Effects of the antidepressant medication duloxetine on brain metabolites in persistent depressive disorder: A randomized, controlled trial
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The few imaging studies combined with an RCT design have shown that SSRIs/SNRIs normalize pre-existing abnormalities in brain structure, function, and metabolism.
“The few imaging studies that have been combined with an RCT design to provide stronger causal inference of the effects of these medications have shown that they normalize pre-existing abnormalities in brain structure [59], function [60], and metabolism [123].”
From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [123]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mediation Models for Longitudinal Data in Developmental Research
Selig, J. P., & Preacher, K. J. (2009) · Research in Human Development · doi:10.1080/15427600902911247 · Cited by 804 · see citing works
Neurochemistry of major depression: a study using magnetic resonance spectroscopy
Godlewska, B. R., Near, J., & Cowen, P. J. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3687-y · Cited by 97 · see citing works
Flagged first, then by citations
Research works printed but not linked: 62
- [1]American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition: DSM-5. 5th ed. Washington, DC: American Psychiatric Pub; 2013.
- [2]Howland RH. General Health, Health-Care Utilization, and Medical Comorbidity in Dysthymia. International Journal of Psychiatry in Medicine. 1993; 23(3): 211– 38. 10.2190/AXCU-P704-23XQ-CQTR ISI:A1993MD61900001. 8270354 · DOI
- [3]Griffiths J, Ravindran AV, Merali Z, Anisman H. Dysthymia: a review of pharmacological and behavioral factors. Mol Psychiatr. 2000; 5(3): 242– 61. 10.1038/sj.mp.4000697 ISI:000087661000008. 10889527 · DOI
- [4]Arnold DL, de Stefano N, Matthews PM, Trapp BD. N-acetylaspartate: usefulness as an indicator of viable neuronal tissue. Ann Neurol. 2001; 50: 823– 5. 11761486
- [5]Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiological Reviews. 2000; 80(3): 1107– 213. ISI:000088088900009. 10.1152/physrev.2000.80.3.1107 10893433 · DOI · Paper page
- [6]Brosnan JT, Brosnan ME. Creatine: Endogenous metabolite, dietary, and therapeutic supplement. Annual Review of Nutrition. 2007; 27: 241– 61. 10.1146/annurev.nutr.27.061406.093621 ISI:000251280400014. 17430086 · DOI · Paper page
- [7]Andres RH, Ducraya AD, Schlattner U, Wallimann T, Widmer HR. Functions and effects of creatine in the central nervous system. Brain Research Bulletin. 2008; 76(4): 329– 43. 10.1016/j.brainresbull.2008.02.035 ISI:000256724200001. 18502307 · DOI
- [8]Almeida LS, Salomons GS, Hogenboom R, Jakobs C, Schoffelmeer ANM. Exocytotic release of creatine in rat brain. Synapse. 2006; 60(2): 118– 23. 10.1002/syn.20280 ISI:000238238500004. 16715490 · DOI
- [9]Royes LF, Fighera MR, Furian AF, Oliveira MS, Fiorenza NG, Ferreira J, et al Neuromodulatory effect of creatine on extracellular action potentials in rat hippocampus: Role of NMDA receptors. Neurochemistry International. 2008; 53(1–2): 33– 7. 10.1016/j.neuint.2008.04.008 ISI:000258016800005. 18541342 · DOI
- [10]Miller BL, Chang L, Booth R, Ernst T, Cornford M, Nikas D, et al In vivo 1H MRS choline: correlation with in vitro chemistry/histology. Life Sci. 1996; 58(22): 1929– 35. Epub 1996/01/01. 10.1016/0024-3205(96)00182-8. 8637421 · DOI
- [11]Rothman DL, Behar KL, Hyder F, Shulman RG. In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annu Rev Physiol. 2003; 65: 401– 27. Epub 2003/01/14. 10.1146/annurev.physiol.65.092101.142131. 12524459 · DOI · Paper page
- [12]Yildiz-Yesiloglu A, Ankerst DP. Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis. Psychiatry Res. 2006; 147(1): 1– 25. Epub 2006/06/30. 10.1016/j.pscychresns.2005.12.004. 16806850 · DOI · Paper page
- [13]Riley CA, Renshaw PF. Brain choline in major depression: A review of the literature. Psychiatry Res Neuroimaging. 2018; 271: 142– 53. Epub 2017/11/28. 10.1016/j.pscychresns.2017.11.009. 29174766 · DOI
- [14]MacMaster FP, Kusumakar V. Choline in pediatric depression. Mcgill J Med. 2006; 9(1): 24– 7. Epub 2006/01/01. 19529805 PMC2687891
- [15]MacMaster FP, Moore GJ, Russell A, Mirza Y, Taormina SP, Buhagiar C, et al Medial temporal N-acetyl-aspartate in pediatric major depression. Psychiat Res-Neuroim. 2008; 164(1): 86– 9. 10.1016/j.pscychresns.2007.12.022 ISI:000261023800009. 18703320 PMC2653710 · DOI
- [16]Njau S, Joshi SH, Espinoza R, Leaver AM, Vasavada M, Marquina A, et al Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression. J Psychiatr Neurosci. 2017; 42(1): 6– 16. 10.1503/jpn.150177 ISI:000392404700003. 27327561 PMC5373714 · DOI
- [17]Wang Y, Jia YB, Xu GY, Ling XY, Liu SR, Huang L. Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: A proton magnetic resonance spectroscopy study. J Affect Disorders. 2012; 136(3): 620– 6. 10.1016/j.jad.2011.10.020 ISI:000301996000055. 22129769 · DOI
- [18]Zhong SM, Wang Y, Zhao GX, Xiang Q, Ling XY, Liu SR, et al Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: A proton magnetic resonance spectroscopy study. J Affect Disorders. 2014; 168: 380– 6. 10.1016/j.jad.2014.07.024 ISI:000341483100051. 25106035 · DOI
- [19]Gabbay V, Bradley KA, Mao X, Ostrover R, Kang G, Shungu DC. Anterior cingulate cortex gamma-aminobutyric acid deficits in youth with depression. Transl Psychiatry. 2017; 7(8): e1216 Epub 2017/09/12. 10.1038/tp.2017.187 28892070 PMC5611750 · DOI
- [20]Flores-Ramos M, Salinas M, Carvajal-Lohr A, Rodriguez-Bores L. The role of gamma-aminobutyric acid in female depression. Gaceta Medica De Mexico. 2017; 153(4): 488– 97. 10.24875/Gmm.17002544 ISI:000412700700010. 28991279 · DOI
- [21]Romeo B, Choucha W, Fossati P, Rotge JY. Meta-analysis of central and peripheral gamma-aminobutyric acid levels in patients with unipolar and bipolar depression. J Psychiatr Neurosci. 2018; 43(1): 58– 66. 10.1503/jpn.160228 ISI:000419003100006. 29252166 PMC5747536 · DOI · Paper page
- [23]Moriguchi S, Takamiya A, Noda Y, Horita N, Wada M, Tsugawa S, et al Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies. Mol Psychiatry. 2018 Epub 2018/10/14. 10.1038/s41380-018-0252-9. 30315224 PMC6755980 · DOI · Paper page
- [24]Kondo DG, Hellem TL, Sung YH, Kim N, Jeong EK, Delmastro KK, et al Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder. Depress Res Treat. 2011; 2011: 650450 Epub 2011/01/05. 10.1155/2011/650450 21197097 PMC3003951 · DOI
- [25]Horga G, Kaur T, Peterson BS. Annual Research Review: Current limitations and future directions in MRI studies of child-and adult-onset developmental psychopathologies. J Child Psychol Psyc. 2014; 55(6): 659– 80. 10.1111/jcpp.12185 ISI:000336006400012. 24438507 PMC4029914 · DOI
- [26]Bansal R, Hellerstein DJ, Peterson BS. Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness. Mol Psychiatr. 2018; 23(2): 375– 83. 10.1038/mp.2017.34 ISI:000423441700023. 28265119 PMC5589468 · DOI · Paper page
- [27]Hellerstein DJ, Stewart JW, McGrath PJ, Deliyannides DA, Batchelder ST, Black SR, et al A randomized controlled trial of duloxetine versus placebo in the treatment of nonmajor chronic depression. The Journal of clinical psychiatry. 2012; 73(7): 984– 91. Epub 2012/08/21. 10.4088/JCP.11m07230. 22901348 · DOI
- [28]Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB. Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport. 1996; 7(8): 1397– 400. Epub 1996/05/31.. 8856684
- [29]Demougeot C, Garnier P, Mossiat C, Bertrand N, Giroud M, Beley A, et al N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury. J Neurochem. 2001; 77(2): 408– 15. 10.1046/j.1471-4159.2001.00285.x ISI:000168072700006. 11299303 · DOI
- [30]Posner J, Hellerstein DJ, Gat I, Mechling A, Klahr K, Wang ZS, et al Antidepressants Normalize the Default Mode Network in Patients With Dysthymia. Jama Psychiat. 2013; 70(4): 373– 82. 10.1001/jamapsychiatry.2013.455 ISI:000320853400003. 23389382 PMC3935731 · DOI · Paper page
- [31]Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960; 23: 56– 62. Epub 1960/02/01. 10.1136/jnnp.23.1.56 14399272 PMC495331 · DOI · Paper page
- [32]Hellerstein DJ, Batchelder ST, Lee A, Borisovskaya M. Rating dysthymia: an assessment of the construct and content validity of the Cornell Dysthymia Rating Scale. J Affect Disorders. 2002; 71(1–3): 85– 96. Pii S0165-0327(01)00371-8 10.1016/S0165-0327(01)00371-8 ISI:000177824700010. 12167504 · DOI
- [33]Dong ZC, Peterson B. The rapid and automatic combination of proton MRSI data using multi-channel coils without water suppressionl. Magnetic Resonance Imaging. 2007; 25(8): 1148– 54. 10.1016/j.mri.2007.01.005 ISI:000250148700004. 17905247 PMC2367158 · DOI
- [34]Hao X, Xu D, Bansal R, Dong Z, Liu J, Wang Z, et al Multimodal magnetic resonance imaging: The coordinated use of multiple, mutually informative probes to understand brain structure and function. Hum Brain Mapp. 2013; 34(2): 253– 71. Epub 2011/11/15. 10.1002/hbm.21440. 22076792 PMC4284056 · DOI · Paper page
- [35]Lebon V, Petersen KF, Cline GW. Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci. 2002; 22(5): 1523– 31. 11880482 PMC2995528
- [36]Bansal R, Hellerstein DJ, Peterson BS. Evidence for Neuroplastic Compensation in the Cerebral Cortex of Persons with Dysthymia. Mol Psychiatr. 2017;In Press. PMC5589468 28265119
- [37]Viola P, Wells, W. M., editor Alignment by Maximization of Mutual Information. IEEE Proc of the 5th Int Conf on Computer Vision; 1995 June 20–23; Boston, MA.
- [38]O'Neill J, Dong Z, Bansal R, Ivanov I, Hao X, Desai J, et al Proton Chemical Shift Imaging of the Brain in Pediatric and Adult Developmental Stuttering. Jama Psychiat. 2017; 74(1): 85– 94. Epub 2016/11/29. 10.1001/jamapsychiatry.2016.3199. 27893013 · DOI
- [39]Schuff N, Ezekiel F, Gamst AC, Amend DL, Capizzano AA, Maudsley AA, et al Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging. Magnetic Resonance in Medicine. 2001; 45(5): 899– 907. 10.1002/Mrm.1119 ISI:000168444000021. 11323817 PMC1851682 · DOI
- [40]Buchli R, Meier D, Martin E, Boesiger P. Assessment of Absolute Metabolite Concentrations in Human Tissue by P-31 Mrs in-Vivo.2. Muscle, Liver, Kidney. Magnetic Resonance in Medicine. 1994; 32(4): 453– 8. 10.1002/mrm.1910320405 ISI:A1994PJ32300004. 7997109 · DOI
- [41]Buchli R, Duc CO, Martin E, Boesiger P. Assessment of Absolute Metabolite Concentrations in Human Tissue by P-31 Mrs in-Vivo.1. Cerebrum, Cerebellum, Cerebral Gray and White-Matter. Magnetic Resonance in Medicine. 1994; 32(4): 447– 52. 10.1002/mrm.1910320404 ISI:A1994PJ32300003. 7997108 · DOI
- [42]Hedeker D, Gibbons RD, Waternaux C. Sample size estimation for longitudinal designs with attrition: Comparing time-related contrasts between two groups. Journal of Educational and Behavioral Statistics. 1999; 24(1): 70– 93. 10.3102/10769986024001070 ISI:000079266400004. · DOI
- [43]Benjamini Y, Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Annals of Statistics. 2001; 29(4): 1165– 88. ISI:000172838100012.
- [45]Hellerstein DJ, Stewart JW, McGrath PJ, Deliyannides DA, Batchelder ST, Black SR, et al A Randomized Controlled Trial of Duloxetine Versus Placebo in the Treatment of Nonmajor Chronic Depression. Journal of Clinical Psychiatry. 2012; 73(7): 984– 91. 10.4088/JCP.11m07230 ISI:000315000200010. 22901348 · DOI
- [46]Bansal R, Hellerstein DJ, Peterson BS. Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness. Mol Psychiatry. 2017 Epub 2017/03/08. 10.1038/mp.2017.34. 28265119 PMC5589468 · DOI · Paper page
- [47]Hedeker DR, Gibbons RD. Longitudinal data analysis. Hoboken, N.J: Wiley-Interscience; 2006. xx, 337 p. p.
- [49]Bind MA, Vanderweele TJ, Coull BA, Schwartz JD. Causal mediation analysis for longitudinal data with exogenous exposure. Biostatistics. 2016; 17(1): 122– 34. 10.1093/biostatistics/kxv029 26272993 PMC4731412 · DOI
- [51]Sobel ME. Asymptotic confidence intervals for indirect effects in structural equation models. Sociological Methodology. 1982; 13: 290– 312.
- [52]Maia TV, Cooney RE, Peterson BS. The neural bases of obsessive-compulsive disorder in children and adults. Dev Psychopathol. 2008; 20(4): 1251– 83. Epub 2008/10/08. 10.1017/S0954579408000606 18838041 PMC3079445 · DOI · Paper page
- [53]Marsh R, Gorman DA, Royal J, Peterson BS. Disturbances of fronto-striatal circuits in Tourette syndrome and obsessive-compulsive disorder. Neuroimaging in Developmental Clinical Neuroscience. 2009: 199– 216. 10.1017/Cbo9780511757402.016 ISI:000313574600014. · DOI
- [54]Schroll H, Hamker FH. Computational models of basal-ganglia pathway functions: focus on functional neuroanatomy. Front Syst Neurosci. 2013; 7: 122 Epub 2014/01/15. 10.3389/fnsys.2013.00122 24416002 PMC3874581 · DOI
- [55]Yager LM, Garcia AF, Wunsch AM, Ferguson SM. The ins and outs of the striatum: role in drug addiction. Neuroscience. 2015; 301: 529– 41. Epub 2015/06/28. 10.1016/j.neuroscience.2015.06.033 26116518 PMC4523218 · DOI
- [56]Phan KL, Wager T, Taylor SF, Liberzon I. Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. NeuroImage. 2002; 16(2): 331– 48. 10.1006/nimg.2002.1087 ISI:000176119300004. 12030820 · DOI · Paper page
- [57]Quarto T, Blasi G, Maddalena C, Viscanti G, Lanciano T, Soleti E, et al Association between Ability Emotional Intelligence and Left Insula during Social Judgment of Facial Emotions. PLoS One. 2016; 11(2). ARTN e0148621 10.1371/journal.pone.0148621 ISI:000370038400059. 26859495 PMC4747486 · DOI
- [58]Haber SN. Corticostriatal circuitry. Dialogues in Clinical Neuroscience. 2016; 18(1): 7– 21. ISI:000390191700002. 27069376 PMC4826773
- [59]Wang Y, Jia YB, Chen XJ, Ling XY, Liu SR, Xu GY, et al Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: effects of treatment. Journal of Psychopharmacology. 2012; 26(11): 1463– 70. 10.1177/0269881112450781 ISI:000309839100008. 22706518 · DOI
- [60]Haller S, Zaharchuk G, Thomas DL, Lovblad KO, Barkhof F, Golay X. Arterial Spin Labeling Perfusion of the Brain: Emerging Clinical Applications. Radiology. 2016; 281(2): 337– 56. 10.1148/radiol.2016150789 ISI:000393199200003. 27755938 · DOI
- [61]Ho TC, Wu J, Shin DD, Liu TT, Tapert SF, Yang G, et al Altered Cerebral Perfusion in Executive, Affective, and Motor Networks During Adolescent Depression. Journal of the American Academy of Child and Adolescent Psychiatry. 2013; 52(10): 1076– 91. 10.1016/j.jaac.2013.07.008 ISI:000325309400012. 24074474 PMC3825460 · DOI
- [62]Duhameau B, Ferre JC, Jannin P, Gauvrit JY, Verin M, Millet B, et al Chronic and treatment-resistant depression: A study using arterial spin labeling perfusion MRI at 3 Tesla. Psychiat Res-Neuroim. 2010; 182(2): 111– 6. 10.1016/j.pscychresns.2010.01.009 ISI:000278701500005. 20427157 · DOI
- [63]Amen DG, Krishnamani P, Meysami S, Newberg A, Raji CA. Classification of Depression, Cognitive Disorders, and Co-Morbid Depression and Cognitive Disorders with Perfusion SPECT Neuroimaging. Journal of Alzheimers Disease. 2017; 57(1): 253– 66. 10.3233/Jad-161232 ISI:000396270500021. 28211813 · DOI
- [64]Gardner A, Astrand D, Oberg J, Jacobsson H, Jonsson C, Larsson S, et al Towards mapping the brain connectome in depression: Functional connectivity by perfusion SPECT. Psychiat Res-Neuroim. 2014; 223(2): 171– 7. 10.1016/j.pscychresns.2014.05.008 ISI:000340014300015. 24931481 · DOI
- [65]Oishi K, Faria AV, van Zijl PCM, Mori S. MRI Atlas of Human White Matter Academic Press; 2010.
- [66]Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, et al An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage. 2006; 31(3): 968– 80. 10.1016/j.neuroimage.2006.01.021 ISI:000238358500003. 16530430 · DOI · Paper page
Cited by
Sorted by citations
Peterson, B. S., West, A. E., Weisz, J. R., Mack, W. J., Kipke, M. D., Findling, R. L., Mittman, B. S., Bansal, R., Piantadosi, S., Takata, G., et al. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03314-y · Cited by 13 · see citing works
Self-citation
- Authors
- Bansal, R., Hellerstein, D. J., Sawardekar, S., O’Neill, J., & Peterson, B. S.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-07-19
- Volume
- 14
- Issue
- 7
- Pages
- e0219679
- ISSN
- 1932-6203
- PMC
- PMC6641507
- Cited by
- 9
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review