Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD
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INTRODUCTION: Successful development of effective β-site amyloid precursor protein cleaving enzyme 1 (BACE1)-targeted therapies for early stages of Alzheimer's disease requires biomarker-guided intervention strategies. METHODS: We investigated whether key biological factors such as sex, apolipoprotein E (APOE ε4) allele, and age affect longitudinal plasma BACE1 concentrations in a large monocenter cohort of individuals at risk for Alzheimer's disease. We explored the relationship between plasma BACE1 concentrations and levels of brain amyloid-β (Aβ) deposition, using positron emission tomography global standard uptake value ratios. RESULTS: Baseline and longitudinal mean concentrations of plasma BACE1 were significantly higher in women than men. We also found a positive significant impact of plasma BACE1 on baseline Aβ-positron emission tomography global standard uptake value ratios. DISCUSSION: Our results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials.
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Plasma BACE1 concentrations are associated with amyloid-PET quantitative measures in cognitively healthy individuals at risk for AD.
“A recent study showed an association between plasma BACE1 concentrations and amyloid-positron emission tomography quantitative measures in a cohort of cognitively healthy individuals at risk for AD (86).”
From The β-Secretase BACE1 in Alzheimer’s Disease (2021) · cites this paper as [86]
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- Patrizia A. Chiesa (Paris), Jean-Christophe Corvol (Paris), Augusto Claudio Cuello (Montr eal), Jeffrey L. Cummings (Las Vegas), Herman Depypere (Gent), Bruno Dubois (Paris), Andrea Duggento (Rome), Enzo Emanuele (Rob- bio), Valentina Escott-Price (Cardiff), Howard Federoff (Ir- vine), Maria Teresa Ferretti (Z€ urich), Massimo Fiandaca (Irvine), Richard A. Frank (Malvern), Francesco Garaci (Rome), Hugo Geerts (Berwyn), Filippo S. Giorgi (Pisa), Edward J. Goetzl (San Francisco), Manuela Graziani (Roma), Marion Haberkamp (Bonn), Marie-Odile Habert (Paris), Harald Hampel (Paris), Karl Herholz (Manchester), Felix Hernandez (Madrid), Dimitrios Kapogiannis (Balti- more), Eric Karran (Cambridge), Steven J. Kiddle (Cam- bridge), Seung H. Kim (Seoul), Yosef Koronyo (Los Angeles), Maya Koronyo-Hamaoui (Los Angeles), Todd Langevin (Minneapolis-Saint Paul), St ephane Leh ericy (Paris), Pablo Lemercier (Paris), Alejandro Luc ıa (Madrid), Simone Lista (Paris), Jean Lorenceau (Paris), Dalila Mango (Rome), Mark Mapstone (Irvine), Christian Neri (Paris), Robert Nistic o (Rome), Sid E. O'Bryant (Fort Worth), Gio- vanni Palermo (Pisa), George Perry (San Antonio), Craig Ritchie (Edinburgh), Simone Rossi (Siena), Amira Saidi (Rome), Emiliano Santarnecchi (Siena), Lon S. Schneider (Los Angeles), Olaf Sporns (Bloomington), Nicola Toschi (Rome), Steven R. Verdooner (Sacramento), Andrea Ver- gallo (Paris), Nicolas Villain (Paris), Lindsay A. Weliko- vitch (Montr eal), Janet Woodcock (Silver Spring), Erfan Younesi (Esch-sur-Alzette). References
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The β-Secretase BACE1 in Alzheimer’s Disease
Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.001 · Cited by 694 · see citing works
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- Authors
- Vergallo, A., Houot, M., Cavedo, E., Lemercier, P., Vanmechelen, E., De Vos, A., Habert, M., Potier, M., Dubois, B., Lista, S., Hampel, H., INSIGHT‐preAD study group, & (APMI), A. P. M. I.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- ADx NeuroSciences (BE)
- ADx NeuroSciences NV Ghent Belgium
- Sorbonne Université (FR)
- Corresponding author
- Vergallo, Andrea
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2019-10
- Volume
- 15
- Issue
- 10
- Pages
- 1274-1285
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2980640997
- Cited by
- 32
- References
- 37
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by-nc-nd)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
- HAL (submittedVersion, cc-by-nc)
- HAL (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion, cc-by-nc-nd)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by-nc-nd)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion, cc-by-nc-nd)
- Funders
- AXA Research Fund
- Agence Nationale de la Recherche
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- BACE1
- MeSH terms
- Aged, Alzheimer Disease, Apolipoproteins E, Brain, Cognition, Female, Humans, Male, Sex Factors, Biomarkers, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Positron-Emission Tomography, Amyloid Precursor Protein Secretases, Healthy Volunteers
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