Cited by 1,080Diet, Metabolism, and DiseaseMetabolomics and Mass Spectrometry StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Interplay between lipids and branched-chain amino acids in development of insulin resistance

Open access
Newgard, Christopher B.·2012·Cell Metabolism

Abstract

Fatty acids (FA) and FA-derived metabolites have long been implicated in the development of insulin resistance and type 2 diabetes. Surprisingly, application of metabolomics technologies has revealed that branched-chain amino acids (BCAA) and related metabolites are more strongly associated with insulin resistance than many common lipid species. Moreover, the BCAA-related signature is predictive of incident diabetes and intervention outcomes and uniquely responsive to therapeutic interventions. Nevertheless, in animal feeding studies, BCAA supplementation requires the background of a high-fat diet to promote insulin resistance. This Perspective develops a model to explain how lipids and BCAA may synergize to promote metabolic diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2012.01.024

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Chronic elevations in incomplete oxidation of fatty acids and branched chain amino acids might foster a mitochondrial microenvironment conducive to ROS production.

    “Thus, chronic elevations in incomplete oxidation of fatty acids and branched chain amino acids (Newgard, 2012) might foster a mitochondrial microenvironment that is conducive to ROS production.”

    From Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle (2012) · cites this paper as Newgard, 2012

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 58 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Newgard, C. B.
Affiliations
Duke University (US)
Corresponding author
Newgard, Christopher B.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2012-05
Volume
15
Issue
5
Pages
606-614
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2079195246
Cited by
1,080
References
58
Citations by year
2026: 54 · 2025: 72 · 2024: 66 · 2023: 80 · 2022: 106 · 2021: 116 · 2020: 86 · 2019: 82 · 2018: 83 · 2017: 71 · 2016: 89 · 2015: 48 · 2014: 69 · 2013: 46 · 2012: 12
FWCI
7.55
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Pfizer
  • GlaxoSmithKline
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (P01DK058398)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
branched-chain amino acids, insulin resistance, type 2 diabetes, fatty acids, lipid metabolism, high-fat diet, BCAA supplementation, metabolomics, metabolic disorders, predictive biomarkers
MeSH terms
Amino Acids, Branched-Chain, Animals, Humans, Insulin Resistance, Metabolic Diseases, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review