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Obesity in Schizophrenia
Open accessAbstract
Over the last three decades, an epidemic of obesity has markedly affected patients suffering from mental illnesses such as schizophrenia.Antipsychotic medications used to treat schizophrenia are considered as major culprits.The aim of this review is to first consider risk factors, to then outline negative sequelae of obesity for this population, and finally to address timing and content of recommended clinical interventions.Medical databases were searched with the terms ""weight," "obesity," and "schizophrenia."Selection of articles was guided by date of publication; recent papers are preferentially cited.The main findings were that, in addition to antipsychotic medications, socio-economics, lifestyle, immune factors, and circadian rhythms also contribute to obesity risk.A barrier to effective health promotion within psychiatry has been the concern that fears about gaining weight might stop individuals with schizophrenia from taking needed antipsychotic medication.Recommendations, therefore, are to keep the dose of antipsychotic medication as low as possible, avoid polypharmacy, encourage healthy eating and physical activity, address sleep problems and substance use, monitor weight, blood pressure, and metabolic parameters regularly, utilize motivational interviewing techniques and peer support, pay special attention to special needs such as those of women during pregnancy, and include bariatric surgery as a potential intervention.Conclusion: Besides careful attention to medication regimens, the literature supports the active encouragement and support of patient self-management strategies to both prevent and manage obesity in schizophrenia.
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“Weight gain is a major adverse effect of second-generation antipsychotics, affecting quality of life (4), personal recovery, and somatic morbidity and is a common reason for antipsychotic discontinuation (5).”
From Reversibility of Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis (2021) · cites this paper as [4]
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“The strategies are essentially the same as they are in the general population (64), with the added provisos that attempts at health promotion often do not reach this socially isolated population, that psychiatric patients may not regularly see a primary care provider for health screening and monitoring, that the motiv…”
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Reversibility of Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis
Speyer, H., Westergaard, C., Albert, N., Karlsen, M., Stürup, A. E., Nordentoft, M., & Krogh, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.577919 · Cited by 44
Metadata
- Authors
- Seeman, M. V.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Seeman, Mary V.
- Venue
- Journal of Obesity Management
- Publisher
- Open Access Pub
- Published
- 2016
- Volume
- 1
- Issue
- 1
- Pages
- 10-24
- ISSN
- 2574-450X (ISSN-L)
- OpenAlex
- W2752683757
- Cited by
- 10
- References
- 8
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal Of Obesity Management (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- obesity, schizophrenia, antipsychotic-induced weight gain, obesity risk factors, socioeconomic factors, lifestyle factors, immunological factors, circadian rhythm, antipsychotic dose reduction, polypharmacy, healthy eating, physical activity, sleep disorders, substance use, weight monitoring, metabolic parameters, motivational interviewing, peer support, bariatric surgery, pregnancy, self-management
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