Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays

Universal Definition of Myocardial Infarction

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Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction

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Universal definition of myocardial infarction: Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction

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Cardiac troponin I. A marker with high specificity for cardiac injury.

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Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population

de Lemos, J. A., Drazner, M. H., Omland, T., Ayers, C. R., Khera, A., Rohatgi, A. K., Hashim, I. A., Berry, J. D., Das, S. R., Morrow, D. A., et al. (2010) · JAMA · doi:10.1001/jama.2010.1768 · Cited by 1,103

Analytical Validation of a High-Sensitivity Cardiac Troponin T Assay

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Association of Serial Measures of Cardiac Troponin T Using a Sensitive Assay With Incident Heart Failure and Cardiovascular Mortality in Older Adults

deFilippi, C. R., de Lemos, J. A., Christenson, R. H., Gottdiener, J. S., Kop, W. J., Zhan, M., & Seliger, S. L. (2010) · JAMA · doi:10.1001/jama.2010.1708 · Cited by 715

Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction

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National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes

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Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction

Reichlin, T., Irfan, A. B., Twerenbold, R., Reiter, M., Hochholzer, W., Burkhalter, H., Bassetti, S., Steuer, S., Winkler, K., Peter, F., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.023937 · Cited by 459

High-sensitivity cardiac troponin assays and acute coronary syndrome: a matter of sex?

Rocco, E., Rosa, G. L., Liuzzo, G., & Biasucci, L. M. (2019) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000811 · Cited by 23

Effect of Artichoke (cynara scolymus) on cardiac markers, lipid profile and antioxidants levels in tissue of HFD-induced obesity

Salem, M. B., Affes, H., Dhouibi, R., Charfi, S., Turki, M., Hammami, S., Ayedi, F., Sahnoun, Z., Zeghal, K. M., & Ksouda, K. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1670213 · Cited by 24

Cardiac biomarker measurement by point of care testing – Development, rationale, current state and future developments

Collinson, P. O. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.05.018 · Cited by 23

The Metabolic Pathway of Cardiac Troponins Release: Mechanisms and Diagnostic Role

Chaulin, A. M. (2022) · Cardiology Research · doi:10.14740/cr1351 · Cited by 22

Cardiac Troponin I Reveals Diagnostic and Prognostic Superiority to Aminoterminal Pro-B-Type Natriuretic Peptide in Sepsis and Septic Shock

Forner, J., Schupp, T., Weidner, K., Rusnak, J., Jawhar, S., Dulatahu, F., Brück, L. M., Behnes, M., Hoffmann, U., Bertsch, T., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216592 · Cited by 23

Incremental value of heart-type fatty acid-binding protein in suspected acute myocardial infarction early after symptom onset

Schoenenberger, A. W., Stallone, F., Walz, B., Bergner, M., Twerenbold, R., Reichlin, T., Zogg, B., Jaeger, C., Erné, P., & Mueller, C. E. (2015) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872615571256 · Cited by 23

How acute changes in cardiac troponin concentrations help to handle the challenges posed by troponin elevations in non-ACS-patients

Wildi, K. S., Twerenbold, R., & Mueller, C. E. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.09.003 · Cited by 23

The impact of antibody selection on the detection of cardiac troponin I

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Sensitive troponin assays in patients with suspected acute coronary syndrome: Results from the multicenter rule out myocardial infarction using computer assisted tomography II trial

Januzzi, J. L., Sharma, U. C., Zakroysky, P., Truong, Q. A., Woodard, P. K., Pope, J., Hauser, T. H., Mayrhofer, T., Nagurney, J. T., Schoenfeld, D., et al. (2015) · American Heart Journal · doi:10.1016/j.ahj.2014.12.023 · Cited by 23

High-Sensitivity Troponin I in Stable Patients with Atherosclerotic Disease in the TRA 2°P - TIMI 50 Trial

Eisen, A., Bonaca, M. P., Jarolı́m, P., Scirica, B. M., White, H. D., Tendera, M., Dellborg, M., Nicolau, J. C., Morais, J., Fox, K. A. A., et al. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.264788 · Cited by 23

Diagnosis of perioperative myocardial infarction after heart valve surgery with new cut-off point of high-sensitivity troponin T and new electrocardiogram or echocardiogram changes

Cubero-Gallego, H., Lorenzo, M., Heredia, M., Gómez, I., & Tamayo, E. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.02.013 · Cited by 23

High-sensitivity cardiac troponin T and prognosis in patients with ST-segment elevation myocardial infarction

Ndrepepa, G., Kufner, S., Hoyos, M., Harada, Y., Xhepa, E., Hieber, J., Cassese, S., Fusaro, M., Laugwitz, K., Schunkert, H., et al. (2018) · Journal of Cardiology · doi:10.1016/j.jjcc.2018.02.014 · Cited by 22

Sex-Related Aspects of Biomarkers in Cardiac Disease

Mingels, A. M. A., & Kimenai, D. M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_33 · Cited by 23

The Role of Troponin for Acute Heart Failure

Harrison, N. E., Favot, M. J., & Levy, P. D. (2019) · Current Heart Failure Reports · doi:10.1007/s11897-019-0420-5 · Cited by 23

Delta Cardiac Troponin Values in Practice: Are We Ready to Move Absolutely Forward to Clinical Routine?

Apple, F. S., & Morrow, D. A. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.175414 · Cited by 23

Cardiovascular biomarkers in clinical studies of type 2 diabetes

Baldassarre, M. P. A., Andersen, A., Consoli, A., Knop, F. K., & Vilsbøll, T. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13247 · Cited by 22

Widespread Introduction of a High-Sensitivity Troponin Assay: Assessing the Impact on Patients and Health Services

Greenslade, J. H., Parsonage, W. A., Stephensen, L., McCormack, L., Ashover, S., Milburn, T., Berndt, S., Than, M. P., Brain, D., & Cullen, L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061883 · Cited by 22

Pathophysiological mechanisms underlying increased circulating cardiac troponin in noncardiac surgery: a narrative review

Pinto, B. B., & Ackland, G. L. (2024) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.12.017 · Cited by 23

Cardiac Troponins I and T as Biomarkers of Cardiomyocyte Injury—Advantages and Disadvantages of Each

Osredkar, J., Bajrić, A., Možina, H., Lipar, L., & Jerin, A. (2024) · Applied Sciences · doi:10.3390/app14146007 · Cited by 24

Men are different than women: It's true for cardiac troponin too

Apple, F. S., & Jaffe, A. S. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.06.008 · Cited by 22

Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a sensitive troponin I assay

Body, R. M., Burrows, G., Carley, S. D., & Lewis, P. (2015) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563215576976 · Cited by 22

Chemiluminometric Immunosensor for High-Sensitivity Cardiac Troponin I Employing a Polymerized Enzyme Conjugate as a Tracer

Lim, G.-S., Seo, S.-M., Paek, S., Kim, S., Jeon, J.-W., Kim, D., Cho, I., & Paek, S. (2015) · Scientific Reports · doi:10.1038/srep14848 · Cited by 22

Acute chest pain in the high-sensitivity cardiac troponin era: A changing role for noninvasive imaging?

Smulders, M. W., Kietselaer, B., Schalla, S. M., Bucerius, J. A., Jaarsma, C., van Dieijen‐Visser, M. P., Mingels, A. M. A., Rocca, H. B., Post, M. J., Das, M., et al. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.03.025 · Cited by 22

Troponin Testing in Patients Without Chest Pain or Electrocardiographic Ischemic Changes

Shimoni, Z., Arbuzov, R., & Froom, P. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2017.03.032 · Cited by 22

Biologic variability of cardiac troponin I in healthy dogs and dogs with different stages of myxomatous mitral valve disease using standard and high‐sensitivity immunoassays

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White blood cell population dynamics for risk stratification of acute coronary syndrome

Chaudhury, A., Noiret, L., & Higgins, J. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1709228114 · Cited by 22

The use of blood biomarkers in precision medicine for the primary prevention of atherosclerotic cardiovascular disease: a review

Sweeney, T. E., Quispe, R., Das, T. M., Juraschek, S. P., Martin, S. S., & Michos, E. D. (2021) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2021.1930531 · Cited by 24

Physical Activity, Subclinical Myocardial Injury, and Risk of Heart Failure Subtypes in Black Adults

Patel, K. V., Simek, S. C., Ayers, C. R., Neeland, I. J., deFilippi, C. R., Seliger, S. L., Lonergan, K., Minniefield, N. E., Mentz, R. J., Correa, A., et al. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.04.003 · Cited by 22

Highly sensitive troponin and coronary computed tomography angiography in the evaluation of suspected acute coronary syndrome in the emergency department

Ferencik, M., Hoffmann, U., Bamberg, F., & Januzzi, J. L. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw005 · Cited by 22

An Appeal to Medical Journal Editors: The Need for a Full Description of Laboratory Methods and Specimen Handling in Clinical Study Reports

Rifai, N., Annesley, T. M., Berg, J. P., Brugnara, C., DELVIN, E. E., Lamb, E. J., Ness, P. M., Plebani, M., Wick, M. R., Wu, A. H. B., et al. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2011.178426 · Cited by 22

TRAPID or Trapped?

Jaffe, A. S. (2016) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2016.01.009 · Cited by 21

Convalescent troponin and cardiovascular death following acute coronary syndrome

Adamson, P. D., McAllister, D., Pilbrow, A. P., Pickering, J. W., Poppe, K., Shah, A. S. V., WHALLEY, G. A., Ellis, C., Mills, N. L., Newby, D. E., et al. (2019) · Heart · doi:10.1136/heartjnl-2019-315084 · Cited by 21

Urinary troponin concentration as a marker of cardiac damage in pregnancies complicated with preeclampsia

Potkonjak, A.-M., Rudman, S. S., Gabaj, N. N., Kuna, K., Košec, V., Stanec, Z., Zovak, M., Tučkar, N., Djaković, I., Prkačin, I., et al. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110252 · Cited by 21

Cardiac troponin release in athletes: what do we know and where should we go?

Janssen, S. L. J. E., Berge, K., Luiken, T. T. J., Aengevaeren, V. L., & Eijsvogels, T. M. H. (2023) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100629 · Cited by 22

Cardiac troponin assays in the management of heart failure

Torre, M., & Jarolı́m, P. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.12.027 · Cited by 21

Epitope mapping and targeted quantitation of the cardiac biomarker troponin by SID ‐ MRM mass spectrometry

Zhao, C., Trudeau, B., Xie, H., Prostko, J. C., Fishpaugh, J. R., & Ramsay, C. S. (2014) · PROTEOMICS · doi:10.1002/pmic.201300150 · Cited by 21

Is It Time to Do Away With the 99th Percentile for Cardiac Troponin in the Diagnosis of Acute Coronary Syndrome and the Assessment of Cardiac Risk?

Hickman, P. E., Lindahl, B., Potter, J. M., Venge, P., Koerbin, G., & Eggers, K. M. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2013.217711 · Cited by 21

Elevated troponin I level assessed by a new high-sensitive assay and the risk of poor outcomes in patients with acute heart failure

Zymliński, R., Sokolski, M., Siwołowski, P., Biegus, J., Nawrocka, S., Jankowska, E. A., Todd, J., Yerramilli, R., Estis, J., Banasiak, W., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.01.012 · Cited by 21

Asia-Pacific consensus statement on the optimal use of high-sensitivity troponin assays in acute coronary syndromes diagnosis: focus on hs-TnI

Tan, J. W. C., Lam, C. S. P., Kasim, S. S., Aw, T. C., Abanilla, J. M., Chang, W., Dang, V. P., Iboleon-Dy, M. A. M., Mumpuni, S. S., Phommintikul, A., et al. (2017) · Heart Asia · doi:10.1136/heartasia-2016-010818 · Cited by 21

Prognostic effect of troponin elevation in patients undergoing carotid endarterectomy with regional anesthesia – A prospective study

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The Asia-Pacific Society of Cardiology (APSC) Expert Committee Consensus Recommendations for Assessment of Suspected Acute Coronary Syndrome Using High-Sensitivity Cardiac Troponin T in the Emergency Department

Tan, W. C. J., Inoue, K., AbdelWareth, L., Giannitsis, E., Kasim, S. S., Shiozaki, M., Aw, T. C., Cheng, F. C., Ho, D. T., Li, Y., et al. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0874 · Cited by 21

The Prognostic Value of High-Sensitive Troponin I in Stable Coronary Artery Disease Depends on Age and Other Clinical Variables

Carda, R., Aceña, Á., Pello, A. M., Cristóbal, C., Tarín, N., Huelmos, A. I., Alonso, J. J., Asensio, D., Lorenzo, Ó., Martı́n-Ventura, J. L., et al. (2015) · Cardiology · doi:10.1159/000381259 · Cited by 21

Providing Rapid Out of Hospital Acute Cardiovascular Treatment 3 (PROACT-3)

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Performances of the heart fatty acid protein assay for the rapid diagnosis of acute myocardial infarction in ED patients

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High-sensitivity cardiac troponin T is more helpful in detecting peri-operative myocardial injury and apoptosis during coronary artery bypass graft surgery

Koçak, F. E., Koçak, C., Aksoy, A., Işıklar, Ö. Ö., Akçılar, R., Özdomanic, İ. F., Unsal, C., Celenk, M., & Altuntas, I. (2015) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2015-052 · Cited by 21

Diagnosis and Management of Heart Failure

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Documento de consenso de expertos. Tercera definición universal del infarto de miocardio

Thygesen, K. A., Alpert, J. S., Jaffe, A. S., Simoons, M. L., CHAITMAN, B. R., White, H. D., (Dinamarca), K. T., Alpert, J. S., White, H. D., Jaffe, A. S., et al. (2013) · Revista Española de Cardiología · doi:10.1016/j.recesp.2012.11.005 · Cited by 20

Evaluation of assays for troponin I in healthy horses and horses with cardiac disease

Vekens, N. V. D., Decloedt, A., Sys, S. U., Ven, S., Clercq, D. D., & van Loon, G. (2014) · The Veterinary Journal · doi:10.1016/j.tvjl.2014.11.015 · Cited by 20

Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy

Carlton, E. W., Pickering, J. W., Greenslade, J. H., Cullen, L., Than, M. P., Kendall, J., Body, R. M., Parsonage, W. A., Khattab, A., & Greaves, K. (2017) · Heart · doi:10.1136/heartjnl-2017-311983 · Cited by 20

High-Sensitivity Cardiac Troponin I as a Gatekeeper for Coronary Computed Tomography Angiography and Stress Testing in Patients with Acute Chest Pain

Ferencik, M., Mayrhofer, T., Lu, M. T., Woodard, P. K., Truong, Q. A., Peacock, W. F., Bamberg, F., Sun, B., Fleg, J. L., Nagurney, J. T., et al. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2017.275552 · Cited by 20

The State of Cardiac Troponin Assays: Looking Bright and Moving in the Right Direction

Apple, F. S., & Saenger, A. K. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2013.203307 · Cited by 20

Improving the 510(k) FDA Process for Cardiac Troponin Assays: In Search of Common Ground

Apple, F. S., Hollander, J. E., Wu, A. H. B., & Jaffe, A. S. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.229286 · Cited by 20

Trends in admissions for chest pain after the introduction of high-sensitivity cardiac troponin T

Bandstein, N., Ljung, R., Lundbäck, M., Johansson, M., & Holzmann, M. J. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.04.028 · Cited by 20

The HEART score in predicting major adverse cardiac events in patients presenting to the emergency department with possible acute coronary syndrome: protocol for a systematic review and meta-analysis

Byrne, C. J., Toarta, C., Backus, B. E., & Holt, T. (2018) · Systematic Reviews · doi:10.1186/s13643-018-0816-4 · Cited by 22

High‐Sensitivity Cardiac Troponin I for Risk Stratification in Older Adults

Tang, O., Matsushita, K., Coresh, J., Hoogeveen, R. C., Windham, B. G., Ballantyne, C. M., & Selvin, E. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16912 · Cited by 20

Third universal definition of myocardial infarction

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External Evaluation of the D imension V ista 1500® Intelligent Lab System

Bruneel, A., Dehoux, M., Barnier, A., & Boutten, A. (2012) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21539 · Cited by 20

Troponin assays in the assessment of the equine myocardium

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Analytical validation and establishment of reference intervals for a ‘high-sensitivity’ cardiac troponin-T assay in horses

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New and Emerging Biomarkers in Cardiovascular Disease

Cahill, L. E., Bertoia, M. L., Aroner, S. A., Mukamal, K. J., & Jensen, M. K. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0661-y · Cited by 20

Prognostic Implications of Low Level Cardiac Troponin Elevation Using High‐Sensitivity Cardiac Troponin T

Grinstein, J., Bonaca, M. P., Jarolı́m, P., Conrad, M. J., Bohula, E. A., Deenadayalu, N., D, E. B. M., Giugliano, R. P., Newby, L. K., Sabatine, M. S., et al. (2015) · Clinical Cardiology · doi:10.1002/clc.22379 · Cited by 19

Valor pronóstico de la troponina T de alta sensibilidad tras intervención coronaria percutánea en pacientes con enfermedad coronaria estable

Ndrepepa, G., Braun, S., Cassese, S., Mayer, K., Lohaus, R., Lahmann, A. L., Fusaro, M., Laugwitz, K., Schunkert, H., & Kastrati, A. (2016) · Revista Española de Cardiología · doi:10.1016/j.recesp.2016.02.023 · Cited by 19

High-sensitivity cardiac troponin testing in routine practice: economic and organizational advantages

Galli, C., & Lippi, G. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.07.04 · Cited by 19

Acute coronary syndromes diagnosis, version 2.0: Tomorrow's approach to diagnosing acute coronary syndromes?

Body, R. M. (2018) · Turkish Journal of Emergency Medicine · doi:10.1016/j.tjem.2018.05.005 · Cited by 19

Prognostic Value of a Novel and Established High-Sensitivity Troponin I Assay in Patients Presenting with Suspected Myocardial Infarction

Sörensen, N. A., Ludwig, S., Makarova, N., Neumann, F., Lehmacher, J., Hartikainen, T. S., Haller, P. M., Keller, T., Blankenberg, S., Westermann, D., et al. (2019) · Biomolecules · doi:10.3390/biom9090469 · Cited by 19

Point‐of‐Care Fluorescence Immunoassay for Cardiac Panel Biomarkers

Kim, T. K., Oh, S. W., Hong, S., Mok, Y. J., & Choi, E. Y. (2014) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21704 · Cited by 19

Commutability of Possible External Quality Assessment Materials for Cardiac Troponin Measurement

Zhang, S., Zeng, J., Zhang, C., Li, Y., Zhao, H., Cheng, F., Yu, S., Wang, M., & Chen, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102046 · Cited by 19

Do we really need high-sensitivity troponin immunoassays in the emergency department? Maybe not

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Smartphone and home-based liquid crystal sensor for rapid screening of acute myocardial infarction by naked-eye observation and image analysis

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Clinical Biochemistry of Serum Troponin

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Prognostic Value of High-sensitivity Troponin T After Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease

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High-sensitive troponin T increase after hemodialysis is associated with left ventricular global longitudinal strain and ultrafiltration rate

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Biomarkers

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for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers†

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