwide pooled prevalence for functional abdominal pain disorders was 13.5% (95% CI 11.8-15.3), of which irritable bowel syndrome was reported most frequently (8.8%, 95% CI 6.2-11.9). The prevalence across studies ranged widely from 1.6% to 41.2%. Higher pooled prevalence rates were reported in South America (16.8%) and Asia (16.5%) compared to Europe (10.5%). And a higher pooled prevalence was reported when using the Rome III criteria (16.4%, 95% CI 13.5-19.4). Functional abdominal pain disorders are shown to occur significantly more in girls (15.9% vs. 11.5%, pooled OR 1.5) and is associated with the presence of anxiety and depressive disorders, stress and traumatic life events. CONCLUSION: Functional abdominal pain disorders are a common problem worldwide with irritable bowel syndrome as most encountered abdominal pain-related functional gastrointestinal disorder. Female gender, psychological disorders, stress and traumatic life events affect prevalence.
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Prevalence rates of FSS vary considerably due to differences in case definitions, assessment instruments and study populations.
“Prevalence rates vary considerably due to differences in case definitions, assessment instruments and study populations.1–3”
From Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial (2016) · cites this paper as [1]
The Discussion attributes substantial heterogeneity in pediatric functional abdominal pain prevalence to methodological differences, and Table 2 compares case definitions, questionnaires, and reporting methods. However, the Results say prevalence was almost identical for validated versus nonvalidated questionnaires and for child versus parent reports. The paper also addresses pediatric abdominal pain disorders, not FSS generally, so it does not fully support the broader claim or each proposed cause of variation. (LLM, conf=0.84)
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Self-citation
- Authors
- Korterink, J. J., Diederen, K., Benninga, M. A., & Tabbers, M. M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Korterink, Judith J.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-05-20
- Volume
- 10
- Issue
- 5
- Pages
- e0126982
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4439136
- OpenAlex
- W324818206
- Cited by
- 481
- References
- 101
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 36 · 2023: 48 · 2022: 58 · 2021: 65 · 2020: 53 · 2019: 28 · 2018: 46 · 2017: 29 · 2016: 33 · 2015: 6
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- functional abdominal pain, irritable bowel syndrome, prevalence, incidence, sex differences, anxiety disorders, depressive disorders, stress, traumatic life events, Rome III criteria, functional gastrointestinal disorders, regional variation
- MeSH terms
- Child, Geography, Humans, Surveys and Questionnaires, Reproducibility of Results, Abdominal Pain, Prevalence
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