The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells
Open accessAbstract
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1β response is mediated by innate receptors in macrophages and lung epithelial cells. NLRP3 is crucial in macrophages; however, which sensors elicit IL-1β secretion in lung epithelial cells remains undetermined. Here, we describe for the first time the relative roles of the host innate receptors RIG-I (DDX58), TLR3, and NLRP3 in the IL-1β response to IAV in primary lung epithelial cells. To activate IL-1β secretion, these cells employ partially redundant recognition mechanisms that differ from those described in macrophages. RIG-I had the strongest effect through a MAVS/TRIM25/Riplet-dependent type I IFN signaling pathway upstream of TLR3 and NLRP3. Notably, RIG-I also activated the inflammasome through interaction with caspase 1 and ASC in primary lung epithelial cells. Thus, NS1, an influenza virulence factor that inhibits the RIG-I/type I IFN pathway, strongly modulated the IL-1β response in lung epithelial cells and in ferrets. The NS1 protein derived from a highly pathogenic strain resulted in increased interaction with RIG-I and inhibited type I IFN and IL-1β responses compared to the least pathogenic virus strains. These findings demonstrate that in IAV-infected lung epithelial cells RIG-I activates the inflammasome both directly and through a type I IFN positive feedback loop.
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Cites
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
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Immune Signaling by RIG-I-like Receptors
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Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H., Pickles, R. J., & Ting, J. P.-Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.005 · Cited by 1,113
Self-citationThe Pathology of Influenza Virus Infections
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Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.
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Cited by
Kuriakose, T., Man, S. M., Subbarao Malireddi, R. K., Karki, R., Kesavardhana, S., Place, D. E., Neale, G., Vogel, P., & Kanneganti, T.-D. (2016) · Science Immunology · doi:10.1126/sciimmunol.aag2045 · Cited by 818
Discriminating self from non-self in nucleic acid sensing
Schlee, M., & Hartmann, G. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.78 · Cited by 593
Influenza virus-induced lung injury: pathogenesis and implications for treatment
Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 503
Genetic adaptation and Neandertal admixture shaped the immune system of human populations
Quach, H., Rotival, M., Pothlichet, J., Loh, Y.-H. E., Dannemann, M., Zidane, N., Laval, G., Patin, E., Harmant, C., Lopez, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.024 · Cited by 475
Self-citationHost Immune Response to Influenza A Virus Infection
Chen, X., Liu, S., Goraya, M. U., Maarouf, M., Huang, S., & Chen, J.-L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00320 · Cited by 462
Metadata
- Authors
- Pothlichet, J., Meunier, I., Davis, B. K., Ting, J. P.-Y., Skamene, E., von Messling, V., & Vidal, S. M.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-04-11
- Volume
- 9
- Issue
- 4
- Pages
- e1003256
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2094184533
- Cited by
- 227
- References
- 6
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Pothlichet, J., Meunier, I., Davis, B. K., Ting, J. P.-Y., Skamene, E., von Messling, V., & Vidal, S. M. (2013). Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1003256
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