Molecular mechanisms of neurodegeneration in Alzheimer's disease

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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More hippocampal neurons in adult mice living in an enriched environment

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Mechanisms and Functional Implications of Adult Neurogenesis

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Neurodegenerative Tauopathies

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Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

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Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892 · see citing works

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

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The role of apolipoprotein E in Alzheimer's disease

Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661 · see citing works

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of alzheimer’s disease.

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APP Processing and Synaptic Function

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works

Purification and cloning of amyloid precursor protein β-secretase from human brain

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Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

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Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592 · see citing works

Translating cell biology into therapeutic advances in Alzheimer's disease

Selkoe, D. J. (1999) · Nature · doi:10.1038/399a023 · Cited by 1,588 · see citing works

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Patrick, G. N., Zukerberg, L. R., Nikolić, M., de la Monte, S. M., Dikkes, P., & Tsai, L. (1999) · Nature · doi:10.1038/45159 · Cited by 1,541 · see citing works

Wnt signalling regulates adult hippocampal neurogenesis

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Amyloid pores from pathogenic mutations

Lashuel, H. A., Hartley, D. M., Petre, B. M., Walz, T., & Lansbury, P. T. (2002) · Nature · doi:10.1038/418291a · Cited by 1,291 · see citing works

Neurotoxicity induces cleavage of p35 to p25 by calpain

Lee, M.-S., Kwon, Y. T., Li, M., Peng, J., Friedlander, R. M., & Tsai, L. (2000) · Nature · doi:10.1038/35012636 · Cited by 1,057 · see citing works

A decade of CDK5

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AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

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Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

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Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. (2001) · Nature Neuroscience · doi:10.1038/85059 · Cited by 1,001 · see citing works

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

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Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

Li, S., Hong, S., Shepardson, N. E., Walsh, D. M., Shankar, G. M., & Selkoe, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.012 · Cited by 972 · see citing works

Increased hippocampal neurogenesis in Alzheimer's disease

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Notch signalling regulates stem cell numbers in vitro and in vivo

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Tau in Alzheimer's disease.

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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

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Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

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Metabolic Regulation of Brain Aβ by Neprilysin

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Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

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Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

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Some morphometric aspects of the brain in senile dementia of the alzheimer type

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Alzheimer's disease

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Cai, H., Wang, Y.-S., McCarthy, D., Wen, H., Borchelt, D., Price, D. L., & Wong, P. (2001) · Nature Neuroscience · doi:10.1038/85064 · Cited by 791 · see citing works

Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

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Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

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Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

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Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.

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2010 Alzheimer's disease facts and figures

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Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease

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Axonal Self-Destruction and Neurodegeneration

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Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus

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Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

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The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.Preprint

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Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways

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Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease

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Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets

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-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

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A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

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Amyloid-β oligomers: their production, toxicity and therapeutic inhibition

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New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment

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The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain

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Vesicle Permeabilization by Protofibrillar α-Synuclein Is Sensitive to Parkinson's Disease-Linked Mutations and Occurs by a Pore-like Mechanism

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Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3

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Untitled work

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Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

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Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

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Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP Sw,Ind ) mice

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Oligomers on the Brain: the Emerging Role of Soluble Protein Aggregates in Neurodegeneration.

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Role of microtubule-associated proteins in the control of microtubule assembly

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Glycogen synthase kinase 3: a drug target for CNS therapies

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Structural Correlates of Cognition in Dementia: Quantification and Assessment of Synapse Change

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Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

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The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease

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Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

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The presenilins and Alzheimer's disease

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Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease

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Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

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Glycogen synthase kinase‐3 inhibition is integral to long‐term potentiation

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Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress

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Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus.

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Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

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Patterns of gliosis in alzheimer's disease and aging cerebrum

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Neurogenesis and Alzheimer's disease: At the crossroads

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Causative and susceptibility genes for Alzheimer’s disease: a review

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Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex

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Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease

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Neuroprotective Effects of Regulators of the Glycogen Synthase Kinase-3β Signaling Pathway in a Transgenic Model of Alzheimer's Disease Are Associated with Reduced Amyloid Precursor Protein Phosphorylation

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Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory

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Mechanisms of Neuronal Death in Alzheimer's Disease

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Memory Dysfunction

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