The relevance of heat shock regulation in fungal pathogens of humans
Open accessAbstract
Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.
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- Authors
- Brown, A. J. P., Leach, M. D., & Nicholls, S.
- Affiliations
- University of Aberdeen (GB)
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2010-07
- Volume
- 1
- Issue
- 4
- Pages
- 330-332
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- PMC
- PMC3073299
- OpenAlex
- W2037695964
- Cited by
- 30
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 3 · 2013: 1 · 2012: 4
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Virulence (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (214004, 080088)
- European Commission
- Biotechnology and Biological Sciences Research Council (BB/D009308/1, BB/F000111/1, BB/F00513X/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- heat shock response, HSF1, Candida albicans, fungal pathogens, HSP90, yeast-to-hypha transition, morphogenesis, molecular chaperones, thermal homeostasis, febrile patients, human fungal infections
- MeSH terms
- Heat Shock Transcription Factors, Candida albicans, DNA-Binding Proteins, Heat-Shock Proteins, Humans, Transcription Factors, Gene Expression Regulation, Fungal, HSP90 Heat-Shock Proteins, Heat-Shock Response
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