The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The Macaque Gut Microbiome in Health, Lentiviral Infection, and Chronic Enterocolitis
Open accessAbstract
The vertebrate gut harbors a vast community of bacterial mutualists, the composition of which is modulated by the host immune system. Many gastrointestinal (GI) diseases are expected to be associated with disruptions of host-bacterial interactions, but relatively few comprehensive studies have been reported. We have used the rhesus macaque model to investigate forces shaping GI bacterial communities. We used DNA bar coding and pyrosequencing to characterize 141,000 sequences of 16S rRNA genes obtained from 100 uncultured GI bacterial samples, allowing quantitative analysis of community composition in health and disease. Microbial communities of macaques were distinct from those of mice and humans in both abundance and types of taxa present. The macaque communities differed among samples from intestinal mucosa, colonic contents, and stool, paralleling studies of humans. Communities also differed among animals, over time within individual animals, and between males and females. To investigate changes associated with disease, samples of colonic contents taken at necropsy were compared between healthy animals and animals with colitis and undergoing antibiotic therapy. Communities from diseased and healthy animals also differed significantly in composition. This work provides comprehensive data and improved methods for studying the role of commensal microbiota in macaque models of GI diseases and provides a model for the large-scale screening of the human gut microbiome.
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Cites
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Self-citationObesity alters gut microbial ecology
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Self-citationProkaryotes: The unseen majority
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“human nuclear genome by two orders of magnitude [1,2], and these genes contribute many essential metabolic functions to the host.”
BackgroundMicrobial translocation is a cause of systemic immune activation in chronic HIV infection
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A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
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Cited by
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
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Self-citationThe role of gut microbiota in immune homeostasis and autoimmunity
Wu, H.-J., & Wu, E. (2012) · Gut Microbes · doi:10.4161/gmic.19320 · Cited by 1,426
How informative is the mouse for human gut microbiota research?
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Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract
Charlson, E. S., Bittinger, K., Haas, A. R., Fitzgerald, A. S., Frank, I., Yadav, A., Bushman, F. D., & Collman, R. G. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201104-0655oc · Cited by 1,144
Self-citation
Metadata
- Authors
- McKenna, P., Hoffmann, C., Minkah, N., Aye, P. P., Lackner, A., Liu, Z., Lozupone, C. A., Hamady, M., Knight, R., & Bushman, F. D.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-02-01
- Volume
- 4
- Issue
- 2
- Pages
- e20
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2124006710
- Cited by
- 437
- References
- 12
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- gold
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