A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides
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The NNF assay initially relied on rat cortical cells, but recent adaptations integrate human iPSC-derived neurons and primary human astroglia to improve human relevance and circumvent differences between species.
“Initially, the NNF assay relied on rat cortical cells, but recent adaptations integrate human induced pluripotent stem cell (iPSC)-derived neurons (SynFire induced neurons), and primary human astroglia to improve human relevance and circumvent differences between species (Bartmann et al., 2023).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Bartmann et al., 2023
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Potential developmental neurotoxicity of pesticides used in Europe
Bjørling-Poulsen, M., Andersen, H. R., & Grandjean, P. (2008) · Environmental Health · doi:10.1186/1476-069x-7-50 · Cited by 407 · see citing works
Blum, J., Masjosthusmann, S., Bartmann, K., Bendt, F., Dolde, X., Dönmez, A., Förster, N., Holzer, A.-K., Hübenthal, U., Keßel, H. E., et al. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2022.137035 · Cited by 105 · see citing works
Self-citationHarrill, J. A., Freudenrich, T., Wallace, K., Ball, K., Shafer, T. J., & Mundy, W. R. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.04.001 · Cited by 86 · see citing works
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- ity in vitro testing assays for use in integrated approaches for test- ing and assessment. EFSA Support Publ 18, 6924E. doi:10.2903/ sp.efsa.2021.en-6924 · DOI
- Dach, K., Bendt, F., Huebenthal, U. et al. (2017). BDE-99 impairs differentiation of human and mouse NPCs into the oligoden- droglial lineage by species-specific modes of action. Sci Rep 7, 44861. doi:10.1038/srep44861 · DOI
- Das, K. P., Freudenrich, T. M. and Mundy, W. R. (2004). Assess. - ment of PC12 cell differentiation and neurite growth: A compa- rison of morphological and neurochemical measures. Neurotoxi- col Teratol 26, 397-406. doi:10.1016/j.ntt.2004.02.006 · DOI
- Di Consiglio, E., Pistollato, F., Mendoza-De Gyves, E. et al. (2020). Integrating biokinetics and in vitro studies to evaluate develop- mental neurotoxicity induced by chlorpyrifos in human iPSC- derived neural stem cells undergoing differentiation towards neuronal and glial cells. Reprod Toxicol 98, 174-188. doi: 10.1016/j.reprotox.2020.09.010 · DOI
- Doretto, S., Malerba, M., Ramos, M. et al. (2011). Oligodendro- cytes as regulators of neuronal networks during early postnatal development. PLoS One 6, 19849. doi:10.1371/journal.pone. 0019849 · DOI
- Druwe, I., Freudenrich, T. M., Wallace, K. et al. (2015). Sensitivity of neuroprogenitor cells to chemical-induced apoptosis using a multiplexed assay suitable for high-throughput screening. Toxi- cology 333, 14-24. doi:10.1016/J.TOX.2015.03.011 · DOI
- Druwe, I., Freudenrich, T. M., Wallace, K. et al. (2016). Compari- son of human induced pluripotent stem cell-derived neurons and rat primary cortical neurons as in vitro models of neurite out- growth. Appl Vitr Toxicol 2, 26-36. doi:10.1089/aivt.2015.0025 · DOI
- Dubois, J., Benders, M., Borradori-Tolsa, C. et al. (2008). Primary cortical folding in the human newborn: An early marker of lat- er functional development. Brain 131, 2028-2041. doi:10.1093/ BRAIN/AWN137 EFSA (2013). Scientific Opinion on the developmental neurotoxic- ity potential of acetamiprid and imidacloprid. EFSA J 11, 3471. doi:10.2903/j.efsa.2013.3471 · DOI
- Frank, C. L., Brown, J. P., Wallace, K. et al. (2017). Developmental neurotoxicants disrupt activity in cortical networks on micro- electrode arrays: Results of screening 86 compounds during neural network formation. Toxicol Sci 160, 121-135. doi:10. 1093/toxsci/kfx169 · DOI
- Fritsche, E., Alm, H., Baumann, J. et al. (2015). Literature review on in vitro and alternative developmental neurotoxicity (DNT) testing methods. EFSA Support Publ 12, 778E. doi:10.2903/ sp.efsa.2015.en-778 · DOI
- Fritsche, E. (2017). Report on Integrated Testing Strategies for the identification and evaluation of chemical hazards associated with the developmental neurotoxicity (DNT), to facilitate discussions at the Joint EFSA/OECD Workshop on DNT. EFSA Support Publ 14, 1191E. doi:10.2903/sp.efsa.2017.en-1191 · DOI
- Fritsche, E., Crofton, K. M., Hernandez, A. F. et al. (2017). OECD/ EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes. ALTEX 34, 311-315. doi:10.14573/altex.1701171 · DOI · Paper page
- Fritsche, E., Barenys, M., Klose, J. et al. (2018a). Current availabil- ity of stem cell-based in vitro methods for developmental neu- neurospheres recorded by microelectrode arrays (MEA). In J. Llorens and M. Barenys (eds), Experimental Neurotoxicology Methods (473-488). Neuromethods 172. New York: Humana. doi:10.1007/978-1-0716-1637-6_22 · DOI
- Baumann, J., Barenys, M., Gassmann, K. et al. (2014). Compa- rative human and rat "neurosphere assay" for developmental neurotoxicity testing. Curr Protoc Toxicol 59, 12.21.1-12.21.24. doi:10.1002/0471140856. · DOI
- TX1221S59 · DOI
- Baumann, J., Dach, K., Barenys, M. et al. (2015). Application of the neurosphere assay for DNT hazard assessment: Challenges and limitations. In Methods in Pharmacology and Toxicology (29). Totowa, NJ: Humana Press. doi:10.1007/7653_2015_49 · DOI
- Baumann, J., Gassmann, K., Masjosthusmann, S. et al. (2016). Comparative human and rat neurospheres reveal species differ- ences in chemical effects on neurodevelopmental key events. Arch Toxicol 90, 1415-1427. doi:10.1007/S00204-015-1568-8 · DOI · Paper page
- Bennett, D., Bellinger, D. C., Birnbaum, L. S. et al. (2016). Project TENDR: Targeting environmental neuro-developmental risks the TENDR consensus statement. Environ Health Perspect 124, A118-A122. doi:10.1289/EHP358 · DOI · Paper page
- Brown, J. P., Hall, D., Frank, C. L. et al. (2016). Evaluation of a microelectrode array-based assay for neural network ontog- eny using training set chemicals. Toxicol Sci 154, 126-139. doi:10.1093/toxsci/kfw147 · DOI
- Carstens, K. E., Carpenter, A. F., Martin, M. M. et al. (2022). Integrating data from in vitro new approach methodologies for developmental neurotoxicity. Toxicol Sci 187, 62-79. doi:10. 1093/toxsci/kfac018 · DOI
- Coecke, S., Goldberg, A. M., Allen, S. et al. (2007). Workgroup report: Incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk as- sessment strategies. Environ Health Perspect 115, 924-931. doi: 10.1289/ehp.9427 · DOI
- Crofton, K. M., Mundy, W. R., Lein, P. J. et al. (2011). Develop- mental neurotoxicity testing: Recommendations for developing alternative methods for the screening and prioritization of chem- icals. ALTEX 28, 9-15. doi:10.14573/altex.2011.1.009 · DOI
- Crofton, K. M., Mundy, W. R. and Shafer, T. J. (2012). Develop- mental neurotoxicity testing: A path forward. Congenit Anom 52, 140-146. doi:10.1111/j.1741-4520.2012.00377.x · DOI
- Crofton, K., Fritsche, E., Ylikomi, T. et al. (2014). International STakeholder NETwork (ISTNET) for creating a developmental neurotoxicity testing (DNT) roadmap for regulatory purposes. ALTEX 31, 223-224. doi:10.14573/altex.1402121 · DOI
- Crofton, K. M. and Mundy, W. R. (2021). External scientific report on the interpretation of data from the developmental neurotoxic- munoreactivity patterns of GFAP, S100, AQP4 and YKL-40. J Anat 235, 590-615. doi:10.1111/JOA.12948 · DOI
- Hyvärinen, T., Hyysalo, A., Kapucu, F. E. et al. (2019). Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: Comparison to rat cortical cultures. Sci Rep 9, 17125. doi:10.1038/s41598-019- 53647-8 · DOI
- Ishii, M. N., Yamamoto, K., Shoji, M. et al. (2017). Human induced pluripotent stem cell (hiPSC)-derived neurons respond to con- vulsant drugs when co-cultured with hiPSC-derived astrocytes. Toxicology 389, 130-138. doi:10.1016/j.tox.2017.06.010 · DOI
- Johnstone, A. F. M., Gross, G. W., Weiss, D. G. et al. (2010). Mi- croelectrode arrays: A physiologically based neurotoxicity test- ing platform for the 21 st century. Neurotoxicology 31, 331-350. doi:10.1016/j.neuro.2010.04.001 · DOI
- Johnston, G. A. R. (2013). Advantages of an antagonist: Bicucull- ine and other GABA antagonists. Br J Pharmacol 169, 328-336. doi:10.1111/BPH.12127 · DOI
- Karlin, A. (2002). Emerging structure of the nicotinic acetylcholine receptors. Nat Rev Neurosci 3, 102-114. doi:10.1038/nrn731 · DOI
- Klose, J., Tigges, J., Masjosthusmann, S. et al. (2021). TBBPA targets converging key events of human oligodendrocyte devel- opment resulting in two novel AOPs. ALTEX 38, 215-234. doi: 10.14573/altex.2007201 · DOI
- Koch, K., Bartmann, K., Hartmann, J. et al. (2022). Scientific va. - lidation of human neurosphere assays for developmental neu- rotoxicity evaluation. Front Toxicol 4, 816370. doi:10.3389/ ftox.2022.816370 · DOI · Paper page
- Kosnik, M. B., Strickland, J. D., Marvel, S. W. et al. (2020). Con- centration-response evaluation of ToxCast compounds for multi- variate activity patterns of neural network function. Arch Toxicol 94, 469-484. doi:10.1007/s00204-019-02636-x · DOI
- Kramer, N. I., Di Consiglio, E., Blaauboer, B. J. et al. (2015). Bio- kinetics in repeated-dosing in vitro drug toxicity studies. Toxicol In Vitro 30, 217-224. doi:10.1016/j.tiv.2015.09.005 · DOI
- Krug, A. K., Balmer, N. V., Matt, F. et al. (2013). Evaluation of a human neurite growth assay as specific screen for developmen- tal neurotoxicants. Arch Toxicol 87, 2215-2231. doi:10.1007/ s00204-013-1072-y · DOI
- Kuehn, B. M. (2010). Increased risk of ADHD associated with ear- ly exposure to pesticides, PCBs. JAMA 304, 27-28. doi:10.1001/ jama.2010.860 · DOI
- Leist, M. and Hartung, T. (2013). Reprint: Inflammatory findings on species extrapolations: Humans are definitely no 70-kg mice. ALTEX 30, 227-230. doi:10.14573/altex.2013.2.227 · DOI
- Leonzino, M., Busnelli, M., Antonucci, F. et al. (2016). The timing of the excitatory-to-inhibitory GABA switch is regulated by the oxytocin receptor via KCC2. Cell Rep 15, 96-103. doi:10.1016/j. celrep.2016.03.013 · DOI
- Little, D., Ketteler, R., Gissen, P. et al. (2019). Using stem cell-de- rived neurons in drug screening for neurological diseases. Neurobiol Aging 78, 130-141. doi:10.1016/j.neurobiolaging. 2019.02.008 · DOI
- Maccioni, R. B. and Cambiazo, V. (1995). Role of microtubule-as- sociated proteins in the control of microtubule assembly. Phys Rev 75, 835-864. doi:10.1152/physrev.1995.75.4.835 · DOI
- rotoxicity (DNT) testing. Toxicol Sci 165, 21-30. doi:10.1093/ toxsci/kfy178 · DOI
- Fritsche, E., Grandjean, P., Crofton, K. M. et al. (2018b). Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) test- ing for regulatory purposes. Toxicol Appl Pharmacol 354, 3-6. doi:10.1016/J.TAAP.2018.02.004 · DOI · Paper page
- Glantz, L. A., Gilmore, J. H., Hamer, R. M. et al. (2007). Syn- aptophysin and PSD-95 in the human prefrontal cortex from mid-gestation into early adulthood. Neuroscience 149, 582-591. doi:10.1016/j.neuroscience.2007.06.036 · DOI · Paper page
- Goldman, L. R. and Koduru, S. (2000). Chemicals in the environ- ment and developmental toxicity to children: A public health and policy perspective. Environ Health Perspect 108, 443-448. doi:10.1289/EHP.00108S3443 · DOI
- Grandjean, P. and Landrigan, P. (2006). Developmental neurotoxic- ity of industrial chemicals. Lancet 368, 2167-2178. doi:10.1016/ S0140-6736(06)69665-7 · DOI · Paper page
- Hama, H., Hara, C., Yamaguchi, K. et al. (2004). PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes. Neuron 41, 405-415. doi:10.1016/S0896-6273(04)00007-8 · DOI
- Hardy, A., Benford, D., Halldorsson, T. et al. (2017). Guidance on the use of the weight of evidence approach in scientific assess- ments. EFSA J 15, e04971. doi:10.2903/j.efsa.2017.4971 · DOI
- Harrill, J. A., Freudenrich, T. M., Machacek, D. W. et al. (2010). Quantitative assessment of neurite outgrowth in human embry- onic stem cell-derived hN2 cells using automated high-content image analysis. Neurotoxicology 31, 277-290. doi:10.1016/j. neuro.2010.02.003 · DOI
- Harrill, J. A., Robinette, B. L. and Mundy, W. R. (2011). Use of high content image analysis to detect chemical-induced chang- es in synaptogenesis in vitro. Toxicol In Vitro 25, 368-387. doi:10.1016/j.tiv.2010.10.011 · DOI
- Harrill, J. A., Robinette, B. L., Freudenrich, T. et al. (2013). Use of high content image analyses to detect chemical-mediated effects on neurite sub-populations in primary rat cortical neurons. Neu- rotoxicology 34, 61-73. doi:10.1016/j.neuro.2012.10.013 · DOI
- Hernández-Jerez, A., Adriaanse, P., Aldrich, A. et al. (2021). De- velopment of Integrated Approaches to Testing and Assessment (IATA) case studies on developmental neurotoxicity (DNT) risk assessment. EFSA J 19, e06599. doi:10.2903/j.efsa.2021.6599 · DOI
- Hoelting, L., Klima, S., Karreman, C. et al. (2016). Stem cell-de- rived immature human dorsal root ganglia neurons to identify peripheral neurotoxicants. Stem Cells Transl Med 5, 476-487. doi:10.5966/SCTM.2015-0108 · DOI
- Hofrichter, M., Nimtz, L., Tigges, J. et al. (2017). Comparative per- formance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro. Stem Cell Res 25, 72-82. doi:10.1016/J.SCR.2017.10.013 · DOI
- Holst, C. B., Brøchner, C. B., Vitting-Seerup, K. et al. (2019). As- trogliogenesis in human fetal brain: Complex spatiotemporal im- cal evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system. Sci Rep 8, 10416. doi:10.1038/s41598- 018-28835-7 OECD (2007). Test No. 426: Developmental Neurotoxicity Study. OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects. http://www.oecd.org/dataoecd/20/52/37622194. pdf (accessed 22.07.2021) · DOI
- Okado, N., Kakimi, S. and Kojima, T. (1979). Synaptogenesis in the cervical cord of the human embryo: Sequence of synapse for- mation in a spinal reflex pathway. J Comp Neurol 184, 491-517. doi:10.1002/cne.901840305 · DOI
- Oulhote, Y. and Bouchard, M. F. (2013). Urinary metabolites of organophosphate and pyrethroid pesticides and behavioral prob- lems in Canadian children. Environ Health Perspect 121, 1378- 1384. doi:10.1289/ehp.1306667 · DOI
- Paolicelli, R. C. and Ferretti, M. T. (2017). Function and dysfunc- tion of microglia during brain development: Consequences for synapses and neural circuits. Front Synaptic Neurosci 9, 9. doi:10.3389/fnsyn.2017.00009 · DOI
- Paparella, M., Bennekou, S. H. and Bal-Price, A. (2020). An analysis of the limitations and uncertainties of in vivo develop- mental neurotoxicity testing and assessment to identify the po- tential for alternative approaches. Reprod Toxicol 96, 327-336. doi:10.1016/j.reprotox.2020.08.002 · DOI
- Pistollato, F., Carpi, D., Mendoza-de Gyves, E. et al. (2021). Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures. Re- prod Toxicol 105, 101-119. doi:10.1016/j.reprotox.2021.08.007 · DOI
- Pitzer, E. M., Williams, M. T. and Vorhees, C. V. (2021). Effects of pyrethroids on brain development and behavior: Deltamethrin. Neurotoxicol Teratol 87, 106983. doi:10.1016/j.ntt.2021.106983 · DOI
- Radio, N. M., Breier, J. M., Shafer, T. J. et al. (2008). Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening. Toxicol Sci 105, 106-118. doi:10.1093/toxsci/ kfn114 · DOI
- Robinette, B. L., Harrill, J. A., Mundy, W. R. et al. (2011). In vitro assessment of developmental neurotoxicity: Use of microelec- trode arrays to measure functional changes in neuronal network ontogeny. Front Neuroeng 4, 1-9. doi:10.3389/fneng.2011.00001 · DOI
- Rodier, P. M. (1995). Developing brain as a target of toxicity. En- viron Health Perspect 103, Suppl 6, 73-76. doi:10.1289/ehp. · DOI
- 95103s673 · DOI
- Saavedra, L., Wallace, K., Freudenrich, T. F. et al. (2021). Compar- ison of acute effects of neurotoxic compounds on network activi- ty in human and rodent neural cultures. Toxicol Sci 180, 295-312. doi:10.1093/toxsci/kfab008 · DOI
- Sachana, M., Bal-Price, A., Crofton, K. M. et al. (2019). Interna- tional regulatory and scientific effort for improved developmen- tal neurotoxicity testing. Toxicol Sci 167, 45-57. doi:10.1093/ toxsci/kfy211 · DOI
- Sagiv, S. K., Thurston, S. W., Bellinger, D. C. et al. (2010). Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children. Am J Epi- demiol 171, 593-601. doi:10.1093/aje/kwp427 · DOI
- Macdonald, R. L., Rogers, C. J. and Twyman, R. E. (1989). Kinet- ic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture. J Physiol 410, 479-499. doi:10.1113/jphysiol.1989.sp017545 · DOI
- Mack, C. M., Lin, B. J., Turner, J. D. et al. (2014). Burst and prin- cipal components analyses of MEA data for 16 chemicals de- scribe at least three effects classes. Neurotoxicology 40, 75-85. doi:10.1016/j.neuro.2013.11.008 · DOI
- Martin, M. M., Baker, N. C., Boyes, W. K. et al. (2022). An ex- pert-driven literature review of "negative" chemicals for devel- opmental neurotoxicity (DNT) in vitro assay evaluation. Neuro- toxicol Teratol 93, 107117. doi:10.1016/j.ntt.2022.107117 · DOI · Paper page
- Masjosthusmann, S., Becker, D., Petzuch, B. et al. (2018). A tran- scriptome comparison of time-matched developing human, mouse and rat neural progenitor cells reveals human unique- ness. Toxicol Appl Pharmacol 354, 40-55. doi:10.1016/j.taap. 2018.05.009 · DOI
- Masjosthusmann, S., Blum, J., Bartmann, K. et al. (2020). Estab- lishment of an a priori protocol for the implementation and in- terpretation of an in-vitro testing battery for the assessment of developmental neurotoxicity. EFSA Support Publ 17, 1938E. doi:10.2903/sp.efsa.2020.en-1938 · DOI · Paper page
- Missale, C., Nash, S. R., Robinson, S. W. et al. (1998). Dopamine receptors: From structure to function. Physiol Rev 78, 189-225. doi:10.1152/physrev.1998.78.1.189 · DOI · Paper page
- Miyamoto, A., Wake, H., Ishikawa, A. W. et al. (2016). Microglia contact induces synapse formation in developing somatosensory cortex. Nat Commun 7, 12540. doi:10.1038/ncomms12540 · DOI · Paper page
- Neuman, R. S., Ben-Ari, Y., Gho, M. et al. (1988). Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxal- ine-2,3-dione (CNQX) in the hippocampus in vitro. Neurosci Lett 92, 64-68. doi:10.1016/0304-3940(88)90743-4 · DOI
- Nimtz, L., Klose, J., Masjosthusmann, S. et al. (2019). The neu- rosphere assay as an in vitro method for developmental neu- rotoxicity (DNT) evaluation. Neuromethods 145, 141-168. doi:10.1007/978-1-4939-9228-7_8 · DOI
- Nimtz, L., Hartmann, J., Tigges, J. et al. (2020). Characterization and application of electrically active neuronal networks establis- hed from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation. Stem Cell Res 45, 101761. doi:10.1016/j.scr.2020.101761 · DOI
- NRC -National Research Council (2000). Scientific Frontiers in Developmental Toxicology and Risk Assessment. National Acad- emies Press. doi:10.17226/9871 · DOI
- Nyffeler, J., Dolde, X., Krebs, A. et al. (2017). Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library. Arch Toxicol 91, 3613-3632. doi:10.1007/s00204-017-1977-y · DOI
- Ockleford, C., Adriaanse, P., Hougaard Bennekou, S. et al. (2018). Scientific opinion on pesticides in foods for infants and young children. EFSA J 16, e05286. doi:10.2903/j.efsa.2018.5286 · DOI
- Odawara, A., Katoh, H., Matsuda, N. et al. (2016). Physiological maturation and drug responses of human induced pluripotent stem cell-derived cortical neuronal networks in long-term cul- ture. Sci Rep 6, 26181. doi:10.1038/srep26181 · DOI
- Odawara, A., Matsuda, N., Ishibashi, Y. et al. (2018). Toxicologi- Tukker, A. M., Wijnolts, F. M. J., de Groot, A. et al. (2020b). Ap- plicability of hiPSC-derived neuronal co-cultures and rodent pri- mary cortical cultures for in vitro seizure liability assessment. Toxicol Sci 178, 71-87. doi:10.1093/toxsci/kfaa136 · DOI
- Uhlhaas, P. and Singer, W. (2006). Neural synchrony in brain disor- ders: Relevance for cognitive dysfunctions and pathophysiology. Neuron 52, 155-168. doi:10.1016/j.neuron.2006.09.020 · DOI · Paper page
- Wagner-Schuman, M., Richardson, J. R., Auinger, P. et al. (2015). Association of pyrethroid pesticide exposure with attention-defi- cit/hyperactivity disorder in a nationally representative sample of U.S. children. Environ Health 14, 44. doi:10.1186/s12940-015- 0030-y · DOI
- Xue, Z., Li, X., Su, Q. et al. (2013). Effect of synthetic pyrethroid pesticide exposure during pregnancy on the growth and development of infants. Asia Pac J Public Health 25, Suppl 4, 72S-79S. doi:10.1177/1010539513496267 · DOI
- Zhang, L. I. and Poo, M. M. (2001). Electrical activity and devel- opment of neural circuits. Nat Neurosci 4, Suppl, 1207-1214. doi:10.1038/NN753 · DOI
- Zhang, R., Zhang, H., Chen, B. et al. (2020). Fetal bovine serum attenuating perfluorooctanoic acid-inducing toxicity to multiple human cell lines via albumin binding. J Hazard Mater 389, 122109. doi:10.1016/j.jhazmat.2020.122109 · DOI
- Zhang, Y., Xu, Y.-Y., Sun, W.-J. et al. (2016). FBS or BSA inhibits EGCG induced cell death through covalent binding and the reduction of intracellular ROS production. Biomed Res Int 2016, 5013409. doi:10.1155/2016/5013409 · DOI
- A high-content image analysis (HCA) approach for phenotyp- ic developmental neurotoxicity (DNT) screenings of organ- oid neurosphere cultures in vitro. Arch Toxicol 91, 2017-2028. doi:10.1007/s00204-016-1852-2 · DOI
- Seki, T. (2002). Expression patterns of immature neuronal mark- ers PSA-NCAM, CRMP-4 and NeuroD in the hippocampus of young adult and aged rodents. J Neurosci Res 70, 327-334. doi:10.1002/jnr.10387 · DOI
- Shafer, T. J., Rijal, S. O. and Gross, G. W. (2008). Complete in- hibition of spontaneous activity in neuronal networks in vitro by deltamethrin and permethrin. Neurotoxicology 29, 203-212. doi:10.1016/j.neuro.2008.01.002 · DOI
- Shafer, T. J. (2019). Application of microelectrode array approach- es to neurotoxicity testing and screening. Adv Neurobiol 22, 275- 297. doi:10.1007/978-3-030-11135-9_12 · DOI
- Sheets, L. P., Li, A. A., Minnema, D. J. et al. (2016). A critical re- view of neonicotinoid insecticides for developmental neurotox- icity. Crit Rev Toxicol 46, 153-190. doi:10.3109/10408444.201 5.1090948 · DOI
- Shelton, J. F., Geraghty, E. M., Tancredi, D. J. et al. (2014). Neu- rodevelopmental disorders and prenatal residential proximity to agricultural pesticides: The charge study. Environ Health Per- spect 122, 1103-1109. doi:10.1289/ehp.1307044 · DOI · Paper page
- Smirnova, L., Hogberg, H. T., Leist, M. et al. (2014). Food for thought ... Developmental neurotoxicity -Challenges in the 21 st century and in vitro opportunities. ALTEX 31, 129-156. doi: 10.14573/altex.1403271 · DOI
- Stern, M., Gierse, A., Tan, S. et al. (2014). Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity. Arch Toxicol 88, 127-136. doi:10.1007/S00204-013-1098-1 · DOI
- Takahashi, K., Tanabe, K., Ohnuki, M. et al. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872. doi:10.1016/j.cell.2007.11.019 · DOI · Paper page
- Tapia, C. M., Folorunso, O., Singh, A. K. et al. (2020). Effects of deltamethrin acute exposure on Nav1.6 channels and me- dium spiny neurons of the nucleus accumbens. Toxicology 440, 152488. doi:10.1016/j.tox.2020.152488 · DOI
- Terron, A. and Bennekou, S. H. (2018). Towards a regulatory use of alternative developmental neurotoxicity testing (DNT). Toxicol Appl Pharmacol 354, 19-23. doi:10.1016/j.taap.2018.02.002 · DOI
- Toscano, C. D. and Guilarte, T. R. (2005). Lead neurotoxicity: From exposure to molecular effects. Brain Res Rev 49, 529-554. doi:10.1016/j.brainresrev.2005.02.004 · DOI
- Tsuji, R. and Crofton, K. M. (2012). Developmental neurotoxicity guideline study: Issues with methodology, evaluation and regula- tion*. Congenit Anom (Kyoto) 52, 122-128. doi:10.1111/J.1741- 4520.2012.00374. · DOI
- X · DOI
- Tukker, A. M., Bouwman, L. M. S., van Kleef, R. G. D. M. et al. (2020a). Perfluorooctane sulfonate (PFOS) and perfluoroocta- noate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro. Sci Rep 10, 5311. doi:10.1038/s41598-020-62152-2 · DOI
Cited by
Sorted by citations
Spänle, J. V., Haiber, L. M., & Seeger, B. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1800157 · Cited by 1 · see citing works
- Authors
- Bartmann, K.
- Venue
- ALTEX
- Publisher
- ALTEX Edition
- Published
- 2023
- Pages
- 452-470
- ISSN
- 1868-596X
- Cited by
- 22
- References
- 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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