Cited by 30Heat shock proteins researchFungal and yeast genetics researchFungal Infections and Studies

The relevance of heat shock regulation in fungal pathogens of humans

Open access
Brown, Alistair J.P., Leach, Michelle D., Nicholls, Susan·2010·Virulence

Abstract

Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4161/viru.1.4.12364

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Odds FC. Candida and candidosis: a review and bibliography, 2 nd ed. Bailliere Tindall, London 1988.
  2. Matthews RC, Burnie JP, Howat D, Rowland T, Walton F. Autoantibody to Hsp90 can mediate pro- tection against systemic candidosis. Immunol 1991; 74:20-4.

Cited by

Sorted by citations

Authors
Brown, A. J. P., Leach, M. D., & Nicholls, S.
Affiliations
University of Aberdeen (GB)
Venue
Virulence
Published
2010-07
Volume
1
Issue
4
Pages
330-332
ISSN
  • 2150-5594 (ISSN-L)
  • 2150-5608
OpenAlex
W2037695964
Cited by
30
References
36
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 3 · 2013: 1 · 2012: 4
FWCI
0.65
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Virulence (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust (214004, 080088)
  • European Commission
  • Biotechnology and Biological Sciences Research Council (BB/D009308/1, BB/F000111/1, BB/F00513X/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
heat shock response, HSF1, Candida albicans, fungal pathogens, HSP90, yeast-to-hypha transition, morphogenesis, molecular chaperones, thermal homeostasis, febrile patients, human fungal infections
MeSH terms
Heat Shock Transcription Factors, Candida albicans, DNA-Binding Proteins, Heat-Shock Proteins, Humans, Transcription Factors, Gene Expression Regulation, Fungal, HSP90 Heat-Shock Proteins, Heat-Shock Response

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review