The DOI matches its Crossref record, with a small difference in title or year; 7 of the 7 references it cites were found in a registry or an index.
Disruption of Neurogenesis in the Subventricular Zone of Adult Mice,and in Human Cortical Neuronal Precursor Cells in Culture, by Amyloid β-Peptideby Amyloid β-Peptide
Abstract
The adult mammalian brain contains populations of stem cells that can proliferate and then differentiate into neurons or glia. The highest concentration of such neural progenitor cells (NPC) is located in the subventricular zone (SVZ) and these cells can produce new olfactory bulb and cerebral cortical neurons. NPC may provide a cellular reservoir for replacement of cells lost during normal cell turnover and after brain injury. However, neurogenesis does not compensate for neuronal loss in age-related neurodegenerative disorders such as Alzheimer's disease (AD), suggesting the possibility that impaired neurogenesis contributes to the pathogenesis of such disorders. We now report that amyloid beta-peptide (Abeta), a self-aggregating neurotoxic protein thought to cause AD, can impair neurogenesis in the SVZ/cerebral cortex of adult mice and in human cortical NPC in culture. The proliferation and migration of NPC in the SVZ of amyloid precursor protein (APP) mutant mice, and in mice receiving an intraventricular infusion of Abeta, were greatly decreased compared to control mice. Studies of NPC neurosphere cultures derived from human embryonic cerebral cortex showed that Abeta can suppress NPC proliferation and differentiation, and can induce apoptosis. The adverse effects of Abeta on neurogenesis were associated with a disruption of calcium regulation in the NPC. Our data show that Abeta can impair cortical neurogenesis, and suggest that this adverse effect of Abeta contributes…
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Decline of neural stem/precursor cell function in the subventricular zone and hippocampus is established in aging and various AD mouse models.
“The decline of neural stem/precursor cell (NPC) function in the subventricular zone (SVZ) and the hippocampus has been established in both aging (Leeman et al., 2018) and various AD mouse models (Haughey et al., 2002; López-Toledano and Shelanski, 2004; Mu and Gage, 2011; Rodríguez et al., 2009; Rodríguez and Verkhratsky, 2011; Sakamoto et al., 2014; Winner et al., 2011).”
From Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model (2022) · cites this paper as Haughey et al., 2002
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“Conversely, neurogenesis can be impaired by prenatal stress (Lemaire et al., 2000) and by exposure to methamphetamine (Teuchert-Noodt et al.”
BackgroundCellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
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Increased hippocampal neurogenesis in Alzheimer's disease
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634794100 · Cited by 971
Molecular mechanisms of neurodegeneration in Alzheimer's disease
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Neurogenic Effect of -Amyloid Peptide in the Development of Neural Stem Cells
Lopez-Toledano, M. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0974-04.2004 · Cited by 241
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Wilson, E. N., Do Carmo, S., Iulita, M. F., Hall, H., Ducatenzeiler, A., Marks, A. R., Allard, S., Jia, D. T., Windheim, J., & Cuello, A. C. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.169 · Cited by 56
Enterovirus 71 infects brain-derived neural progenitor cells
Huang, H.-I., Lin, J.-Y., Chen, H.-H., Yeh, S.-B., Kuo, R.-L., Weng, K.-F., & Shih, S.-R. (2014) · Virology · doi:10.1016/j.virol.2014.09.017 · Cited by 25
Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model
Reinitz, F., Chen, E. Y., Nicolis di Robilant, B., Chuluun, B., Antony, J., Jones, R. C., Gubbi, N., Lee, K., Ho, W. H. D., Kolluru, S. S., et al. (2022) · eLife · doi:10.7554/elife.66037 · Cited by 18
Metadata
- Authors
- Haughey, N. J., Liu, D., Nath, A., Borchard, A. C., & Mattson, M. P.
- Venue
- NeuroMolecular Medicine
- Published
- 2002
- Volume
- 1
- Issue
- 2
- Pages
- 125-136
- ISSN
- 1535-1084
- Cited by
- 203
- References
- 7
- Language
- en
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