Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays

Universal Definition of Myocardial Infarction

Thygesen, K. A., Alpert, J. S., White, H. D., TASK FORCE MEMBERS: Chairpersons: Kristian Thygesen (Denmark), J. S. A. (., Biomarker Group: Allan S. Jaffe, C. (., ECG Group: Bernard Chaitman, C.-O. (., Imaging Group: Richard Underwood, C. (., Intervention Group: Jean-Pierre Bassand, C.-O. (., Mendis, S., Implementation Group: Lars C. Wallentin Coordinator (Sweden), F. F.-A. (., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187397 · Cited by 4,422

Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction

Thygesen, K. A. (2007) · Circulation · Cited by 3,126

Universal definition of myocardial infarction: Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction

Task Force Members, Thygesen, K. A., Alpert, J. S., White, H. D., Biomarker Group, Jaffe, A. S., Apple, F. S., Galvani, M., Katus, H. A., Newby, L. K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm355 · Cited by 2,536

Cardiac troponin I. A marker with high specificity for cardiac injury.

Adams, J. E., Bodor, G. S., Dávila‐Román, V. G., Delmez, J. A., Apple, F. S., Ladenson, J. H., & Jaffe, A. S. (1993) · Circulation · doi:10.1161/01.cir.88.1.101 · Cited by 1,149

Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population

de Lemos, J. A., Drazner, M. H., Omland, T., Ayers, C. R., Khera, A., Rohatgi, A. K., Hashim, I. A., Berry, J. D., Das, S. R., Morrow, D. A., et al. (2010) · JAMA · doi:10.1001/jama.2010.1768 · Cited by 1,103

Analytical Validation of a High-Sensitivity Cardiac Troponin T Assay

Giannitsis, E., Kurz, K., Hallermayer, K., Jarausch, J., Jaffe, A. S., & Katus, H. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.132654 · Cited by 1,087

Association of Serial Measures of Cardiac Troponin T Using a Sensitive Assay With Incident Heart Failure and Cardiovascular Mortality in Older Adults

deFilippi, C. R., de Lemos, J. A., Christenson, R. H., Gottdiener, J. S., Kop, W. J., Zhan, M., & Seliger, S. L. (2010) · JAMA · doi:10.1001/jama.2010.1708 · Cited by 715

Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction

Katus, H. A., Remppis, A. B., Scheffold, T., Diederich, K. W., & Kübler, W. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90466-x · Cited by 557

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes

NACB WRITING GROUP MEMBERS, Morrow, D. A., Cannon, C. P., Jesse, R. L., Newby, L. K., Ravkilde, J., Storrow, A. B., Wu, A. H. B., Christenson, R. H., Christenson, R. H., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.084194 · Cited by 475

Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction

Reichlin, T., Irfan, A. B., Twerenbold, R., Reiter, M., Hochholzer, W., Burkhalter, H., Bassetti, S., Steuer, S., Winkler, K., Peter, F., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.023937 · Cited by 459

Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial

Miller, J. B., Cook, B. C., Gandolfo, C. M., Mills, N. L., Mahler, S. A., Levy, P. D., Parikh, S. S., Krupp, S., Nour, K., Klausner, H., et al. (2024) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2024.04.024 · Cited by 15

A Risk Assessment Score and Initial High‐sensitivity Troponin Combine to Identify Low Risk of Acute Myocardial Infarction in the Emergency Department

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J. H., Cullen, L., Parsonage, W. A., Carlton, E. W., Richards, M., Troughton, R. W., Pemberton, C., et al. (2017) · Academic Emergency Medicine · doi:10.1111/acem.13343 · Cited by 15

Evaluation of analytical performance of a chemiluminescence enzyme immunoassay (CLEIA) for cTnI using the automated AIA-CL2400 platform

Masotti, S., Musetti, V., Prontera, C., Storti, S., Passino, C., Zucchelli, G., & Clerico, A. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-1101 · Cited by 15

High-sensitivity troponin T release profile in off-pump coronary artery bypass grafting patients with normal postoperative course

Wen, G., Gu, C., Chen, C., Chen, W., Cang, Z.-Q., Wang, Y., Shi, C., & Zhang, Y. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-018-0893-2 · Cited by 15

Analytical performance of cardiac troponin assays – Current status and future needs

Aakre, K. M., Saeed, N. A., Wu, A. H. B., & Kavsak, P. A. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.06.021 · Cited by 15

Optimal Detection of Acute Myocardial Injury and Infarction with Cardiac Troponin: Beyond the 99th Percentile, into the High-Sensitivity Era

Mullins, K., & Christenson, R. H. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-01350-w · Cited by 15

Usefulness of Beta2-Microglobulin as a Predictor of All-Cause and Nonculprit Lesion-Related Cardiovascular Events in Acute Coronary Syndromes (from the PROSPECT Study)

Möckel, M. M., Müller, R., Searle, J., Slagman, A. C., Bruyne, B. D., Serruys, P. W. J. C., Weisz, G., Xu, K., Holert, F., Müller, C., et al. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.07.017 · Cited by 15

Combining presentation high-sensitivity cardiac troponin I and glucose measurements to rule-out an acute myocardial infarction in patients presenting to emergency department with chest pain

Greenslade, J. H., Kavsak, P. A., Parsonage, W. A., Shortt, C. R., Than, M. P., Pickering, J. W., Aldous, S., & Cullen, L. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.11.019 · Cited by 15

Rapid homogeneous immunoassay for cardiac troponin I using switchable lanthanide luminescence

Päkkilä, H., Malmi, E., Lahtinen, S., & Soukka, T. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.06.042 · Cited by 15

Serial measurements of high-sensitivity cardiac troponin T after exercise stress test in stable coronary artery disease

Raja, A. A., Ruwald, M. H., Dalsgaard, M., Rossing, K., Steffensen, R., & Iversen, K. K. (2013) · Biomarkers · doi:10.3109/1354750x.2013.776635 · Cited by 15

Electronic Medical Record–Based Performance Improvement Project to Document and Reduce Excessive Cardiac Troponin Testing

Love, S. A., McKinney, Z. J., Sandoval, Y. B., Smith, S. W., Kohler, R., Murakami, M. M., & Apple, F. S. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.234310 · Cited by 15

Heart failure biomarkers at point-of-care: current utilization and future potential

Christenson, E. S., Collinson, P. O., deFilippi, C. R., & Christenson, R. H. (2014) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2014.882772 · Cited by 15

The clinical utility of CK-MB measurement in patients suspected of acute coronary syndrome

Kim, J., & Hashim, I. A. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.030 · Cited by 15

Cardiac troponin T is associated with mortality in patients admitted to critical care in a UK major trauma centre: a retrospective database analysis

Crewdson, K., Thompson, J., & Thomas, M. (2018) · Journal of the Intensive Care Society · doi:10.1177/1751143718767782 · Cited by 15

Analytical validation of novel cardiac biomarkers used in clinical trials

Wu, A. H. B. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.01.016 · Cited by 15

Overview of Clinical Pathology and the Horse

Lester, S., Mollat, W. H., & Bryant, J. E. (2015) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2015.04.004 · Cited by 15

Implementation of an early rule-out pathway for myocardial infarction using a high-sensitivity cardiac troponin T assay

Sandeman, D., Syed, M. B. J., Kimenai, D. M., Lee, K. K., Anand, A., Joshi, S. S., Dinnel, L., Wenham, P. R., Campbell, K. L., Jarvie, M., et al. (2021) · Open Heart · doi:10.1136/openhrt-2021-001769 · Cited by 14

Cardiac Troponin I but Not N-Terminal Pro-B-Type Natriuretic Peptide Predicts Outcomes in Cardiogenic Shock

Schupp, T., Rusnak, J., Forner, J., Weidner, K., Ruka, M., Egner-Walter, S., Dudda, J., Bertsch, T., Kittel, M., Behnes, M., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13091348 · Cited by 14

Repeat Measurements of High Sensitivity Troponins for the Prediction of Recurrent Cardiovascular Events in Patients With Established Coronary Heart Disease: An Analysis From the KAROLA Study

Jansen, H., Jaensch, A., Schöttker, B., Dallmeier, D., Schmucker, R., Brenner, H., Köenig, W., & Rothenbacher, D. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.011882 · Cited by 14

Cardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease

Nilsson, U. A., Mills, N. L., McAllister, D., Bäckman, H., Stridsman, C., Hedman, L., Rönmark, E., Fujisawa, T., Blomberg, A., & Lindberg, A. (2020) · Respiratory Research · doi:10.1186/s12931-020-01430-z · Cited by 15

Cardiac troponin as a novel tool for cardiovascular risk prediction in ambulatory populations

Everett, B. M. (2016) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2016.06.002 · Cited by 14

High sensitivity troponin and valvular heart disease

McCarthy, C. P., Donnellan, E., Phelan, D. M. J., Griffin, B. P., Enriquez-Sarano, M. L., & McEvoy, J. W. (2017) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2017.01.004 · Cited by 14

Trivializing an Elevated Troponin

Januzzi, J. L., & McCarthy, C. P. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.10.042 · Cited by 14

High-sensitivity point-of-care measurement of cardiac troponin

Cullen, L., Mair, J. M., Hammarsten, O., Stengaard, C., Boeddinghaus, J., Daniels, L. B., Huber, K., Giannitsis, E., Jaffe, A. S., Kimenai, D. M., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf407 · Cited by 14

High sensitivity troponin, analytical advantages, clinical benefits and clinical challenges – An update

Collinson, P. O. (2021) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2021.02.001 · Cited by 13

Comparison of heart, grace and TIMI scores to predict major adverse cardiac events from chest pain in a Spanish health care region

Arispe, I. N. S. R., Sol, J., Gil, A. C., Trujillano, J., Ortega, M., & Torres, O. Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-44214-3 · Cited by 13

Cardioprotective and Antifibrotic Effects of Low-Dose Renin–Angiotensin–Aldosterone System Inhibitors in Type 1 Diabetic Rat Model

Balogh, D. B., Molnár, Á., Dégi, A. A., Toth, A., Lénárt, L., Saeed, A., Bárczi, A., Szabo, A. J., Wagner, L. J., Reusz, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242317043 · Cited by 13

Evaluation of analytical performance and comparison of clinical results of the new generation method AccuTnI + 3 for the measurement of cardiac troponin I using both patients and quality control plasma samples

Storti, S., Masotti, S., Prontera, C., Franzini, M., Buzzi, P., Casagranda, I., Ciofini, E., Zucchelli, G. C., Ndreu, R., Passino, C., et al. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.09.016 · Cited by 13

Novel Nanomonitor ultra-sensitive detection of troponin T

Barrett, T. W., Shanmugam, N. R., Selvam, A. P., Kazmierczak, S. C., & Prasad, S. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.013 · Cited by 13

Cardiac Troponin I Associated with the Development of Unrecognized Myocardial Infarctions Detected with MRI

Barbier, C. E., Themudo, R. E., Bjerner, T., Johansson, L. O. M., Lindahl, B., Venge, P., Lind, L., & Ahlström, H. K. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.222430 · Cited by 13

High-Sensitivity Troponin Release Profile After Cardiac Surgery

Markman, P. L., Tantiongco, J.-P., Bennetts, J. S., & Baker, R. A. (2016) · Heart Lung and Circulation · doi:10.1016/j.hlc.2016.09.017 · Cited by 13

Chasing myocardial outcomes: perioperative myocardial infarction and cardiac troponin

Royo, M. B., & Fleisher, L. A. (2015) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-015-0539-0 · Cited by 13

High-sensitivity detection of cardiac troponin I with UV LED excitation for use in point-of-care immunoassay

Rodenko, O., Eriksson, S., Tidemand‐Lichtenberg, P., Troldborg, C. P., Fodgaard, H., van Os, S., & Pedersen, C. (2017) · Biomedical Optics Express · doi:10.1364/boe.8.003749 · Cited by 13

Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update

Rasmi, Y., Mosa, O. F., Alipour, S., Heidari, N., Javanmard, F., Golchin, A., & Aziz, S. G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.821155 · Cited by 13

Cardiac troponins: Mechanisms of release and role in healthy and diseased subjects

Ragusa, R., Masotti, S., Musetti, V., Rocchiccioli, S., Prontera, C., Perrone, M. A., Passino, C., Clerico, A., & Caselli, C. (2022) · BioFactors · doi:10.1002/biof.1925 · Cited by 13

Gender Specificities of Cardiac Troponin Serum Levels: From Formation Mechanisms to the Diagnostic Role in Case of Acute Coronary Syndrome

Chaulin, A. M. (2023) · Life · doi:10.3390/life13020267 · Cited by 13

Availability of highly sensitive troponin assays and acute coronary syndrome care: insights from the SNAPSHOT registry

Cullen, L., French, J. K., Briffa, T. G., Redfern, J., Hammett, C. J. K., Brieger, D. B., Parsonage, W. A., Lefkovits, J., Ellis, C., Astley, C. M., et al. (2015) · The Medical Journal of Australia · doi:10.5694/mja13.00275 · Cited by 13

Novel sensitive cardiac troponin I immunoassay free from troponin I-specific autoantibody interference

Savukoski, T., Jacobino, J., Laitinen, P. H., Lindahl, B., Venge, P., Ristiniemi, N., Wittfooth, S., & Pettersson, K. S. I. (2014) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-1044 · Cited by 13

Transitioning high sensitivity cardiac troponin I (hs-cTnI) into routine diagnostic use: More than just a sensitivity issue

Lee, G. R., Browne, T. C., Guest, B., Khan, I., Murphy, E., McGorrian, C., Mahon, N., & Fitzgibbon, M. C. (2016) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2016.01.001 · Cited by 13

Advances in Cardiac Biomarkers of Acute Coronary Syndrome

Saenger, A. K., & Korpi-Steiner, N. L. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.07.001 · Cited by 13

Direct immunomagnetic detection of low abundance cardiac biomarker by aptamer DNA nanocomplex

Wong, K.-W., Xu, D., He, D., Wong, M. S., & Li, H. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.04.035 · Cited by 13

Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction

Limkakeng, A. T., Hertz, J. T., Lerebours, R. C., Kuchibhatla, M. N., McCord, J., Singer, A. J., Apple, F. S., Peacock, W. F., Christenson, R. H., & Nowak, R. M. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.06.072 · Cited by 13

Vascular Proteomics

Barderas, M. G., Vivanco, F., & Álvarez‐Llamas, G. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-405-0_1 · Cited by 13

A new immunochemistry platform for a guideline-compliant cardiac troponin T assay at the point of care: proof of principle

Lopez‐Calle, E., Espindola, P., Spinke, J., Lutz, S., Nichtl, A., Tgetgel, A., Herbert, N., Marcinowski, M., Klepp, J., Fischer, T., et al. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-1078 · Cited by 13

Temporal Changes of Stable High‐Sensitivity Cardiac Troponin T Levels and Prognosis

Roos, A., Edgren, G., & Holzmann, M. J. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.025082 · Cited by 12

Circulating Biomarkers for Monitoring Chemotherapy-Induced Cardiotoxicity in Children

Meo, L., Savarese, M., Munno, C., Mirabelli, P., Ragno, P., Leone, O., & Alfieri, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122712 · Cited by 12

Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: a prospective cohort study

Greenslade, J. H., Cullen, L., Than, M. P., Aldous, S. J., Chu, K., Brown, A. F., Richards, M., Pemberton, C. J., George, P. M., & Parsonage, W. A. (2013) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2013.04.016 · Cited by 12

Use of a highly-sensitive cardiac troponin I assay in a screening population for hypertrophic cardiomyopathy: a case-referent study

McGorrian, C., Lyster, S., Roy, A. K., Tarrant, H., Codd, M., Doran, P., Fitzgibbon, M. C., Galvin, J., & Mahon, N. (2013) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-13-70 · Cited by 12

A prospective study of patients with refractory angina: outcomes and the role of high‐sensitivity troponin T

Poppi, N. T., Gowdak, L. H. W., Dourado, L. O. C., Adam, E. L., Leite, T. N. P., Mioto, B. M., Krieger, J. E., César, L. A. M., & Pereira, A. C. (2016) · Clinical Cardiology · doi:10.1002/clc.22599 · Cited by 12

Diagnostic Reclassification by a High-Sensitivity Cardiac Troponin Assay

Mumma, B. E., Casey, S. D., Dang, R. K., Polen, M. K., Kaur, J. C., Rodrigo, J., Tancredi, D. J., Narverud, R. A., Amsterdam, E. A., & Tran, N. K. (2020) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2020.06.047 · Cited by 12

Biochemical markers in the diagnosis of myocardial infarction

Janota, T. (2014) · Cor et Vasa · doi:10.1016/j.crvasa.2014.06.007 · Cited by 12

High sensitivity troponin in the management of tachyarrhythmias

Mariathas, M., Gemmell, C., Olechowski, B., Nicholas, Z., Mahmoudi, M., & Curzen, N. P. (2017) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2017.11.011 · Cited by 13

Implementation of High-Sensitivity Cardiac Troponin: Challenges From the International Experience

Howell, S. J., Amsterdam, E. A., Mumma, B. E., López, J. E., & Tran, N. K. (2018) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0000000000000156 · Cited by 12

Analytical validation of a conventional cardiac troponin I assay for dogs and cats

Langhorn, R., Yrfelt, J. D., Stjernegaard, C. S., Christiansen, L. B., Olsen, L. H., & Nielsen, L. N. (2018) · Veterinary Clinical Pathology · doi:10.1111/vcp.12681 · Cited by 12

Biomarker developments in heart failure

Wettersten, N. W., & Maisel, A. S. (2019) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000596 · Cited by 12

Commutability of external quality assessment materials for point‐of‐care glucose testing using the Clinical and Laboratory Standards Institute and International Federation of Clinical Chemistry approaches

Wang, Y., Plebani, M., Sciacovelli, L., Zhang, S., Wang, Q., & Zhou, R. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23327 · Cited by 13

Analytical characterization and clinical performance evaluation of a new point-of-care testing system for high-sensitivity cardiac troponin I assay

Zhang, R., Hong, Y., Shi, J. R., Zhao, R., Song, Y., Li, Z., & Wang, Q. (2021) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/00045632211027604 · Cited by 12

Non-Natriuretic Peptide Biomarkers in Heart Failure with Preserved and Reduced Ejection Fraction

Oikonomou, E. K., Vogiatzi, G., Tsalamandris, S., Mourouzis, K., Siasos, G., Lazaros, G. A., Skotsimara, G., Marinos, G., Vavuranakis, M., & Tousoulis, D. (2018) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0376 · Cited by 11

Cardiac troponins in chronic kidney disease patients with special emphasis on their importance in acute coronary syndrome

Szczykowska, J., Hryszko, T., & Naumnik, B. (2019) · Advances in Medical Sciences · doi:10.1016/j.advms.2018.08.016 · Cited by 11

Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis

Li, M., Guo, Z., Zhang, D., Xu, X., Romeiro, F. G., Mancuso, A., Zhang, J., Feng, R., Zhou, X., Hong, C., et al. (2020) · Gastroenterology Research and Practice · doi:10.1155/2020/4019289 · Cited by 11

Intact Transition Epitope Mapping—Force Differences between Original and Unusual Residues (ITEM-FOUR)

Röwer, C., Ortmann, C., Neamțu, A., El‐Kased, R. F., & Glocker, M. O. (2023) · Biomolecules · doi:10.3390/biom13010187 · Cited by 11

Biomarkers in acute coronary artery disease

Freynhofer, M. K., Tajsić, M., Wojta, J., & Huber, K. (2012) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-012-0148-2 · Cited by 12

TnI-Ultra assay measurements in cancer patients: Comparison with the conventional assay and clinical implication

Salvatici, M., Cardinale, D. M., Botteri, E., Bagnardi, V., Mauro, C., Cassatella, M. C., Lentati, P., Bottari, F., Zorzino, L., Passerini, R., et al. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.898325 · Cited by 11

Peri-operative troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay: comparisons with hs-cTnT and contemporary cTnI assays

Lee, G. R., Jhanji, S., Tarrant, H., James, S., Pearse, R. M., & Fitzgibbon, M. C. (2013) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563213494078 · Cited by 11

Raccomandazioni del Gruppo di Studio sui marcatori miocardici (GdS MM) di SIPMeL per l’implementazione di Point-of-care testing (POCT) per la determinazione della troponina (cTn)

Cappelletti, P., Morandini, M., Moretti, M., Malloggi, L., Stenner, E., Rubin, D., Mazzei, D. F., Cassin, M., & Galli, G. A. (2016) · La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine · doi:10.1007/s13631-015-0105-3 · Cited by 11

Frequency of Increase in Cardiac Troponin Levels After Peripheral Arterial Operations (Carotid Endarterectomy, Abdominal Aorta Procedure, Distal Bypass) and Their Effect on Medical Management

Sandoval, Y. B., Zakharova, M., Rector, T. S., Brilakis, E. S., Drexel, T., McFalls, E. O., & García, S. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.08.087 · Cited by 11

False decrease of high-sensitivity cardiac troponin T assay in pneumatic tube system samples

Wei, J., Wu, Y., Ling, Y., Chen, X., Zhu, Q. N., & Xu, J. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.05.027 · Cited by 11

Immunosensor for rapid detection of human cardiac troponin I, a biomarker for myocardial infarction

Chen, H., Liang, J., Li, H., Li, M., Chen, L., Dong, H. Y., Wang, Y., Wu, Q., Li, B., Jiang, G., et al. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.107431 · Cited by 11

Rationale and Design of the Cardiac CARE Trial: A Randomized Trial of Troponin-Guided Neurohormonal Blockade for the Prevention of Anthracycline Cardiotoxicity

Henriksen, P. A., Hall, P. S., Oikonomidou, O., Macpherson, I. R., Maclean, M., Lewis, S. C., McVicars, H., Broom, A., Scott, F., McKay, P., et al. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.121.009445 · Cited by 11

Cardiac troponins: 25 years on the stage and still improving their clinical value

Alquézar‐Arbé, A., Sionís, A., & Ordóñez‐Llanos, J. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1410777 · Cited by 11

High sensitivity troponin: The Sisyphean pursuit of zero percent miss rate for acute coronary syndrome in the ED

Summers, S., Long, B., April, M. D., Koyfman, A., & Hunter, C. J. (2018) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2018.03.075 · Cited by 11

An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports

Rifai, N., Annesley, T. M., Berg, J. P., Brugnara, C., DELVIN, E. E., Lamb, E. J., Ness, P. M., Plebani, M., Wick, M. R., Wu, A. H. B., et al. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2011-0904 · Cited by 11

Biomarkers of Importance in Monitoring Heart Condition After Acute Myocardial Infarction

Aleksova, A., Fluca, A. L., Beltrami, A. P., Dozio, E., Sinagra, G., Marketou, M. E., & Janjusevic, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm14010129 · Cited by 11

Cardiac Troponin

McGrath, S., Alaour, B., Kampourakis, T., & Marber, M. S. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.101695 · Cited by 10

Fracción aminoterminal del propéptido natriurético cerebral y troponina ultrasensible en el dolor torácico agudo de origen incierto. Un subestudio del estudio PITAGORAS

Sanchís, J. M., Bardajı́, A., Bosch, X., Loma-Osorio, P., Marín, F. R., Sánchez, P. L., Calvo, F., y, P. A., Hernández, C., Serrano, S., et al. (2013) · Revista Española de Cardiología · doi:10.1016/j.recesp.2012.11.002 · Cited by 10

Prognostic value of high-sensitive cardiac troponin I in asymptomatic chronic hemodialysis patients

Maresca, B., Manzione, A., Moioli, A., Salerno, G., Cardelli, P., Punzo, G., Barberi, S., & Mené, P. (2019) · Journal of Nephrology · doi:10.1007/s40620-019-00610-5 · Cited by 10

P ost Exercise Cardiac Troponin I Release and Clearance in Normal Standardbred Racehorses

Rossi, T. M., Pearl, D. L., Pyle, W. G., MAXIE, M. G., Kavsak, P. A., & Physick‐Sheard, P. W. (2015) · Equine Veterinary Journal · doi:10.1111/evj.12486_62 · Cited by 11

Kinetics of Highly Sensitive Troponin T after Cardiac Surgery

Omar, A. S., Sudarsanan, S., Hanoura, S. E., Osman, H. M., Sivadasan, P. C., Shouman, Y., Tuli, A. K., Singh, R., & Khulaifi, A. A. (2015) · BioMed Research International · doi:10.1155/2015/574546 · Cited by 10

The Evolving Role of Cardiac Troponin in the Evaluation of Cardiac Disorders

Anaya, P., & Moliterno, D. J. (2013) · Current Cardiology Reports · doi:10.1007/s11886-013-0420-0 · Cited by 10

Analytical evaluation of point of care cTnT and clinical performances in an unselected population as compared with central laboratory highly sensitive cTnT

Dupuy, A., Sebbane, M., Roubille, F., Coste, T., Bargnoux, A. S., Badiou, S., Kuster, N., & Cristol, J. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.09.027 · Cited by 10

The diagnostic value of two commercially available human cTnI assays in goat kids with myocarditis

Karapınar, T., Eröksüz, Y., Hayırlı, A., BEYTUT, E., Kaynar, Ö., Baydar, E., Sözdutmaz, İ., & Işıdan, H. (2016) · Veterinary Clinical Pathology · doi:10.1111/vcp.12328 · Cited by 10

Appropriate use of serum troponin testing in general practice: a narrative review

Aroney, C. N., & Cullen, L. (2016) · The Medical Journal of Australia · doi:10.5694/mja16.00263 · Cited by 10

Troponin assays: developing indications

Mariathas, M., & Curzen, N. P. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32342-5 · Cited by 10

Copeptin with high-sensitivity troponin at presentation is not inferior to serial troponin measurements for ruling out acute myocardial infarction

Kim, K. S., Suh, G. J., Song, S. H., Jung, Y. S., Kim, T., Shin, S. M., Kang, M. W., & Lee, M. S. (2020) · Clinical and Experimental Emergency Medicine · doi:10.15441/ceem.19.013 · Cited by 10

Identifying Cardiac Diseases using Cardiac Biomarkers in Rhesus Macaques (Macaca mulatta)

Ueda, Y., Yee, J. L., Williams, A., Roberts, J. A., Christe, K. L., & Stern, J. A. (2020) · Comparative Medicine · doi:10.30802/aalas-cm-19-000117 · Cited by 10

Genetic polymorphisms of human cardiac troponins as an unrecognized challenge for diagnosing myocardial injury

Lippi, G., & Cervellin, G. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.12.221 · Cited by 10

Prevalence of Troponin Elevations in Patients With Cardiac Arrest and Implications for Assessing Quality of Care in Hypothermia Centers

Kontos, M. C., Ornato, J. P., Kurz, M. C., Roberts, C. S., Gossip, M. R., Dhindsa, H. S., Reid, R. D., & Peberdy, M. A. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.05.024 · Cited by 10

High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study

Nowak, R. M., Mueller, C. E., Giannitsis, E., Christ, M., Ordóñez‐Llanos, J., deFilippi, C. R., McCord, J., Body, R. M., Panteghini, M., Jernberg, T., et al. (2017) · Biomarkers · doi:10.1080/1354750x.2017.1334154 · Cited by 10

Cardiac involvement in myotonic dystrophy: The role of troponins and N-terminal pro B-type natriuretic peptide

Valaperta, R., Siena, C. D., Cardani, R., Lombardia, F., Cenko, E., Rampoldi, B., Fossati, B., Brigonzi, E., Rigolini, R., Gaia, P., et al. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.020 · Cited by 10

Validation of a 0/1 h Algorithm for Rapid Diagnosis of Myocardial Infarction Using a High-Sensitivity Troponin I Assay

Lehmacher, J., Toprak, B., Sörensen, N. A., der Kellen, R. B., Goßling, A., Hartikainen, T. S., Haller, P. M., Schock, A., Twerenbold, R., Zeller, T., et al. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvad019 · Cited by 9

Sex and race differences in the performance of the European Society of Cardiology 0/1‐h algorithm with high‐sensitivity troponin T

Supples, M., Snavely, A., O'Neill, J., Ashburn, N., Allen, B. R., Christenson, R., Nowak, R., Wilkerson, R. G., Mumma, B., Madsen, T., et al. (2023) · Clinical Cardiology · doi:10.1002/clc.24199 · Cited by 8

A Biomarker-Based Diagnostic Model for Cardiac Dysfunction in Childhood Cancer Survivors

Leerink, J. M., Feijen, E. A. M., de Baat, E. C., Merkx, R., van der Pal, H. J. H., Tissing, W. J. E., Louwerens, M., van den Heuvel‐Eibrink, M. M., Versluys, B. A. B., van Dalen, E. C., et al. (2024) · JACC CardioOncology · doi:10.1016/j.jaccao.2024.02.008 · Cited by 9

Stato dell’arte dei marcatori cardiaci in Italia: la III indagine del GdS MM SIMeL

Cappelletti, P., Galli, G. A., Malloggi, L., Stenner, E., Moretti, M., Morandini, M., Rubin, D., & Cassin, M. (2014) · La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine · doi:10.1007/s13631-014-0069-8 · Cited by 9

The 99th percentile and imprecision of point-of-care cardiac troponin I in comparison to central laboratory tests in a large reference population

Greiser, A., Winter, T., Mahfoud, H., Kallner, A., Ittermann, T., Masuch, A., Lübenow, N., Kohlmann, T., Greinacher, A., Nauck, M. A., et al. (2017) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2017.08.006 · Cited by 9

Raccomandazioni del GdS MM SIPMeL per l'uso dei biomarcatori cardiaci nella diagnostica di NSTEMI. Parte prima: cosa dicono le linee guida

Malloggi, L., Cappelletti, P., Manno, M. L., Stenner, E., Moretti, M., Veneziani, F., Burgio, M. A., Gamboni, A., Cassin, M., Morandini, M., et al. (2021) · La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine · doi:10.23736/s1825-859x.20.00082-1 · Cited by 9

Association between troponin level and medium-term mortality in 20 000 hospital patients

Hinton, J., Mariathas, M., Gabara, L., Allan, R., Nicholas, Z., Kwok, C. S., Ramamoorthy, S., Calver, A., Corbett, S. J., Jabbour, R. J., et al. (2023) · Heart · doi:10.1136/heartjnl-2023-322463 · Cited by 9

Challenges in harmonizing integrated healthcare network laboratories: Multi-center evaluation of the AccuTnI+3 troponin assay

Greene, D. N., Holmes, D. T., Liang, J., Kwong, S.-L., Lorey, T. S., & Petrie, M. S. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.11.009 · Cited by 9

Prediction of coronary heart disease or heart failure using high‐sensitivity cardiac troponin T: A pilot study

Árnadóttir, Á., Vestergaard, K. R., Sölétormos, G., Steffensen, R., Goetze, J. P., & Iversen, K. K. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13009 · Cited by 9

Prognostic Value of High-Sensitivity Cardiac Troponin I in Patients with Non-Ischaemic Heart Failure: Insights from China

Tian, P., Zhao, X., Huang, L., Feng, J., Zhao, L., Liang, L., Huang, B., Zhang, Y., & Zhang, J. (2022) · ESC Heart Failure · doi:10.1002/ehf2.14065 · Cited by 9

Effects of hemolysis on the diagnostic accuracy of cardiac troponin I for the diagnosis of myocardial infarction

Puelacher, C., Twerenbold, R., Mosimann, T., Boeddinghaus, J., Giménez, M. R., Wildi, K. S., Jaeger, C., Reichlin, T., Schneider, J., Honegger, U., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.378 · Cited by 9

Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care

Apple, F. S., Sandoval, Y., Jaffe, A. S., & Ordonez-Llanos, J. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2016.255109 · Cited by 408

for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers†

Assays, T., & Collinson, P. O. (2016)

Evaluation of analytical performance of immunoassay methods for cTnI and cTnT: From theory to practice

Clerico, A., Zaninotto, M., Padoan, A., Masotti, S., Musetti, V., Prontera, C., Ndreu, R., Zucchelli, G., Passino, C., Migliardi, M., et al. (2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.005 · Cited by 64

High-sensitivity cardiac troponin assays: Answers to frequently asked questions

Chenevier‐Gobeaux, C., Bonnefoy‐Cudraz, E., Charpentier, S., Dehoux, M., Lefèvre, G., Meune, C., & Ray, P. (2015) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2014.11.001 · Cited by 42

High-Sensitivity Cardiac Troponin Assays: What Analytical and Clinical Issues Need to Be Addressed before Introduction into Clinical Practice?

Apple, F. S. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2009.138727 · Cited by 20