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Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease?

Steinfelder, Svenja, O’Regan, Noëlle Louise, Hartmann, Susanne·2016·PLOS Pathogens
DOI 10.1371/journal.ppat.1005480PMC PMC4839649
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Fig 1 Origin and activation spectrum of murine and human macrophages. Modified from Murray et al. [1] and focused on M1 and M2 macrophages only.
Fig 1 Origin and activation spectrum of murine and human macrophages. Modified from Murray et al. [1] and focused on M1 and M2 macrophages only.CC BY · PubMed Central
Fig 2 Anti-inflammatory macrophages derived from the intestine, tissue, or blood, stimulated by helminths or their products, and their mechanism of action.
Fig 2 Anti-inflammatory macrophages derived from the intestine, tissue, or blood, stimulated by helminths or their products, and their mechanism of action.CC BY · PubMed Central
Fig 3 Experimental evidence and clinical trials highlighting the potential of helminth and macrophage therapy. + = positive outcome,— = no improved outcome, # = under investigation, o = no data available, * and coeliac disease. IBD: Inflammatory bowel disease, MS: Multiple sclerosis, RA: Rheumatoid arthritis. [A]: NCT01279577, [B]: NCT01576471, [C]: NCT01434693, [D]: NCT01953354, [E]: NCT01433471, [F]: NCT01661933, [G]: NCT014113243, [H]: NCT00645749, [I]: NCT01006941, [J]: NCT01470521, [K]: DHRS0005323.
Fig 3 Experimental evidence and clinical trials highlighting the potential of helminth and macrophage therapy. + = positive outcome,— = no improved outcome, # = under investigation, o = no data available, * and coeliac disease. IBD: Inflammatory bowel disease, MS: Multiple sclerosis, RA: Rheumatoid arthritis. [A]: NCT01279577, [B]: NCT01576471, [C]: NCT01434693, [D]: NCT01953354, [E]: NCT01433471, [F]: NCT01661933, [G]: NCT014113243, [H]: NCT00645749, [I]: NCT01006941, [J]: NCT01470521, [K]: DHRS0005323.CC BY · PubMed Central

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Metadata

Authors
Steinfelder, S., O’Regan, N. L., & Hartmann, S.
Venue
PLOS Pathogens
Publisher
Public Library of Science (PLoS)
Published
2016-04-21
Volume
12
Issue
4
Pages
e1005480
ISSN
1553-7374
DOI
10.1371/journal.ppat.1005480
PMC
PMC4839649
Cited by
36
References
3
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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