Cited by 130Heat shock proteins researchAntifungal resistance and susceptibilityFungal and yeast genetics research

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Hsp90 Orchestrates Stress Response Signaling Governing Fungal Drug Resistance

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Cowen, Leah E.·2009·PLoS Pathogens

DOI 10.1371/journal.ppat.1000471PMC PMC2726949

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Abstract

The emergence of drug resistance in microbial pathogens provides a poignant example of an evolutionary process with a profound impact on human health.Fungal drug resistance poses a particular concern given the limited number of clinically useful antifungal drugs and the growing population of immunocompromised individuals vulnerable to life-threatening fungal disease [1].The efficacy of most antifungal drugs is compromised either by host toxicity, fungistatic rather than fungicidal activity, or by the emergence of drug resistance.Recent studies have revealed that compromising the function of the molecular chaperone Hsp90 can render resistant pathogens more responsive to treatment and can thwart the evolution of fungal drug resistance [2].

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Figure 1 Hsp90's role in fungal drug resistance. Compromising Hsp90 function enhances the activity of fungistatic antifungal drugs, creating fungicidal drug combinations, and can block the evolution of drug resistance. Middle panel, left column indicates that in a wild-type fungal cell (shown in yellow) Hsp90 stabilizes calcineurin, enabling calcineurin-dependent stress responses that are required to survive exposure to fungistatic antifungal drugs (azoles and echinocandins for C. albicans and echinocandins for A. fumigatus). Middle panel, right column indicates that compromising Hsp90 function abrogates calcineurin-dependent stress responses, rendering fungistatic agents fungicidal (dead fungal cell shown in grey). Top panel, in S. cerevisiae, a rapid selection regime favors the emergence of Hsp90-dependent azole resistance (orange fungal cell with dashed perimeter to indicate that resistance is contingent upon Hsp90-mediated stress responses). Bottom panel, in S. cerevisiae, a gradual selection regime favors the emergence of Hsp90-independent resistance (orange fungal cell with solid perimeter).CC BY · PubMed Central

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Authors: Cowen, L. E.
Affiliations: University of Toronto (CA)
Corresponding author: Cowen, Leah E.
ORCID: Cowen, Leah E.
Venue: PLoS Pathogens
Publisher: Public Library of Science (PLoS)
Published: 2009-08-28
Volume: 5
Issue: 8
Pages: e1000471
ISSN: 1553-7366 (ISSN-L)
1553-7374
DOI: 10.1371/journal.ppat.1000471
PMC: PMC2726949
OpenAlex: W2022326366
Cited by: 130
References: 21
Citations by year: 2026: 4 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 11 · 2018: 6 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 12 · 2013: 10 · 2012: 8
FWCI: 3.35
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Pathogens (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: HSP90, molecular chaperones, fungal drug resistance, antifungal agents, stress signaling, immunocompromised patients, fungal pathogens, drug resistance evolution
MeSH terms: Antifungal Agents, Aspergillus fumigatus, Azoles, Candida albicans, Phenotype, Signal Transduction, HSP90 Heat-Shock Proteins, Calcineurin, Drug Resistance, Fungal, Echinocandins

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Hsp90 Orchestrates Stress Response Signaling Governing Fungal Drug Resistance

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