Lactobacillus paracasei feeding improves immune control of influenza infection in mice
Open accessAbstract
Respiratory tract infections such as flu cause severe morbidity and mortality and are among the leading causes of death in children and adults worldwide. Commensal microbiota is critical for orchestrating tissue homeostasis and immunity in the intestine. Probiotics represent an interesting source of immune modulators and several clinical studies have addressed the potential beneficial effects of probiotics against respiratory infections. Therefore, we have investigated the mechanisms of protection conferred by L. paracasei CNCM I-1518 strain in a mouse model of influenza infection. Notably, local myeloid cells accumulation is generated in the lungs after seven days feeding with L. paracasei prior to viral infection. L. paracasei-fed mice showed reduced susceptibility to the influenza infection, associated with less accumulation of inflammatory cells in the lungs, faster viral clearance and general health improvement. Interestingly, Allobaculum was significantly increased in L. paracasei-fed mice 7 days after influenza infection, even if the gut microbiota composition was not altered overall. L. paracasei-purified peptidoglycan partially recapitulated the protective phenotype observed with the entire bacteria. Collectively, our results demonstrate that oral consumption of L. paracasei CNCM I-1518 modulates lung immunity was associated with an improved control of influenza infection. These results further extend the beneficial role for certain lactobacilli to alleviate the burden of respiratory tract infections.
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In a rodent model of influenza infection, ingestion of L. paracasei CNCM I-1518 reduced susceptibility to influenza infection, reduced inflammatory cell infiltration into the lungs, and increased the rate of viral clearance.
“Belkacem et al. [159] used the probiotic strain L. paracasei CNCM I-1518 in a rodent model of influenza infection and reported that the ingestion of the strain reduced susceptibility to influenza infection, reduced inflammatory cell infiltration into the lungs, and increased the rate of viral clearance.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [159]
Ingestion of probiotic strain L. paracasei CNCM I-1518 reduced susceptibility to influenza infection, reduced inflammatory cell infiltrates in lungs, and enhanced speed of viral clearance in an influenza infection rodent model.
“However, promising data from an influenza infection rodent model has revealed that the ingestion of probiotic strain L. paracasei CNCM I-1518 reduced susceptibility to influenza infection, reduced inflammatory cell infiltrates in the lungs and enhanced the speed of viral clearance (Belkacem et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Belkacem et al., 2017
Purified peptidoglycans from the strain were able to partially reproduce the effect of intact cells.
“Furthermore, purified peptidoglycans (major cell wall components) from the strain were able to partially reproduce the effect of the intact cells.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Belkacem et al., 2017
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- Authors
- Belkacem, N., Serafini, N., Wheeler, R., Derrien, M., Boucinha, L., Couesnon, A., Cerf-Bensussan, N., Gomperts Boneca, I., Di Santo, J. P., Taha, M.-K., & Bourdet-Sicard, R.
- Affiliations
- Institut Pasteur (FR)
- Inserm (FR)
- Danone (France) (FR)
- BIOASTER (FR)
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-09-20
- Volume
- 12
- Issue
- 9
- Pages
- e0184976
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5607164
- OpenAlex
- W2754161296
- Cited by
- 108
- References
- 57
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 13 · 2023: 8 · 2022: 13 · 2021: 31 · 2020: 12 · 2019: 9 · 2018: 5
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Danone (30000221)
- Danone Nutricia Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- Lactobacillus paracasei, probiotics, influenza, respiratory infections, lung immunity, Allobaculum, peptidoglycan, gut microbiota, viral clearance, immunomodulation
- MeSH terms
- Lacticaseibacillus paracasei, Animals, Female, Immunity, Cellular, Mice, Inbred BALB C, Orthomyxoviridae, Orthomyxoviridae Infections, Respiratory Tract Infections, Colony Count, Microbial, Probiotics, Mice
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