Cited by 861Acute Myocardial Infarction ResearchClinical Laboratory Practices and Quality ControlBiomarkers in Disease Mechanisms

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays

Apple, Fred S, Collinson, Paul O, for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers·2012·Clinical Chemistry

DOI 10.1373/clinchem.2011.165795

Open this paper in CoChat — free account

Abstract

BACKGROUND: Cardiac troponins I (cTnI) and T (cTnT) have received international endorsement as the standard biomarkers for detection of myocardial injury, for risk stratification in patients suspected of acute coronary syndrome, and for the diagnosis of myocardial infarction. An evidence-based clinical database is growing rapidly for high-sensitivity (hs) troponin assays. Thus, clarifications of the analytical principles for the immunoassays used in clinical practice are important. CONTENT: The purpose of this mini-review is (a) to provide a background for the biochemistry of cTnT and cTnI and (b) to address the following analytical questions for both hs cTnI and cTnT assays: (i) How does an assay become designated hs? (ii) How does one realistically define healthy (normal) reference populations for determining the 99th percentile? (iii) What is the usual biological variation of these analytes? (iv) What assay imprecision characteristics are acceptable? (v) Will standardization of cardiac troponin assays be attainable? SUMMARY: This review raises important points regarding cTnI and cTnT assays and their reference limits and specifically addresses hs assays used to measure low concentrations (nanograms per liter or picograms per milliliter). Recommendations are made to help clarify the nomenclature. The review also identifies further challenges for the evolving science of cardiac troponin measurement. It is hoped that with the introduction of these concepts, both laboratorians and clinicians can develop a more unified view of how these assays are used worldwide in clinical practice.

Integrity signals

Registry

Crossref · 10.1373/clinchem.2011.165795

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Universal Definition of Myocardial Infarction
Thygesen, K. A., Alpert, J. S., White, H. D., TASK FORCE MEMBERS: Chairpersons: Kristian Thygesen (Denmark), J. S. A. (., Biomarker Group: Allan S. Jaffe, C. (., ECG Group: Bernard Chaitman, C.-O. (., Imaging Group: Richard Underwood, C. (., Intervention Group: Jean-Pierre Bassand, C.-O. (., Mendis, S., Implementation Group: Lars C. Wallentin Coordinator (Sweden), F. F.-A. (., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187397 · Cited by 4,422
Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction
Thygesen, K. A. (2007) · Circulation · Cited by 3,126
Universal definition of myocardial infarction: Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
Task Force Members, Thygesen, K. A., Alpert, J. S., White, H. D., Biomarker Group, Jaffe, A. S., Apple, F. S., Galvani, M., Katus, H. A., Newby, L. K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm355 · Cited by 2,536
Self-citation
Cardiac troponin I. A marker with high specificity for cardiac injury.
Adams, J. E., Bodor, G. S., Dávila‐Román, V. G., Delmez, J. A., Apple, F. S., Ladenson, J. H., & Jaffe, A. S. (1993) · Circulation · doi:10.1161/01.cir.88.1.101 · Cited by 1,149
Self-citation
Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population
de Lemos, J. A., Drazner, M. H., Omland, T., Ayers, C. R., Khera, A., Rohatgi, A. K., Hashim, I. A., Berry, J. D., Das, S. R., Morrow, D. A., et al. (2010) · JAMA · doi:10.1001/jama.2010.1768 · Cited by 1,103
Analytical Validation of a High-Sensitivity Cardiac Troponin T Assay
Giannitsis, E., Kurz, K., Hallermayer, K., Jarausch, J., Jaffe, A. S., & Katus, H. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.132654 · Cited by 1,087
Association of Serial Measures of Cardiac Troponin T Using a Sensitive Assay With Incident Heart Failure and Cardiovascular Mortality in Older Adults
deFilippi, C. R., de Lemos, J. A., Christenson, R. H., Gottdiener, J. S., Kop, W. J., Zhan, M., & Seliger, S. L. (2010) · JAMA · doi:10.1001/jama.2010.1708 · Cited by 715
Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction
Katus, H. A., Remppis, A. B., Scheffold, T., Diederich, K. W., & Kübler, W. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90466-x · Cited by 557
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes
NACB WRITING GROUP MEMBERS, Morrow, D. A., Cannon, C. P., Jesse, R. L., Newby, L. K., Ravkilde, J., Storrow, A. B., Wu, A. H. B., Christenson, R. H., Christenson, R. H., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.084194 · Cited by 475
Self-citation
Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction
Reichlin, T., Irfan, A. B., Twerenbold, R., Reiter, M., Hochholzer, W., Burkhalter, H., Bassetti, S., Steuer, S., Winkler, K., Peter, F., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.023937 · Cited by 459

Flagged first, then by citations

Show all 41 references

Research works printed but not linked: 1

Apple, 2011, Short-term biological variation of cardiac troponin I measured with three high-sensitivity assays [Abstract], Clin Chem, 57, C05

Sorted by citations

Items 201–300 of 860

Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women
Shah, A. S. V., Ferry, A. V., & Mills, N. L. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0839-9 · Cited by 39
Clinical implications of isolated troponinemia following immune checkpoint inhibitor therapy
Delombaerde, D. L., Vervloet, D., Franssen, C., Croes, L., Gremonprez, F., Prenen, H., Peeters, M., & Vulsteke, C. (2021) · ESMO Open · doi:10.1016/j.esmoop.2021.100216 · Cited by 42
Head-to-head comparison of high-sensitivity troponin T and sensitive-contemporary troponin I regarding heart failure risk stratification
de Antonio, M., Lupón, J., Galán, A., Vila, J., Zamora, E., Urrútia, A., Díez, C., Coll, R., Altimir, S., & Bayés‐Genís, A. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.08.014 · Cited by 39
The clinical and diagnostic performance characteristics of the high sensitivity Abbott cardiac troponin I assay
Collinson, P. O., Gaze, D. C., & Goodacre, S. W. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.12.017 · Cited by 38
Self-citation
The Role of Cardiac Biomarkers in the Diagnosis and Management of Patients Presenting with Suspected Acute Coronary Syndrome
Christenson, E. S., & Christenson, R. H. (2013) · Annals of Laboratory Medicine · doi:10.3343/alm.2013.33.5.309 · Cited by 38
High-sensitivity cardiac troponin T levels in the emergency department in patients with chest pain but no myocardial infarction
Carlsson, A. C., Bandstein, N., Roos, A., Hammarsten, O., & Holzmann, M. J. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.087 · Cited by 38
Serial Sampling of High-Sensitivity Cardiac Troponin T May Not Be Required for Prediction of Acute Myocardial Infarction Diagnosis in Chest Pain Patients with Highly Abnormal Concentrations at Presentation
Mueller‐Hennessen, M., Mueller, C. E., Giannitsis, E., Biener, M., Vafaie, M., deFilippi, C. R., Christ, M., Ordóñez‐Llanos, J., Panteghini, M., Plebani, M., et al. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.258392 · Cited by 38
The organisational value of diagnostic strategies using high-sensitivity troponin for patients with possible acute coronary syndromes: a trial-based cost-effectiveness analysis
Jülicher, P., Greenslade, J. H., Parsonage, W. A., & Cullen, L. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-013653 · Cited by 38
High-sensitivity cardiac troponin I and risk of cardiovascular disease in an Australianpopulation-based cohort
Zhu, K., Knuiman, M. W., Divitini, M., Murray, K., Lim, E. M., John, A. S., Walsh, J. P., & Hung, J. (2017) · Heart · doi:10.1136/heartjnl-2017-312093 · Cited by 38
Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay
Body, R. M., Almashali, M., Morris, N., Moss, P., Jarman, H., Appelboam, A., Parris, R. J., Chan, L., Walker, A., Harrison, M., et al. (2019) · Heart · doi:10.1136/heartjnl-2018-313825 · Cited by 38
Dynamic Changes in High-Sensitivity Cardiac Troponin I in Response to Anthracycline-Based Chemotherapy
Tzolos, E., Adamson, P. D., Hall, P. S., Macpherson, I. R., Oikonomidou, O., MacLean, M., Lewis, S. C., McVicars, H., Newby, D. E., Mills, N. L., et al. (2019) · Clinical Oncology · doi:10.1016/j.clon.2019.11.008 · Cited by 38
Effect of Particle Size and Surface Chemistry of Photon‐Upconversion Nanoparticles on Analog and Digital Immunoassays for Cardiac Troponin
Brandmeier, J. C., Raiko, K., Farka, Z., Peltomaa, R., Mickert, M. J., Hlaváček, A., Skládal, P., Soukka, T., & Gorris, H. H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100506 · Cited by 40
Troponin Elevations Only Detected With a High‐sensitivity Assay: Clinical Correlations and Prognostic Significance
Korley, F. K., Schulman, S. P., Sokoll, L. J., DeFilippis, A. P., Stolbach, A. I., Bayram, J. D., Saheed, M. O., Omron, R., Fernandez, C. M., Lwin, A. T., et al. (2014) · Academic Emergency Medicine · doi:10.1111/acem.12417 · Cited by 37
Universal MI Definition Update for Cardiovascular Disease
White, H. D., Thygesen, K. A., Alpert, J. S., & Jaffe, A. S. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0492-5 · Cited by 40
Biomarkers as Predictors of Cardiac Toxicity From Targeted Cancer Therapies
Witteles, R. M. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2016.03.016 · Cited by 37
Direct Comparison of 2 Rule-Out Strategies for Acute Myocardial Infarction: 2-h Accelerated Diagnostic Protocol vs 2-h Algorithm
Wildi, K. S., Cullen, L., Twerenbold, R., Greenslade, J. H., Parsonage, W. A., Boeddinghaus, J., Nestelberger, T., Sabti, Z., Giménez, M. R., Puelacher, C., et al. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2016.268359 · Cited by 39
High‐Sensitivity Troponin T and C‐Reactive Protein Have Different Prognostic Values in Hemo‐ and Peritoneal Dialysis Populations: A Cohort Study
Chen, T., Hassan, H. I. C., Qian, P. C., Vu, M., & Makris, A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007876 · Cited by 37
Cardiac Troponin I and T Are Associated with Left Ventricular Function and Structure: Data from the Akershus Cardiac Examination 1950 Study
Lyngbakken, M. N., Aagaard, E. N., Kvisvik, B., Berge, T., Pervez, M. O., Brynildsen, J., Tveit, A., Steine, K., Røsjø, H. R., & Omland, T. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa023 · Cited by 36
Discordance of High-Sensitivity Troponin Assays in Patients With Suspected Acute Coronary Syndromes
Karády, J., Mayrhofer, T., Ferencik, M., Nagurney, J. T., Udelson, J. E., Kammerlander, A. A., Fleg, J. L., Peacock, W. F., Januzzi, J. L., Köenig, W., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.046 · Cited by 37
The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform
Soetkamp, D., Raedschelders, K., Mastali, M., Sobhani, K., Bairey Merz, C. N., & Van Eyk, J. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1387054 · Cited by 36
Biomarkers in cardiorenal syndromes
Tan, K. M. L., & Sethi, S. K. (2014) · Translational research · doi:10.1016/j.trsl.2014.04.011 · Cited by 37
Providing Rapid Out of Hospital Acute Cardiovascular Treatment 4 (PROACT‐4)
Ezekowitz, J. A., Welsh, R. C., Weiss, D., Chan, M. C. Y., Keeble, W., Khadour, F., Sharma, S., Tymchak, W. J., Sookram, S., Brass, N. S., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002859 · Cited by 36
Randomized Comparison of High-Sensitivity Troponin Reporting in Undifferentiated Chest Pain Assessment
Chew, D. P., Zeitz, C. J., Worthley, M. I., Grantham, H. J. M., Beltrame, J. F., Arstall, M. A., Coates, P. S., Astley, C. M., Quinn, S. J., Ratcliffe, J., et al. (2016) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.115.002488 · Cited by 36
The European Biological Variation Study (EuBIVAS): weekly biological variation of cardiac troponin I estimated by the use of two different high-sensitivity cardiac troponin I assays
Ceriotti, F., Marco, J. D.-G., Fernández–Calle, P., Maregnani, A., Aarsand, A. K., Coşkun, A., Jonker, N., Sandberg, S., & Carobene, A. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-1182 · Cited by 36
Altered preoperative coagulation and fibrinolysis are associated with myocardial injury after non-cardiac surgery
Górka, J., Polok, K., Iwaniec, T., Górka, K., Włudarczyk, A., Fronczek, J., Devereaux, P. J., Eikelboom, J. W., Musiał, J., & Szczeklik, W. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex081 · Cited by 36
Conventional and novel diagnostic biomarkers of acute myocardial infarction: a promising role for circulating microRNAs
Recchioni, R., Marcheselli, F., Olivieri, F., Ricci, S., Procopio, A. D., & Antonicelli, R. (2013) · Biomarkers · doi:10.3109/1354750x.2013.833294 · Cited by 35
Usefulness of high-sensitivity troponin T for the evaluation of patients with acute chest pain and no or minimal myocardial damage
Sanchís, J. M., Bardajı́, A., Bosch, X., Loma-Osorio, P., Marín, F. R., Sanchez, P. L., Núñez, J. E., Carratalá, A., & Barrabés, J. A. (2012) · American Heart Journal · doi:10.1016/j.ahj.2012.05.015 · Cited by 35
High-sensitivity cardiac troponin I and incident coronary heart disease among asymptomatic older adults
Iribarren, C., Chandra, M., Rana, J. S., Hlatky, M. A., Fortmann, S. P., Quertermous, T., & Go, A. S. (2016) · Heart · doi:10.1136/heartjnl-2015-309136 · Cited by 35
Impact of high-sensitivity cardiac troponin implementation on emergency department length of stay, testing, admissions, and diagnoses
Ford, J. S., Chaco, E., Tancredi, D. J., & Mumma, B. E. (2021) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2021.02.021 · Cited by 35
SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes
Hodrea, J., Saeed, A., Molnár, Á., Fintha, A., Bárczi, A., Wagner, L. J., Szabo, A. J., Fekete, A., & Balogh, D. B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263285 · Cited by 35
Distribution of antiphospholipid antibodies in a large population-based German cohort
Manukyan, D., Rossmann, H., Schulz, A., Zeller, T., Pfeiffer, N., Binder, H., Münzel, T. F., Beutel, M. E., Müller‐Calleja, N., Wild, P. S., et al. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0014 · Cited by 35
C ardiac R emote I schemic P reconditioning Prior to E lective Vascular S urgery (CRIPES): A Prospective, Randomized, Sham‐Controlled Phase II Clinical Trial
Garcia, S. A., Rector, T. S., Zakharova, M., Herrmann, R. R., Adabağ, S., Bertog, S. C., Sandoval, Y. B., Santilli, S. M., Brilakis, E. S., & McFalls, E. O. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003916 · Cited by 34
Biomarkers for monitoring chemotherapy-induced cardiotoxicity
Cao, L., Zhu, W., Wagar, E. A., & Meng, Q. H. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2016.1261270 · Cited by 34
Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study
Lyngbakken, M. N., Røsjø, H. R., Holmen, O. L., Dalen, H., Hveem, K., & Omland, T. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.301069 · Cited by 34
Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents
Geva, A., Patel, M. M., Newhams, M. M., Young, C. C., Son, M. B. F., Kong, M. Y. F., Maddux, A. B., Hall, M. W., Riggs, B. J., Singh, A. R., et al. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.101112 · Cited by 33
Fifth Universal Definition of Myocardial Infarction (2026)
Mills, N. L., Newby, L. K., Zaman, S. J., Almahmeed, W. A., Bucciarelli‐Ducci, C., Colvin, M. M., Dangas, G., DeVon, H. A., Dharmakumar, R., Gaziano, T. A., et al. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2026.07.025 · Cited by 40
Incidence of Undetectable, Measurable, and Increased Cardiac Troponin I Concentrations Above the 99th Percentile Using a High-Sensitivity vs a Contemporary Assay in Patients Presenting to the Emergency Department
Love, S. A., Sandoval, Y. B., Smith, S. W., Nicholson, J., Cao, J., Ler, R., Schulz, K. M., & Apple, F. S. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.256305 · Cited by 33
Self-citation
Novel biomarkers predicting cardiac function after acute myocardial infarction
Feistritzer, H., Klug, G., Reinstadler, S. J., Reindl, M., Mayr, A., Mair, J. M., & Metzler, B. (2016) · British Medical Bulletin · doi:10.1093/bmb/ldw027 · Cited by 33
Establishing the upper reference limit of Galectin-3 in healthy blood donors
Agnello, L., Bellia, C., Sasso, B. L., Pivetti, A., Muratore, M., Scazzone, C., Bivona, G., Lippi, G., & Ciaccio, M. (2017) · Biochemia Medica · doi:10.11613/bm.2017.030709 · Cited by 33
A review of cardiac troponin I detection by surface enhanced Raman spectroscopy: Under the spotlight of point-of-care testing
Saviñon-Flores, A. I., Saviñon-Flores, F., Trejo, G., Méndez, E., Ţălu, Ş., González‐Fuentes, M. A., & Méndez‐Albores, A. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1017305 · Cited by 32
Influence of Nitrous Oxide Anesthesia, B-Vitamins, and MTHFR Gene Polymorphisms on Perioperative Cardiac Events
Nägele, P., Brown, F., Francis, A. M., Scott, M. G., Gage, B. F., & Miller, J. P. (2013) · Anesthesiology · doi:10.1097/aln.0b013e31829761e3 · Cited by 33
Elevated Baseline Cardiac Troponin Levels in the Elderly – Another Variable to Consider?
Webb, I. G., Yam, S. T., Cooke, R., Aitken, A., Larsen, P., & Harding, S. A. (2014) · Heart Lung and Circulation · doi:10.1016/j.hlc.2014.07.071 · Cited by 33
Head-to-head comparison of cardiac troponin T and troponin I in patients without acute coronary syndrome: a systematic review
Árnadóttir, Á., Klein, C. F., & Iversen, K. K. (2017) · Biomarkers · doi:10.1080/1354750x.2017.1335779 · Cited by 32
Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction
Wildi, K. S., Singeisen, H., Twerenbold, R., Badertscher, P., Wussler, D. N., Klinkenberg, L. J. J., Meex, S. J. R., Nestelberger, T., Boeddinghaus, J., Miró, Ò., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.136 · Cited by 32
Cardiac Troponin - diagnostic problems and impact on cardiovascular disease
Alaour, B., Liew, F., & Kaier, T. E. (2018) · Annals of Medicine · doi:10.1080/07853890.2018.1530450 · Cited by 35
Subclinical Cardiovascular Disease and Fall Risk in Older Adults: Results From the Atherosclerosis Risk in Communities Study
Juraschek, S. P., Daya, N. R., Appel, L. J., Miller, E. R., Matsushita, K., Michos, E. D., Windham, B. G., Ballantyne, C. M., & Selvin, E. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16041 · Cited by 32
Nationwide trends in acute coronary syndrome by subtype in New Zealand 2006–2016
Wang, T. K. M., Grey, C., Jiang, Y., Jackson, R., & Kerr, A. (2019) · Heart · doi:10.1136/heartjnl-2019-315655 · Cited by 34
A liquid-crystal-based immunosensor for the detection of cardiac troponin I
Xia, C., Zhou, D. F., Su, Y., Zhou, G., Yao, L., Sun, W., & Liu, Y. (2020) · The Analyst · doi:10.1039/d0an00425a · Cited by 32
Outliers affecting cardiac troponin I measurement: comparison of a new high sensitivity assay with a contemporary assay on the Abbott ARCHITECT analyser
Sawyer, N. K., Blennerhassett, J. B., Lambert, R., Sheehan, P., & Vasikaran, S. D. (2013) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563213499737 · Cited by 32
Finding and Applying Evidence During Clinical Rounds
Sackett, D. L., & Straus, S. E. (2011) · Cited by 32
Use of Observed Within-Person Variation of Cardiac Troponin in Emergency Department Patients for Determination of Biological Variation and Percentage and Absolute Reference Change Values
Simpson, A. J., Potter, J. M., Koerbin, G., Oakman, C., Cullen, L., Wilkes, G., Scanlan, S. L., Parsonage, W. A., & Hickman, P. E. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2013.219410 · Cited by 31
Determination of high-sensitivity cardiac troponin I 99th percentile upper reference limits in a healthy Korean population
Ji, M., Moon, H., Hur, M., & Yun, Y. (2016) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2016.01.027 · Cited by 32
Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time
Hijazi, Z., Lindahl, B., Oldgren, J., Andersson, U., Lindbäck, J., Granger, C. B., Alexander, J. H., Gersh, B. J., Hanna, M., Harjola, V., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004851 · Cited by 31
Clinical Features and Outcomes of Emergency Department Patients With High-Sensitivity Cardiac Troponin I Concentrations Within Sex-Specific Reference Intervals
Sandoval, Y. B., Smith, S. W., Sexter, A., Gunsolus, I. L., Schulz, K. M., & Apple, F. S. (2019) · Circulation · doi:10.1161/circulationaha.118.038284 · Cited by 31
Self-citation
Meta-analysis of preoperative high-sensitivity cardiac troponin measurement in non-cardiac surgical patients at risk of cardiovascular complications
Zhao, B.-C., Liu, W. H., Deng, Q.-W., Zhuang, P.-P., Liu, J., Li, C., & Liu, K. (2020) · British journal of surgery · doi:10.1002/bjs.11305 · Cited by 31
Pre-analytical considerations in biomarker research: focus on cardiovascular disease
Revuelta‐López, E., Barallat, J., Cserkóová, A., Gálvez‐Montón, C., Jaffe, A. S., Januzzi, J. L., & Bayés‐Genís, A. (2021) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2021-0377 · Cited by 31
Two-dimensional paper chromatography-based fluorescent immunosensor for detecting acute myocardial infarction markers
Cho, J., Kim, M.-H., Mok, R.-S., Jeon, J.-W., Lim, G.-S., Chai, C.-Y., & Paek, S. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.07.026 · Cited by 31
Acute coronary syndrome – the present and future role of biomarkers1)
Lindahl, B. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-0074 · Cited by 31
An Alternating Current Electroosmotic Flow‐Based Ultrasensitive Electrochemiluminescence Microfluidic System for Ultrafast Monitoring, Detection of Proteins/miRNAs in Unprocessed Samples
Xiong, H., Zhu, C., Dai, C., Ye, X., Li, Y., Li, P., Yang, S., Ashraf, G., Wei, D., Chen, H., et al. (2023) · Advanced Science · doi:10.1002/advs.202307840 · Cited by 30
Troponin T is a strong marker of mortality in hospitalized patients
Iversen, K. K., Køber, L., Gøtze, J. P., Dalsgaard, M., Nielsen, H., Boesgaard, S., Bay, M., Kirk, V., & Nielsen, O. W. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.006 · Cited by 30
Laboratory diagnostics of myocardial infarction – troponins and beyond
Lackner, K. J. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0572 · Cited by 30
Impact of Statin Use on Exercise-Induced Cardiac Troponin Elevations
Eijsvogels, T. M. H., Januzzi, J. L., Taylor, B. A., Isaacs, S. K., d’Hemecourt, P. A., Zaleski, A. L., Dyer, S., Troyanos, C., Weiner, R. B., Thompson, P. D., et al. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.05.047 · Cited by 30
High-sensitivity cardiac troponins in everyday clinical practice
Mair, J. M. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i4.175 · Cited by 30
Association of Cardiac Troponin I With Disease Severity and Outcomes in Patients With Pulmonary Hypertension
Vélez-Martínez, M., Ayers, C. R., Mishkin, J. D., Bartolome, S., Garcia, C. K., Torres, F., Drazner, M. H., de Lemos, J. A., Turer, A. T., & Chin, K. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.02.036 · Cited by 30
Skeletal myopathies as a non-cardiac cause of elevations of cardiac troponin concentrations
Giannitsis, E., Mueller, C. E., & Katus, H. A. (2019) · Diagnosis · doi:10.1515/dx-2019-0045 · Cited by 30
Clinical Pathology
York, M. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803620-4.00014-1 · Cited by 30
Current Applications of Cardiac Troponin T for the Diagnosis of Myocardial Damage
Vašatová, M., Pudil, R., Horáček, J. M., & Büchler, T. (2013) · Advances in clinical chemistry · doi:10.1016/b978-0-12-407680-8.00002-6 · Cited by 29
Measurement of High-Sensitivity Troponin T in Noncardiac Medical Intensive Care Unit Patients
Baron, J. M., Lewandrowski, E. L., Januzzi, J. L., Bajwa, E. K., Thompson, B., & Lewandrowski, K. B. (2014) · American Journal of Clinical Pathology · doi:10.1309/ajcplvqqy35xtfvn · Cited by 29
Biomarkers in Heart Failure: The Importance of Inconvenient Details
Miller, W. L., & Jaffe, A. S. (2015) · ESC Heart Failure · doi:10.1002/ehf2.12071 · Cited by 29
Paper-based cascade cationic isotachophoresis: Multiplex detection of cardiac markers
Guo, S., Schlecht, W. D., Li, L., & Dong, W. (2019) · Talanta · doi:10.1016/j.talanta.2019.07.007 · Cited by 28
The role of cardiac biomarkers in cardiovascular disease risk assessment
Collinson, P. O. (2014) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000081 · Cited by 28
Self-citation
Non-ST Elevation Acute Coronary Syndromes: A Comprehensive Review
Bob‐Manuel, T., Ifedili, I., Reed, G. L., Ibebuogu, U. N., & Khouzam, R. N. (2017) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2017.04.006 · Cited by 33
High sensitivity cardiac troponin in patients with chest pain
Shah, A. S. V., Newby, D. E., & Mills, N. L. (2013) · BMJ · doi:10.1136/bmj.f4222 · Cited by 27
Comparison Between Soluble ST2 and High-Sensitivity Troponin I in Predicting Short-Term Mortality for Patients Presenting to the Emergency Department With Chest Pain
Marino, R., Magrini, L., Orsini, F., Russo, V., Cardelli, P., Salerno, G., Hur, M., Somma, S. D., & GREAT NETWORK (2016) · Annals of Laboratory Medicine · doi:10.3343/alm.2017.37.2.137 · Cited by 27
Usefulness of combining admission brain natriuretic peptide (BNP) plus hospital discharge bioelectrical impedance vector analysis (BIVA) in predicting 90 days cardiovascular mortality in patients with acute heart failure
On Behalf of Great Network, Santarelli, S., Russo, V., Lalle, I., Berardinis, B. D., Navarin, S., Magrini, L., Piccoli, A., Codognotto, M., Castello, L. M., et al. (2016) · Internal and Emergency Medicine · doi:10.1007/s11739-016-1581-9 · Cited by 27
Association of High‐Sensitivity Troponin T and I Blood Concentrations With All‐Cause Mortality and Cardiovascular Outcome in Stable Patients—Results From the INTERCATH Cohort
Bay, B., Goßling, A., Blaum, C. M., Kroeger, F., Koppe, L., Lorenz, T., Koester, L., Clemmensen, P. M., Westermann, D., Kirchhof, P. F., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024516 · Cited by 27
Creatine Kinase–MB
Singh, G., & Baweja, P. S. (2014) · American Journal of Clinical Pathology · doi:10.1309/ajcpbik3g4bwejko · Cited by 27
Cardiac myosin-binding protein C is a novel marker of myocardial injury and fibrosis in aortic stenosis
Anand, A., Chin, C., Shah, A. S. V., Kwieciński, J., Vesey, A. T., Cowell, J., Weber, E., Kaier, T. E., Newby, D. E., Dweck, M. R., et al. (2017) · Heart · doi:10.1136/heartjnl-2017-312257 · Cited by 28
Direct Comparison of Cardiac Troponin T and I Using a Uniform and a Sex-Specific Approach in the Detection of Functionally Relevant Coronary Artery Disease
Mueller, D. L., Puelacher, C., Honegger, U., Walter, J. E., Badertscher, P., Schaerli, N., Strebel, I., Twerenbold, R., Boeddinghaus, J., Nestelberger, T., et al. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.286971 · Cited by 27
Point: The Use of Sex-Specific Cutpoints for High-Sensitivity Cardiac Troponin Assays
Cullen, L., & Mills, N. L. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.254672 · Cited by 26
Diagnosis, Investigation and Management of Patients with Acute and Chronic Myocardial Injury
Taggart, C., Wereski, R., Mills, N. L., & Chapman, A. R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112331 · Cited by 27
Safety Biomarkers in Preclinical Development
Sasseville, V. G., Mansfield, K. G., & Brees, D. (2013) · Veterinary Pathology · doi:10.1177/0300985813505117 · Cited by 26
Estimation of age- and comorbidities-adjusted percentiles of high-sensitivity cardiac troponin T levels in the elderly
Kuster, N., Monnier, K., Baptista, G., Dupuy, A., Badiou, S., Bargnoux, A., Jeandel, C., & Cristol, J. (2014) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-0121 · Cited by 26
The Confounding Effects of Non-cardiac Pathologies on the Interpretation of Cardiac Biomarkers
Nishimura, M., Brann, A. M., Chang, K., & Maisel, A. S. (2018) · Current Heart Failure Reports · doi:10.1007/s11897-018-0398-4 · Cited by 26
Cardiac Troponins and Cardiovascular Disease Risk Prediction
Shah, A. S. V., Keene, S. J., Pennells, L. A. M., Kaptoge, S., Kimenai, D. M., Walker, M. R., Halley, J., Rocha, S., Hoogeveen, R. C., Gudnason, V. G., et al. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.02.016 · Cited by 25
Pilot study on harmonization of cardiac troponin I immunoassays using patients and quality control plasma samples. On behalf of the Italian Section of the European Ligand Assay Society (ELAS) and of the Study Group on Cardiovascular Biomarkers of the Società Italiana di Biochimica Clinica (SIBioC)
Clerico, A., Ripoli, A., Masotti, S., Prontera, C., Storti, S., Fortunato, A., Buzzi, P., Casagranda, I., Franzini, M., Ndreu, R., et al. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.017 · Cited by 25
Troponin in early presenters to rule out myocardial infarction
Lowry, M. T. H., Doudesis, D., Boeddinghaus, J., Kimenai, D. M., Bularga, A., Taggart, C., Wereski, R., Ferry, A. V., Stewart, S. D., Tuck, C. E., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad376 · Cited by 25
Self-citation
Increased circulating High-Sensitivity Troponin T concentrations in children and adolescents with obesity and the metabolic syndrome: A marker for early cardiac damage?
Pervanidou, P., Akalestos, A., Bastaki, D., Apostolakou, F., Papassotiriou, I., & Chrousos, G. P. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.012 · Cited by 25
An algorithm for rule-in and rule-out of acute myocardial infarction using a novel troponin I assay
Lindahl, B., Jernberg, T., Badertscher, P., Boeddinghaus, J., Eggers, K. M., Frick, M., Giménez, M. R., Linder, R. B. A., Ljung, L., Martinsson, A., et al. (2016) · Heart · doi:10.1136/heartjnl-2016-309951 · Cited by 25
Cardiac Troponins and High-sensitivity Cardiac Troponin Assays
Conrad, M. J., & Jarolı́m, P. (2014) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2013.11.008 · Cited by 26
High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide predict mortality in stable coronary artery disease: results from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
Giannitsis, E., Spanuth, E., Horsch, A., Kleber, M. E., Koch, W., Grammer, T. B., Köenig, W., & März, W. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0786 · Cited by 24
Multimarker Approach to Risk Stratification for Long-Term Mortality in Patients on Chronic Hemodialysis
Ishii, J., Takahashi, H., Kitagawa, F., Kuno, A., Okuyama, R., Kawai, H., Muramatsu, T., Naruse, H., Motoyama, S., Matsui, S., et al. (2015) · Circulation Journal · doi:10.1253/circj.cj-14-0915 · Cited by 24
Single test rule-out of acute myocardial infarction using the limit of detection of a new high-sensitivity troponin I assay
Body, R. M., Morris, N., & Collinson, P. O. (2020) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2020.02.014 · Cited by 24
Self-citation
Identification of Key Genes as Early Warning Signals of Acute Myocardial Infarction Based on Weighted Gene Correlation Network Analysis and Dynamic Network Biomarker Algorithm
Song, C., Qiao, Z., Chen, L., Ge, J., Zhang, R., Yuan, S., Bian, X., Wang, C., Liu, Q., Jia, L., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.879657 · Cited by 23
Serial cardiac troponin differences measured on four contemporary analyzers: Relative differences, actual differences and reference change values compared
Pretorius, C. J., Wilgen, U., & Ungerer, J. P. J. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.07.001 · Cited by 23
Consideration of high-sensitivity troponin values below the 99th percentile at presentation: Does it improve diagnostic accuracy?
Meune, C., Balmelli, C., Vogler, E., Twerenbold, R., Reiter, M., Reichlin, T., Haaf, P., Drexler, B., Wildi, K. S., Hoeller, R., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.06.011 · Cited by 23
Effectiveness of practices for improving the diagnostic accuracy of Non ST Elevation Myocardial Infarction in the Emergency Department: A Laboratory Medicine Best Practices™ systematic review
Layfield, C., Rose, J., Alford, A., Snyder, S. R., Apple, F. S., Chowdhury, F. M., Kontos, M. C., Newby, L. K., Storrow, A. B., Tanasijevic, M. J., et al. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.01.014 · Cited by 23
Self-citation
Remnant cholesterol predicts periprocedural myocardial injury following percutaneous coronary intervention in poorly-controlled type 2 diabetes.
Zeng, R.-X., Li, S., Zhang, M.-Z., Li, X.-L., Zhu, C.-G., Guo, Y.-L., Zhang, Y., & Li, J.-J. (2017) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.12.010 · Cited by 20
Understanding cardiac troponin part 1: avoiding troponinitis
Body, R. M., & Carlton, E. W. (2017) · Emergency Medicine Journal · doi:10.1136/emermed-2017-206812 · Cited by 23
Cross-Sectional Associations Between Cardiac Biomarkers, Cognitive Performance, and Structural Brain Changes Are Modified by Age
Veugen, M. G. J., Henry, R. M. A., Rocca, H. B., Dagnelie, P. C., Schram, M. T., van Agtmaal, M. J. M., Kallen, C., Sep, S. J. S., van Boxtel, M. P. J., Bekers, O., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311082 · Cited by 23

Authors: Apple, F. S., Collinson, P. O., & for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers
Affiliations: University of Minnesota (US)
St George's Hospital (GB)
Corresponding author: Apple, Fred S
ORCID: Apple, Fred S
Collinson, Paul O
Venue: Clinical Chemistry
Publisher: Oxford University Press (OUP)
Published: 2012-01-01
Volume: 58
Issue: 1
Pages: 54-61
ISSN: 0009-9147 (ISSN-L)
1530-8561
DOI: 10.1373/clinchem.2011.165795
OpenAlex: W2151231511
Cited by: 861
References: 41
Citations by year: 2026: 26 · 2025: 39 · 2024: 33 · 2023: 42 · 2022: 44 · 2021: 51 · 2020: 53 · 2019: 58 · 2018: 63 · 2017: 87 · 2016: 88 · 2015: 69 · 2014: 75 · 2013: 81 · 2012: 46
FWCI: 11.14
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Siemens
Abbott
Radiometer
B.R.A.H.M.S.
Roche
Alere
Instrumentation Laboratories
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords: high-sensitivity troponin I, high-sensitivity troponin T, cardiac troponin assays, assay standardization, reference limits, biological variation, assay imprecision, myocardial injury biomarkers, acute coronary syndrome, myocardial infarction diagnosis
MeSH terms: Humans, Immunoassay, Myocardial Infarction, Myocardium, Reference Values, Sensitivity and Specificity, Biomarkers, Troponin I, Troponin T, Acute Coronary Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks