Cited by 288Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

Wolf, Susanne A., Kronenberg, Golo, Lehmann, Kathrin, Blankenship, Aaron, Overall, Rupert, Staufenbiel, Matthias, Kempermann, Gerd·2006·Biological Psychiatry

Abstract

Background In aging mice, activity maintains hippocampal plasticity and adult hippocampal neurogenesis at a level corresponding to a younger age. Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD). Methods Amyloid precursor protein (APP)-23 mice were housed under standard or enriched conditions or in cages equipped with a running wheel. We assessed beta-amyloid plaque load, adult hippocampal neurogenesis, spatial learning, and mRNA levels of trophic factors in the brain. Results Despite stable beta-amyloid plaque load, enriched-living mice showed improved water maze performance, an up-regulation of hippocampal neurotrophin (NT-3) and brain-derived neurotrophic factor (BDNF) and increased hippocampal neurogenesis. In contrast, despite increased bodily fitness, wheel-running APP23 mice showed no change in spatial learning and no change in adult hippocampal neurogenesis but a down-regulation of hippocampal and cortical growth factors. Conclusions We conclude that structural and molecular prerequisites for activity-dependent plasticity are preserved in mutant mice with an AD-like pathology. Our study might help explain benefits of activity for the aging brain but also demonstrates differences between physical and more cognitive activity. It also suggests a possible cellular correlate for the dissociation between structural and functional pathology often found in AD.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2006.04.004

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The extant literature provides some clues about molecular and cellular pathways supporting interactive effects of different factors, but much remains to be discovered.

    “although the extant literature provides some clues concerning the molecular and cellular pathways that support the interactive effects of different factors, much remains to be discovered in further research on multimodal interventions”

Cites

Flagged first, then by citations

2 of the 93 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Wolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G.
Affiliations
  • Max Delbrück Center (DE)
  • Novartis (Switzerland) (CH)
Corresponding author
Kempermann, Gerd
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-12
Volume
60
Issue
12
Pages
1314-1323
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2020895118
Cited by
288
References
93
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 14 · 2019: 13 · 2018: 19 · 2017: 19 · 2016: 14 · 2015: 15 · 2014: 9 · 2013: 22 · 2012: 17
FWCI
13.07
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
Alzheimer's disease, APP23 mice, physical activity, wheel running, environmental enrichment, adult hippocampal neurogenesis, hippocampal plasticity, amyloid plaques, spatial learning, brain-derived neurotrophic factor, neurotrophin-3, growth factors, cognitive activity, brain aging
MeSH terms
Alzheimer Disease, Animals, Brain, Cell Count, Cerebral Cortex, Cognition, Environment, Female, Hippocampus, Insulin-Like Growth Factor I, Mice, Transgenic, Motor Activity, RNA, Messenger, Fibroblast Growth Factor 2, Amyloid beta-Protein Precursor, Disease Progression, Maze Learning, Brain-Derived Neurotrophic Factor, Reverse Transcriptase Polymerase Chain Reaction, Nerve Growth Factor, Neurotrophin 3, Vascular Endothelial Growth Factor A, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review