Cited by 214Fatty Acid Research and HealthGut microbiota and healthProbiotics and Fermented Foods

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N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota

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Pusceddu, Matteo M., El Aidy, Sahar, Crispie, Fiona, O’Sullivan, Orla, Cotter, Paul, Stanton, Catherine, Kelly, Philip, Cryan, John F., Dinan, Timothy G.·2015·PLOS ONE

DOI 10.1371/journal.pone.0139721PMC PMC4591340

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Abstract

BACKGROUND: Early life stress is a risk factor for many psychiatric disorders ranging from depression to anxiety. Stress, especially during early life, can induce dysbiosis in the gut microbiota, the key modulators of the bidirectional signalling pathways in the gut-brain axis that underline several neurodevelopmental and psychiatric disorders. Despite their critical role in the development and function of the central nervous system, the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) on the regulation of gut-microbiota in early-life stress has not been explored. METHODS AND RESULTS: Here, we show that long-term supplementation of eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) (80% EPA, 20% DHA) n-3 PUFAs mixture could restore the disturbed gut-microbiota composition of maternally separated (MS) female rats. Sprague-Dawley female rats were subjected to an early-life stress, maternal separation procedure from postnatal days 2 to 12. Non-separated (NS) and MS rats were administered saline, EPA/DHA 0.4 g/kg/day or EPA/DHA 1 g/kg/day, respectively. Analysis of the gut microbiota in adult rats revealed that EPA/DHA changes composition in the MS, and to a lesser extent the NS rats, and was associated with attenuation of the corticosterone response to acute stress. CONCLUSIONS: In conclusion, EPA/DHA intervention alters the gut microbiota composition of both neurodevelopmentally normal and early-life stressed animals. This study offers insights into the interaction between n-3 PUFAs and gut microbes, which may play an important role in advancing our understanding of disorders of mood and cognitive functioning, such as anxiety and depression.

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Authors: Pusceddu, M. M., El Aidy, S., Crispie, F., O’Sullivan, O., Cotter, P., Stanton, C., Kelly, P., Cryan, J. F., & Dinan, T. G.
Affiliations: University College Cork (IE)
Teagasc - The Irish Agriculture and Food Development Authority (IE)
Corresponding author: Dinan, Timothy G.
ORCID: Pusceddu, Matteo M.
Crispie, Fiona
Cotter, Paul
Stanton, Catherine
Kelly, Philip
Cryan, John F.
Dinan, Timothy G.
Venue: PLOS ONE
Publisher: Public Library of Science (PLoS)
Published: 2015-10-01
Volume: 10
Issue: 10
Pages: e0139721
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0139721
PMC: PMC4591340
OpenAlex: W2152995125
Cited by: 214
References: 51
Citations by year: 2026: 2 · 2025: 10 · 2024: 18 · 2023: 14 · 2022: 17 · 2021: 19 · 2020: 26 · 2019: 30 · 2018: 31 · 2017: 27 · 2016: 19 · 2015: 1
FWCI: 25.06
Type: journal article
Language: en
Update notices: correction (2015-10-30)
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by)
Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
Funders: Pfizer
GlaxoSmithKline
Mead Johnson Nutrition
Food Institutional Research Measure
Science Foundation Ireland (07/CE/B1368 and 12/RC/2273, 12/RC/2273, 12/RC/, 12/IA/1537, 07/CE/B1368)
APC Microbiome Institute
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, early life stress, maternal separation, gut microbiota, dysbiosis, gut-brain axis, anxiety, depression, brain development, dietary supplementation
MeSH terms: Gastrointestinal Microbiome, Animals, Behavior, Animal, Female, Male, Maternal Deprivation, Neuropsychological Tests, Stress, Psychological, Fatty Acids, Omega-3, Rats, Sprague-Dawley, Rats

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N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota

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