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Cited by 58Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Globular Adiponectin Augments Insulin Secretion from Pancreatic Islet β Cells at High Glucose Concentrations

Gu, Weiqiong, Li, Xiaoying, Liu, Changqin, Yang, Jun, Ye, Lei, Tang, Jingfen, Gu, Yuanjun, Yang, Yisheng, Hong, Jie, Zhang, Yifei, Chen, Mingdao, Ning, Guang·2006·Endocrine
DOI 10.1385/endo:30:2:217
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Abstract

Adiponectin plays an important role in improving insulin resistance and preventing atherosclerosis. However it has been rarely reported that adiponectin influences insulin secretion because its receptor was identified in human islet beta cells. In order to investigate the direct effect of adiponectin on pancreatic islet beta cells, we performed an insulin secretion test in purified rat islets, which were incubated with adiponectin (100 ng/mL) at low (3.3 mM) and high (16.7 mM) glucose concentrations. Furthermore, cell lysates were extracted from the adiponectin-treated islets for p-AMPKalpha assay. RTPCR and immunohistochemical examination showed both adiponectin receptor 1 (AdipoR1) and receptor 2 (AdipoR2) were expressed in islet cells and AdipoR1 was predominantly expressed. Insulin secretion was significantly increased in the presence of adiponectin for 6 h at high glucose concentration. Meanwhile, the levels of phosphorylated AMPK increased with adiponectin treatment at high glucose concentrations. It is concluded that adiponectin augments insulin secretion from pancreatic islet beta cells at high glucose concentration through AMPK activation.

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Crossref · 10.1385/endo:30:2:217

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32 of 32 references verified0 citation errors · 0 not checkable

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  • Adiponectin is involved in glucose and fatty acid metabolism, forestalls β-cell apoptosis, and induces insulin gene expression and release; the latter mediated by ERK/Akt pathway in one study and AMPK pathway in another.

    “Adiponectin is not only involved in glucose and fatty acid metabolism269 but it also forestalls β-cell apoptosis and induces insulin gene expression and release;270 the latter was mediated by the ERK/Akt pathway in one study270 and by the AMPK pathway in another study.271”

    From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [271]

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Metadata

Authors
Gu, W., Li, X., Liu, C., Yang, J., Ye, L., Tang, J., Gu, Y., Yang, Y., Hong, J., Zhang, Y., Chen, M., & Ning, G.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Shanghai University (CN)
Corresponding author
Ning, Guang
ORCID
Venue
Endocrine
Publisher
Springer Science and Business Media LLC
Published
2006
Volume
30
Issue
2
Pages
217-222
ISSN
0969-711X (ISSN-L)
DOI
10.1385/endo:30:2:217
OpenAlex
W1997335175
Cited by
58
References
32
Citations by year
2024: 1 · 2023: 2 · 2022: 8 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 2 · 2016: 4 · 2015: 1 · 2014: 8 · 2013: 5 · 2012: 3
FWCI
2.03
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
adiponectin, insulin secretion, pancreatic beta cells, AdipoR1, AdipoR2, AMPK activation, high glucose, glucose-stimulated insulin secretion
MeSH terms
Insulin Secretion, Animals, Cells, Cultured, Glucose, Insulin, Male, Multienzyme Complexes, Phosphorylation, Protein Kinases, Receptors, Cell Surface, Rats, Sprague-Dawley, Protein Serine-Threonine Kinases, Insulin-Secreting Cells, Rats, Adiponectin, Receptors, Adiponectin, AMP-Activated Protein Kinases

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