Cited by 861Acute Myocardial Infarction ResearchClinical Laboratory Practices and Quality ControlBiomarkers in Disease Mechanisms

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays

Apple, Fred S, Collinson, Paul O, for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers·2012·Clinical Chemistry

DOI 10.1373/clinchem.2011.165795

Open this paper in CoChat — free account

Abstract

BACKGROUND: Cardiac troponins I (cTnI) and T (cTnT) have received international endorsement as the standard biomarkers for detection of myocardial injury, for risk stratification in patients suspected of acute coronary syndrome, and for the diagnosis of myocardial infarction. An evidence-based clinical database is growing rapidly for high-sensitivity (hs) troponin assays. Thus, clarifications of the analytical principles for the immunoassays used in clinical practice are important. CONTENT: The purpose of this mini-review is (a) to provide a background for the biochemistry of cTnT and cTnI and (b) to address the following analytical questions for both hs cTnI and cTnT assays: (i) How does an assay become designated hs? (ii) How does one realistically define healthy (normal) reference populations for determining the 99th percentile? (iii) What is the usual biological variation of these analytes? (iv) What assay imprecision characteristics are acceptable? (v) Will standardization of cardiac troponin assays be attainable? SUMMARY: This review raises important points regarding cTnI and cTnT assays and their reference limits and specifically addresses hs assays used to measure low concentrations (nanograms per liter or picograms per milliliter). Recommendations are made to help clarify the nomenclature. The review also identifies further challenges for the evolving science of cardiac troponin measurement. It is hoped that with the introduction of these concepts, both laboratorians and clinicians can develop a more unified view of how these assays are used worldwide in clinical practice.

Integrity signals

Registry

Crossref · 10.1373/clinchem.2011.165795

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Universal Definition of Myocardial Infarction
Thygesen, K. A., Alpert, J. S., White, H. D., TASK FORCE MEMBERS: Chairpersons: Kristian Thygesen (Denmark), J. S. A. (., Biomarker Group: Allan S. Jaffe, C. (., ECG Group: Bernard Chaitman, C.-O. (., Imaging Group: Richard Underwood, C. (., Intervention Group: Jean-Pierre Bassand, C.-O. (., Mendis, S., Implementation Group: Lars C. Wallentin Coordinator (Sweden), F. F.-A. (., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187397 · Cited by 4,422
Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction
Thygesen, K. A. (2007) · Circulation · Cited by 3,126
Universal definition of myocardial infarction: Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
Task Force Members, Thygesen, K. A., Alpert, J. S., White, H. D., Biomarker Group, Jaffe, A. S., Apple, F. S., Galvani, M., Katus, H. A., Newby, L. K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm355 · Cited by 2,536
Self-citation
Cardiac troponin I. A marker with high specificity for cardiac injury.
Adams, J. E., Bodor, G. S., Dávila‐Román, V. G., Delmez, J. A., Apple, F. S., Ladenson, J. H., & Jaffe, A. S. (1993) · Circulation · doi:10.1161/01.cir.88.1.101 · Cited by 1,149
Self-citation
Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population
de Lemos, J. A., Drazner, M. H., Omland, T., Ayers, C. R., Khera, A., Rohatgi, A. K., Hashim, I. A., Berry, J. D., Das, S. R., Morrow, D. A., et al. (2010) · JAMA · doi:10.1001/jama.2010.1768 · Cited by 1,103
Analytical Validation of a High-Sensitivity Cardiac Troponin T Assay
Giannitsis, E., Kurz, K., Hallermayer, K., Jarausch, J., Jaffe, A. S., & Katus, H. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.132654 · Cited by 1,087
Association of Serial Measures of Cardiac Troponin T Using a Sensitive Assay With Incident Heart Failure and Cardiovascular Mortality in Older Adults
deFilippi, C. R., de Lemos, J. A., Christenson, R. H., Gottdiener, J. S., Kop, W. J., Zhan, M., & Seliger, S. L. (2010) · JAMA · doi:10.1001/jama.2010.1708 · Cited by 715
Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction
Katus, H. A., Remppis, A. B., Scheffold, T., Diederich, K. W., & Kübler, W. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90466-x · Cited by 557
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes
NACB WRITING GROUP MEMBERS, Morrow, D. A., Cannon, C. P., Jesse, R. L., Newby, L. K., Ravkilde, J., Storrow, A. B., Wu, A. H. B., Christenson, R. H., Christenson, R. H., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.084194 · Cited by 475
Self-citation
Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction
Reichlin, T., Irfan, A. B., Twerenbold, R., Reiter, M., Hochholzer, W., Burkhalter, H., Bassetti, S., Steuer, S., Winkler, K., Peter, F., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.023937 · Cited by 459

Flagged first, then by citations

Show all 41 references

Research works printed but not linked: 1

Apple, 2011, Short-term biological variation of cardiac troponin I measured with three high-sensitivity assays [Abstract], Clin Chem, 57, C05

Sorted by citations

Items 601–700 of 860

Cardiac Troponin and Exercise; Still Much to Learn
Parsonage, W. A., & Ruane, L. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.05.112 · Cited by 5
What are normal high-sensitivity troponin-T values in a large multi-ethnic Asian population?
Aw, T. C., Phua, S. K., Lam, C.-W., & Wong, M.-S. (2017) · Blood Heart and Circulation · doi:10.15761/bhc.1000109 · Cited by 5
Effect of Health and Training on Ultrasensitive Cardiac Troponin in Marathon Runners
Bishop, E. N., Dang, T., Morrell, H., Estis, J., & Bishop, J. J. (2019) · The Journal of Applied Laboratory Medicine · doi:10.1373/jalm.2018.026153 · Cited by 5
Effect of racing on cardiac troponin I concentration and associations with cardiac rhythm disturbances in Standardbred racehorses
Rossi, T. M., Kavsak, P. A., MAXIE, M. G., Pearl, D. L., Pyle, W. G., & Physick‐Sheard, P. W. (2021) · Journal of Veterinary Cardiology · doi:10.1016/j.jvc.2021.02.002 · Cited by 6
Comparison of Perioperative High-Sensitive Troponin T and Troponin I Assays in Cardiac Surgery
Masseli, F., Masseli, M., Dolscheid‐Pommerich, R., Stoffel‐Wagner, B., & Schiller, W. (2021) · Heart Lung and Circulation · doi:10.1016/j.hlc.2021.08.006 · Cited by 5
Clinically Acquired High Sensitivity Cardiac Troponin T is a Poor Predictor of Reduced Left Ventricular Ejection Fraction After ST Elevation Myocardial Infarction: A National Cohort Study–ANZACS-QI 65
McLeod, P., Coffey, S., Sneddon, K. M. B., Williams, M. J. A., Kerr, A., & Pemberton, J. (2022) · Heart Lung and Circulation · doi:10.1016/j.hlc.2022.07.014 · Cited by 5
Evaluation of Dual Marker Approach Using Heart-Type Fatty Acid Binding Protein and High Sensitivity Troponin-I as an Alternative to Serial Sampling for Diagnosis of Acute Myocardial Infarction.
Kulshrestha, M. R., Raj, A., Tiwari, V., Chandra, S., TIWARI, B. C., & Jha, A. K. (2022) · PubMed Central · Cited by 5
Preprocedural N-terminal pro-B-type natriuretic peptide as a useful marker for predicting periprocedural myocardial injury following percutaneous coronary intervention in diabetic patients without cardiac dysfunction
Zeng, R., Li, X., Zhang, M., Wang, X., Guo, Y., Zhu, C., Ren, Y., Li, S., Zhang, Y., Liu, G., et al. (2015) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2015.1060518 · Cited by 5
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Statement by the Consortium of Laboratory Medicine Journal Editors
Rifai, N., Annesley, T. M., Berg, J. P., Brugnara, C., DELVIN, E. E., Lamb, E. J., Ness, P. M., Plebani, M., Wick, M. R., Wu, A. H. B., et al. (2012) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2011.201201 · Cited by 5
Cardiac biomarkers by point-of-care testing – back to the future?
Collinson, P. O. (2020) · Journal of Laboratory Medicine · doi:10.1515/labmed-2019-0180 · Cited by 5
Self-citation
Challenges of serial troponin testing: A symphony in need for harmony
Biener, M., Katus, H. A., & Giannitsis, E. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.06.095 · Cited by 5
Rapid diagnosis of different cardiovascular disease events from early released cardiac biomarkers, cTnI, BNP, and CRP, by biosensor technology
Ullah, R., Khan, M., Huang, Y., & Wang, G. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1600695 · Cited by 4
Considerations and pragmatic strategies for implementation of point of care testing for high sensitivity cardiac troponin into the acute care setting
Collinson, P. O., Lam, L., Pickering, J. W., Christenson, R. H., Hoovels, L. V., Jafri, L., Cullen, L., Jaffe, A. S., Apple, F. S., Hammarsten, O., et al. (2026) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2026-0210 · Cited by 4
Self-citation
Cardiac troponin at the point of care in acute and chronic coronary syndromes
McDermott, M., Tew, Y. Y., Cooper, J. G., Harry, D., & Mills, N. L. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16503 · Cited by 4
Effect of a last generation cardiac troponin assay on patients' management: A real world emergency department experience
Mion, M. M., Bragato, G., Zaninotto, M., Vettore, G., Tosato, F., Babuin, L., Iliceto, S., & Plebani, M. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.01.002 · Cited by 4
Immuno-analytical approach and its application for cardiac disease marker detection
El‐Kased, R. F. (2018) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2018.1518241 · Cited by 4
Contrasting Trends in Acute Coronary Syndrome Hospitalisation and Coronary Revascularisation in New Zealand 2006–2016: A National Data Linkage Study (ANZACS-QI 27)
Wang, T. K. M., Grey, C., Jiang, Y., Jackson, R., & Kerr, A. (2019) · Heart Lung and Circulation · doi:10.1016/j.hlc.2019.11.015 · Cited by 4
Evaluation of a New Skeletal Troponin I Assay in Patients with Idiopathic Inflammatory Myopathies
Bamberg, K., Mehtälä, L., Arola, O., Laitinen, S., Nordling, P., Strandberg, M., Strandberg, N., Paltta, J., Mali, M., Espinosa‐Ortega, F., et al. (2020) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfz016 · Cited by 4
Update on global conversion to high sensitivity cardiac troponin assays
Collinson, P. O. (2023) · Journal of Laboratory and Precision Medicine · doi:10.21037/jlpm-22-64 · Cited by 4
Self-citation
Suspected myocardial infarction in the emergency department: An evaluation of clinical thresholds for the Beckman Coulter Access hsTnI high‐sensitivity cardiac troponin I assay
Meek, R., Cullen, L., Lu, Z. X., Nasis, A., Kühn, L., & Sorace, L. (2023) · Emergency Medicine Australasia · doi:10.1111/1742-6723.14282 · Cited by 4
Frequency, compliance, and yield of cardiac testing after high-sensitivity troponin accelerated diagnostic protocol implementation
Baugh, C. W., Blankstein, R., Ganguli, I., Januzzi, J. L., Morrow, D. A., Joseph, J. W., Jordan, C. E., Donohoe, G., Fofi, J. M., McKinley, K., et al. (2023) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2023.07.014 · Cited by 4
Multicenter Comparison of Four Contemporary Sensitive Troponin Immunoassays
Salvagno, G. L., Giavarina, D., Meneghello, M., Musa, R., Aloe, R., Rin, G. D., & Lippi, G. (2013) · Journal of Medical Biochemistry · doi:10.2478/jomb-2014-0015 · Cited by 4
An Inhibitor of the δPKC Interaction with the d Subunit of F1Fo ATP Synthase Reduces Cardiac Troponin I Release from Ischemic Rat Hearts: Utility of a Novel Ammonium Sulfate Precipitation Technique
Ogbi, M., Obi, I., & Johnson, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070580 · Cited by 4
The diagnostic challenge of myocardial infarction in critically ill patients: do high-sensitivity troponin measurements add more clarity or more confusion?
Klouche, K., Jonquet, O., & Cristol, J. (2014) · Critical Care · doi:10.1186/cc13909 · Cited by 4
High-sensitivity cardiac troponin: do think twice, it’s not all right
Ungerer, J. P. J., & Pretorius, C. J. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0025 · Cited by 4
Cardiac Injury, Maladaptation, and Heart Failure Incidence
Milks, M. W., & Nambi, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54835-9.00008-9 · Cited by 5
The Prognostic Role of Early Postoperative Troponin I in Lung Transplantation—A Retrospective 7-Year Analysis
Andrei, S., Kantor, E., Asssadi, M., Boutten, A., Pellenc, Q., Jébrak, G., Godement, M., Abbas, S., Atchade, E., Tran‐Dinh, A., et al. (2021) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2021.11.007 · Cited by 4
Prognostic Value of Cardiac Troponin I in Patients with Ventricular Tachyarrhythmias
Akın, İ., Behnes, M., Müller, J., Forner, J., Abumayyaleh, M., Mashayekhi, K., Akin, M., Bertsch, T., Weidner, K., Rusnak, J., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11112987 · Cited by 4
Modern View on the Role of Sex-Specific Levels of High-Sensitive Cardiospecific Troponins T and I in the Diagnosis of Myocardial Infarction
Chaulin, A. M. (2023) · Cardiology Research · doi:10.14740/cr1450 · Cited by 4
Bilateral remote ischemic conditioning in children: A two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgery
Drury, N. E., van Doorn, C. A., Woolley, R. L., Amos-Hirst, R. J., Bi, R., Spencer, C., Morris, K., Montgomerie, J., Stickley, J., Crucean, A. C., et al. (2024) · JTCVS Open · doi:10.1016/j.xjon.2024.02.018 · Cited by 4
Understanding cardiac troponin part 2: early rule out of acute coronary syndrome
Carlton, E. W., & Body, R. M. (2018) · Emergency Medicine Journal · doi:10.1136/emermed-2017-207161 · Cited by 4
Myocardial injury after non-cardiac surgery: Time to shed the ignorance
Coetzee, E., & Biccard, B. M. (2018) · South African Medical Journal · doi:10.7196/samj.2018.v108i6.13346 · Cited by 4
Incentivising the rapid diagnosis of acute coronary syndromes in England and Wales
Body, R. M. (2020) · European Journal of Emergency Medicine · doi:10.1097/mej.0000000000000706 · Cited by 4
A retrospective HEART risk score comparation of acute non-traumatic chest pain patients in an emergency department in Spain
Arispe, I. N. S. R., Marsal, J. R., Torres, O. Y., & Ortega, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-02682-5 · Cited by 4
Myocarditis and the military patient
Cox, A. T., White, S., Ayalew, Y., Boos, C. J., Haworth, K., & McKenna, W. J. (2015) · Journal of the Royal Army Medical Corps · doi:10.1136/jramc-2015-000500 · Cited by 5
Diagnosing myocardial infarction by serial measurement of high sensitivity troponin — What type of relative change value (delta) and how much should it be?
Collinson, P. O. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.05.035 · Cited by 4
Self-citation
RAPPID: a platform of ratiometric bioluminescent sensors for homogeneous immunoassaysPreprint
Ni, Y., Rosier, B. J. H. M., van Aalen, E. A., Hanckmann, E. T. L., Biewenga, L., Pistikou, A. M., Timmermans, B. J. R., Vu, C., Roos, S., Arts, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.31.363044 · Cited by 4
Cardiac Troponin Thresholds in Children and Young Adults: A Multi-Center Cohort Study
Thurston, A. J. F., Røys, E. Å., Røysland, R., Skadberg, Ø., Decrue, F., Kimenai, D. M., Mills, N. L., & Aakre, K. M. (2025) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfaf205 · Cited by 3
Fifth Universal Definition of Myocardial Infarction (2026): On Behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
Mills, N. L., Newby, L. K., Zaman, S., Almahmeed, W. A., Bucciarelli‐Ducci, C., Colvin, M. M., Dangas, G., DeVon, H. A., Dharmakumar, R., Gaziano, T. A., et al. (2026) · Circulation · doi:10.1161/cir.0000000000001477 · Cited by 3
Impact on Patient Management and Outcome of Switching between 2 Contemporary Sensitive Cardiac Troponin Assays
Wilen, C. B., Szymanski, J. J., Hung, S., Rajan, A., Lavigne, P. M., Char, D. M., Geltman, E. M., & Scott, M. G. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2015.238089 · Cited by 3
Terminology of cardiac troponin assays and data censoring
Jarolı́m, P. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0258 · Cited by 3
Multi-Center Study of the 99th Percentile Value of High-Sensitivity Troponin I in A Normal Healthy Chinese Population
Zhong, R., Wang, H., Zhihua, T., Chen, Q., Zhang, Z., Pu, X., Wang, L., Chen, W., Yuan, H., Cao, Y., et al. (2017) · Clinical Investigation · doi:10.4172/clinical-investigation.1000111 · Cited by 3
Case Report Detailing an Inferior Myocardial Infarction, Third-Degree Heart Block, and Cardiogenic Shock
James, D., & London, L. (2021) · Journal of Emergency Nursing · doi:10.1016/j.jen.2021.04.003 · Cited by 3
Potential impact of a novel pathway for suspected myocardial infarction utilising a new high-sensitivity cardiac troponin I assay
Meek, R., Cullen, L., Lu, Z. X., Nasis, A., Kühn, L., & Sorace, L. (2021) · Emergency Medicine Journal · doi:10.1136/emermed-2020-210812 · Cited by 3
Prognostic Significance of High-Sensitivity Troponin T in Nonischemic Heart Failure with Reduced Ejection Fraction
Öztekin, G. M. Y. (2023) · Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology · doi:10.5543/tkda.2023.26900 · Cited by 3
Achieving Equity in Emergency Medicine Quality Measures Requires a Sex and Gender Lens
Thomas, Y. T., Jarman, A. F., Faynshtayn, N. G., Buehler, G., Andrabi, S., & McGregor, A. J. (2023) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2023.03.063 · Cited by 3
Cardiovascular Biomarkers in Acute Myocardial Infarction
Vassalle, C., Sabatino, L., & Pepe, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-25879-4_9 · Cited by 3
Exercise-Induced Troponin Elevation in High-Performance Cross-Country Skiers
Kastner, T., Frohberg, F., Hesse, J., Wolfarth, B., & Wuestenfeld, J. C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082335 · Cited by 4
Evaluating the Commutability of Reference Materials for α-Fetoprotein: Accurate Value Assignment With Multiple Systems and Trueness Verification
Zhang, J., Zhao, J., Wang, Q., Zhang, R., & Yue, Y. (2024) · Annals of Laboratory Medicine · doi:10.3343/alm.2023.0447 · Cited by 3
Defensive Medicine in an Emergency Department: The Overuse of High-Sensitivity Cardiac Troponin I Testing
Sayyad, M. H., Levi, N., Bruoha, S., Zalut, T., Taha, L., Karmi, M., Perel, N., Maller, T., Zacks, N., Sherm, M., et al. (2024) · Life · doi:10.3390/life14121563 · Cited by 3
The Importance of the Troponin Biomarker in Myocardial Infarction
Negahdary, M., Namayandeh, S. M., Behjati‐Ardakani, M., Ghobadzadeh, S., Dehghani, H., & Soltani, M. (2016) · Journal of Biology and Today s World · doi:10.15412/j.jbtw.01050101 · Cited by 3
Mitigating clinical waste in the trauma intensive care unit: Limited clinical utility of cardiac troponin testing for trauma patients with atrial fibrillation
Motz, B. M., Baimas‐George, M. R., Barnes, T. E., Ragunanthan, B. V., Symanski, J. D., Christmas, A. B., Sing, R. F., & Ross, S. W. (2019) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2019.07.033 · Cited by 3
Clinical Pathology
York, M. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-387815-1.00008-3 · Cited by 3
High-Sensitivity Cardiac Troponin I Levels Below 99th Percentile Upper Reference Limit in Patients Presenting with Suspicion of Acute Coronary Syndrome (ACS) in Emergency Department at a Tertiary Care Hospital in Karachi, Pakistan
Kanani, F., Zubairi, A. M., Zubairy, M. A., & Maqsood, S. (2022) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-022-00532-7 · Cited by 3
Gender Characteristics of the Levels of Cardiac Troponins in Blood Serum and the Importance of Using Information About them in the Tactics of Diagnosis of Acute Coronary Syndrome (Literature Review)
Chaulin, A. M. (2022) · Лабораторная диагностика Восточная Европа · doi:10.34883/pi.2022.11.3.008 · Cited by 3
Acute Troponin Elevation and the Classification of Myocardial Infarction
Paixao, A. R. M., & de Lemos, J. A. (2014) · JAMA · doi:10.1001/jama.2014.5554 · Cited by 3
Advances in the detection and quantification of candidate and established biomarkers in heart failure
Pop, C., Crişan Gianina, C., Loghin, F., & Mogoşan Cristina, I. (2013) · Revista română de medicină de laborator · doi:10.2478/rrlm-2013-0029 · Cited by 3
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports
Rifai, N., Annesley, T. M., Berg, J. P., Brugnara, C., DELVIN, E. E., Lamb, E. J., Ness, P. M., Plebani, M., Wick, M. R., & Wu, A. H. B. (2012) · Transfusion · doi:10.1111/j.1537-2995.2012.03620.x · Cited by 3
N-terminal Pro-brain Natriuretic Peptide and High-sensitivity Troponin in the Evaluation of Acute Chest Pain of Uncertain Etiology. A PITAGORAS Substudy
Sanchís, J. M., Bardajı́, A., Bosch, X., Loma-Osorio, P., Marín, F. R., Sanchez, P. L., Calvo, F., y, P. A., Hernández, C., Serrano, S., et al. (2013) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2012.11.004 · Cited by 3
Nasjonale anbefalinger for tolkning av troponinverdier ved diagnostikk av akutt hjerteinfarkt
Aakre, K. M., Rotevatn, S., Hagve, T., Bendz, B., Landaas, S., & Trovik, T. S. (2013) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.13.0647 · Cited by 3
Effect of a 180 mg ticagrelor loading dose on myocardial necrosis in patients undergoing elective percutaneous coronary intervention: A preliminary study
Xu, Q., Sun, Y., Zhang, Y., Liu, B., Lu, F. Y., Shen, C., Li, Y., & Meng, S. (2017) · Cardiology Journal · doi:10.5603/cj.a2017.0002 · Cited by 3
Cardiac troponins: Current status
Das, B., & Mishra, T. K. (2017) · Journal of Indian College of Cardiology · doi:10.1016/j.jicc.2016.12.006 · Cited by 3
Impact of the Australian gender specific thresholds using the Abbott high sensitivity troponin I assay in clinical care
Bender, R., Njue, F., Vasikaran, S. D., Lambert, R., Rankin, J. M., Hillis, G. S., & Bell, D. A. (2017) · Pathology · doi:10.1016/j.pathol.2017.03.004 · Cited by 3
Commutability of external quality assessment materials for serum magnesium and calcium measurements
Yan, Y., Pu, Y., Long, Q., Zhang, J., Zhang, T., Zhou, W., Zeng, J., Zhang, C., Chen, W., & Zhang, C. (2019) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2019.1636404 · Cited by 3
Il problema dei falsi positivi e falsi negativi di troponina. Parte IV: Raccomandazioni del Gruppo di Studio sui Marcatori Miocardici (GdS MM) SIPMeL
Veneziani, F., Moretti, M., Stenner, E., Manno, M. L., Morandini, M., Galli, G. A., Burgio, M. A., Malloggi, L., Marino, G., Maria, D. D., et al. (2019) · La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine · doi:10.23736/s1825-859x.19.00019-7 · Cited by 3
An appeal to medical journal editors: The need for a full description of laboratory methods and specimen handling in clinical study reports
Rifai, N., Annesley, T. M., Berg, J. P., Brugnara, C., DELVIN, E. E., Lamb, E. J., Ness, P. M., Plebani, M., Wick, M. R., Wu, A. H. B., et al. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.01.009 · Cited by 3
High-sensitivity cardiac troponins in health and disease
Klinkenberg, L. J. J. (2016) · doi:10.26481/dis.20160304lk · Cited by 3
High-Sensitivity Troponin in the General Population
Ho, J. E. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.06.015 · Cited by 3
Biosensors for the diagnosis of heart disease
Fakanya, W., Altıntaş, Z., & Tothill, I. E. (2013) · doi:10.4155/ebo.13.459 · Cited by 3
A IMPORTÂNCIA DOS MARCADORES DE NECROSE MIOCÁRDICA NO DIAGNÓSTICO DO INFARTO AGUDO DO MIOCÁRDIO
Bezerra, L. M. R., Cardoso, A. M. S., Ferreira, L. F., Pugliese, G. N., Brito, R. T., Oliveira, P. R., Barcellos, W. D. S., & Rocha, C. C. S. (2023) · RECIMA21 - Revista Científica Multidisciplinar · doi:10.47820/recima21.v4i8.3835 · Cited by 2
A Single High-Sensitivity Cardiac Troponin T Strategy for Ruling Out Myocardial Infarction
Gilje, P., Mohammad, M. A., Roos, A., Ekelund, U. E. G., Björk, J., Lindahl, B., Holzmann, M. J., & Mokhtari, A. (2024) · Emergency Medicine International · doi:10.1155/2024/2241528 · Cited by 2
High-sensitivity cardiac troponin I-guided combination angiotensin receptor blockade and beta blocker therapy to prevent anthracycline cardiotoxicity: the Cardiac CARE RCT
Henriksen, P. A., MacLean, M., Atter, M., Lewis, S. C., & Rodríguez, A. (2024) · Efficacy and Mechanism Evaluation · doi:10.3310/aptu2400 · Cited by 2
Early prediction of orthodontic gingival enlargement using S100A4: a biomarker-based risk stratification model
Escorcia, V. H. S., Plazas-Román, J. E., Caballero, A. J. D., Martínez, A. M., & Ardila, C. M. (2025) · Odontology · doi:10.1007/s10266-025-01194-2 · Cited by 2
High sensitivity troponin-I and myocardial injury after noncardiac surgery for cancer in a large prospective cohort
Liu, T., McCormick, P. J., Amar, D., Tan, K. S., Lee, J., Fischer, G. W., Jackson, L., Daghfal, D., Ramanathan, L. V., Chen, C. L., et al. (2025) · BMC Anesthesiology · doi:10.1186/s12871-025-03488-y · Cited by 2
Analytical Performance of the Sixth Generation High-Sensitivity Cardiac Troponin T Assay
Ge, M., Daniels, L., Seely, S., McLawhon, R. W., Fitzgerald, R. L., & Suhandynata, R. T. (2026) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfag055 · Cited by 2
Recognition-Mediated Electrochemiluminescence Sensors: Recent Five-Year Breakthroughs and Future Directions in Acute Myocardial Infarction Biomarker Analysis
Nan, S., Zhu, Z., Xie, Y., Wang, F., Lv, T., Gao, Y., Wang, P., Zhang, H., & Liang, A. (2026) · Journal of Analysis and Testing · doi:10.1007/s41664-026-00456-4 · Cited by 2
Biomarker Profiling of Neurovascular Diseases in Patients with Stage 5 Chronic Kidney Disease
Lee, J., Bontekoe, J., Trac, B., Bansal, V., Biller, J., Hoppensteadt, D., Maia, P., Walborn, A., & Fareed, J. (2018) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029618807565 · Cited by 2
Biotin interference in cardiac troponin immunoassay – where the wild things are?
Collinson, P. O. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-0936 · Cited by 2
Self-citation
An Algorithmic Approach Is Superior to the 99th Percentile Upper Reference Limits of High Sensitivity Troponin as a Threshold for Safe Discharge from the Emergency Department
Kang, T., Kim, G. S., Byun, Y. S., Kim, J., Kim, S., Chang, J., & Yoo, S. J. (2021) · Medicina · doi:10.3390/medicina57101083 · Cited by 2
Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation
Chen, F.-L., Shang, L.-D., Lin, Y., Chang, B.-Y., & Hsiao, Y. (2022) · Biosensors · doi:10.3390/bios13010060 · Cited by 2
High sensitivity troponin-I threshold to predict perioperative myocardial infarction
Friedman, T., Leviner, D. B., Chan, V., Yanagawa, B., Orbach, A., Natour, A. E. H., Weis, A., Sharoni, E., & Bolotin, G. (2023) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-023-02323-0 · Cited by 2
Cardiac troponin I as predictor for cardiac and other mortality in the German randomized lung cancer screening trial (LUSI)
Cortés-Ibáñez, F. O., Johnson, T., Mascalchi, M., Katzke, V. A., Delorme, S., & Kaaks, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-57889-z · Cited by 2
Effect of change of high‐sensitivity troponin I assay on emergency department diagnosis and disposition of patients with possible acute coronary syndrome
Pickering, J. W., Kelland, S., Williams, O., Kim, J., Aldous, S. J., Joyce, L. R., & Than, M. P. (2025) · Emergency Medicine Australasia · doi:10.1111/1742-6723.70022 · Cited by 2
Prognostic utility of high-sensitivity troponins according to atherosclerotic vascular disease severity
Rohde, J. S., Brunner, F. J., Goßling, A., Graap, H., Arnold, N., Blaum, C. M., Kellner, C., Pieper, L., Köster, L., Lorenz, T., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119167 · Cited by 2
High-sensitivity cardiac troponin I and risk of dementia: the 25-year longitudinal Whitehall II study
Chen, Y., Shipley, M. J., Anand, A., Kimenai, D. M., Ebmeier, K. P., Sabia, S., Singh‐Manoux, A., Deanfield, J. E., Mika Kivimaki, B., Livingston, G., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf834 · Cited by 2
Troponin, delta change and the evolution of cardiac biomarkers – back to the future (again)
Collinson, P. O. (2018) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563218774809 · Cited by 2
Self-citation
Chest pain and high-sensitivity troponin: What is the evidence?
Ashmore, D. (2015) · SAGE Open Medicine · doi:10.1177/2050312115577729 · Cited by 2
Clinical Use and Measurement of Cardiac Troponin (cTn)
Yap, C. Y., Phua, S. K., & Aw, T. C. (2012) · Proceedings of Singapore Healthcare · doi:10.1177/201010581202100211 · Cited by 2
Caracterización de los pacientes con diagnóstico presuntivo de síndrome coronario agudo sin elevación del segmento ST que asisten a un servicio de urgencias
Díaz-Granados, L. E. S., Mendoza, O., Bohórquez, J. A. M., Cabrera, J. P. P., Sánchez, A. C. G., Alfaro, K. L. H., & Jiménez, O. A. P. (2018) · Revista Colombiana de Cardiología · doi:10.1016/j.rccar.2017.09.006 · Cited by 2
Biomarkers to Assist in the Evaluation of Chest Pain
Sekhon, N., & Peacock, W. F. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54835-9.00011-9 · Cited by 2
Troponin in Suspected Coronary Artery Disease
Collinson, P. O. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.020 · Cited by 2
Self-citation
Identification of acute myocardial infarction in elderly patients using optimized highly sensitive troponin I thresholds
von Jeinsen, B., Liebetrau, C., Palapies, L., Tzikas, S., Zeller, T., Bickel, C., Schmidt, A., Marco Tubaro, U., Lackner, K. J., Sar, F., et al. (2019) · Biomarkers · doi:10.1080/1354750x.2019.1606276 · Cited by 2
A look back: diagnosing myocardial infarction in the era of high-sensitivity troponin after the High-STEACS trial
Anand, A., & Mills, N. L. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz274 · Cited by 2
Cardiovascular Effects of Cancer Therapy
Minasian, L. M., Davis, M., & Ky, B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00042-6 · Cited by 2
Acute myocardial infarction with normal electrocardiogram and biomarkers of cardiac injury: A case report
Zha, K., Chen, W., & Ye, Q. (2022) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12990 · Cited by 2
Comparison of ADVIA Centaur ultra-sensitive and high-sensitive assays for troponin I in serum
Osredkar, J., Fabjan, T., Kumer, K., Tršan, J., Poljančič, L., Košir, M., Racman, P. V., Snoj, N., Finderle, P., & Možina, H. (2022) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2022.e00293 · Cited by 2
The Predictive Power of the 14–51 Ng/L High Sensitive Troponin T (hsTnT) Values for Predicting Cardiac Revascularization in a Clinical Setting
de Jongh, F. W., Pouwels, S., Jongh, M. C. D., Dubois, E. A., & van Schaik, R. H. N. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11237147 · Cited by 2
Evaluation of Age and Sex Differences in Contemporary versus High-Sensitivity Troponin I Measurement in Hospitalized Patients
Alkhalaileh, H., Wei, R., Rivera, A. C., Göksel, M., Lee, J. K. Y., Mazzaferri, E. L., Jones, J., & Li, J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082428 · Cited by 2
Relationship between cold water swimming and increased cardiac markers: A pilot study
Brož, P., Rajdl, D., Racek, J., Zeman, V., Novák, J., & Trefil, L. (2017) · Klinická biochemie a metabolismus · doi:10.61568/kbm.2017.005 · Cited by 2
Two desired epitopes of cTnI benefit for preparation of standardized monoclonal antibodies
Junjie, Y., Yang, Q., Li, W., Yu, J., Xie, J., Xiang, J., & Wang, H. (2019) · Chirality · doi:10.1002/chir.23058 · Cited by 2

Authors: Apple, F. S., Collinson, P. O., & for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers
Affiliations: University of Minnesota (US)
St George's Hospital (GB)
Corresponding author: Apple, Fred S
ORCID: Apple, Fred S
Collinson, Paul O
Venue: Clinical Chemistry
Publisher: Oxford University Press (OUP)
Published: 2012-01-01
Volume: 58
Issue: 1
Pages: 54-61
ISSN: 0009-9147 (ISSN-L)
1530-8561
DOI: 10.1373/clinchem.2011.165795
OpenAlex: W2151231511
Cited by: 861
References: 41
Citations by year: 2026: 26 · 2025: 39 · 2024: 33 · 2023: 42 · 2022: 44 · 2021: 51 · 2020: 53 · 2019: 58 · 2018: 63 · 2017: 87 · 2016: 88 · 2015: 69 · 2014: 75 · 2013: 81 · 2012: 46
FWCI: 11.14
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Siemens
Abbott
Radiometer
B.R.A.H.M.S.
Roche
Alere
Instrumentation Laboratories
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords: high-sensitivity troponin I, high-sensitivity troponin T, cardiac troponin assays, assay standardization, reference limits, biological variation, assay imprecision, myocardial injury biomarkers, acute coronary syndrome, myocardial infarction diagnosis
MeSH terms: Humans, Immunoassay, Myocardial Infarction, Myocardium, Reference Values, Sensitivity and Specificity, Biomarkers, Troponin I, Troponin T, Acute Coronary Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks