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Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes

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Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma

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Antioxidant and neuroprotective effects of mGlu3 receptor activation on astrocytes aged in vitro

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Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair

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Senescent Astrocytes: A New Player in Brain Aging and Cognitive Decline

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Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer’s Disease

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Cellular Senescence in Glial Cells: Implications for Multiple Sclerosis

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Hypoxia, Acidification and Inflammation: Partners in Crime in Parkinson’s Disease Pathogenesis?

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Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support

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Cisplatin Provokes Peripheral Nociception and Neuronal Features of Therapy-Induced Senescence and Calcium Dysregulation in Rats

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Microglia: Rheostats of space radiation effects in the CNS microenvironment

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Involvement of astrocyte senescence in Alzheimer's disease

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Radiation-Induced Brain Injury with Special Reference to Astrocytes as a Therapeutic Target.

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Multi‐Omic Analysis of Glutamate Excitotoxicity in Primary Neuronal Cultures

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Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

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Targeting therapy-induced senescence as a novel strategy to combat chemotherapy-induced peripheral neuropathy

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Mechanisms of Transsynaptic Degeneration in the Aging Brain

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The fate of neuronal synapse homeostasis in aging, infection, and inflammation

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Cognitive disorders: Potential astrocyte-based mechanism

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A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity

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Δ133p53α-mediated inhibition of astrocyte senescence and neurotoxicity as a possible therapeutic approach for neurodegenerative diseases

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An update on healthspan and lifespan enhancing attributes of tea amidst the emerging understanding of aging biology

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Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1–42 oligomers, triggering distinct paths of reactivity and senescence

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hESC-derived extracellular vesicles enriched with MFGE-8 and the GSH redox system act as senotherapeutics for neural stem cells in ischemic stroke

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Potential Function of 3,5‐Dihydroxy‐4‐Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice

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Inhibition of miR-21 Promotes Cellular Senescence in NT2-Derived Astrocytes

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Pharmacological evidence for glutamatergic pathway involvement in the antidepressant-like effects of 2-phenyl-3-(phenylselanyl)benzofuran in male Swiss mice

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Role of astrocytes in Alzheimer's disease pathogenesis and the impact of exercise-induced remodeling

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Exploiting glial cell functions for neurodegeneration therapy

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Astrocytes of the Brain: Retinue Plays the King

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Research progress of cell senescence in Alzheimer's disease: mechanisms and therapy

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Effects of in vitro exposure of perfluorooctanoic acid and monocrotophos on astroglia SVG p12 cells

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The relationships between neuroglial and neuronal changes in Alzheimer’s disease, and the related controversies II: gliotherapies and multimodal therapy

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Astrocytes in Brain Aging and Neurodegeneration: Cellular Mechanisms and Interventional Strategies

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Minor Allele Frequencies and Molecular Pathways Differences for SNPs Associated with Amyotrophic Lateral Sclerosis in Subjects Participating in the UKBB and 1000 Genomes Project

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Identification of markers for neurescence through transcriptomic profiling of postmortem human brains

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Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

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A compendium of circulating biomarkers of senescence in humans: Insights on mechanistic impact across health domains and modulation by therapeutic interventions

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Excitotoxicity and the Kynurenine Pathway in Multiple Sclerosis

Tan, L. S. Y., & Lim, C. K. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_146 · Cited by 2

Differences between cultured astrocytes from neonatal and adult Wistar rats: focus on in vitro aging experimental models

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Enhanced Differentiation of Human Neural Stem Cells into Cortical Neurons Using 3D Chitosan Scaffolds

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Exploring the Role of Senescent Cells in Neurodegenerative Pathology: A Window Into Promising Therapeutic Avenues

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Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes

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Effects of senescence on astrocyte to brain endothelial cell signaling

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Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss

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Astrocytes and Their Role in the Development and Progression of Alzheimer’s Disease: Gatekeepers of Neurodegeneration

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Senolytic treatment with dasatinib and quercetin selectively improves cardiac autonomic balance in obesity

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Senotherapeutics: Emerging pharmacological strategies to target cellular senescence

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Neurovascular unit senescence as a driver of blood–brain barrier dysfunction in Alzheimer’s disease：Mechanisms, consequences, and therapeutic implications

Yao, M., Liu, A., Xing, L., Song, J., Yang, Y., Yue, X., & Li, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103260 · Cited by 1

Astrocyte Senescence Disrupts the Extracellular Mitochondrial Compartment and Compromises Bioenergetic Support to Human Neurons

Amorim, P., Hayashide, L. D. S., Leocadio, V. E., Marques, M., Navarra, I., de Andrade, C. B. V., de Carvalho, J. J., Pinto, R. S., & Diniz, L. P. (2026) · Antioxidants · doi:10.3390/antiox15091127 · Cited by 1

The role of glutamate in a multifactorial scenario of Alzheimer’ disease associated with depression and poor sleep

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The Synergistic Roles of Glial Cells and Non-Coding RNAs in the Pathogenesis of Alzheimer’s Disease and Related Dementias (ADRDs)

Risen, S. J., Wahl, D., LaRocca, T. J., & Moreno, J. A. (2025) · Neuroglia · doi:10.3390/neuroglia6020022 · Cited by 1

Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration

Reina-Gonzalez, P., Ay, M., Langley, M. R., Plunk, E. C., Strazdins, R., Abu-Salah, A., Anchan, A., Shah, A., & Sarkar, S. (2025) · Toxicological Sciences · doi:10.1093/toxsci/kfaf088 · Cited by 1

Single-cell profiling of skeletal muscle reveals a novel senolytic target: CRYABPreprint

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The Glial Aging & Senescence Hypothesis of Late-onset Alzheimer’sPreprint

Lau, V. Z., Ramer, L. M., & Tremblay, M. (2022) · Preprints.org · doi:10.20944/preprints202109.0437.v2 · Cited by 1

Biophysical basis for the induction of glioblastoma-like phenotype in astrocytesPreprint

Starck, L., Sarem, M., Heimrich, B., Sawarkar, R., Ritz, M., Hütter, G., & Shastri, V. P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.31.551259 · Cited by 1

Declining intracellular proteostasis capacity drives misfolded protein secretion in senescent human cellsPreprint

Watts, T., Johnston, H. E., Al-Mufti, Y., Odle, R., Hodgson, R. E., Okkenhaug, H., Carr, H. L., Cranwell, S., Wu, E., Walker, S. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.07.674107 · Cited by 1

Lactate promotes longevity through redox-driven lipid remodeling in Caenorhabditis elegansPreprint

Tauffenberger, A., Netherland, P. J., Fiumelli, H., Meisel, J. D., Schroeder, F. C., & Magistretti, P. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.25.678523 · Cited by 1

Excitotoxicity and the kynurenine pathway in multiple sclerosis

Tan, L. S. Y., & Lim, C. K. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_146-1

How Senescent Glia Drive And Underlie Alzheimer’s Disease: A Predictive ModelPreprint

Lau, V. Z., Ramer, L. M., & Tremblay, M. (2021) · Preprints.org · doi:10.20944/preprints202109.0437.v1

Ингибирование miR-21 способствует процессу старения полученных из клеток NT2 астроцитов

Balint, V., Stanisavljevic-Ninkovic, D., Anastasov, N., Lazić, S., Kovacevic-Grujicic, N., Stevanović, M. J., & Lazic, A. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521110075

Editorial: Role of Senescence in Neurodegenerative Diseases

Tüzer, F., Chinta, S. J., & Viel, T. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.907670

Pez cebra: modelado de senescencia en el contexto de la enfermedad y la regeneración

Carrillo-Rosas, S., Rios-Perez, A. D., & Zampedri, C. (2022) · Investigación en Discapacidad · doi:10.35366/107513

Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6 micePreprint

Timonina, D., Hormazabal, G. V., Heckenbach, I., Anderton, E., Haky, L., Floro, A., Riley, R. R., Kwok, R., Breslin, S., Ingle, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.17.562803 · Cited by 1

Cellular Senescence

Fülöp, T., Cohen, A. A., Larbi, A., & Witkowski, J. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-55022-5_10

Evaluation of Circ-Nrf2s Expression on Oxidative Stress Condition and Prediction Its Interaction with mi-RNAs and Proteins

Amini, J., Arezumand, R., Sanadgol, N., & Alesheikh, P. (2024) · Pharmaceutical Sciences · doi:10.34172/ps.2024.17

Irisina, uma miocina como terapia para Doença de Alzheimer: revisão integrativa

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Age - and sex-specific changes in astroglial glutamine synthetase activity in rats with neurodegenerative pathology

Khairova, V. (2025) · Fìzìologìčnij žurnal · doi:10.15407/fz71.01.038

Aging and Multiple Sclerosis

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Additional file 1 of Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry

Liu, F.-C., Cheng, M.-L., Lo, C.-J., Hsu, W.-C., Lin, G., & Lin, H.-T. (2023) · Figshare · doi:10.6084/m9.figshare.22620902

Oxidative stress-driven transcriptomic remodeling in human astrocytes reveals network signatures associated with neurodegenerative and cardiovascular processes

Bota, P. M., Picón-Pagès, P., Fanlo-Ucar, H., Almabhouh, S., Bagudanch, O., Zeylan, M. E., Senyuz, S., Gohl, P., Molina-Fernández, R., Fernandez-Fuentes, N., et al. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.12.032

Plasminogen Activator Inhibitor 1, Cell Senescence, and Aging-Related Diseases

Liu, R.-M., & Nakamya, M. F. (2026) · Cells · doi:10.3390/cells15060551 · Cited by 1

Age-related decline of platelet-derived growth factor receptor alpha in mesenchyme surrounding meibomian gland leads to meibomian gland dysfunction

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