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Cited by 38Diabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, DietAdipokines, Inflammation, and Metabolic Diseases

Validation of surrogate markers for metabolic syndrome and cardiometabolic risk factor clustering in children and adolescents: A nationwide population-based study

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Seo, Ji-Young, Kim, Jae Hyun·2017·PLOS ONE
DOI 10.1371/journal.pone.0186050PMC PMC5648147
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Abstract

Prevalence of metabolic syndrome (MetS) in children is increasing and identifying the risk factors for MetS during childhood is an important first step to prevent chronic diseases later in life. The aim of the present study was to evaluate the prevalence of MetS and cardiometabolic risk factor (CMRF) clustering among Korean children and adolescents and to validate the associated anthropometric and laboratory surrogate markers. We used data from the 2011-2014 Korean National Health and Nutrition Examination Survey. In total, data for 2,935 subjects (1539 boys, 52.6%) aged 10-19 years were assessed. MetS was defined by central obesity plus any two or more of CMRFs such as abdominal obesity, hypertension, hyperglycemia, hypertriglyceridemia, and decreased high density lipoprotein cholesterol (HDL-C) using the International Diabetes Federation criteria for children and adolescents. The presence of two or more CMRFs was classified as CMRF clustering. The prevalence of MetS and CMRF clustering in this group was found to be 1.8% and 8.9%, respectively. The receiver operating characteristic analysis of MetS and CMRF clustering, and the area under the curve (95% confidence interval) of surrogate markers revealed that the waist circumference to height ratio [0.960 (95% CI 0.959-0.960), cut-off 0.491] showed the highest predictability for MetS whereas triglyceride to HDL-C ratio [0.891 (95% CI 0.891-0.892), cut-off 2.63] showed the highest predictability for CMRF clustering. Long-term follow-up is needed for further validation.

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  • Pediatric abdominal obesity is a strong predictor of cardiometabolic risk factors and cardiovascular disease in adulthood.

    “Several studies have recently identified pediatric abdominal obesity as a strong predictor of cardiometabolic risk factors and cardiovascular disease in adulthood.11,12”

    From Reference Values for Waist Circumference and Waist–Height Ratio in Korean Children and Adolescents (2022) · cites this paper as [12]

    The Conclusions (page unavailable) identify waist-to-height ratio as a reliable predictor of metabolic syndrome in Korean children and adolescents, supporting the link between abdominal size and pediatric cardiometabolic risk. The Introduction says cardiometabolic risk-factor clustering can track into adulthood, but the paper does not establish that pediatric abdominal obesity predicts cardiovascular disease in adulthood; its Conclusions call for long-term follow-up. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • WC and WHtR are important abdominal obesity-related indicators associated with cardiometabolic risk factors and metabolic syndrome.

    “WC and WHtR are important abdominal obesity-related indicators associated with cardiometabolic risk factors and MS.12”

    From Reference Values for Waist Circumference and Waist–Height Ratio in Korean Children and Adolescents (2022) · cites this paper as [12]

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Cited by

Sorted by citations

Authors
Seo, J.-Y., & Kim, J. H.
Affiliations
  • Eulji University (KR)
  • Seoul National University (KR)
Corresponding author
Kim, Jae Hyun
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2017-10-19
Volume
12
Issue
10
Pages
e0186050
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0186050
PMC
PMC5648147
OpenAlex
W2766432003
Cited by
38
References
2
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 12 · 2020: 6 · 2019: 3 · 2018: 3
FWCI
2.60
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Eulji University (2012EMBRISN0002)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
metabolic syndrome, children and adolescents, surrogate markers, triglyceride to HDL cholesterol ratio, abdominal obesity, hypertension, hypertriglyceridemia, hyperglycemia, HDL cholesterol, prevalence, Korean adolescents
MeSH terms
Adolescent, Adult, Child, Female, Humans, Male, Nutrition Surveys, Risk Factors, Biomarkers, Cluster Analysis, Metabolic Syndrome, Young Adult, Republic of Korea

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