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Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons
Open accessAbstract
Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also develop gastrointestinal symptoms, such as vomiting and diarrhea. However, the molecular mechanisms remain incompletely defined. Using an influenza mouse model, we found that influenza pulmonary infection can significantly alter the intestinal microbiota profile through a mechanism dependent on type I interferons (IFN-Is). Notably, influenza-induced IFN-Is produced in the lungs promote the depletion of obligate anaerobic bacteria and the enrichment of Proteobacteria in the gut, leading to a "dysbiotic" microenvironment. Additionally, we provide evidence that IFN-Is induced in the lungs during influenza pulmonary infection inhibit the antimicrobial and inflammatory responses in the gut during Salmonella-induced colitis, further enhancing Salmonella intestinal colonization and systemic dissemination. Thus, our studies demonstrate a systemic role for IFN-Is in regulating the host immune response in the gut during Salmonella-induced colitis and in altering the intestinal microbial balance after influenza infection.
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“Using animal models of pulmonary infections by influenza and respiratory syncytial virus (RSV), multiple groups have shown that the gut microbiome is clearly impacted by respiratory viral infections, despite the lack of detectable respiratory virus in the gut”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [44]
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Metadata
- Authors
- Deriu, E., Boxx, G. M., He, X., Pan, C., Benavidez, S. D., Cen, L., Rozengurt, N., Shi, W., & Cheng, G.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Cheng, Genhong
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-05-05
- Volume
- 12
- Issue
- 5
- Pages
- e1005572
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC4858270
- OpenAlex
- W2345507899
- Cited by
- 280
- References
- 68
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 30 · 2023: 28 · 2022: 44 · 2021: 47 · 2020: 34 · 2019: 14 · 2018: 20 · 2017: 18 · 2016: 4
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Figshare (cc-by)
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI056154, RO1 AI069120)
- National Institutes of Health (P30 DK041301)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Keywords
- influenza virus, gut microbiota, type I interferon, Salmonella, colitis, dysbiosis, obligate anaerobes, Proteobacteria, intestinal immunity, systemic dissemination
- MeSH terms
- Gastrointestinal Microbiome, Animals, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Interferon Type I, Mice, Inbred C57BL, Orthomyxoviridae Infections, Salmonella Infections, Animal, Immunoblotting, Mice, Knockout, Mice, Coinfection, Real-Time Polymerase Chain Reaction
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