Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice
Open accessAbstract
There is increasing interest in the bidirectional communication between the mammalian host and prokaryotic cells. Catecholamines (CA), candidate molecules for such communication, are presumed to play an important role in the gut lumen; however, available evidence is limited because of the lack of actual data about luminal CA. This study evaluated luminal CA levels in the gastrointestinal tract and elucidated the involvement of gut microbiota in the generation of luminal CA by comparing the findings among specific pathogen-free mice (SPF-M), germ-free mice (GF-M), and gnotobiotic mice. Substantial levels of free dopamine and norepinephrine were identified in the gut lumen of SPF-M. The free CA levels in the gut lumen were lower in GF-M than in SPF-M. The majority of CA was a biologically active, free form in SPF-M, whereas it was a biologically inactive, conjugated form in GF-M. The association of GF-M with either Clostridium species or SPF fecal flora, both of which have abundant β-glucuronidase activity, resulted in the drastic elevation of free CA. The inoculation of E. coli strain into GF-M induced a substantial amount of free CA, but the inoculation of its mutant strain deficient in the β-glucuronidase gene did not. The intraluminal administration of DA increased colonic water absorption in an in vivo ligated loop model of SPF-M, thus suggesting that luminal DA plays a role as a proabsorptive modulator of water transport in the colon. These results indicate that gut microbiota play a critical role in the generation of free CA in the gut lumen.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SPF mice had substantially higher levels of free, biologically active dopamine and NE in the gut lumen of the ileum and colon than germ-free mice.
“Asano et al [48] discovered that SPF mice had substantially higher levels of free, biologically active dopamine and NE in the gut lumen of the ileum and colon than GF mice.”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [48]
Acute glutamine supplementation during and after exercise sufficient to prevent the post-exercise fall in plasma glutamine concentrations has no effect on salivary IgA nor lymphocyte function.
“Acute glutamine supplementation taken during and after exercise in sufficient amounts to prevent the post-exercise fall in plasma glutamine concentrations have no effect on salivary IgA nor lymphocyte function [48]”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [48]
Germ-free mice show decreased noradrenaline in the cecal lumen and tissue, which is restored with colonization.
“Germ-free mice show decreased noradrenaline in the cecal lumen and tissue, which is restored with colonization (231).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [231]
Cites
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
Self-citationPrinciples and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 1× · see citing works
“Numerous kinds of bacteria inhabit the close proximity of the gastrointestinal tract of mammals; thus such an interkingdom signaling through CA is presumed to be performed continually in the gut lumen (37) and to play an important role in the regulation of various pathophysiological functions.”
BackgroundCatecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
Eisenhofer, G., Kopin, I. J., & Goldstein, D. S. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.1 · Cited by 1,072 · see citing works
Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C., & Koga, Y. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1739 · Cited by 1,070 · see citing works
Self-citationInter-kingdom signalling: Communication between bacteria and their hosts
Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761 · see citing works
The QseC sensor kinase: A bacterial adrenergic receptor
Clarke, M. B., Hughes, D. T., Zhu, C., Boedeker, E. C., & Sperandio, V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604343103 · Cited by 621 · see citing works
The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
Caballero‐Franco, C., Keller, K., Simone, C. D., & Chadee, K. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00265.2006 · Cited by 493 · see citing works
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
Singh, S. K., Yamashita, A., & Gouaux, E. (2007) · Nature · doi:10.1038/nature06038 · Cited by 414 · see citing works
Catecholamine induced growth of gram negative bacteria
Lyte, M., & Ernst, S. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90273-r · Cited by 396 · see citing works
Bansal, T., Englert, D. L., Lee, J., Hegde, M., Wood, T. K., & Jayaraman, A. (2007) · Infection and Immunity · doi:10.1128/iai.00630-07 · Cited by 358 · see citing works
Impact of intestinal microbiota on intestinal luminal metabolome
Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Kurihara, S., Sawaki, E., Koga, Y., & Benno, Y. (2012) · Scientific Reports · doi:10.1038/srep00233 · Cited by 334 · see citing works
Self-citationThe immunoregulatory role of dopamine: An update
Sarkar, C., Basu, B., Chakroborty, D., Dasgupta, P., & Basu, S. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.015 · Cited by 323 · see citing works
Microbial endocrinology and infectious disease in the 21st century
Lyte, M. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2003.11.004 · Cited by 268 · see citing works
Li, Z., Schmauss, C., Cuenca, A., Ratcliffe, E., & Gershon, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4720-05.2006 · Cited by 262 · see citing works
Modulation of Gene Expression via Disruption of NF-κB Signaling by a Bacterial Small Molecule
Kravchenko, V. V., Kaufmann, G. F., Mathison, J. C., Scott, D. A., Katz, A. Z., Grauer, D. C., Lehmann, M. D., Meijler, M. M., Janda, K. D., & Ulevitch, R. J. (2008) · Science · doi:10.1126/science.1156499 · Cited by 213 · see citing works
Alverdy, J., Holbrook, C., Rocha, F., Seiden, L., Licheng, R., Wu, Musch, M., Chang, E., Ohman, D., & Suh, S. (2000) · Annals of Surgery · doi:10.1097/00000658-200010000-00003 · Cited by 207 · see citing works
Clayburgh, D. R., Musch, M. W., Leitges, M., Fu, Y., & Turner, J. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29218 · Cited by 203 · see citing works
Mebolism of drugs and other xenobiotics in the gut lumen and wall
Ilett, K. F., Tee, L. B. G., Reeves, P. T., & Minchin, R. F. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90036-2 · Cited by 201 · see citing works
Inter-kingdom signaling: chemical language between bacteria and host
Pacheco, A. R., & Sperandio, V. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.01.006 · Cited by 190 · see citing works
Evolutionary Considerations of Neurotransmitters in Microbial, Plant, and Animal Cells
Roshchina, V. V. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5576-0_2 · Cited by 188 · see citing works
Neuroendocrine–Bacterial Interactions in a Neurotoxin-Induced Model of Trauma
Lyte, M., & Bailey, M. T. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1997.5130 · Cited by 168 · see citing works
Tsavkelova, E. A., Botvinko, I. V., Кудрин, В. С., & Oleskin, A. V. (2000) · PubMed · Cited by 162 · see citing works
Kendall, M. M., Rasko, D. A., & Sperandio, V. (2007) · Infection and Immunity · doi:10.1128/iai.00550-07 · Cited by 126 · see citing works
Nakano, K., Yamaoka, K., Hanami, K., Saito, K., Sasaguri, Y., Yanagihara, N., Tanaka, S., KATSUKI, I., Matsushita, S., & Tanaka, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002475 · Cited by 123 · see citing works
Vlisidou, I., Lyte, M., van Diemen, P. M., Hawes, P. C., Monaghan, P., Wallis, T. S., & Stevens, M. P. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5446-5451.2004 · Cited by 117 · see citing works
Isolation and Characterization of Strain MMB-1 (CECT 4803), a Novel Melanogenic Marine Bacterium
Solano, F., Garcia, E., Perez, D., et al. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.9.3499-3506.1997 · Cited by 114 · see citing works
Production of an autoinducer of growth by norepinephrine culturedEscherichia coliO157:H7
Lyte, M., Frank, C. D., & Green, B. T. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb08196.x · Cited by 111 · see citing works
Lyte, M., & Ernst, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1068 · Cited by 100 · see citing works
Spectrofluorimetric determination of catecholamines with 1,2-diphenylethylenediamine
Nohta, H., Mitsui, A., & Ohkura, Y. (1984) · Analytica Chimica Acta · doi:10.1016/s0003-2670(00)85197-1 · Cited by 97 · see citing works
A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio
Hernández‐Romero, D., Sánchez-Amat, A., & Solano, F. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05038.x · Cited by 96 · see citing works
Reddy, B. S., Mangat, S., Weisburger, J. H., & Wynder, E. L. (1977) · PubMed · Cited by 96 · see citing works
Gastrointestinal pH measurement in rats: influence of the microbial flora, diet and fasting
Ward, F. W., & Coates, M. E. (1987) · Laboratory Animals · doi:10.1258/002367787781268693 · Cited by 78 · see citing works
GRAEF, V., Furuya, E., & NISHIKAZE, O. (1977) · Clinical Chemistry · doi:10.1093/clinchem/23.3.532 · Cited by 74 · see citing works
Identification and regional distribution of the dopamine D 1A receptor in the gastrointestinal tract
Vaughan, C. J., Aherne, A. M., Lane, E., et al. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.2.r599 · Cited by 66 · see citing works
Hydrolysis of iodothyronine conjugates by intestinal bacteria
Hazenberg (1988) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1988.tb02709.x-i1 · Cited by 55 · see citing works
Enzymatic deconjugation of catecholamines in human and rat plasma and red blood cell lysate
Yoneda, S., Alexander, N., & Vlachakis, N. D. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90749-x · Cited by 49 · see citing works
Dietary nucleic acids promote a shift in Th1/Th2 balance toward Th1‐dominant immunity
Sudo, N., Aiba, Takaki, Tanaka, Yu, Oyama, Koga, & Kubo (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00811.x · Cited by 46 · see citing works
Self-citationCatecholamine Glucuronidation: An Important Metabolic Pathway for Dopamine in the Rat
Wang, P., Kuchel, O., Buu, N. T., et al. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb13587.x · Cited by 44 · see citing works
Kim, D., YoungHo, J. I. N., Jung, E. A., et al. (1995) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.18.1184 · Cited by 38 · see citing works
Effect of Some Biologically Active Amines on the Cecum Wall of Germfree Rats.
Strandberg, K., Sedvall, G., Midtvedt, T., et al. (1966) · Experimental Biology and Medicine · doi:10.3181/00379727-121-30864 · Cited by 37 · see citing works
Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium
Lam, R. S., App, E. M., Nahirney, D., et al. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00475.x · Cited by 34 · see citing works
RENAL CLEARANCE OF FERROCYANIDE IN THE DOG
Berliner, R. W., Kennedy, T. J., & Hilton, J. G. (1950) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1950.160.2.325 · Cited by 33 · see citing works
Glucuronide and sulfate catecholamine conjugates in rat and human plasma
Claustre, J., Sérusclat, P., & Peyrin, L. (1983) · Journal of Neural Transmission · doi:10.1007/bf01243495 · Cited by 29 · see citing works
Free and conjugated catecholamines in digestive tissues of rats
Gaudin, C., Ruget, G., Selz, F., et al. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90177-8 · Cited by 28 · see citing works
Regulation of Cl- secretion by 2-adrenergic receptors in mouse colonic epithelium
Lam, R. S., App, E. M., Nahirney, D., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.036806 · Cited by 26 · see citing works
The Gut's Clostridium Cocktail
Barnes, M. J., & Powrie, F. M. (2011) · Science · doi:10.1126/science.1201291 · Cited by 21 · see citing works
Luminal dopamine modulates canine ileal water and electrolyte transport
Barry, M. K., Maher, M. M., Gontarek, J. D., et al. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02212695 · Cited by 17 · see citing works
Charoenphandhu, N., Laohapitakworn, S., Kraidith, K., et al. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.087 · Cited by 16 · see citing works
Antibacterial action of interferon preparations
Коробов, В. П., Ratner, E. N., Сузина, Н. Е., et al. (1988) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1988.tb02707.x · Cited by 15 · see citing works
SHIGA, A., Sasaki, T. G., & HORII, N. (1987) · The Japanese Journal of Veterinary Science · doi:10.1292/jvms1939.49.973 · Cited by 13 · see citing works
Luminal adrenergic agents modulate ileal transport: Discrimination between α1 and α2 receptors
Barry, M. K., Aloisi, J. D., Pickering, S. P., et al. (1994) · The American Journal of Surgery · doi:10.1016/0002-9610(94)90067-1 · Cited by 12 · see citing works
β-Glucuronidase activity in germ-free, monoassociated and conventional mice
Cardona, M. E., Norin, E. L., & Midtvedt, T. (2006) · Microbial Ecology in Health and Disease · doi:10.1080/08910600600733264 · Cited by 5 · see citing works
β-Glucuronidase activity in germ-free, monoassociated and conventional mice
Cardona, M. E., Norin, E. L., & Midtvedt, T. (2006) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v18i1.7698 · Cited by 4 · see citing works
[Importance of the liver and the digestive tract in the formation of catecholamine conjugates].
Shibata, O., Morooka, H., Hara, K., et al. (1988) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Interactions between the microbiota, immune and nervous systems in health and disease
Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4476 · Cited by 1,900 · see citing works
Neurotransmitter modulation by the gut microbiota
Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527 · see citing works
Interactions between the microbiota and pathogenic bacteria in the gut
Bäumler, A. J., & Sperandio, V. (2016) · Nature · doi:10.1038/nature18849 · Cited by 1,420 · see citing works
Martin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.04.003 · Cited by 1,284 · see citing works
Commensal clostridia: Leading players in the maintenance of gut homeostasis
Lopetuso, L. R., Scaldaferri, F., Petito, V., & Gasbarrini, A. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-23 · Cited by 753 · see citing works
Clark, A., & Mach, N. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-016-0155-6 · Cited by 583 · see citing works
“free catecholamines suggesting that the gut microbiota plays a role in their synthesis through dopamine regulation [48].”
BackgroundInfluentialMicrobiota and host determinants of behavioural phenotype in maternally separated mice
De Palma, G., Blennerhassett, P., Lu, J., Deng, Y., Park, A. J., Green, W., Denou, E., Silva, M. A., Santacruz, A., Sanz, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8735 · Cited by 517 · see citing works
Brain gut microbiome interactions and functional bowel disorders
Mayer, E. A., Savidge, T., & Shulman, R. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.037 · Cited by 496 · see citing works
Microbiota-gut-brain axis: Modulator of host metabolism and appetite
van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461 · see citing works
Gut microbiota and the neuroendocrine system
Farzi, A., Fröhlich, E. E., & Holzer, P. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0600-5 · Cited by 478 · see citing works
Gut Bacteria and Neurotransmitters
Dicks, L. M. T. (2022) · Microorganisms · doi:10.3390/microorganisms10091838 · Cited by 482 · see citing works
Microbiota-derived metabolites as drivers of gut–brain communication
Ahmed, H., Leyrolle, Q., Koistinen, V., Kärkkäinen, O., Layé, S., Delzenne, N., & Hanhineva, K. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2102878 · Cited by 462 · see citing works
Neuropeptides and the Microbiota-Gut-Brain Axis
Holzer, P., & Farzi, A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_9 · Cited by 451 · see citing works
Mikulska, J., Juszczyk, G., Gawrońska-Grzywacz, M., & Herbet, M. (2021) · Brain Sciences · doi:10.3390/brainsci11101298 · Cited by 450 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Gut microbiome and depression: what we know and what we need to know
Winter, G., Hart, R. A., Charlesworth, R. P. G., & Sharpley, C. F. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0072 · Cited by 394 · see citing works
Gut microbial molecules in behavioural and neurodegenerative conditions
Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00381-0 · Cited by 379 · see citing works
Gut-brain Axis and migraine headache: a comprehensive review
On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS), Arzani, M., Jahromi, S. R., Ghorbani, Z., Vahabizad, F., Martelletti, P., Ghaemi, A., Sacco, S., & Togha, M. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-1078-9 · Cited by 366 · see citing works
Why does the microbiome affect behaviour?
Johnson, K. V.-A., & Foster, K. R. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0014-3 · Cited by 333 · see citing works
Towards microbial fermentation metabolites as markers for health benefits of prebiotics
Verbeke, K. A., Boobis, A. R., Chiodini, A., Edwards, C. A., Franck, A., Kleerebezem, M., Nauta, A., Raes, J., van Tol, E. A. F., & Tuohy, K. M. (2015) · Nutrition Research Reviews · doi:10.1017/s0954422415000037 · Cited by 343 · see citing works
The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320 · see citing works
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Gut microbiota–brain axis in depression: the role of neuroinflammation
Carlessi, A. S., Borba, L. A., Zugno, A. I., Quevedo, J., & Réus, G. Z. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14631 · Cited by 243 · see citing works
The function of gut microbiota in immune-related neurological disorders: a review
Sittipo, P., Choi, J., Lee, S., & Lee, Y. K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02510-1 · Cited by 221 · see citing works
Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication
El Aidy, S., Dinan, T. G., & Cryan, J. F. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.002 · Cited by 215 · see citing works
Regulation of gut luminal serotonin by commensal microbiota in mice
Hata, T., Asano, Y., Yoshihara, K., Kimura-Todani, T., Miyata, N., Zhang, X.-T., Takakura, S., Aiba, Y., Koga, Y., & Sudo, N. (2017) · PLOS ONE · doi:10.1371/journal.pone.0180745 · Cited by 211 · see citing works
Self-citationMicrobial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works
Parkinson’s Disease and the Gastrointestinal Microbiome
Lubomski, M., Tan, A. H., Lim, S.-Y., Holmes, A. J., Davis, R. L., & Sue, C. M. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09320-1 · Cited by 172 · see citing works
Time to test antibacterial therapy in Alzheimer’s disease
Panza, F., Lozupone, M., Solfrizzi, V., Watling, M., & Imbimbo, B. P. (2019) · Brain · doi:10.1093/brain/awz244 · Cited by 161 · see citing works
Bacterial Adrenergic Sensors Regulate Virulence of Enteric Pathogens in the Gut
Moreira, C. G., Russell, R., Mishra, A. A., Narayanan, S., Ritchie, J. M., Waldor, M. K., Curtis, M. M., Winter, S. E., Weinshenker, D., & Sperandio, V. (2016) · mBio · doi:10.1128/mbio.00826-16 · Cited by 157 · see citing works
“This two-way-street communication is currently gaining appreciation given that there are important relationships between neurotransmitters and the GI microbiota, with the microbiota inducing biosynthesis of the serotonin neurotransmitter (72) and modulating the levels of active epinephrine and norepinephrine in the gu…”
InfluentialImpact of the gut microbiota, prebiotics, and probiotics on human health and disease
Lai, H.-C., Young, J., Lin, C.-S., Chang, C.-J., Lu, C.-C., Martel, J., Ojcius, D., & Ko, Y.-F. (2014) · Biomedical Journal · doi:10.4103/2319-4170.138314 · Cited by 153 · see citing works
Microbiota–neuroepithelial signalling across the gut–brain axis
Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147 · see citing works
Role of the Gut Microbiome in Autism Spectrum Disorders
Pulikkan, J., Mazumder, A., & Grace, T. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-05542-4_13 · Cited by 142 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Microbial endocrinology: Host-bacteria communication within the gut microbiome
Sandrini, S., Aldriwesh, M., Alruways, M., & Freestone, P. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0615 · Cited by 130 · see citing works
Hata, T., Miyata, N., Takakura, S., Yoshihara, K., Asano, Y., Kimura-Todani, T., Yamashita, M., Zhang, X.-T., Watanabe, N., Mikami, K., et al. (2019) · Endocrinology · doi:10.1210/en.2019-00408 · Cited by 116 · see citing works
Hussain, T., Murtaza, G., Kalhoro, D. H., Kalhoro, M. S., Metwally, E., Chughtai, M. I., Mazhar, M. U., & Khan, S. A. (2021) · Animal Nutrition · doi:10.1016/j.aninu.2020.11.005 · Cited by 110 · see citing works
Li, L., Rao, S., Cheng, Y., Zhuo, X., Deng, C., Xu, N., Zhang, H., & Yang, L. (2019) · MicrobiologyOpen · doi:10.1002/mbo3.810 · Cited by 109 · see citing works
“…serotonin, (Freestone & Lyte, 2008) Lactobacillus produced gamma‐aminobutyric acid (GABA), low level of corticos‐ terone in probiotics‐treated mice, (Asano et al., 2012) decreased levels of insulin, (Karlsson et al., 2013) low glucagon‐like peptide‐1 (GLP‐1) levels in antibiotic‐treated mice,…”
BackgroundPotential roles of gut microbiota and microbial metabolites in Parkinson’s disease
Zheng, S.-Y., Li, H.-X., Xu, R.-C., Miao, W.-T., Dai, M.-Y., Ding, S.-T., & Liu, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101347 · Cited by 101 · see citing works
Microbiome: Bacterial broadband
Eisenstein, M. (2016) · Nature · doi:10.1038/533s104a · Cited by 95 · see citing works
Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67 · see citing works
Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms
Kato, S., Sato, T., Fujita, H., Kawatani, M., & Yamada, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-88612-x · Cited by 59 · see citing works
The Role of the Microbiota-Gut-Brain Axis in the Development of Alzheimer’s Disease
Wiatrak, B., Balon, K., Jawień, P., Bednarz, D., Jęśkowiak, I., & Szeląg, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094862 · Cited by 58 · see citing works
QseC inhibition as an antivirulence approach for colitis-associated bacteria
Rooks, M. G., Veiga, P., Reeves, A. Z., Lavoie, S., Yasuda, K., Asano, Y., Yoshihara, K., Michaud, M., Wardwell-Scott, L., Gallini, C. A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612836114 · Cited by 57 · see citing works
Self-citationAlzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?
Arrona Cardoza, P., Spillane, M. B., & Morales Marroquin, E. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab022 · Cited by 53 · see citing works
Gut Microbiome and Modulation of <scp>CNS</scp> Function
Osadchiy, V., Martin, C. R., & Mayer, E. A. (2019) · Comprehensive Physiology · doi:10.1002/cphy.c180031 · Cited by 53 · see citing works
Enteric neuropathy in diabetes: Implications for gastrointestinal function
Abdalla, M. M. I. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i22.2852 · Cited by 45 · see citing works
The Many Faces of Microbiota-Gut-Brain Axis in Autism Spectrum Disorder
Gonçalves, C. L., Doifode, T., Rezende, V. L., Costa, M. A., Rhoads, J. M., & Soutullo, C. A. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122357 · Cited by 42 · see citing works
Zhang, T., Han, Y., Wang, J., Hou, D., Deng, H., Deng, Y. L., & Song, Z. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00176 · Cited by 38 · see citing works
Lyte, M., Villageliú, D. N., Crooker, B. A., & Brown, D. R. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13589 · Cited by 38 · see citing works
Liang, S.-C., Sun, C.-K., Chang, C.-H., Cheng, Y.-S., Tzang, R.-F., Chiu, H.-J., Wang, M. Y., Cheng, Y.-C., & Hung, K.-C. (2024) · BJPsych Open · doi:10.1192/bjo.2023.645 · Cited by 20 · see citing works
Dietary Protein and Colonic Microbiota
Boudry, G., Le Huërou-Luron, I., & Michel, C. (2016) · The Molecular Nutrition of Amino Acids and Proteins · doi:10.1016/b978-0-12-802167-5.00015-3 · Cited by 5 · see citing works
- Authors
- Asano, Y., Hiramoto, T., Nishino, R., Aiba, Y., Kimura, T., Yoshihara, K., Koga, Y., & Sudo, N.
- Affiliations
- Kyushu University (JP)
- Tokai University (JP)
- Corresponding author
- Sudo, Nobuyuki
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2012-12-01
- Volume
- 303
- Issue
- 11
- Pages
- G1288-G1295
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2099594801
- Cited by
- 659
- References
- 55
- Citations by year
- 2026: 30 · 2025: 49 · 2024: 59 · 2023: 56 · 2022: 70 · 2021: 111 · 2020: 67 · 2019: 62 · 2018: 41 · 2017: 31 · 2016: 29 · 2015: 21 · 2014: 24 · 2013: 8 · 2012: 1
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Kyushu University Institutional Repository (QIR) (Kyushu University) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (24659350)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut microbiota, catecholamines, dopamine, norepinephrine, beta-glucuronidase, Clostridium, Escherichia coli, germ-free mice, gnotobiotic mice, colonic water absorption, host-microbe communication
- MeSH terms
- Animals, Catecholamines, Cecum, Clostridium, Dopamine, Escherichia coli, Feces, Female, Germ-Free Life, Glucuronidase, Intestinal Absorption, Male, Norepinephrine, Specific Pathogen-Free Organisms, Water, Gastrointestinal Tract, Mice, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
