Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models
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BACKGROUND AND PURPOSE: Chronic alcohol intake associated with an inappropriate diet can cause lesions in multiple organs and tissues and complicate the tissue repair process. In a systematic review, we analyzed the relevance of alcohol and high fat consumption to cutaneous and repair, compared the main methodologies used and the most important parameters tested. Preclinical investigations with murine models were assessed to analyze whether the current evidence support clinical trials. METHODS: The studies were selected from MEDLINE/PubMed and Scopus databases, according to Fig 1. All 15 identified articles had their data extracted. The reporting bias was investigated according to the ARRIVE (Animal Research: Reporting of in Vivo Experiments) strategy. RESULTS: In general, animals offered a high-fat diet and alcohol showed decreased cutaneous wound closure, delayed skin contraction, chronic inflammation and incomplete re-epithelialization. CONCLUSION: In further studies, standardized experimental design is needed to establish comparable study groups and advance the overall knowledge background, facilitating data translatability from animal models to human clinical conditions.
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High-fat diets delay healing of the skin by promoting skin oxidative stress and inflammatory responses, reducing protein synthesis, and may also cause morphological changes in skin and damage to matrix remodeling.
“High-fat diets delay healing of the skin by promoting skin oxidative stress and inflammatory responses, reducing protein synthesis, and may also cause morphological changes in skin and damage to matrix remodeling [87,88].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [88]
The effect of a high-fat diet is mainly to cause aging of the skin by causing skin oxidative stress to produce inflammatory damage.
“In general, the effect of a high-fat diet is mainly to cause aging of the skin by causing skin oxidative stress to produce inflammatory damage.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [88]
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- Authors
- Rosa, D. F., Sarandy, M. M., Novaes, R. D., da Matta, S. L. P., & Gonçalves, R. V.
- Affiliations
- Universidade Federal de Viçosa (BR)
- Universidade Federal de Alfenas (BR)
- Corresponding author
- Gonçalves, Reggiani Vilela
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-05-11
- Volume
- 12
- Issue
- 5
- Pages
- e0176240
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5426595
- OpenAlex
- W2614005909
- Cited by
- 19
- References
- 67
- Citations by year
- 2025: 7 · 2024: 5 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 1
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Keywords
- high-fat diet, alcohol, skin wound healing, skin repair, re-epithelialization, skin contraction, chronic inflammation, mouse model, translational research
- MeSH terms
- Administration, Cutaneous, Ethanol, Animals, Humans, Skin, Wound Healing, Models, Animal, Mice, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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