The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Dynamics of the Cellular Metabolome during Human Cytomegalovirus Infection
Open accessAbstract
Viral replication requires energy and macromolecular precursors derived from the metabolic network of the host cell. Despite this reliance, the effect of viral infection on host cell metabolic composition remains poorly understood. Here we applied liquid chromatography-tandem mass spectrometry to measure the levels of 63 different intracellular metabolites at multiple times after human cytomegalovirus (HCMV) infection of human fibroblasts. Parallel microarray analysis provided complementary data on transcriptional regulation of metabolic pathways. As the infection progressed, the levels of metabolites involved in glycolysis, the citric acid cycle, and pyrimidine nucleotide biosynthesis markedly increased. HCMV-induced transcriptional upregulation of specific glycolytic and citric acid cycle enzymes mirrored the increases in metabolite levels. The peak levels of numerous metabolites during infection far exceeded those observed during normal fibroblast growth or quiescence, demonstrating that HCMV markedly disrupts cellular metabolic homeostasis and institutes its own specific metabolic program.
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Cites
Pyruvate kinase type M2 and its role in tumor growth and spreading
Mazurek, S., Boschek, C. B., Hugo, F., & Eigenbrodt, E. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.04.009 · Cited by 812
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Self-citationA New Description of Cellular Quiescence
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Self-citationRole of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues
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Global metabolite analysis of yeast: evaluation of sample preparation methods
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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Guo, J. Y., Chen, H.-Y., Mathew, R., Fan, J., Strohecker, A. M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemons, J. M. S., Karantza, V., et al. (2011) · Genes & Development · doi:10.1101/gad.2016311 · Cited by 1,323
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Multifaceted roles for lipids in viral infection
Heaton, N. S., & Randall, G. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.03.007 · Cited by 381
Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics
Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D., & Llinás, M. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.01.004 · Cited by 289
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Metadata
- Authors
- Munger, J., Bajad, S. U., Coller, H. A., Shenk, T., & Rabinowitz, J. D.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006
- Volume
- 2
- Issue
- 12
- Pages
- e132
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2141935262
- Cited by
- 417
- References
- 27
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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