An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery
Open accessAbstract
Bariatric surgery is currently one of the most effective treatments for obesity and leads to significant weight reduction, improved cardiovascular risk factors and overall survival in treated patients. To date, most studies focused on short-term effects of bariatric surgery on the metabolic profile and found high variation in the individual responses to surgery. The aim of this study was to identify relevant metabolic changes not only shortly after bariatric surgery (Roux-en-Y gastric bypass) but also up to one year after the intervention by using untargeted metabolomics. 132 serum samples taken from 44 patients before surgery, after hospital discharge (1-3 weeks after surgery) and at a 1-year follow-up during a prospective study (NCT01271062) performed at two study centers (Austria and Switzerland). The samples included 24 patients with type 2 diabetes at baseline, thereof 9 with diabetes remission after one year. The samples were analyzed by using liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS, HILIC-QExactive). Raw data was processed with XCMS and drift-corrected through quantile regression based on quality controls. 177 relevant metabolic features were selected through Random Forests and univariate testing and 36 metabolites were identified. Identified metabolites included trimethylamine-N-oxide, alanine, phenylalanine and indoxyl-sulfate which are known markers for cardiovascular risk. In addition we found a significant decrease in alanine after one year in the group of patients with diabetes remission relative to non-remission. Our analysis highlights the importance of assessing multiple points in time in subjects undergoing bariatric surgery to enable the identification of biomarkers for treatment response, cardiovascular benefit and diabetes remission. Key-findings include different trend pattern over time for various metabolites and demonstrated that short term changes should not necessarily be used to identify important long term effects of bariatric surgery.
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People after bariatric surgery show short- and long-term higher plasma TMAO levels.
“Some studies have demonstrated that people after bariatric surgery show short- and long-term higher plasma TMAO levels.”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [65]
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Bariatric surgery modulates circulating and cardiac metabolites.
Ashrafian, H., Li, J. V., Spagou, K., Harling, L., Masson, P., Darzi, A., Nicholson, J., Holmes, E., & Athanasiou, T. (2014) · Journal of Proteome Research · doi:10.1021/pr400748f · Cited by 51 · cited 3× · see citing works
“TMAO is derived from the gut bacterial metabolism of choline, it has been shown to be directly associated with cardiovascular outcome and was suggested as a potential metabolic link between gut microbiome and cardiovascular diseases [56,71,72].”
BackgroundResultSelective iteratively reweighted quantile regression for baseline correction
Liu, X., Zhang, Z., Sousa, P. F. M., Chen, C., Ouyang, M., Wei, Y., Liang, Y., Chen, Y., & Chaoping, Z. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7610-x · Cited by 34 · see citing works
Hanzu, F. A., Vinaixa, M., Papageorgiou, A. G., Párrizas, M., Correig, X., Delgado, S., Carmona, F., Samino, S., Vidal, J., & Gomis, R. (2013) · Obesity · doi:10.1002/oby.20541 · Cited by 34 · see citing works
Short-Term Changes of the Urine Metabolome After Bariatric Surgery
Friedrich, N., Budde, K., Wolf, T., Jungnickel, A., Grotevendt, A., Dreßler, M., Völzke, H., Blüher, M., Nauck, M. A., Lohmann, T., et al. (2012) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2012.0066 · Cited by 33 · cited 1× · see citing works
“Our results also showed an increasing trend in glycine levels which has previously been described as a short-term effect of bariatric surgery [35] and inversely related to type 2 diabetes [63,64].”
ResultMetabolic Effects of Bariatric Surgery in Insulin-Sensitive Morbidly Obese Subjects
Jiménez, A., Perea, V., Corcelles, R., Moize, V. L., Lacy, A. M., & Vidal, J. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0817-7 · Cited by 26 · cited 1× · see citing works
“Rapid metabolic improvements within the first few weeks after gastric bypass surgery have recently been described but are difficult to explain by the relatively small weight loss during this short period of time [15,16].”
BackgroundQuality of life after bariatric surgery
Dixon, J. B., & Blazeby, J. M. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70021-x · Cited by 21 · see citing works
Systems analysis and the prediction and prevention of Type 2 diabetes mellitus
Bergman, R. N., Stefanovski, D., & Kim, S. P. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.05.007 · Cited by 21 · see citing works
Goldfine, A. B., & Patti, M. (2014) · Diabetes · doi:10.2337/db13-1918 · Cited by 18 · see citing works
Diabetes - the Role of Metabolomics in the Discovery of New Mechanisms and Novel Biomarkers
Dunn, W. B. (2012) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-012-0282-9 · Cited by 10 · see citing works
Metabolomics Yield a Novel Biomarker for Predicting Diabetes Mellitus Risk in Humans
Arora, P. K. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000528 · Cited by 6 · cited 1× · see citing works
“study which showed an increase of PC38:6 in the first 42 days after bariatric surgery [68].”
Background
Flagged first, then by citations
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Janeiro, M., Ramírez, M., Milagro, F., Martínez, J., & Solas, M. (2018) · Nutrients · doi:10.3390/nu10101398 · Cited by 631 · see citing works
Major microbiota dysbiosis in severe obesity: fate after bariatric surgery
Aron-Wisnewsky, J., Prifti, E., Belda, E., Ichou, F., Kayser, B. D., Dao, M. C., Verger, E. O., Hedjazi, L., Bouillot, J.-L., Chevallier, J.-M., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316103 · Cited by 418 · see citing works
“57 Compared with lean individuals, glycine decreases in obesity.”
BackgroundMagouliotis, D. E., Tasiopoulou, V. S., Sioka, E., Chatedaki, C., & Zacharoulis, D. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2595-8 · Cited by 148 · see citing works
“TMAO, a metabolite known as cardiovascular marker [12], was elevated in postsurgery measurements, in both studies [32, 38] that evaluated it.”
BackgroundInfluentialLiang, D., Li, Z., Vlaanderen, J. J., Tang, Z., Jones, D. P., Vermeulen, R. C. H., & Sarnat, J. A. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11851 · Cited by 92 · see citing works
Inborn Errors of Metabolism in the Era of Untargeted Metabolomics and Lipidomics
Ismail, I. T., Showalter, M. R., & Fiehn, O. (2019) · Metabolites · doi:10.3390/metabo9100242 · Cited by 85 · see citing works
Heianza, Y., Sun, D., Smith, S. R., Bray, G. A., Sacks, F. M., & Qi, L. (2018) · Diabetes Care · doi:10.2337/dc17-2108 · Cited by 80 · see citing works
“findings, a few studies of morbidly obese patients showed that levels of choline (6,34) and L-carnitine (6) decreased after bariatric surgery along with weight loss and also that circulating Figure 1—Trajectories of changes in BW andWC according to initial changes (D) in TMAO (panels A and B), choline (panels C and D)…”
BackgroundOktaviono, Y. H., Lamara, A. D., Saputra, P. B. T., Arnindita, J. N., Pasahari, D., Saputra, M. E., & Suasti, N. M. A. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.8893 · Cited by 87 · see citing works
Regulation of body weight: Lessons learned from bariatric surgery
Albaugh, V. L., He, Y., Münzberg, H., Morrison, C. D., Yu, S., & Berthoud, H. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101517 · Cited by 77 · see citing works
“[88] Narath SH, Mautner SI, Svehlikova E, Schultes B, Pieber TR, Sinner FM, et al.”
BackgroundJuárez‐Fernández, M., Román-Sagüillo, S., Porras, D., García‐Mediavilla, M. V., Linares, P., Ballesteros-Pomar, M. D., Urioste-Fondo, A., Álvarez-Cuenllas, B., González‐Gallego, J., Sánchez‐Campos, S., et al. (2021) · Nutrients · doi:10.3390/nu13082519 · Cited by 71 · see citing works
“The reduction in BCAA levels as a consequence of bariatric surgery could be a normalization of the altered amino acid profile associated with obesity [49,52,53], which has been linked to an impairment of glucose homeostasis [48,49].”
BackgroundResultInfluentialKorsholm, A. S., Kjær, T. N., Ørnstrup, M. J., & Pedersen, S. B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030554 · Cited by 71 · see citing works
“Previously, metabolomics made it possible to determine changes in the human plasma metabolome caused by various conditions and diseases like sleep restriction [11,12], diabetes [13], and bariatric surgery [14].”
BackgroundChanges in gut microbiota composition after bariatric surgery: a new balance to decode
Palmisano, S., Campisciano, G., Silvestri, M., Guerra, M., Giuricin, M., Casagranda, B., Comar, M., & de Manzini, N. (2020) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-019-04321-x · Cited by 72 · see citing works
Day-Walsh, P. E., Shehata, E., Saha, S., Savva, G. M., Nemeckova, B., Speranza, J., Kellingray, L., Narbad, A., & Kroon, P. A. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02572-6 · Cited by 61 · see citing works
Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide
Loo, R. L., Chan, Q. M., Nicholson, J. K., & Holmes, E. C. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00851 · Cited by 60 · see citing works
Albóniga, O. E., González, O., Alonso, R. M., Yun Xu, A., & Goodacre, R. (2020) · Metabolomics · doi:10.1007/s11306-020-1636-9 · Cited by 59 · see citing works
Wijayatunga, N. N., Sams, V. G., Dawson, J., Mancini, M. L., Mancini, G. J., & Moustaïd‐Moussa, N. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3045 · Cited by 57 · see citing works
“However, some studies have reported reduction of serum alanine post bariatric surgery(10) and that reduction of alanine is greater with remission of diabetes.(45) However, data on remission of diabetes for the study participants are not available for the present study to comment on this aspect.”
Application of Metabolomics to Study Effects of Bariatric Surgery
Samczuk, P., Ciborowski, M., & Kretowski, A. J. (2018) · Journal of Diabetes Research · doi:10.1155/2018/6270875 · Cited by 55 · see citing works
“Among AA, the frequently modulated group was branched-chain amino acids (BCAA)—isoleucine [7, 25, 32, 33, 35, 36, 38, 40, 42, 45], leucine [7, 32, 34–36, 38, 40, 42], and valine [7, 25, 26, 32, 33, 35, 36, 38, 40, 42, 45].”
BackgroundInfluentialEyüpoğlu, D., Guzelce, E. C., Açıkgöz, A., Uyanık, E., Bjørndal, B., Berge, R. K., Svardal, A. M., & Yıldız, B. O. (2019) · Clinical Endocrinology · doi:10.1111/cen.14101 · Cited by 51 · see citing works
Geneviève, L. D., Martani, A., Mallet, M. C., Wangmo, T., & Elger, B. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226015 · Cited by 49 · see citing works
Metabolomic signatures after bariatric surgery – a systematic review
Vaz, M. E. D. L., Pereira, S. S., & Monteiro, M. P. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09695-5 · Cited by 49 · see citing works
“This is consistent with the increase of AAAs derived gut microbiota metabolites (p-cresol, indoxyl sulfate, phenol sulfate and 3-indolelactic acid) after bariatric surgery [17, 19, 20, 29, 32, 37].”
BackgroundMethodResultInfluentialIdentification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment
Hagemann, C. A., Zhang, C., Hansen, H. H., Jorsal, T., Rigbolt, K. T. G., Madsen, M. R., Bergmann, N. C., Heimbürger, S. M. N., Falkenhahn, M., Theis, S., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa803 · Cited by 44 · see citing works
Liu, R., Sun, M., Zhang, G., Lan, Y., & Yang, Z. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.09.065 · Cited by 42 · see citing works
“RF, ANN, and penalized LR have been applied to conventional untargeted metabolomic research, such as identification of detected metabolites through liquid chromatography-mass spectrometry (LC-MS) measurements,[41] prediction of chromatographic retention time,[42] and evaluation of metabolic changes.[43] In our study,…”
MethodA role for foregut tyrosine metabolism in glucose tolerance
Körner, J., Cline, G. W., Slifstein, M., Barba, P., Rayat, G. R., Febres, G., Leibel, R. L., Maffei, A., & Harris, P. E. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.02.008 · Cited by 41 · see citing works
Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?
Debédat, J., Amouyal, C., Aron‐Wisnewsky, J., & Clément, K. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00738-3 · Cited by 40 · see citing works
Dong, T. S., Gupta, A., Jacobs, J. P., Lagishetty, V., Gallagher, E., Bhatt, R. R., Vora, P. P., Osadchiy, V., Stains, J., Balioukova, A., et al. (2020) · Nutrients · doi:10.3390/nu12102924 · Cited by 40 · see citing works
Gutiérrez‐Repiso, C., Moreno‐Indias, I., & Tinahones, F. J. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09676-8 · Cited by 37 · see citing works
“After RYGB several studies showed an increase in TMAO levels [75, 84, 85], so long-term follow-up studies will shed light over TMAO levels as a useful cardiovascular risk marker after bariatric surgery.”
BackgroundPantelis, A. G. (2022) · Metabolites · doi:10.3390/metabo12050458 · Cited by 34 · see citing works
“(4) Associated medical problems (including T2DM): Existing evidence focuses on the metabolic aspects of metabolomics on patients who undergo BMS [22,29].”
BackgroundMethod“Gear mechanism” of bariatric interventions revealed by untargeted metabolomics
Samczuk, P., Łuba, M., Godzień, J., Mastrangelo, A., Hady, H. R., Dadan, J., Barbas, C., Górska, M., Kretowski, A. J., & Ciborowski, M. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.01.016 · Cited by 33 · see citing works
Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community
Shah, R. V., Hwang, S., Yeri, A., Tanrıverdi, K., Pico, A. R., Yao, C., Murthy, V. L., Ho, J. E., Vitseva, O. I., Demarco, D., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311928 · Cited by 32 · see citing works
Kokkinos, A. D., Tsilingiris, D., Simati, S., Stefanakis, K., Angelidi, A. M., Tentolouris, N., Anastasiou, I. A., Connelly, M. A., Alexandrou, A. P., & Mantzoros, C. S. (2024) · Metabolism · doi:10.1016/j.metabol.2023.155773 · Cited by 24 · see citing works
Abidi, W. M., Nestoridi, E., Feldman, H. A., Stefater, M. A., Clish, C. B., Thompson, C. C., & Stylopoulos, N. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05714-3 · Cited by 24 · see citing works
Pantelis, A. G., Stravodimos, G., & Lapatsanis, D. P. (2021) · Obesity Surgery · doi:10.1007/s11695-021-05548-x · Cited by 24 · see citing works
Jones, B. J., Sands, C. J., Αλεξιάδου, Κ., MINNION, J. S., Tharakan, G., Behary, P., Ahmed, A. R., Purkayastha, S., Lewis, M. R., Bloom, S. R., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab608 · Cited by 22 · see citing works
“Plasma trimethylamine-N-oxide (TMAO) was increased with RYGB and slightly decreased with VLCD (Figure 5A); this effect of RYGB has been described on other occasions (40,41).”
BackgroundBibliometric analysis of metabolic surgery for type 2 diabetes: current status and future prospects
Song, Y., & Zhao, F. (2022) · Updates in Surgery · doi:10.1007/s13304-021-01201-5 · Cited by 20 · see citing works
“Some studies shown that trimethylamine nitric oxide (TMAO) increases after RyGB both in animal and human [12, 13].”
BackgroundMetabolic liability for weight gain in early adulthood
Murthy, V. L., Mosley, J. D., Perry, A., Jacobs, D. R., Tanrıverdi, K., Zhao, S., Sawicki, K. T., Carnethon, M. R., Wilkins, J. T., Nayor, M. G., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101548 · Cited by 14 · see citing works
Bagheri, M., Tanrıverdi, K., Iafrati, M. D., Mosley, J. D., Freedman, J. E., & Ferguson, J. F. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155955 · Cited by 14 · see citing works
Lee, S. J., Park, Y. S., Kim, Y. J., Han, S., Hwang, G., Han, Y., Heo, Y., Ha, E., & Ha, T. K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215091 · Cited by 12 · see citing works
“Recent observational studies have reported TMAO levels to be elevated after bariatric surgery [13,14].”
BackgroundWang, M., Huang, Y., Xin, M., Li, T., Wang, X., Fang, Y., Liang, S., Cai, T., Xu, X., Dong, L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1156471 · Cited by 10 · see citing works
“KEYWORDS obesity, bariatric surgery, cancer, metabolites, anti-tumor immunity Abbreviations: SCFAs, Short-chain fatty acids; GLOBOCAN: Global Cancer Statistics; BMI, Body mass index; LCFAs, Long-chain fatty acids; TMAO, Trimethylamine N-oxide; TMA, Trimethylamine; FXRa, Farnisoid X receptor a; TGR5, Takeda G-protein-c…”
BackgroundInfluentialPrecision Medicine in Bariatric Procedures
Gala, K. S., Ghusn, W., & Acosta, A. J. (2024) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2024.03.004 · Cited by 9 · see citing works
State-of-the-art in LC–MS Approaches for Probing the Polar Metabolome
Lioupi, A., Marinaki, M., Virgiliou, C., Gika, H., Wilson, I. D., & Theodoridis, G. A. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839163524-00001 · Cited by 8 · see citing works
Wang, Z., Yang, H.-W., Zhao, C., Wei, J., Wang, J., Han, Z., Tao, J., Xu, Z., Ju, X., Tan, R., et al. (2017) · Medical Science Monitor · doi:10.12659/msm.905168 · Cited by 7 · see citing works
Hughes, A., Vangeenderhuysen, P., Graeve, M. D., Pomian, B., Nawrot, T. S., Raes, J., Cameron, S. J. S., & Vanhaecke, L. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c03124 · Cited by 6 · see citing works
Canyelles, M., Pérez, A., Junza, A., Miñambres, I., Yanes, Ó., Sardà, H., Rotllán, N., Julve, J., Benı́tez, S., Sánchez‐Quesada, J. L., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12112783 · Cited by 6 · see citing works
“This contrasts with the results of two previous prospective studies involving morbidly obese subjects undergoing bariatric surgery that showed higher circulating TMAO concentrations [24,25].”
ResultPerron, I. J., Keenan, B. T., Chellappa, K., Lahens, N. F., Yohn, N. L., Shockley, K. R., Pack, A. I., & Veasey, S. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196743 · Cited by 7 · see citing works
Patel, K., Levesque, K., Mark, V., Pierini, E., Rojas, B., Ahlers, M. J., Shah, A. M., & Laferrère, B. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12964 · Cited by 6 · see citing works
“However, GLP-1 may be only one of many mediators of glucose control after RYGB, because the infusion of the GLP-1 receptor inhibitor exendin (9-39) worsens postprandial glucose only minimally after RYGB.”
BackgroundMetabolomics as a Critical Tool for Studying Clinical Surgery
Gao, Z., Zhou, W., Lv, X., & Wang, X. (2023) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2022.2162810 · Cited by 5 · see citing works
“[34] In spite of the fact that sampling time points vary from one study to another, it is hard to specify the optimum sampling point, studies with different sampling points are all worthwhile.”
Mitra, A. T., Wing, O., Das, B., Gómez, N. B. G., Khwaja, H. A., Parmar, C. D., & Fehervari, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-20078-7 · Cited by 7 · see citing works
Schultes, B. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2757-8 · Cited by 4 · see citing works
Self-citationMechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
Mansor, F., & Hanipah, Z. N. (2022) · Metabolites · doi:10.3390/metabo12111134 · Cited by 4 · see citing works
Postoperative Metabolic Phenoreversion in Clear Cell Renal Cell Carcinoma
Manzi, M., Zabalegui, N., & Monge, M. E. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00293 · Cited by 4 · see citing works
Ryu, S., Hayashi, Y., Yagishita, S., Takahashi, A., Yokoi, A., Ohuchi, M., & Hamada, A. (2022) · Journal of Chromatography B · doi:10.1016/j.jchromb.2022.123366 · Cited by 3 · see citing works
Bariatric Surgery - Past and Present
Kanat, B. H., Kutluer, N., & Doğan, S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100966 · Cited by 2 · see citing works
Jamialahmadi, T., Simental‐Mendía, L. E., Zengin, G., Almahmeed, W. A., Kesharwani, P., & Sahebkar, A. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230523155750 · Cited by 2 · see citing works
Gut Microbiota in Obesity and Bariatric Surgery: Where Do We Stand?
Georgiou, K. E. (2021) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-59642-2_6 · Cited by 2 · see citing works
Bruno, J., Verano, M., Vanegas, S. M., Weinshel, E. H., Fielding, C. R., Lofton, H. F., Fielding, G., Schwack, B. F., Chua, D. L., Wang, C., et al. (2022) · Obesity Medicine · doi:10.1016/j.obmed.2022.100434 · Cited by 2 · see citing works
Current and Potential Applications of Artificial Intelligence in Metabolic Bariatric Surgery
Pantelis, A. G. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106365 · Cited by 2 · see citing works
Foula, M. S., Bamalan, O. A., Foula, A. S., Eldamati, A. M., Alratrout, H. A., AlQatari, A. A., Alsaleem, H., Aldabaeab, A. E., Foula, H. S., Zakaria, H. M., et al. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08908-7 · Cited by 1 · see citing works
OBSOLETE: Metabolomics in Cardiovascular Research
Salomaa, V. V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99571-0
Brandão, C. F. C. E. C. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2019.tde-10042019-092726
Metabolomics in Cardiovascular Research
Salomaa, V. V., & Inouye, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99571-1
Huang, Z., Liu, C., Zhao, X., & Guo, Y. H. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2489721
“…that TMAO levels increase after RYGB (Ashrafian et al., 2014; Gralka et al., 2015; Huang et al., 2021; Lee et al., 2021; Li et al., 2011, 2022; Narath et al., 2016; Shen & Ahlers, 2019; Shi et al., 2021; Tremaroli et al., 2015; Trøseid et al., 2016), but the trend of TMAO changes after SG is…”
Almazrouei, B., Mousa, M., Marzouka, N., Barajas-Gamboa, J. S., Abril, C. M., & AlSafar, H. S. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-02002-1
“Narath S. et al. [45] reported significant declines in sarcosine ( p = 0.031), pyroglutamic acid ( p = 0.044), alanine ( p = 0.005) and leucyl-proline ( p = 0.049) in patients with diabetes remission compared to those without remission after bariatric surgery.”
InfluentialRestaurer la fonction bêta pancréatique de la souris leptine déficiente par la chirurgie bariatrique
Amouyal, C. (2019) · theses.fr (ABES) · doi:10.70675/57e90c8dz951az4b06z95cdzc78f34db6015
Izzo, C., Martina, L., Rusciano, M. R., Trotta, A., Cristina, G., Visco, V., Carrizzo, A., Masarone, M., Persico, M., Pilone, V., et al. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03231-y
“Bariatric surgery has been shown to cause significant changes in metabolomic profiles, including decreases in branched-chain amino acids (BCAAs), trimethylamine-N-oxide (TMAO), phenylalanine, and other cardiotoxic metabolites linked to negative cardiovascular outcomes [16].”
InfluentialRemodeling of Oncogene-Related Molecular Networks Following Bariatric Surgery: a Multi-Omics Study
salhi, M., Al-Shahabi, S., Khatoon, S., Asif, A., Naeem, M., Chowdhury, M. E. H., Pedersen, S., Shahid, F., Khan, M. J., Shi, Z., et al. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08959-w
“Post-MBS bile acid profiles have been linked to changes in enterohepatic signaling through pathways including FXR and TGR5 [34–36], while metabolites such as TMAO, dimethyl sulfone, and p-cresol sulfate may reflect alterations in gut microbial metabolism [37].”
- Authors
- Narath, S. H., Mautner, S. I., Svehlikova, E., Schultes, B., Pieber, T. R., Sinner, F. M., Gander, E., Libiseller, G., Schimek, M. G., Sourij, H., & Magnes, C.
- Affiliations
- Joanneum Research (AT)
- eSwiss Medical and Surgical Center (CH)
- Medical University of Graz (AT)
- Corresponding author
- Narath, Sophie H.
- Mautner, Selma I.
- Schultes, Bernd
- Pieber, Thomas R.
- Sinner, Frank M.
- Gander, Edgar
- Libiseller, Gunnar
- Schimek, Michael G.
- Sourij, Harald
- Magnes, Christoph
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-09-01
- Volume
- 11
- Issue
- 9
- Pages
- e0161425
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5008721
- OpenAlex
- W2513217409
- Cited by
- 65
- References
- 83
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 3 · 2019: 12 · 2018: 8 · 2017: 6
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- This work was supported financially by the Austrian Federal Ministry for Transport, Innovation and Technology (bmvit), Project Met2Net, EFSD/MSD Clinical Research Programme 2009
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bariatric surgery, Roux-en-Y gastric bypass, obesity, type 2 diabetes remission, serum metabolomics, untargeted metabolomics, trimethylamine N-oxide, indoxyl sulfate, alanine, phenylalanine, cardiovascular risk markers, treatment response biomarkers, longitudinal metabolic changes
- MeSH terms
- Adult, Austria, Chromatography, High Pressure Liquid, Female, Humans, Male, Middle Aged, Mass Spectrometry, Switzerland, Gastric Bypass, Bariatric Surgery, Metabolomics
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