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Cited by 264

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production

Open access
Johnson, Ashley R., Caudill, Cassie L., Tumbleston, John R., Bloomquist, Cameron J., Moga, Katherine A., Ermoshkin, Alexander, Shirvanyants, David, Mecham, Sue J., Luft, J. Christopher, DeSimone, Joseph M.·2016·PLOS ONE
DOI 10.1371/journal.pone.0162518
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Abstract

Microneedles, arrays of micron-sized needles that painlessly puncture the skin, enable transdermal delivery of medications that are difficult to deliver using more traditional routes. Many important design parameters, such as microneedle size, shape, spacing, and composition, are known to influence efficacy, but are notoriously difficult to alter due to the complex nature of microfabrication techniques. Herein, we utilize a novel additive manufacturing ("3D printing") technique called Continuous Liquid Interface Production (CLIP) to rapidly prototype sharp microneedles with tuneable geometries (size, shape, aspect ratio, spacing). This technology allows for mold-independent, one-step manufacturing of microneedle arrays of virtually any design in less than 10 minutes per patch. Square pyramidal CLIP microneedles composed of trimethylolpropane triacrylate, polyacrylic acid and photopolymerizable derivatives of polyethylene glycol and polycaprolactone were fabricated to demonstrate the range of materials that can be utilized within this platform for encapsulating and controlling the release of therapeutics. These CLIP microneedles effectively pierced murine skin ex vivo and released the fluorescent drug surrogate rhodamine.

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Crossref · 10.1371/journal.pone.0162518

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Metadata

Authors
Johnson, A. R., Caudill, C. L., Tumbleston, J. R., Bloomquist, C. J., Moga, K. A., Ermoshkin, A., Shirvanyants, D., Mecham, S. J., Luft, J. C., & DeSimone, J. M.
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2016-09-08
Volume
11
Issue
9
Pages
e0162518
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0162518
OpenAlex
W2513825140
Cited by
264
References
34
FWCI
6.35
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production. https://app.cochat.ai/papers/10.1371/journal.pone.0162518
The paper
Johnson, A. R., Caudill, C. L., Tumbleston, J. R., Bloomquist, C. J., Moga, K. A., Ermoshkin, A., Shirvanyants, D., Mecham, S. J., Luft, J. C., & DeSimone, J. M. (2016). Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production. PLOS ONE. https://doi.org/10.1371/journal.pone.0162518

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.