The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Regulation of gut luminal serotonin by commensal microbiota in mice
Open accessAbstract
Gut lumen serotonin (5-hydroxytryptamine: 5-HT) contributes to several gastrointestinal functions such as peristaltic reflexes. 5-HT is released from enterochromaffin (EC) cells in response to a number of stimuli, including signals from the gut microbiota. However, the specific mechanism by which the gut microbiota regulates 5-HT levels in the gut lumen has not yet been clarified. Our previous work with gnotobiotic mice showed that free catecholamines can be produced by the deconjugation of conjugated catecholamines; hence, we speculated that deconjugation by bacterial enzymes may be one of the mechanisms whereby gut microbes can produce free 5-HT in the gut lumen. In this study, we tested this hypothesis using germ-free (GF) mice and gnotobiotic mice recolonized with specific pathogen-free (SPF) fecal flora (EX-GF). The 5-HT levels in the lumens of the cecum and colon were significantly lower in the GF mice than in the EX-GF mice. Moreover, these levels were rapidly increased, within only 3 days after exposure to SPF microbiota. The majority of 5-HT was in an unconjugated, free form in the EX-GF mice, whereas approximately 50% of the 5-HT was found in the conjugated form in the GF mice. These results further support the current view that the gut microbiota plays a crucial role in promoting the production of biologically active, free 5-HT. The deconjugation of glucuronide-conjugated 5-HT by bacterial enzymes is likely one of the mechanisms contributing to free 5-HT production in the gut lumen.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“gut bacteria were shown to deconjugate host-produced catecholamines via the β-glucuronidase enzyme pathway, and thus generate free luminal 5-HT (Asano et al., 2012;Hata et al., 2017).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Hata et al., 2017
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Likewise, 5-HT concentrations in the cecal and colonic lumens are significantly reduced in GF mice (Hata et al., 2017).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Hata et al., 2017
The cited source says what the claim attributes to it.
In the citing paper
“Moreover, in the same study, the conjugated, biologically inactive form of 5-HT was found at a higher percentage in GF mice, whereas the unconjugated, biologically-active form of 5-HT was found in greater concentration in conventionalized GF mice.”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Hata et al., 2017
The cited source says what the claim attributes to it.
In the citing paper
“the gut microbiota are understood to impact the host GI serotonergic system (Hata et al., 2017;O'Mahony et al., 2015).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Hata et al., 2017
The cited source says what the claim attributes to it.
In the citing paper
“The conventionalization of GF mice with a microbiota resulted in increased concentrations of intestinal luminal 5-HT.”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Hata et al., 2017
In the citing paper
“In a rodent study, it was found that mice without an enteric microbiome had only half the amount of serotonin in the circulation when compared to mice with normal gut microbiota [48].”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735
Self-citationMetabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611
Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria
Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342
Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335
Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C., & Koga, Y. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1739 · Cited by 1,070
Self-citationCoates, M. D., Mahoney, C. R., Linden, D. R., Sampson, J. E., Chen, J. C., Blaszyk, H., Crowell, M. D., Sharkey, K. A., Gershon, M. D., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.013 · Cited by 761
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 212
Zhang, X., Yoshihara, K., Miyata, N., Hata, T., Altaisaikhan, A., Takakura, S., Asano, Y., Izuno, S., & Sudo, N. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113653 · Cited by 28
Self-citationWong, O. W. H., Lam, A. M. W., Or, B. P. N., Mo, F. Y. M., Shea, C. K., Lai, K. Y. C., Ma, S. L., Hung, S. F., Chan, S. S. M., Kwong, T. N. Y., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-14785-8 · Cited by 28
Kimmel, M., Verosky, B. G., Chen, H. J., Davis, O., & Gur, T. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.11.014 · Cited by 30
Lyte, J. M., Keane, J., Eckenberger, J., Anthony, N. B., Shrestha, S., Marasini, D., Daniels, K. M., Caputi, V., Donoghue, A. M., & Lyte, M. (2021) · Microbiome · doi:10.1186/s40168-020-00962-2 · Cited by 26
Lyte, J. M., Eckenberger, J., Keane, J., Robinson, K., Bacon, T., Assumpcao, A. L. F. V., Donoghue, A. M., Liyanage, R., Daniels, K. M., Caputi, V., et al. (2024) · Poultry Science · doi:10.1016/j.psj.2023.103393 · Cited by 26
Fung, C., Cools, B., Malagola, S., Martens, T., Tack, J. F., Kazwiny, Y., & Berghe, P. V. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14186 · Cited by 25
The Gut Microbiota–Brain Axis Expands Neurologic Function: A Nervous Rapport
Bauer, K. C., Rees, T., & Finlay, B. B. (2019) · BioEssays · doi:10.1002/bies.201800268 · Cited by 26
Chan, D. G., Ventura, K., Villeneuve, A., Du Bois, P., & Holahan, M. R. (2022) · Journal of Parkinson's Disease · doi:10.3233/jpd-223461 · Cited by 24
Cho, S., Samuel, T. M., Li, T., Howell, B., Baluyot, K., Hazlett, H. C., Elison, J. T., Hongtu Zhu, B., Hauser, J., Sprenger, N., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1216327 · Cited by 24
Serotoninergic system targeting in multiple sclerosis: the prospective for pathogenetic therapy.
Melnikov, M., Sviridova, A., Rogovskii, V., Oleskin, A. V., Boziki, M. K., Bakirtzis, C., Kesidou, E., Grigoriadis, N., & Boyко, A. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102888 · Cited by 24
Yuan, M., Zhang, Z., Liu, T., Hua, F., Liu, Y., & Chen, K. (2024) · Foods · doi:10.3390/foods13132157 · Cited by 23
Decoding the Role of Gut-Microbiome in the Food Addiction Paradigm
Novelle, M. G. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18136825 · Cited by 24
The potential influence of microplastics on the microbiome and disease susceptibility in sea turtles
Iurk, V. B., Ingles, M., Correa, G. S., Silva, C. R., Staichak, G., Pileggi, S. A. V., Christo, S. W., Domit, C., & Pileggi, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174298 · Cited by 21
Saito, H., Nakakita, Y., Segawa, S., & Tsuchiya, Y. (2019) · Beneficial Microbes · doi:10.3920/bm2018.0091 · Cited by 21
Engevik, M., Ruan, W., Visuthranukul, C., Shi, Z., Engevik, K. A., Engevik, A. C., Fultz, R., Schady, D. A., Spinler, J. K., & Versalovic, J. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0216 · Cited by 20
Roussin, L., Gry, E., Macaron, M., Ribes, S., Monnoye, M., Douard, V., Naudon, L., & Rabot, S. (2024) · The FASEB Journal · doi:10.1096/fj.202400334r · Cited by 20
The Gut-Brain Axis and Its Role in Depression
Nanthakumaran, S., Sridharan, S., Somagutta, M. K. R., Arnold, A. A., May, V., Pagad, S., & Malik, B. H. (2020) · Cureus · doi:10.7759/cureus.10280 · Cited by 20
Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options
Huang, W., Zhu, L., Song, W., Zhang, M., Teng, L., & Wu, M. (2022) · Mediators of Inflammation · doi:10.1155/2022/6508046 · Cited by 18
Mental Disorders Linked to Crosstalk between The Gut Microbiome and The Brain
Choi, T.-Y., Choi, Y. P., & Koo, J. W. (2020) · Experimental Neurobiology · doi:10.5607/en20047 · Cited by 18
Alam, K., Nair, L. S., Mukherjee, S., Kaur, K., Singh, M., Kaity, S., Ravichandiran, V., Banerjee, S., & Roy, S. (2024) · Bio-Design and Manufacturing · doi:10.1007/s42242-024-00282-6 · Cited by 16
Lyte, J. M., Koester, L. R., Daniels, K. M., & Lyte, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.827343 · Cited by 16
Liikonen, V., Gómez-Gallego, C., & Kolehmainen, M. (2023) · Proceedings of The Nutrition Society · doi:10.1017/s0029665123003671 · Cited by 15
Commensal human gut microbes produce species specific neuroactive compounds
Tingler, A. M., Packirisamy, C., Gutierrez, A., Horvath, A. E., Grozis, M., Haidacher, S. J., Hoch, K. M., Haag, A. M., Oezguen, N., Engevik, K. A., et al. (2025) · iScience · doi:10.1016/j.isci.2025.114424 · Cited by 14
Li, Y., He, J., Zhang, L., Liu, H., Cao, M., Lin, Y., Xu, S., Che, L., Fang, Z., Feng, B., et al. (2024) · Animal Microbiome · doi:10.1186/s42523-024-00323-6 · Cited by 14
Hromádková, J., Suzuki, Y., Pletts, S., Pyo, J., Ma, T., Chen, Y., Steele, M. A., & Guan, L. L. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17710 · Cited by 14
Shokrollahi, M., Chen, J., & Huizinga, J. D. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13598 · Cited by 14
Measuring Microbiome Effectiveness: A Role for Ingestible Sensors
Smith, D. G., & Jheeta, S. (2020) · Gastrointestinal Disorders · doi:10.3390/gidisord2010002 · Cited by 14
Yuan, F., Harder, J. W., Ma, J., Yin, X., Zhang, X., & Kosiewicz, M. M. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00558 · Cited by 14
Self-citationNazir, M. M., Ghaffar, W., Mustafa, G., Saeed, S., Ijaz, M. U., & Ashraf, A. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04464-6 · Cited by 14
Gut microbiota is an endocrine organ
Demidova, T. Y., Геннадьевна, Л. К., & Oynotkinova, O. S. (2020) · Obesity and metabolism · doi:10.14341/omet12457 · Cited by 13
Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation
Wu, J., Xu, X., Zhang, S., Li, M., Qiu, Y., Lu, G., Zheng, Z., & Huang, H. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04208-2 · Cited by 12
Renesteen, E., Boyajian, J. L., Islam, P., Kassab, A., Abosalha, A. K., Makhlouf, S., Santos, M., Chen, H., Shum-Tim, C., & Prakash, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115351 · Cited by 11
Xu, J., Song, J. M., Xu, H., Li, Z., Ding, M., Qiao, D., Zhang, B., & Li, B. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124229 · Cited by 11
Yaghoubfar, R., Banadkoki, E. Z., Ashrafian, F., Shahryari, A., Kariman, A., Davari, M., Fateh, A., Khatami, S., & Siadat, S. D. (2023) · Anaerobe · doi:10.1016/j.anaerobe.2023.102786 · Cited by 11
Császár-Nagy, N., Bob, P., & Bókkon, I. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2105148 · Cited by 10
Posttraumatic Stress Disorder and the Gut Microbiome
Loupy, K. M., & Lowry, C. A. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.10 · Cited by 10
Tryptophan Metabolism in Obesity: Pathways, Mechanisms, and Therapeutic Perspectives
Shimi, G. (2025) · Current Medical Science · doi:10.1007/s11596-025-00136-x · Cited by 9
Multi-omic analysis of host-microbial interactions central to the gut-brain axis
Simpson, J. B., & Redinbo, M. R. (2022) · Molecular Omics · doi:10.1039/d2mo00205a · Cited by 9
Tough, I. R., Lund, M. L., Patel, B. A., Schwartz, T. W., & Cox, H. M. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14589 · Cited by 9
Lynch, C. M. K., Nagpal, J. K., Luczynski, P., Neufeld, K. M., Dinan, T. G., Clarke, G. A., & Cryan, J. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00012-6 · Cited by 9
Schmid, S. M., & Tolbert, M. K. (2024) · Veterinary Record · doi:10.1002/vetr.4915 · Cited by 9
Microbiome: A Key Regulator of Body-Brain Interactions
O’Riordan, K. J., Aburto, M. R., Nagpal, J. K., Clarke, G. A., & Cryan, J. F. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_6 · Cited by 9
Cauli, O., Guevara-González, J., Guevara-Campos, J., & González, L. (2021) · Current Clinical Pharmacology · doi:10.2174/2772432816666210805141257 · Cited by 9
Yi, S., Liu, X., Huo, Y., Li, X., Tang, Y., & Li, J. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12520 · Cited by 8
Chojnacki, C. J., Gąsiorowska, A., Popławski, T., Błońska, A., Konrad, P., Zajdler, R., Chojnacki, J., & Błasiak, J. (2023) · Nutrients · doi:10.3390/nu15071674 · Cited by 8
Omic methodologies for assessing metal(-loid)s-host-microbiota interplay: A review
Ramírez‐Acosta, S., Arias‐Borrego, A., Navarro, F., Selma‐Royo, M., Calatayud, M., Collado, M. C., Huertas-Abril, P. V., Abril, N., & García‐Barrera, T. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.338620 · Cited by 8
Tian, C., Yang, M., Chen, K., Luo, D., Yue, N.-N., Zhao, H., Zhang, Y., Lu, J., Liang, Y.-J., Song, Y., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s514838 · Cited by 7
Chojnacki, J., Popławski, T., Kaczka, A., Romanowska, N., Chojnacki, C. J., & Gąsiorowska, A. (2024) · Nutrients · doi:10.3390/nu16172981 · Cited by 7
Meng, Y., Feng, Y., Hang, L., Zhou, Y., Wang, E., & Yuan, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.995567 · Cited by 7
Microbiome and Schizophrenia: Current Evidence and Future Challenges
Cordeiro, T. M. E., Zhang, X., Graubics, K., Colwell, R. R., & Teixeira, A. L. (2020) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-020-00206-5 · Cited by 7
Self-citationTryptophan Metabolism and the Microbiome-Gut-Brain Axis
Clarke, G. A., Villalobos-Manríquez, F., & Marin, D. C. (2021) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.13 · Cited by 7
Zheng, R., Huang, S., Feng, P., Liu, S., Jiang, M., Li, H., Zheng, P., Mi, Y., & Li, E. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1557174 · Cited by 6
Suntornsaratoon, P., Ferraris, R. P., Ambat, J., Antonio, J. M., Flores, J., Jones, A., Su, X., Gao, N., & Li, W. V. (2024) · Laboratory Investigation · doi:10.1016/j.labinv.2024.100330 · Cited by 6
Usefulness of the hydrogen breath test in patients with functional dyspepsia
Chojnacki, C. J., Konrad, P., Błońska, A., Chojnacki, J., & Mędrek-Socha, M. (2020) · Gastroenterology Review · doi:10.5114/pg.2020.92690 · Cited by 6
Chiocchetti, R., Galiazzo, G., Giancola, F., Tagliavia, C., Bernardini, C., Forni, M., & Pietra, M. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.802479 · Cited by 6
Exercise as a modulator of gut microbiota for improvement of sleep quality: a narrative review
Zhao, B., Sun, J., Xiang, L., & Su, Z. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1639099 · Cited by 6
Serotonin and the gut microbiome: Pathways, functions, and health implications
Abubaker, S., Miri, S., & Hammami, R. (2026) · The Microbe · doi:10.1016/j.microb.2026.100668 · Cited by 6
Guimarães, G. M., Costa, K., Moura, C. D. S. S., Moreira, S. E. D., Marchiori, J. M., dos Santos, A. C., Batista, R. R. A., Queiroz‐Junior, C. M., Raposo, J. D. A., Braga, F. C., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10413-1 · Cited by 5
Interaction Between Intestinal Serotonin and The Gut Microbiome
Liu, H. (2021) · International Journal of Anatomy & Applied Physiology · doi:10.19070/2572-7451-2100036 · Cited by 5
Gut microbiota and metabolome in sporadic Creutzfeldt–Jakob disease
Kong, Y., Chen, Z., Feng, X., Zuo, Y., & Zhang, J. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11961-2 · Cited by 5
Dong, J., Al‐Issa, M., Feeney, J. S., Shelp, G. V., Poole, E. M., & Cho, C. E. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70044 · Cited by 4
Modulatory activity of N-palmitoyl-D-glucosamine in bridging gut dysbiosis and pain mechanisms
Ricciardi, F., Morace, A. M., Fusco, A., Perrone, M., Limongelli, R., Lucà, S., Montella, M., Pane, K., Franzese, M., Luongo, L., et al. (2025) · Pain · doi:10.1097/j.pain.0000000000003759 · Cited by 4
Microbial dysbiosis alters serotonin signaling in a postinflammatory murine model of visceral pain
Roth, T. D., Russo-Savage, L., Habibyan, Y. B., Keenan, C. M., Wallace, L. E., Nasser, Y., Mawe, G. M., Lavoie, B. A., & Sharkey, K. A. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00240.2025 · Cited by 4
Alterations in Peripheral Metabolites as Key Actors in Alzheimer’s Disease
Sheng, C., Chu, X., He, Y., Ding, Q., Jia, S., Shi, Q.-G., Sun, R., Li, S., Du, W., Liang, Y., et al. (2023) · Current Alzheimer Research · doi:10.2174/1567205020666230825091147 · Cited by 4
Altaisaikhan, A., Yoshihara, K., Hata, T., Miyata, N., Asano, Y., Suematsu, T., Kadota, Y., & Sudo, N. (2023) · Physiological Reports · doi:10.14814/phy2.15882 · Cited by 3
Self-citationKönig, E., Heponiemi, P., Kivinen, S., Räkköläinen, J., Beasley, S. S., Borman, T., Collado, M. C., Hukkinen, V., Junnila, J. J. T., Lahti, L., et al. (2024) · Scientific Reports · doi:10.1038/s41598-023-50791-0 · Cited by 4
The Function of Tryptophan Metabolism in the Gut
Tang, X., Wan, L., Gao, J., Jiang, Q., Hu, S., Xiao, H., Wang, J., Qi, M., Wang, L., Huang, L., et al. (2024) · Springer eBooks · doi:10.1007/978-981-97-4719-1_2 · Cited by 3
Rolle des Mikrobioms und der Darm-Gehirn-Interaktion bei Anorexia nervosa
Trinh, S., Herpertz‐Dahlmann, B., & Seitz, J. (2020) · Nervenheilkunde · doi:10.1055/a-1037-2119 · Cited by 3
The role for the microbiome in the regulation of the circadian clock and metabolism
Anderson, S. T., & Paschos, G. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816843-1.00015-1 · Cited by 3
Role of the gut microbiome in the pathophysiology of brain disorders
Mayer, E. A., Horn, J. V., Mayer, E. D., & Chen, S. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00058-7 · Cited by 2
Puetz, L., Delmont, T. O., Mitchell, A., Finn, R. D., Zhang, G., Shepeleva, D. V., Kharlamova, A. V., Kukekova, A. V., Trut, L. N., & Gilbert, M. T. P. (2026) · Communications Biology · doi:10.1038/s42003-026-09717-5 · Cited by 2
The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A Review
Michire, A., Anghel, R. M., Draghia, P. M., Burlacu, M. G., Georgescu, T. F., Georgescu, D. E., Balcangiu‐Stroescu, A.-E., Văcăroiu, I. A., Barbu, M. A., & Gaube, A. (2022) · Gastrointestinal Disorders · doi:10.3390/gidisord4020008 · Cited by 2
Hernández-Barrueta, T. (2022) · Wiley eBooks · doi:10.1002/9781119804055.ch2 · Cited by 2
Yang, Q., Deng, Z., Pan, G., Shi, C., Li, J., Zhou, L., Yang, X., Zhuang, G., Liu, B., Song, J., et al. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-025-07729-3 · Cited by 1
Gut microbiota and neurotransmitter network underlies EHDPP-induced neurotoxicity in zebrafish
Yan, J., Zhang, Y., Anyu, N., Zukang, Y., Liu, Z., Zhang, S., Di, S., Meng, Z., Qian, Q., Wang, Z., et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.143682 · Cited by 1
Influence of gut microbial flora in body’s serotonin turnover and associated diseases
Choudhuri, S., Panda, J., & Maitra, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822238-6.00030-3 · Cited by 1
Optical Approaches to Understanding Enteric Circuits Along the Radial Axis
Berghe, P. V., & Fung, C. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-05843-1_7 · Cited by 1
Tracing the Evolutionary Origin of the Gut–Brain Axis
Bosch, T. C. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-95954-2_4 · Cited by 1
Novel Therapy of the Carcinoid Syndrome Related Diarrhea
Oțelea, M. R. (2018) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2018.07.001517 · Cited by 1
Frontiers in Neuroscience Imaging
Thaker, A. A., Chien, A. L., & Dubroff, J. G. (2020) · PET Clinics · doi:10.1016/j.cpet.2020.09.014 · Cited by 1
Pratt, J., Hromádková, J., Malmuthuge, N., & Guan, L. L. (2022) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-90303-9_15 · Cited by 1
Smith, D. A., Jheeta, S., Fuentes, H. V., Street, B., & Palacios-Pérez, M. (2022) · Gastrointestinal Disorders · doi:10.3390/gidisord4040028 · Cited by 1
Hromádková, J. (2018) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3h98zw0w · Cited by 1
van der Eijk, J. A. J. (2019) · doi:10.18174/502550 · Cited by 1
Trace aminergic regulation of gastrointestinal inflammation
Gwilt, K. B. (2019) · Digital Repository Service (Northeastern University) · doi:10.17760/d20317947 · Cited by 1
Bester, A., Mileva, K. N., & Gaoua, N. (2026) · Preprints.org · doi:10.20944/preprints202601.0406.v1 · Cited by 1
Serotonin, its Dietary Sources and Relationship of Irritabl Bowel Syndrome
ÖZTEKİN, Y., & Güneş, F. E. (2018) · Turkiye Klinikleri Journal of Internal Medicine · doi:10.5336/intermed.2018-61953
Ipnosi e medicina psicosomatica: responsività del cervello intestinale all'ipnoterapia
Grillo, A., & Piro, A. (2019) · IPNOSI · doi:10.3280/ipn2019-001002
Interaction between Intestinal Microbiota and Serotonin Metabolism
Yaghobfar, R., Vaziri, F., Nojomi, S. A., Fateh, A., Khatami, S., & Siadat, S. D. (2021) · DOAJ (DOAJ: Directory of Open Access Journals)
Gut microbiota plays a role in irritable bowel syndrome by regulating 5-HT metabolism
Feng, Y., Hang, L., Zhou, Y., Jiang, F.-R., & Yuan, J. (2022) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v30.i21.941
Electrochemistry meets mass spectrometry
Sanz, J. A. (2022) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.256856845
Liu, X., & Wu, S. (2023) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v31.i22.922
Future prospective of microbiome-gut brain axis for treatment of CNS disorders
Mane, R., Kashid, S., Mazahir, F., & Yadav, A. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21680-0.00019-5
Glazar, M., & Facchin, S. (2025) · Academia Nutrition and Dietetics · doi:10.20935/acadnutr7951
Lyte, J. M., Keane, J., Eckenberger, J., Anthony, N. B., Shrestha, S., Marasini, D., Daniels, K. M., Caputi, V., Donoghue, A. M., & Lyte, M. (2021) · Figshare · doi:10.6084/m9.figshare.14432462
Lyte, J. M., Keane, J., Eckenberger, J., Anthony, N. B., Shrestha, S., Marasini, D., Daniels, K. M., Caputi, V., Donoghue, A. M., & Lyte, M. (2021) · Figshare · doi:10.6084/m9.figshare.14432480
Additional file 5 of Regulation of serotonin production by specific microbes from piglet gut
Liu, Z., Ling, Y., Peng, Y., Han, S., Ren, Y., Jing, Y., Fan, W., Su, Y., Mu, C., & Zhu, W. (2024) · Figshare · doi:10.6084/m9.figshare.26608227
Additional file 2 of Regulation of serotonin production by specific microbes from piglet gut
Liu, Z., Ling, Y., Peng, Y., Han, S., Ren, Y., Jing, Y., Fan, W., Su, Y., Mu, C., & Zhu, W. (2024) · Figshare · doi:10.6084/m9.figshare.26608218
Lyte, J. M., Keane, J., Eckenberger, J., Anthony, N. B., Shrestha, S., Marasini, D., Daniels, K. M., Caputi, V., Donoghue, A. M., & Lyte, M. (2021) · Figshare · doi:10.6084/m9.figshare.14432516
Metadata
- Authors
- Hata, T., Asano, Y., Yoshihara, K., Kimura-Todani, T., Miyata, N., Zhang, X.-T., Takakura, S., Aiba, Y., Koga, Y., & Sudo, N.
- Affiliations
- Kyushu University (JP)
- Tokai University (JP)
- Corresponding author
- Sudo, Nobuyuki
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-07-06
- Volume
- 12
- Issue
- 7
- Pages
- e0180745
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5500371
- OpenAlex
- W2725296099
- Cited by
- 211
- References
- 39
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 26 · 2023: 22 · 2022: 30 · 2021: 35 · 2020: 33 · 2019: 30 · 2018: 9 · 2017: 2
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kyushu University Institutional Repository (QIR) (Kyushu University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (16H05278, 16K15413)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- commensal microbiota, enterochromaffin cells, serotonin, glucuronidation, bacterial enzymes, gnotobiotic mice, germ-free mice, fecal microbiota transplantation, gut-brain axis, peristalsis
- MeSH terms
- Animals, Chromatography, High Pressure Liquid, Germ-Free Life, Intestinal Mucosa, Intestines, Mice, Inbred BALB C, Serotonin, Reverse Transcriptase Polymerase Chain Reaction, Mice, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
