Inoculation stress hypothesis of environmental enrichment.

Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults

Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(98)00017-8 · Cited by 18,943 · see citing works

Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication

Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works

Child abuse: Adolescent records vs. adult recall

Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820 · see citing works

Causal Relationship Between Stressful Life Events and the Onset of Major Depression

Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,486 · see citing works

Neural consequences of enviromental enrichment

van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works

Stress Without Distress.

Selye, H. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-5-716_1 · Cited by 2,221 · see citing works

The nature of love

Harlow, H. F. (1958) · American Psychologist · doi:10.1037/h0047884 · Cited by 2,022 · cited 4× · see citing works

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works

Allostasis and Allostatic Load Implications for Neuropsychopharmacology

McEwen, B. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00129-3 · Cited by 1,833 · see citing works

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works

Implications of resilience concepts for scientific understanding

RUTTER, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1376.002 · Cited by 1,648 · see citing works

How does stress increase risk of drug abuse and relapse?

Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works

Effects of exercise training on older patients with major depression

Blumenthal, J. A., Babyak, M. A., Moore, K. A., Craighead, W. E., Herman, S., Khatri, P., Waugh, R., Napolitano, M. A., Forman, L. M., Appelbaum, M., et al. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.19.2349 · Cited by 1,277 · see citing works

Conditioned place preference: what does it add to our preclinical understanding of drug reward?

Bardo, M. T., & Bevins, R. A. (2000) · Psychopharmacology · doi:10.1007/s002130000569 · Cited by 1,233 · see citing works

Chronic mild stress-induced anhedonia: A realistic animal model of depression

Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 2× · see citing works

Psychobiology of plasticity: Effects of training and experience on brain and behavior

Rosenzweig, M. R., & Bennett, E. L. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00216-2 · Cited by 972 · see citing works

Arousal and physiological toughness: implications for mental and physical health

Dienstbier, R. A. (1989) · Psychological Review · doi:10.1037/0033-295x.96.1.84 · Cited by 909 · see citing works

Physical activity dose-response effects on outcomes of depression and anxiety

DUNN, A. L., TRIVEDI, M. H., & O???NEAL, H. A. (2001) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200106001-00027 · Cited by 816 · see citing works

The role of stress in drug self-administration

Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674 · see citing works

Principles and Practice of Stress Management

Gauron, E. F. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.2.250-a · Cited by 607 · see citing works

Work-related stress and depressive disorders

Tennant, C. (2001) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00255-0 · Cited by 605 · see citing works

What is in a name? Integrating homeostasis, allostasis and stress

McEwen, B. S., & Wingfield, J. C. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.09.011 · Cited by 592 · see citing works

The effects of an enriched environment on the histology of the rat cerebral cortex

Diamond, M. C., Krech, D., & Rosenzweig, M. R. (1964) · Journal of Comparative Neurology · doi:10.1002/cne.901230110 · Cited by 584 · see citing works

Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Comparison of stressors

Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00256-i · Cited by 571 · see citing works

Corticosterone levels determine individual vulnerability to amphetamine self-administration.

Piazza, P. V., Maccari, S., Deminière, J.-M., Moal, M. L., Mormède, P., & Simon, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.6.2088 · Cited by 567 · see citing works

Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration

Piazza, P. V., Deminiere, J. M., le Moal, M., & Simon, H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90431-a · Cited by 565 · see citing works

Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes

Sinha, R., Garcia, M., Paliwal, P., Kreek, M. J., & Rounsaville, B. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.324 · Cited by 528 · see citing works

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R., & Savonenko, A. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5080-04.2005 · Cited by 517 · see citing works

Delaying the onset of Huntington's in mice

van Dellen, A., Blakemore, C., Deacon, R., York, D. F., & Hannan, A. (2000) · Nature · doi:10.1038/35008142 · Cited by 499 · see citing works

Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice

Duman, C. H., Schlesinger, L., Russell, D. S., & Duman, R. S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.047 · Cited by 465 · see citing works

Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats

Gregus, A., Wintink, A. J., Davis, A. C., & Kalynchuk, L. E. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.013 · Cited by 435 · see citing works

Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period

Erb, S. M., Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/s002130050150 · Cited by 406 · see citing works

Stress-induced craving and stress response in cocaine dependent individuals

Sinha, R., Catapano, D., & O’Malley, S. S. (1999) · Psychopharmacology · doi:10.1007/s002130050898 · Cited by 403 · see citing works

Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway

Greenwood, B. N., Foley, T. E., Le, T. V., Strong, P. V., Loughridge, A. B., Day, H. E. W., & Fleshner, M. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.005 · Cited by 399 · see citing works

Stressful Life Events and Major Depression: Risk Period, Long-Term Contextual Threat, and Diagnostic Specificity

KENDLER, K. S., KARKOWSKI, L. M., & PRESCOTT, C. A. (1998) · The Journal of Nervous & Mental Disease · doi:10.1097/00005053-199811000-00001 · Cited by 380 · see citing works

Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

Spires‐Jones, T. L., Grote, H., Varshney, N. K., Cordery, P. M., van Dellen, A., Blakemore, C. B., & Hannan, A. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1658-03.2004 · Cited by 367 · see citing works

Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans

Rojas Vega, S., Strüder, H. K., Vera Wahrmann, B., Schmidt, A., Bloch, W., & Hollmann, W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.105 · Cited by 357 · see citing works

Untitled work

(1997) · PubMed · Cited by 350 · see citing works

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works

Stress and Alcohol Interaction: An Update of Human Research

Pohorecky, L. A. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00543.x · Cited by 341 · see citing works

Induction of ΔFosB in Reward-Related Brain Structures after Chronic Stress

Perrotti, L. I., Hadeishi, Y., Ulery, P. G., Barrot, M., Monteggia, L. M., Duman, R. S., & Nestler, E. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2542-04.2004 · Cited by 330 · see citing works

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

Hockly, E., Cordery, P., Woodman, B., Mahal, A., van Dellen, A., Blakemore, C., Lewis, C., Hannan, A., & Bates, G. (2002) · Annals of Neurology · doi:10.1002/ana.10094 · Cited by 326 · see citing works

Regional changes in c-fos expression in the basal forebrain and brainstem during adaptation to repeated stress: Correlations with cardiovascular, hypothermic and endocrine responses

Chen, X., & Herbert, J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00532-a · Cited by 313 · see citing works

Time course of the effect of maternal deprivation on the hypothalamic‐pituitary‐adrenal axis in the infant rat

Levine, S. D., Huchton, D. M., Wiener, S. G., & Rosenfeld, P. (1991) · Developmental Psychobiology · doi:10.1002/dev.420240803 · Cited by 304 · see citing works

Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.001 · Cited by 300 · see citing works

Environmental enrichment decreases intravenous self-administration of amphetamine in female and male rats

Bardo, M. T., Klebaur, J. E., Valone, J. M., & Deaton, C. (2001) · Psychopharmacology · doi:10.1007/s002130100720 · Cited by 292 · see citing works

Factor analysis of Forced Swimming test, Sucrose Preference test and Open Field test on enriched, social and isolated reared rats

Sáenz, J. C. B., Rodríguez‐Villagra, O. A., & Trías, J. F. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.12.001 · Cited by 291 · see citing works

Enriched and impoverished environments: Effects on brain and behavior

Rose, S. P. R. (1990) · Neuropsychologia · doi:10.1016/0028-3932(90)90132-8 · Cited by 289 · see citing works

Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

Wolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.004 · Cited by 288 · see citing works

Non-contingent electric footshock facilitates the acquisition of intravenous cocaine self-administration in rats

Goeders, N. E., & Guerin, G. F. (1994) · Psychopharmacology · doi:10.1007/bf02245445 · Cited by 288 · see citing works

Stress and Cocaine Addiction

Goeders, N. E. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.785 · Cited by 286 · see citing works

Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress

Fox, C., Merali, Z., & Harrison, C. R. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.016 · Cited by 283 · see citing works

Effect of Environmental Enrichment on Stress Related Systems in Rats

Moncek, F., Duncko, R., Johansson, B. B., & Jezova, D. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01173.x · Cited by 282 · see citing works

Reversal of cocaine addiction by environmental enrichment

Solinas, M., Chauvet, C., Thiriet, N., Rawas, R. E., & Jaber, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806889105 · Cited by 281 · see citing works

Increased Drug-Reinforced Behavior due to Food Deprivation

Carroll, M. E., & Meisch, R. A. (1984) · Advances in behavioral pharmacology · doi:10.1016/b978-0-12-004704-8.50008-0 · Cited by 275 · see citing works

Stress response of rats to handling and experimental procedures

Gärtner, K., Büttner, D., Döhler, K.-D., Friedel, R., Lindena, J., & TRAUTSCHOLD, I. (1980) · Laboratory Animals · doi:10.1258/002367780780937454 · Cited by 265 · see citing works

Nature of love: Simplified.

Harlow, H. F., & Suomi, S. J. (1970) · American Psychologist · doi:10.1037/h0029383 · Cited by 263 · see citing works

Neuroendocrine responses to experimentally-induced psychological stress in healthy humans

Gerra, G., Zaimovic, A., Mascetti, G. G., Gardini, S., Zambelli, U., Timpano, M., Raggi, M. A., & Brambilla, F. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00046-9 · Cited by 262 · see citing works

Plasma catecholamine, corticosterone and glucose responses to repeated stress in rats: Effect of interstressor interval length

de Boer, S. F., Koopmans, S. J., Slangen, J. L., & van der Gugten, J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90361-7 · Cited by 259 · see citing works

Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum

Brenes, J. C., Rodríguez‐Villagra, O. A., & Fornaguera, J. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.11.004 · Cited by 258 · see citing works

Cocaine-but not food-seeking behavior is reinstated by stress after extinction

Ahmed, S. H., & Koob, G. F. (1997) · Psychopharmacology · doi:10.1007/s002130050347 · Cited by 257 · see citing works

Prevention and treatment of drug addiction by environmental enrichment

Solinas, M., Thiriet, N., Chauvet, C., & Jaber, M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.002 · Cited by 256 · see citing works

Current Status of Co-Occurring Mood and Substance Use Disorders: A New Therapeutic Target

Pettinati, H. M., O’Brien, C. P., & Dundon, W. D. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12010112 · Cited by 254 · see citing works

ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli

Lobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1875-13.2013 · Cited by 245 · see citing works

Endocrine responses to mother‐infant separation in developing rats

Kuhn, C. M., Pauk, J. S., & Schanberg, S. M. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230503 · Cited by 242 · see citing works

Environmental enrichment lowers stress-responsive hormones in singly housed male and female rats

Belz, E. E., Kennell, J. S., Czambel, R. K., Rubín, R. T., & Rhodes, M. E. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.09.005 · Cited by 240 · see citing works

Environmental Enrichment Exacerbates Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

Jankowsky, J. L., Xu, G. M., Fromholt, D., Gonzales, V., & Borchelt, D. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1220 · Cited by 240 · see citing works

Environmental Enrichment Confers Stress Resiliency to Social Defeat through an Infralimbic Cortex-Dependent Neuroanatomical Pathway

Lehmann, M. L., & Herkenham, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0577-11.2011 · Cited by 234 · see citing works

The antidepressant effect of running is associated with increased hippocampal cell proliferation

Bjørnebekk, A., Mathé, A. A., & Brené, S. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005122 · Cited by 231 · see citing works

Social Recovery by Isolation-Reared Monkeys

Harlow, H. F., & Suomi, S. J. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.7.1534 · Cited by 227 · see citing works

An Upside to Adversity?: Moderate Cumulative Lifetime Adversity Is Associated With Resilient Responses in the Face of Controlled Stressors

Seery, M. D., Leo, R. J., Lupien, S. P., Kondrak, C. L., & Almonte, J. L. (2013) · Psychological Science · doi:10.1177/0956797612469210 · Cited by 222 · see citing works

Cocaine induced secretion of ACTH, beta-endorphin, and corticosterone

Moldow, R. L., & Fischman, A. J. (1987) · Peptides · doi:10.1016/0196-9781(87)90065-9 · Cited by 212 · see citing works

Enriched Environment Confers Resistance to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine and Cocaine: Involvement of Dopamine Transporter and Trophic Factors

Bézard, E., Doveró, S., Belin, D., Duconger, S., Jackson-Lewis, V. R., Przedborski, S., Piazza, P. V., Gross, C. E., & Jaber, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-10999.2003 · Cited by 209 · see citing works

Stress inoculation training

Meichenbaum, D. H. (2017) · Routledge eBooks · doi:10.4324/9781315748931-10 · Cited by 209 · see citing works

Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis

Burke, A. R., & Miczek, K. A. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3369-1 · Cited by 207 · see citing works

Stress-induced sensitization to amphetamine and morphine psychomotor effects depend on stress-induced corticosterone secretion

Deroche‐Gamonet, V., Piazza, P. V., Casolini, P., Maccari, S., Moal, M. L., & Simon, H. (1992) · Brain Research · doi:10.1016/0006-8993(92)90205-n · Cited by 207 · see citing works

Psychological stress and environmental adaptation in enriched vs. impoverished housed rats

Larsson, F., Winblad, B. G., & Mohammed, A. H. S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00782-7 · Cited by 205 · see citing works

Enhanced acquisition of cocaine self-administration in adult rats with neonatal isolation stress experience

Kosten, T. A., Miserendino, M. J. D., & Kehoe, P. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02595-6 · Cited by 204 · see citing works

Experience induces structural and biochemical changes in the adult primate brain

Kozorovitskiy, Y., Gross, C. G., Kopil, C., Battaglia, L., McBreen, M., Stranahan, A. M., & Gould, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508817102 · Cited by 202 · see citing works

The Role of Early Adverse Life Events in the Etiology of Depression and Posttraumatic Stress Disorder

Heim, C. C., Owens, M. J., Plotsky, P. M., & Nemeroff, C. B. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48279.x · Cited by 197 · see citing works

Neurobehavioral effects of environmental enrichment and drug abuse vulnerability

Stairs, D. J., & Bardo, M. T. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.01.016 · Cited by 193 · see citing works

Identifying key features of early stressful experiences that produce stress vulnerability and resilience in primates

Parker, K. J., & Dario Maestripieri, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.003 · Cited by 192 · see citing works

Activational effects of social stress on IV cocaine self-administration in rats

Miczek, K. A., Mutschler, N. H., & Mizcek, K. A. (1996) · Psychopharmacology · doi:10.1007/s002130050133 · Cited by 192 · see citing works

Environmental enrichment in BALB/c mice

Roy, V., Belzung, C., Delarue, C., & Chapillon, P. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00561-3 · Cited by 187 · see citing works

Prospective investigation of stress inoculation in young monkeys

Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.933 · Cited by 185 · see citing works

Transient increases in catecholaminergic activity in medial prefrontal cortex and nucleus accumbens shell during novelty

Rebec, G. V., Grabner, C. P., Johnson, M., Pierce, R. C., & Bardo, M. T. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00382-x · Cited by 184 · see citing works

Effect of stressor intensity on habituation of the adrenocortical stress response

Natelson, B. H., Ottenweller, J. E., Cook, J. A., Pitman, D. L., McCarty, R. C., & Tapp, W. N. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90096-0 · Cited by 184 · see citing works

Repeated maternal separation of preweanling rats attenuates behavioral responses to primary and conditioned incentives in adulthood

Matthews, K., Wilkinson, L. S., & Robbins, T. W. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02069-1 · Cited by 178 · see citing works

Environmental Enrichment Produces a Behavioral Phenotype Mediated by Low Cyclic Adenosine Monophosphate Response Element Binding (CREB) Activity in the Nucleus Accumbens

Green, T. A., Alibhai, I. N., Roybal, C. N., Winstanley, C. A., Theobald, D. E. H., Birnbaum, S. G., Graham, A., Unterberg, S., Graham, D. L., Vialou, V., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.022 · Cited by 177 · see citing works

Recurrence of major depressive disorder and its predictors in the general population: results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS)

Hardeveld, F., Spijker, J., De Graaf, R., Nolen, W. A., & Beekman, A. T. F. (2013) · Psychological Medicine · doi:10.1017/s0033291712002395 · Cited by 176 · see citing works

Environmental enrichment during early stages of life reduces the behavioral, neurochemical, and molecular effects of cocaine

Solinas, M., Thiriet, N., Rawas, R. E., Lardeux, V., & Jaber, M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.51 · Cited by 175 · see citing works

Chronic stress differentially regulates glucocorticoid negative feedback response in rats

Mizoguchi, K., Yuzurihara, M., Ishige, A., Sasaki, H., Chui, D., & Tabira, T. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00004-x · Cited by 173 · see citing works

Environmental enrichment decreases intravenous amphetamine self-administration in rats: dose-response functions for fixed- and progressive-ratio schedules

Green, T. A., Gehrke, B. J., & Bardo, M. T. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1134-y · Cited by 172 · see citing works

Tobacco addiction and the dysregulation of brain stress systems

Bruijnzeel, A. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.015 · Cited by 172 · see citing works

Corticosterone release in response to repeated, short episodes of neonatal isolation : evidence of sensitization

McCormick, C. M., Kehoe, P., & Kovacs, S. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00026-4 · Cited by 170 · see citing works

Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats

Shaham, Y., & Stewart, J. (1994) · Psychopharmacology · doi:10.1007/bf02249346 · Cited by 169 · see citing works

Intense cocaine self-administration after episodic social defeat stress, but not after aggressive behavior: dissociation from corticosterone activation

Covington, H. E., & Miczek, K. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0190-5 · Cited by 169 · see citing works

Stress-like responses to common procedures in male rats housed alone or with other rats.

Sharp, J. L., Zammit, T. G., Azar, T. A., & Lawson, D. M. (2002) · PubMed · Cited by 169 · see citing works

Differential reactivity of dopaminergic neurons in the nucleus accumbens in response to different behavioral situations. An in vivo voltammetric study in free moving rats

Louilot, A., Moal, M. L., & Simon, H. (1986) · Brain Research · doi:10.1016/0006-8993(86)90646-3 · Cited by 168 · see citing works

Hypoactivity of the Hypothalamo-Pituitary-Adrenocortical Axis during Recovery from Chronic Variable Stress

Ostrander, M. M., Ulrich‐Lai, Y. M., Choi, D. C., Richtand, N. M., & Herman, J. P. (2006) · Endocrinology · doi:10.1210/en.2005-1041 · Cited by 168 · see citing works

Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats

Goeders, N. E., & Guerin, G. F. (1996) · Brain Research · doi:10.1016/0006-8993(96)00206-5 · Cited by 163 · see citing works

Developmental cascades linking stress inoculation, arousal regulation, and resilience

Lyons, D. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.032.2009 · Cited by 163 · see citing works

Environmental enrichment attenuates locomotor sensitization, but not in vitro dopamine release, induced by amphetamine

Bardo, M. T., Bowling, S. L., Rowlett, J. K., Manderscheid, P. Z., Buxton, S. T., & Dwoskin, L. P. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00413-d · Cited by 159 · see citing works

Locomotor and rewarding effects of amphetamine in enriched, social, and isolate reared rats

Bowling, S. L., & Bardo, M. T. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90553-3 · Cited by 159 · see citing works

Plasma corticosterone concentrations sensitively reflect levels of stimulus intensity in the rat

Hennessy, M. B., Heybach, J. P., Vernikos-Danellis, J., & Levine, S. D. (1979) · Physiology & Behavior · doi:10.1016/0031-9384(79)90321-4 · Cited by 159 · see citing works

Animal models of early life stress: Implications for understanding resilience

Lyons, D. M., Parker, K. J., & Schatzberg, A. F. (2010) · Developmental Psychobiology · doi:10.1002/dev.20429 · Cited by 157 · see citing works

The effect of environmental enrichment on amphetamine-stimulated locomotor activity, dopamine synthesis and dopamine release

Bowling, S. L., Rowlett, J. K., & Bardo, M. T. (1993) · Neuropharmacology · doi:10.1016/0028-3908(93)90144-r · Cited by 157 · see citing works

Role of Corticosterone in Intravenous Cocaine Self-Administration in Rats

Goeders, N. E., & Guerin, G. F. (2008) · Neuroendocrinology · doi:10.1159/000127137 · Cited by 151 · see citing works

Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats

Fediuc, S., Campbell, J. E., & Riddell, M. C. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01416.2005 · Cited by 148 · see citing works

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory

Levi, O., Jongen‐Rêlo, A. L., Feldon, J., Roses, A. D., & Michaelson, D. M. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00045-7 · Cited by 145 · see citing works

Early experiences in hardiness development.

Khoshaba, D. M., & Maddi, S. R. (1999) · Consulting psychology journal · doi:10.1037/1061-4087.51.2.106 · Cited by 145 · see citing works

Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking

Graf, E. N., Wheeler, R. A., Baker, D. L., Ebben, A. L., Hill, J. E., McReynolds, J. R., Robble, M. A., Vranjkovic, O., Wheeler, D., Mantsch, J. R., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1969-13.2013 · Cited by 129 · see citing works

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

Kehne, J. H., McCloskey, T. C., Baron, B. M., Chi, E. M., Harrison, B. L., Whitten, J. P., & Palfreyman, M. G. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90141-c · Cited by 128 · see citing works

Maturation of the Circadian Rhythm of Plasma Corticosterone in the Rat

ALLEN, C. F., & Kendall, J. W. (1967) · Endocrinology · doi:10.1210/endo-80-5-926 · Cited by 127 · see citing works

Psychopathology of Human Adaptation

Kittay, S., Serban, G., Kolb, L. C., & Sabshin, M. (1976) · Springer eBooks · doi:10.1007/978-1-4684-2238-2_1 · Cited by 118 · see citing works

Enduring effects of environmental enrichment from weaning to adulthood on pituitary-adrenal function, pre-pulse inhibition and learning in male and female rats.

Peña, Y., Prunell, M., Rotllant, D., Armario, A., & Escorihuela, R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.019 · Cited by 117 · see citing works

Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Nader, J., Chauvet, C., Rawas, R. E., Favot, L., Jaber, M., Thiriet, N., & Solinas, M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.2 · Cited by 116 · see citing works

Post-weaning housing conditions influence the behavioural effects of cocaine and d -amphetamine

Smith, J. K., Neill, J. C., & Costall, B. (1997) · Psychopharmacology · doi:10.1007/s002130050261 · Cited by 113 · see citing works

Enriched environment prevents chronic stress-induced spatial learning and memory deficits

Wright, R. L., & Conrad, C. D. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.08.025 · Cited by 113 · see citing works

Anti-craving effects of environmental enrichment

Thiel, K. J., Sanabria, F., Pentkowski, N. S., & Neisewander, J. L. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990472 · Cited by 111 · see citing works

A prospective study of stress autonomy versus stress sensitization in adolescents at varied risk for depression.

Morris, M. C., Ciesla, J. A., & Garber, J. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0019036 · Cited by 108 · see citing works

Rats orally self-administer corticosterone

Deroche‐Gamonet, V., Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)90837-d · Cited by 105 · see citing works

The acute glucocorticoid stress response does not differentiate between rewarding and aversive social stimuli in rats

Buwalda, B., Scholte, J. C. M., de Boer, S. F., Coppens, C. M., & Koolhaas, J. M. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.012 · Cited by 105 · see citing works

Effect of regularity of exposure to chronic immobilization stress on the circadian pattern of pituitary adrenal hormones, growth hormone, and thyroid stimulating hormone in the adult male rat

Martı́, O., Gavaldà, A., Jolín, T., & Armario, A. (1993) · Psychoneuroendocrinology · doi:10.1016/0306-4530(93)90056-q · Cited by 103 · see citing works

Cortisol responses to psychosocial stress predict depression trajectories: social-evaluative threat and prior depressive episodes as moderators

Morris, M. C., Rao, U., & Garber, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.059 · Cited by 102 · see citing works

Environmental enrichment alters plus maze, but not maternal defense performance in mice

Friske, J., & Gammie, S. C. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.03.022 · Cited by 101 · see citing works

Environmental enrichment decreases nicotine-induced hyperactivity in rats

Green, T. A., Cain, M. E., Thompson, M., & Bardo, M. T. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1538-3 · Cited by 100 · see citing works

Effects of early stress on behavioral syndromes: An integrated adaptive perspective

Sih, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.03.015 · Cited by 99 · see citing works

Selective Activation of the Hypothalamic Vasopressinergic System in Mice Deficient for the Corticotropin-Releasing Hormone Receptor 1 Is Dependent on Glucocorticoids1

Müller, M. B., Landgraf, R., Preil, J., Sillaber, I., Kresse, A. E., Keck, M. E., Zimmermann, S., Holsboer, F., & Wurst, W. (2000) · Endocrinology · doi:10.1210/endo.141.11.7767 · Cited by 99 · see citing works

Changes in Plasma Adrenocorticotropin, Corticosterone, Corticosteroid‐Binding Globulin, and Hippocampal Glucocorticoid Receptor Occupancy/Translocation in Rat Pups in Response to Stress

Viau, V., Sharma, S., & Meaney, M. J. (1996) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1996.tb00680.x · Cited by 99 · see citing works

Conditioned increase in place preference by access to novel objects: antagonism by MK-801

Bevins, R. A., & Bardo, M. T. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00069-2 · Cited by 98 · see citing works

Early work as a source of developmental discontinuity during the transition to adulthood

Mortimer, J. T., & Staff, J. (2004) · Development and Psychopathology · doi:10.1017/s0954579404040131 · Cited by 97 · see citing works

Environmental-enrichment-related variations in behavioral, biochemical, and physiologic responses of Sprague-Dawley and Long Evans rats.

Konkle, A. T. M., Kentner, A. C., Baker, S. L., Stewart, A., & Bielajew, C. H. (2010) · PubMed Central · Cited by 94 · see citing works

Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi

Hattori, S., Hashimoto, R., Miyakawa, T., Yamanaka, H., Maeno, H., Wada, K., & Kunugi, H. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.036 · Cited by 94 · see citing works

Effects of environmental enrichment on extinction and reinstatement of amphetamine self-administration and sucrose-maintained responding

Stairs, D. J., Klein, E. D., & Bardo, M. T. (2006) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000236271.72300.0e · Cited by 94 · see citing works

Effects of environmental enrichment on the incubation of cocaine craving

Chauvet, C., Goldberg, S. R., Jaber, M., & Solinas, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.014 · Cited by 93 · see citing works

Serum Response Factor Promotes Resilience to Chronic Social Stress through the Induction of ΔFosB

Vialou, V., Maze, I., Renthal, W., LaPlant, Q. C., Watts, E. L., Mouzon, E., Ghose, S., Tamminga, C. A., & Nestler, E. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2496-10.2010 · Cited by 91 · see citing works

Induction of Activating Transcription Factors (ATFs) ATF2, ATF3, and ATF4 in the Nucleus Accumbens and Their Regulation of Emotional Behavior

Green, T. A., Alibhai, I. N., Unterberg, S., Neve, R. L., Ghose, S., Tamminga, C. A., & Nestler, E. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5273-07.2008 · Cited by 89 · see citing works

Effects of Differential Experience on the Brain and Behavior

Rosenzweig, M. R. (2003) · Developmental Neuropsychology · doi:10.1080/87565641.2003.9651909 · Cited by 88 · see citing works

Repeated handling, restraint, or chronic crowding impair the hypothalamic-pituitary-adrenocortical response to acute restraint stress.

Gądek-Michalska, A., & Bugajski, J. (2003) · PubMed · Cited by 87 · see citing works

Differential Rearing Conditions Alter Operant Responding for Ethanol in Outbred Rats

Deehan, G. A., Cain, M. E., & Kiefer, S. W. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00466.x · Cited by 87 · see citing works

Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects

Deinzer, R., Kirschbaum, C., Gresele, C., & Hellhammer, D. H. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00465-9 · Cited by 87 · see citing works

Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats

Grimm, J. W., Osincup, D., Wells, B., Manaois, M., Fyall, A., Buse, C., & Harkness, J. H. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32831c3b18 · Cited by 85 · see citing works

Maternal Separation and Handling Affects Cocaine Self-Administration in Both the Treated Pups as Adults and the Dams

Moffett, M. C., Harley, J., Francis, D. D., Sanghani, S. P., Davis, W. I., & Kuhar, M. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101139 · Cited by 83 · see citing works

Rearing in enriched environment increases parvalbumin-positive small neurons in the amygdala and decreases anxiety-like behavior of male rats

Urakawa, S., Takamoto, K., Hori, E., Sakai, N., Ono, T., & Nishijo, H. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-13 · Cited by 80 · see citing works

Regulation of fosB and ΔfosB mRNA expression: In vivo and in vitro studies

Alibhai, I. N., Green, T. A., Potashkin, J. A., & Nestler, E. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.069 · Cited by 80 · see citing works

Increased glucocorticoid response to a novel stress in rats that have been restrained

Harris, R. B. S., Gu, H., Mitchell, T. D., Endale, L., Russo, M., & Ryan, D. H. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.01.017 · Cited by 79 · see citing works

Acute and repeated stress differentially regulates behavioral, endocrine, neural parameters relevant to emotional and stress response in young and aged rats

Shoji, H., & Mizoguchi, K. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.025 · Cited by 77 · see citing works

Adaptation in the Corticosterone and Hyperthermic Responses to Stress Following Repeated Stressor Exposure

Barnum, C. J., Blandino, P., & Terrence Deak, B. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01571.x · Cited by 75 · see citing works

Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression

Thiel, K. J., Pentkowski, N. S., Peartree, N. A., Painter, M. R., & Neisewander, J. L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.001 · Cited by 75 · see citing works

Repeated exposure to immobilization or two different footshock intensities reveals differential adaptation of the hypothalamic–pituitary–adrenal axis

Rabasa, C., Muñoz-Abellán, C., Daviu, N., Nadal, R. A., & Armario, A. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.022 · Cited by 74 · see citing works

Exposure to chronic stress increases the locomotor response to cocaine and the basal levels of corticosterone in adolescent rats

Lepsch, L. B., Gonzalo, L., Magro, F., DeLucia, R., Scavone, C., & Planeta, C. S. (2005) · Addiction Biology · doi:10.1080/13556210500269366 · Cited by 74 · see citing works

Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice?

Takatsu-Coleman, A. L., Patti, C. L., Zanin, K. A., Zager, A., Carvalho, R. C., Borçoi, A. R., Ceccon, L. M. B., Berro, L. F., Tufik, S., Andersen, M. L., et al. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120050 · Cited by 66 · cited 1× · see citing works

Plasma adrenocorticotropin and cortisol responses to brief high-intensity exercise in humans

Buono, M. J., Yeager, J. E., & Hodgdon, J. A. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.4.1337 · Cited by 65 · see citing works

Induction of Inducible cAMP Early Repressor Expression in Nucleus Accumbens by Stress or Amphetamine Increases Behavioral Responses to Emotional Stimuli

Green, T. A., Alibhai, I. N., Hommel, J. D., Dileone, R., Kumar, A., Theobald, D. E. H., Neve, R. L., & Nestler, E. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0880-06.2006 · Cited by 63 · see citing works

Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue

Puhl, M. D., Blum, J. S., Acosta‐Torres, S., & Grigson, P. S. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32834eb060 · Cited by 63 · see citing works

Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment

Zhang, Y., Crofton, E. J., Li, D., Lobo, M. K., Fan, X., Nestler, E. J., & Green, T. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00297 · Cited by 58 · see citing works

Does the amygdala modulate adaptation to repeated stress?

Carter, R. N., Pinnock, S. B., & Herbert, J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.018 · Cited by 58 · see citing works

Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals

Bouët, V., Fréret, T., Dutar, P., Billard, J., & Boulouard, M. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.04.006 · Cited by 58 · see citing works

Stress Without Distress.

Selye, H. (1977) · School Guidance Worker · Cited by 58 · see citing works

Enriched Environment Influences Adrenocortical Response to Immune Challenge and Glutamate Receptor Gene Expression in Rat Hippocampus

Mlynarik, M., Johansson, B. B., & Ježová, D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.032 · Cited by 57 · see citing works

Exposure to environmental enrichment elicits differential hippocampal cell proliferation: Role of individual responsiveness to anxiety

Leal‐Galicia, P., Saldı́var-González, A., Morimoto, S., & Arias, C. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20322 · Cited by 55 · see citing works

Effects of environmental enrichment on sensitivity to cocaine in female rats: importance of control rates of behavior

Smith, M. A., Iordanou, J. C., Cohen, M. B., Cole, K. T., Gergans, S. R., Lyle, M. A., & Schmidt, K. T. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32832ec568 · Cited by 50 · see citing works

Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats

Skwara, A. J., Karwoski, T. E., Czambel, R. K., Rubín, R. T., & Rhodes, M. E. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.06.003 · Cited by 48 · see citing works

Comorbid depression and substance use disorder: Longitudinal associations between symptoms in a controlled trial

Worley, M. J., Trim, R. S., Roesch, S. C., Mrnak‐Meyer, J., Tate, S. R., & Brown, S. A. (2012) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2011.12.010 · Cited by 48 · see citing works

Psychological stress, cocaine and natural reward each induce endoplasmic reticulum stress genes in rat brain

Pavlovsky, A. A., Boehning, D. F., Li, D., Zhang, Y., Fan, X., & Green, T. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.057 · Cited by 46 · see citing works

Chronic mild stress-induced reductions in saccharin intake depend upon feeding status

Hatcher, J. P., Bell, D. J., Reed, T., & Hagan, J. J. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100408 · Cited by 46 · see citing works

Environmental-induced differences in corticosterone and glucocorticoid receptor blockade of amphetamine self-administration in rats

Stairs, D. J., Prendergast, M., & Bardo, M. T. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2448-4 · Cited by 45 · see citing works

Environmental enrichment during development decreases intravenous self-administration of methylphenidate at low unit doses in rats

Alvers, K. M., Marusich, J. A., Gipson, C. D., Beckmann, J. S., & Bardo, M. T. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283584765 · Cited by 42 · see citing works

Lack of Effect of Corticosterone Administration on Male Sexual Behavior of Rats

Retana‐Márquez, S., Bonilla‐Jaime, H., & Velázquez‐Moctezuma, J. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00437-x · Cited by 42 · see citing works

CIRCADIAN RHYTHM OF CORTICOSTERONE LEVELS IN RAT BRAIN

Butte, J. C., Kakihana, R., & Noble, E. P. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0680235 · Cited by 40 · see citing works

High plasma corticosterone levels persist during frequent automatic blood sampling in rats.

Abelson, K., Adem, B., Royo, F., Carlsson, H., & Hau, J. (2005) · PubMed · Cited by 40 · see citing works

Environmental enrichment, administered after establishment of cocaine self-administration, reduces lever pressing in extinction and during a cocaine context renewal test

Ranaldi, R., Kest, K., Zellner, M. R., & Hachimine, P. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283487365 · Cited by 38 · see citing works

Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer’s disease model

Jeong, Y. H., Kim, J. M., Yoo, J., Lee, S. H., Kim, H., & Suh, Y. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07514.x · Cited by 36 · see citing works

Environmental enrichment enhances the stimulant effect of intravenous amphetamine: Search for a cellular mechanism in the nucleus accumbens

Bardo, M. T., Valone, J. M., Robinet, P. M., Shaw, W., & Dwoskin, L. P. (1999) · Psychobiology · doi:10.3758/bf03332123 · Cited by 35 · see citing works

Adrenocortical activity during conditions of brief social separation in preweaning rats

Hennessy, M. B., & Weinberg, J. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)91231-y · Cited by 35 · see citing works

Behavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent rats

Cruz, F. C., Marin, M. T., Leão, R. M., & Planeta, C. S. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.10.005 · Cited by 34 · see citing works

Environmental enrichment alters protein expression as well as the proteomic response to cocaine in rat nucleus accumbens

Lichti, C. F., Fan, X., English, R. D., Zhang, Y., Li, D., Kong, F., Sinha, M., Andersen, C. R., Spratt, H. M., Luxon, B. A., et al. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00246 · Cited by 32 · see citing works

Acute Stress, But not Corticosterone, Disrupts Short- and Long-Term Synaptic Plasticity in Rat Dorsal Subiculum Via Glucocorticoid Receptor Activation

MacDougall, M. J., & Howland, J. G. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs247 · Cited by 31 · see citing works

The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats

Gill, K. E., Beveridge, T. J. R., Smith, H. R., & Porrino, L. J. (2013) · Brain Research · doi:10.1016/j.brainres.2013.06.021 · Cited by 30 · see citing works

Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence

LEVIN, F. R., Bisaga, A. M., Raby, W. N., Aharonovich, E., Rubin, E., Mariani, J. J., Brooks, D. J., Garawi, F., & Nunes, E. V. (2007) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2006.11.012 · Cited by 30 · see citing works

STUDIES OF WHEEL‐RUNNING REINFORCEMENT: PARAMETERS OF HERRNSTEIN'S (1970) RESPONSE‐STRENGTH EQUATION VARY WITH SCHEDULE ORDER

Belke, T. W. (2000) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2000.73-319 · Cited by 25 · see citing works

Reliability of the Chronic Mild Stress paradigm: Implications for research and animal welfare

Murison, R. C. C., & Hansen, A. L. (2001) · Integrative Psychological and Behavioral Science · doi:10.1007/bf02688795 · Cited by 24 · see citing works

Sex differences in the effects of social and physical environment on novelty-induced exploratory behavior and cocaine-stimulated locomotor activity in adolescent rats

Захарова, Е., Starosciak, A. K., Wade, D., & Izenwasser, S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.01.052 · Cited by 23 · see citing works

Adaptation of the hypothalamic-pituitary-adrenal axis and glucose to repeated immobilization or restraint stress is not influenced by associative signals

Rabasa, C., Delgado‐Morales, R., Muñoz-Abellán, C., Nadal, R. A., & Armario, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.001 · Cited by 23 · see citing works

Differential Phosphoproteome Regulation of Nucleus Accumbens in Environmentally Enriched and Isolated Rats in Response to Acute Stress

Fan, X., Li, D., Zhang, Y., & Green, T. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079893 · Cited by 22 · see citing works

Cocaine-induced stimulation of the rat hypothalamic-pituitary-adrenal axis is progressively attenuated following hourly-interval regimens of the drug

Torres, G., & RIVIER, C. L. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90503-h · Cited by 22 · see citing works

Dynamic Proteomics of Nucleus Accumbens in Response to Acute Psychological Stress in Environmentally Enriched and Isolated Rats

Fan, X., Li, D., Lichti, C. F., & Green, T. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073689 · Cited by 21 · see citing works

Effects of an isolated or enriched environment after handling on sexual maturation and behaviour in male and female rats

Swanson, H. H., & van de Poll, N. E. (1983) · Reproduction · doi:10.1530/jrf.0.0690165 · Cited by 20 · see citing works

An Enriched Rearing Environment Calms Adult Male Rat Sexual Activity: Implication for Distinct Serotonergic and Hormonal Responses to Females

Urakawa, S., Mitsushima, D., Shimozuru, M., Sakuma, Y., & Kondo, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087911 · Cited by 18 · see citing works

Functional changes induced by psychological stress are not enough to cause intestinal inflammation in Sprague–Dawley rats

Jorge, E., Fernández, J. A., Torres, R., Vergara, P., & Martín, M. T. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01507.x · Cited by 12 · see citing works

Ameliorative effects of brief daily periods of social interaction on isolation-induced behavioral and hormonal alterations

Raz, S. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.009 · Cited by 9 · see citing works

[The effect of chronic stress on the activity of the sympathetic-adrenomedullary system].

Dobrakovová, M., Květňanský, R., Opršalová, Z., & Macho, L. (1990) · PubMed · Cited by 5 · see citing works

An adverse early life environment can enhance stress resilience in adulthood

Santarelli, S., Zimmermann, C. A., Kalideris, G., Lesuis, S. L., Arloth, J., Uribe, A., Dournes, C., Balsevich, G., Hartmann, J., Masana, M., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.021 · Cited by 154 · see citing works

Beneficial effects of environmental enrichment on behavior, stress reactivity and synaptophysin/BDNF expression in hippocampus following early life stress

Dandi, Ε., Kalamari, A., Touloumi, O., Lagoudaki, R., Nousiopoulou, E., Simeonidou, C., Spandou, E., & Tata, D. Α. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.03.003 · Cited by 146 · see citing works

Environmental enrichment modulates the response to chronic stress in zebrafish

Marcon, M., Mocelin, R., Benvenutti, R., Costa, T., Herrmann, A. P., de Oliveira, D. L., Koakoski, G., Barcellos, L. J. G., & Piato, Â. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.176735 · Cited by 133 · see citing works

Modelling depression in animals: at the interface of reward and stress pathways

Slattery, D. A., & Cryan, J. F. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4552-6 · Cited by 110 · see citing works

Growth patterns of future orientation among maltreated youth: A prospective examination of the emergence of resilience.

Oshri, A., Duprey, E. B., Kogan, S. M., Carlson, M. W., & Liu, S. (2018) · Developmental Psychology · doi:10.1037/dev0000528 · Cited by 105 · see citing works

Waddington, Dynamic Systems, and Epigenetics

Tronick, E., & Hunter, R. G. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00107 · Cited by 96 · see citing works

GSK3β: a master player in depressive disorder pathogenesis and treatment responsiveness

Duda, P., Hajka, D., Wójcicka, O., Rakus, D., & Gizak, A. (2020) · Cells · doi:10.3390/cells9030727 · Cited by 84 · see citing works

Stress hypothesis overload: 131 hypotheses exploring the role of stress in tradeoffs, transitions, and health

Harris, B. N. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113355 · Cited by 76 · see citing works

Differential impact of stress and environmental enrichment on corticolimbic circuits

Smail, M. A., Smith, B. L., Nawreen, N., & Herman, J. P. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172993 · Cited by 78 · see citing works

Generalization of effects of environmental enrichment on seeking for different classes of drugs of abuse

Sikora, M., Nicolas, C., Istin, M., Jaafari, N., Thiriet, N., & Solinas, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.027 · Cited by 72 · see citing works

Hormesis in Health and Chronic Diseases

Li, X., Yang, T., & Sun, Z. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.007 · Cited by 72 · see citing works

Seeding Stress Resilience through Inoculation

Ashokan, A., Sivasubramanian, M., & Mitra, R. (2016) · Neural Plasticity · doi:10.1155/2016/4928081 · Cited by 71 · see citing works

Neonatal maternal separation delays the GABA excitatory-to-inhibitory functional switch by inhibiting KCC2 expression

Furukawa, M., Tsukahara, T., Tomita, K., Iwai, H., Sonomura, T., Miyawaki, S., & Sato, T. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.143 · Cited by 69 · see citing works

Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell

Crofton, E. J., Nenov, M. N., Zhang, Y., Scala, F., Page, S. A., McCue, D. L., Li, D., Hommel, J. D., Laezza, F., & Green, T. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.020 · Cited by 64 · see citing works

Behavioral and physiological consequences of enrichment loss in rats

Smith, B. L., Lyons, C. E., Correa, F. G., Benoit, S. C., Myers, B., Solomon, M. B., & Herman, J. P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.040 · Cited by 63 · see citing works

Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway

Scala, F., Nenov, M. N., Crofton, E. J., Singh, A. K., Folorunso, O. O., Zhang, Y., Chesson, B. C., Wildburger, N. C., James, T. F., Alshammari, M. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.062 · Cited by 56 · see citing works

Environmental Enrichment and Physical Exercise Attenuate the Depressive-Like Effects Induced by Social Isolation Stress in Rats

Brenes, J. C., Fornaguera, J., & Sequeira‐Cordero, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00804 · Cited by 55 · see citing works

The relative benefits of environmental enrichment on learning and memory are greater when stressed: A meta-analysis of interactions in rodents

Macartney, E. L., Lagisz, M., & Nakagawa, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104554 · Cited by 58 · see citing works

Enduring effect of childhood maltreatment on cortisol and heart rate responses to stress: The moderating role of severity of experiences

Ouellet‐Morin, I., Robitaille, M.-P., Langevin, S., Cantave, C. Y., Brendgen, M. R., & LUPIEN, S. J. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000123 · Cited by 56 · see citing works

Modeling environment through a general exposome factor in two independent adolescent cohorts

Moore, T. M., Visoki, E., Argabright, S. T., DiDomenico, G. E., Sotelo, I., Wortzel, J. D., Naeem, A., Gur, R. C., Gur, R. E., Warrier, V., et al. (2022) · Exposome · doi:10.1093/exposome/osac010 · Cited by 55 · see citing works

Transcriptomics of Environmental Enrichment Reveals a Role for Retinoic Acid Signaling in Addiction

Zhang, Y., Kong, F., Crofton, E. J., Dragosljvich, S. N., Sinha, M., Li, D., Fan, X., Koshy, S., Hommel, J. D., Spratt, H. M., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00119 · Cited by 51 · see citing works

Coping with Stress During Aging: The Importance of a Resilient Brain

Sampedro-Piquero, P., Alvarez-Suarez, P., & Begega, A. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170915141610 · Cited by 41 · see citing works

Environmental Enrichment Blunts Ethanol Consumption after Restraint Stress in C57BL/6 Mice

Marianno, P., Abrahao, K. P., & Camarini, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170317 · Cited by 49 · see citing works

Trauma-Informed Design of Supported Housing: A Scoping Review through the Lens of Neuroscience

Owen, C., & Crane, J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114279 · Cited by 49 · see citing works

Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring

Sparling, J. E., Baker, S. L., & Bielajew, C. H. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.033 · Cited by 47 · see citing works

Hens with benefits: Can environmental enrichment make chickens more resilient to stress?

Ross, M., Rausch, Q., Vandenberg, B., & Mason, G. (2020) · Physiology and Behavior · doi:10.1016/j.physbeh.2020.113077 · Cited by 41 · see citing works

Post-weaning Environmental Enrichment, But Not Chronic Maternal Isolation, Enhanced Ethanol Intake during Periadolescence and Early Adulthood

Berardo, L. R., Fabio, M. C., & Pautassi, R. M. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00195 · Cited by 46 · see citing works

Social isolation after chronic unpredictable mild stress perpetuates depressive-like behaviors, memory deficits and social withdrawal via inhibiting ERK/KEAP1/NRF2 signaling

Si, L., Xiao, L., Xie, Y., Xu, H., Yuan, G., Xu, W., & Wang, G. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.12.092 · Cited by 44 · see citing works

The environmental enrichment model revisited: A translatable paradigm to study the stress of our modern lifestyle

Rojas‐Carvajal, M., Sequeira‐Cordero, A., & Brenes, J. C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15160 · Cited by 44 · see citing works

Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats

González‐Pardo, H., Arias, J. L., Vallejo, G., & Conejo, N. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226377 · Cited by 43 · see citing works

Poly (I:C)-induced maternal immune activation modifies ventral hippocampal regulation of stress reactivity: prevention by environmental enrichment

Zhao, X., Mohammed, R., Tran, H., Erickson, M., & Kentner, A. C. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.018 · Cited by 43 · see citing works

Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood

Kentrop, J., Smid, C. R., Achterberg, E. J. M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00193 · Cited by 41 · see citing works

Stress inoculation in mice induces global resilience

Ayash, S., Schmitt, U., Lyons, D. M., & Müller, M. B. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00889-0 · Cited by 41 · see citing works

Environmental enrichment and its influence on rodent offspring and maternal behaviours, a scoping style review of indices of depression and anxiety

Sparling, J. E., Barbeau, K., Boileau, K., & Konkle, A. T. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172997 · Cited by 40 · see citing works

The influence of anti-predator training, personality and sex in the behavior, dispersion and survival rates of translocated captive-raised parrots

Lopes, A. R. D. S., Rocha, M. D. S., Mozart, G. J., Mesquita, W. U., Silva, G. G. G. R., Vilela, D. A. R., & de Azevedo, C. S. (2017) · Global Ecology and Conservation · doi:10.1016/j.gecco.2017.05.001 · Cited by 39 · see citing works

Neurobehavioral Effects of Restricted and Unpredictable Environmental Enrichment in Rats

Rojas‐Carvajal, M., Sequeira‐Cordero, A., & Brenes, J. C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00674 · Cited by 41 · see citing works

Adolescent environmental enrichment prevents behavioral and physiological sequelae of adolescent chronic stress in female (but not male) rats

Smith, B. L., Morano, R. L., Ulrich‐Lai, Y. M., Myers, B., Solomon, M. B., & Herman, J. P. (2017) · Stress · doi:10.1080/10253890.2017.1402883 · Cited by 38 · see citing works

Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons

Sampedro‐Piquero, P., Castilla‐Ortega, E., Zancada-Menéndez, C., Santín, L. J., & Begega, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.032 · Cited by 36 · see citing works

Neural Response to Pleasant Pictures Moderates Prospective Relationship Between Stress and Depressive Symptoms in Adolescent Girls

Levinson, A. R., Speed, B. C., & Hajcak, G. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2018.1426004 · Cited by 37 · see citing works

Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: Role of angiotensin II

Costa, R., Tamascia, M. L., Sanches, A., Moreira, R. P., Cunha, T. S., Nogueira, M. D., Casarini, D. E., & Marcondes, F. K. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112250 · Cited by 36 · see citing works

Effects of enriched environment on alterations in the prefrontal cortex GFAP- and S100B-immunopositive astrocytes and behavioral deficits in MK-801-treated rats

Rahati, M., Nozari, M., Eslami, H., Shabani, M., & Basiri, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.065 · Cited by 34 · see citing works

Environmental enrichment-inspired pharmacological tools for the treatment of addiction

Solinas, M., Chauvet, C., Lafay‐Chebassier, C., Jaafari, N., & Thiriet, N. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.09.001 · Cited by 34 · see citing works

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review

Hua, M., & Jia, M. (2020) · Neurodegenerative Diseases · doi:10.1159/000513196 · Cited by 36 · see citing works

Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats

Arndt, D. L., Peterson, C. J., & Cain, M. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131709 · Cited by 34 · see citing works

Combining the Antipsychotic Drug Haloperidol and Environmental Enrichment after Traumatic Brain Injury Is a Double-Edged Sword

Folweiler, K. A., Bondi, C. O., Ogunsanya, E., LaPorte, M. J., Leary, J. B., Radabaugh, H. L., Monaco, C. M., & Kline, A. E. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4417 · Cited by 33 · see citing works

Understanding the Role of Environmental Enrichment in Zebrafish Neurobehavioral Models

Volgin, A. D., Yakovlev, O. V., Demin, K. A., de Abreu, M. S., Rosemberg, D. B., Мешалкина, Д. А., Alekseeva, P. A., Friend, A. J., Amstislavskaya, T. G., & Kalueff, A. V. (2018) · Zebrafish · doi:10.1089/zeb.2018.1592 · Cited by 33 · see citing works

Daily exposure to a touchscreen-paradigm and associated food restriction evokes an increase in adrenocortical and neural activity in mice

Mallien, A. S., Palme, R., Richetto, J., Muzzillo, C., Richter, S. H., Vogt, M. A., Inta, D., Riva, M. A., Vollmayr, B., & Gass, P. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.03.009 · Cited by 31 · see citing works

Review: Early life piglet experiences and impacts on immediate and longer-term adaptability

Lucas, M. E., Hemsworth, L. M., & Hemsworth, P. H. (2023) · animal · doi:10.1016/j.animal.2023.100889 · Cited by 30 · see citing works

Corticosterone levels and behavioral changes induced by simultaneous exposure to chronic social stress and enriched environments in NMRI male mice

Mesa‐Gresa, P., Ramos‐Campos, M., & Redolat, R. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.027 · Cited by 30 · see citing works

Nature and nurture: environmental influences on a genetic rat model of depression

Mehta, N. S., Wert, S. L., Morley, C. P., Graf, E. N., & Redei, E. E. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.28 · Cited by 29 · see citing works

Environmental Enrichment During Adolescence Acts as a Protective and Therapeutic Tool for Ethanol Binge-Drinking, Anxiety-Like, Novelty Seeking and Compulsive-Like Behaviors in C57BL/6J Mice During Adulthood

Rodríguez‐Ortega, E., de la Fuente, L., de Amo, E., & Cubero, I. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00177 · Cited by 29 · see citing works

The SEEKING Drive and Its Fixation: A Neuro-Psycho-Evolutionary Approach to the Pathology of Addiction

Alcaro, A., Brennan, A., & Conversi, D. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.635932 · Cited by 28 · see citing works

Environmental enrichment facilitates cocaine abstinence in an animal conflict model

Ewing, S., & Ranaldi, R. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.01.006 · Cited by 29 · see citing works

Early exposure to environmental enrichment modulates the effects of prenatal ethanol exposure upon opioid gene expression and adolescent ethanol intake

Wille‐Bille, A., Bellia, F., Jiménez-García, A., Miranda‐Morales, R. S., D’Addario, C., & Pautassi, R. M. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107917 · Cited by 28 · see citing works

Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix

Smail, M. A., Smith, B. L., Shukla, R., Alganem, K., Eby, H., Bollinger, J. L., Parikh, R. K., Chambers, J. B., Reigle, J. K., Moloney, R. D., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02231-8 · Cited by 27 · see citing works

Environmental enrichment reduces food seeking and taking in rats: A review

Grimm, J. W., & Sauter, F. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172874 · Cited by 27 · see citing works

Influence of daily social stimulation on behavioral and physiological outcomes in an animal model of PTSD

Seetharaman, S., Fleshner, M., Park, C. R., & Diamond, D. M. (2016) · Brain and Behavior · doi:10.1002/brb3.458 · Cited by 26 · see citing works

Animal models in addiction research: A dimensional approach

Lamontagne, S. J., & Olmstead, M. C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.005 · Cited by 25 · see citing works

Barrier–environment interactions along the gut–brain axis and their influence on cognition and behaviour throughout the lifespan

Paton, S. E. J., Solano, J. L., Coulombe-Rozon, F., Lebel, M., & Ménard, C. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220218 · Cited by 24 · see citing works

Review: Environmental enrichment builds functional capacity and improves resilience as an aspect of positive welfare in production animals

Colditz, I. G., Campbell, D. L. M., Ingham, A. B., & Lee, C. (2024) · animal · doi:10.1016/j.animal.2024.101173 · Cited by 27 · see citing works

Introducing the Neuroplastic Narrative: a non-pathologizing biological foundation for trauma-informed and adverse childhood experience aware approaches

Peckham, H. M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1103718 · Cited by 29 · see citing works

Different influences of anxiety models, environmental enrichment, standard conditions and intraspecies variation (sex, personality and strain) on stress and quality of life in adult and juvenile zebrafish: A systematic review

Buenhombre, J., Daza-Cardona, E. A., de Sousa, P. S. L., & Gouvêia, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.047 · Cited by 24 · see citing works

Environmental enrichment during forced abstinence from cocaine self-administration opposes gene network expression changes associated with the incubation effect

Powell, G. L., Vannan, A., Bastle, R. M., Wilson, M. A., Dell’Orco, M., Perrone‐Bizzozero, N. I., & Neisewander, J. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-67966-8 · Cited by 23 · see citing works

Convergent transcriptomics and proteomics of environmental enrichment and cocaine identifies novel therapeutic strategies for addiction

Zhang, Y., Crofton, E. J., Fan, X., Li, D., Kong, F., Sinha, M., Luxon, B. A., Spratt, H. M., Lichti, C. F., & Green, T. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.051 · Cited by 23 · see citing works

Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models

de Abreu, M. S., Giacomini, A. C. V. V., Genário, R., Rech, N., Carboni, J., Lakstygal, A. M., Amstislavskaya, T. G., Demin, K. A., Leonard, B. E., Vlok, M., et al. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172928 · Cited by 22 · see citing works

Environmental enrichment decreases avoidance responses in the elevated T-maze and delta FosB immunoreactivity in anxiety-related brain regions

Lopes, D. A., Souza, T. M. O., de Andrade, J. S., Silva, M. S. C. F., Antunes, H. K. M., Sueur, L. D. P. L., Céspedes, I. C., & Viana, M. D. B. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.012 · Cited by 22 · see citing works

Developmental functions of microglia: Impact of psychosocial and physiological early life stress

Smail, M. A., & Lenz, K. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110084 · Cited by 22 · see citing works

Animal Models of the Impact of Social Stress on Cocaine Use Disorders

Vannan, A., Powell, G. L., Scott, S. N., Pagni, B. A., & Neisewander, J. L. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.005 · Cited by 21 · see citing works

Manipulation of retinoic acid signaling in the nucleus accumbens shell alters rat emotional behavior

Zhang, Y., Crofton, E. J., Smith, T. E. S., Koshy, S., Li, D., & Green, T. A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112177 · Cited by 21 · see citing works

Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review

Malone, S. G., Shaykin, J. D., Stairs, D. J., & Bardo, M. T. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173471 · Cited by 21 · see citing works

Optimising Puppy Socialisation–Short- and Long-Term Effects of a Training Programme during the Early Socialisation Period

Stolzlechner, L., Bonorand, A., & Riemer, S. (2022) · Animals · doi:10.3390/ani12223067 · Cited by 24 · see citing works

Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment

Odeón, M. M., & Acosta, G. B. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109726 · Cited by 19 · see citing works

Mapping accumulative whole-brain activities during environmental enrichment with manganese-enhanced magnetic resonance imaging

Li, R., Wang, X., Lin, F., Song, T., Zhu, X., & Lei, H. C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116588 · Cited by 19 · see citing works

Positive welfare: What does it add to the debate over pig welfare?

Lawrence, A. B., Newberry, R. C., & Špinka, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85676-8.00009-2 · Cited by 19 · see citing works

Biological intersection of sex, age, and environment in the corticotropin releasing factor (CRF) system and alcohol

Agoglia, A. E., Crofton, E. J., & Herman, M. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108045 · Cited by 19 · see citing works

Modulatory action of environmental enrichment on hormonal and behavioral responses induced by chronic stress in rats: Hypothalamic renin-angiotensin system components

Costa, R., Carvalho, M. S. M., Perez, J. D., Moreira, R. P., Cunha, T. S., Casarini, D. E., & Marcondes, F. K. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112928 · Cited by 18 · see citing works

Complex Housing, but Not Maternal Deprivation Affects Motivation to Liberate a Trapped Cage-Mate in an Operant Rat Task

Kalamari, A., Kentrop, J., Danesi, C. H., Graat, E. A. M., van IJzendoorn, M. H., Bakermans‐Kranenburg, M. J., Joëls, M., & van der Veen, R. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.698501 · Cited by 18 · see citing works

The effects of extrinsic stress on somatic markers and behavior are dependent on animal housing conditions

Huzard, D., Mumby, D. G., Sandi, C., Poirier, G. L., & van der Kooij, M. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.07.018 · Cited by 18 · see citing works

The Influence of Environmental Enrichment on Cardiovascular and Behavioral Responses to Social Stress

Normann, M. C., McNeal, N., Dagner, A., Ihm, E., Woodbury, M., & Grippo, A. J. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000558 · Cited by 18 · see citing works

Cytokines and Immune Cells Profile in Different Tissues of Rodents Induced by Environmental Enrichment: Systematic Review

Fernandes, M. S. D. S., Santos, G. C. J., Filgueira, T. O., Gomes, D. A., Barbosa, E. A. S., Santos, T. M., Câmara, N. O. S., Castoldi, Â., & Souto, F. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911986 · Cited by 17 · see citing works

Vitamin C impacts anxiety-like behavior and stress-induced anorexia relative to social environment in SMP30/GNL knockout mice

Koizumi, M., Kondo, Y., 伊坂, 亜., Ishigami, A., & Suzuki, E. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.11.006 · Cited by 17 · see citing works

Developmental expression of anxiety and depressive behaviours after prenatal predator exposure and early life homecage enhancement

Green, A. S., Esser, M. J., & Perrot, T. S. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.11.028 · Cited by 17 · see citing works

Sex-Dependent Effects of Environmental Enrichment on Spatial Memory and Brain-Derived Neurotrophic Factor (BDNF) Signaling in a Developmental “Two-Hit” Mouse Model Combining BDNF Haploinsufficiency and Chronic Glucocorticoid Stimulation

Grech, A. M., Ratnayake, U., Hannan, A. J., van den Buuse, M., & Hill, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00227 · Cited by 17 · see citing works

Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression

Torres-Reverón, A., Rivera-López, L. L., Flores, I., & Appleyard, C. B. (2017) · Reproductive Sciences · doi:10.1177/1933719117741374 · Cited by 17 · see citing works

Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations

Molina, S. J., Buján, G. E., Gonzalez, M. R., Capani, F., Gómez‐Casati, M. E., & Guelman, L. R. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00182 · Cited by 16 · see citing works

Children’s Developmental Needs During the Transition to Kindergarten: What Can Research on Social-Emotional, Motivational, Cognitive, and Self-Regulatory Development Tell Us?

Skinner, E. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-90200-5_2 · Cited by 16 · see citing works

Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcohol Exposure in Adult Rats

Brancato, A., Castelli, V., Lavanco, G., & Cannizzaro, C. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.583122 · Cited by 16 · see citing works

Environmental enrichment influences novelty reactivity, novelty preference, and anxiety via distinct genetic mechanisms in C57BL/6J and DBA/2J mice

Dickson, P. E., & Mittleman, G. (2021) · Scientific Reports · doi:10.1038/s41598-021-83574-6 · Cited by 16 · see citing works

Effects of the combination of chronic unpredictable stress and environmental enrichment on anxiety-like behavior assessed using the elevated plus maze in Swiss male mice: Hypothalamus-Pituitary-Adrenal Axis-mediated mechanisms

Belo-Silva, A. E., Silva, N. K. D. G. T., Marianno, P., Costa, G. D. A., da Rovare, V. P., Bailey, A., Munhoz, C. D., Novaes, L. S., & Camarini, R. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105538 · Cited by 15 · see citing works

Enrichment in the Sucker and Weaner Phase Altered the Performance of Pigs in Three Behavioural Tests

Ralph, C. R., Hebart, M. L., & Cronin, G. M. (2018) · Animals · doi:10.3390/ani8050074 · Cited by 15 · see citing works

Noise‐induced hippocampal oxidative imbalance and aminoacidergic neurotransmitters alterations in developing male rats: Influence of enriched environment during adolescence

Molina, S. J., Buján, G. E., & Guelman, L. R. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22806 · Cited by 15 · see citing works

Enriched Environment Attenuates Enhanced Trait Anxiety in Association with Normalization of Aberrant Neuro-Inflammatory Events

Sah, A., Rooney, S., Kharitonova, M. V., Sartori, S. B., Wolf, S. A., & Singewald, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113052 · Cited by 15 · see citing works

Modified single prolonged stress reduces cocaine self-administration during acquisition regardless of rearing environment

Hofford, R. S., Prendergast, M., & Bardo, M. T. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.023 · Cited by 15 · see citing works

Environmental Enrichment During Adulthood Reduces Sucrose Binge-Like Intake in a High Drinking in the Dark Phenotype (HD) in C57BL/6J Mice

Rodríguez‐Ortega, E., Alcaráz-Iborra, M., de la Fuente, L., de Amo, E., & Cubero, I. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00027 · Cited by 13 · see citing works

Preclinical Models of Stress and Environmental Influences on Binge Eating

Bonaventura, M. V. M. D., Bonaventura, E. M. D., Polidori, C., & Cifani, C. (2020) · Springer eBooks · doi:10.1007/978-3-030-43562-2_7 · Cited by 13 · see citing works

Exposure to an enriched environment reduces alcohol self-administration in Sardinian alcohol-preferring rats

Maccioni, P., Bratzu, J., Lobina, C., Acciaro, C., Corrias, G., Capra, A., Carai, M. A. M., Agabio, R., Muntoni, A. L., Gessa, G. L., et al. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113771 · Cited by 13 · see citing works

Investigating the role of environmental enrichment initiated in adolescence against the detrimental effects of chronic unpredictable stress in adulthood: Sex-specific differences in behavioral and neuroendocrinological findings

Dandi, Ε., Spandou, E., & Tata, D. Α. (2022) · Behavioural Processes · doi:10.1016/j.beproc.2022.104707 · Cited by 13 · see citing works

The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia

Xu, J., Li, Y., Tian, B., Liu, H., Wu, S., & Wang, W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1024649 · Cited by 13 · see citing works

Pre-reproductive Parental Enriching Experiences Influence Progeny’s Developmental Trajectories

Cutuli, D., Berretta, E., Laricchiuta, D., Caporali, P., Gelfo, F., & Petrosini, L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00254 · Cited by 13 · see citing works

New therapeutics for the prevention or amelioration of fetal alcohol spectrum disorders: a narrative review of the preclinical literature

Olivares‐Costa, M., Fabio, M. C., de la Fuente-Ortega, E., Haeger, P. A., & Pautassi, R. M. (2024) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2024.2361442 · Cited by 12 · see citing works

Environmental enrichment as an experimental paradigm to promote stress inoculation-induced resilience

Gregorio, S. (2013) · Frontiers in Human Neuroscience · doi:10.3389/conf.fnhum.2013.210.00066 · Cited by 2 · see citing works

Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.001 · Cited by 300 · see citing works

Environmental enrichment as a tractable approach to promoting psychiatric resilience across the lifespan

Sydnor, V. J., & Luna, B. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02500-4

Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress

Fox, C., Merali, Z., & Harrison, C. R. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.016 · Cited by 283 · see citing works

Preventive effects of an enriched environment on rodent psychiatric disorder models.

Takuma, K., Ago, Y., & Matsuda, T. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11r07cp · Cited by 33 · see citing works