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Autophagy failure in Alzheimer's disease—locating the primary defect

Nixon, Ralph A., Yang, Dun-Sheng·2011·Neurobiology of Disease
DOI 10.1016/j.nbd.2011.01.021PMC PMC3096679
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  • Swelling of endosomal compartments enriched in amyloid precursor protein (APP) peptides, lysosomal deficits, and abnormal accumulation of autophagic vacuoles have been observed in human AD brains and corresponding mouse models.

    “Swelling of endosomal compartments enriched in amyloid precursor protein (APP) peptides (Takahashi et al. 2002), lysosomal deficits, and abnormal accumulation of autophagic vacuoles have been observed in human AD brains and corresponding mouse models (Cataldo et al. 1997), (Nixon and Yang 2011), (Nixon et al. 2005).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Nixon and Yang 2011

  • Dysfunctional autophagosomes and lysosomes are early pathological features in Alzheimer's disease (AD), preceding the classical deposition of amyloid-β plaques and Tau-containing neurofibrillary tangles.

    “Dysfunctional autophagosomes and lysosomes are recognized as early pathological features in Alzheimer's disease (AD), preceding the classical deposition of amyloid-β plaques and Tau-containing neurofibrillary tangles (Nixon and Yang 2011).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Nixon and Yang 2011

  • AD brains show enlarged APP-positive endosomes, lysosomal deficits, and autophagic vacuole accumulation.

    “AD brains show enlarged APP-positive endosomes (Takahashi et al. 2002), lysosomal deficits, and autophagic vacuole accumulation (Cataldo et al. 1997), (Nixon and Yang 2011), (Nixon et al. 2005).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Nixon and Yang 2011

  • Autophagosomal-lysosomal dysfunction is an early feature of Alzheimer's disease (AD), preceding amyloid-β and Tau pathology.

    “Autophagosomal-lysosomal dysfunction is an early feature of Alzheimer's disease (AD), preceding amyloid-β and Tau pathology (Nixon and Yang 2011).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Nixon and Yang 2011

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Metadata

Authors
Nixon, R. A., & Yang, D.-S.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2011-07
Volume
43
Issue
1
Pages
38-45
ISSN
0969-9961
DOI
10.1016/j.nbd.2011.01.021
PMC
PMC3096679
Cited by
595
References
27
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
National Institute on Aging and the Alzheimer's Association

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