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Update on mitochondria and muscle aging: all wrong roads lead to sarcopenia
Open accessAbstract
Sarcopenia is a well-known geriatric syndrome that has been endorsed over the years as a biomarker allowing for the discrimination, at a clinical level, of biological from chronological age. Multiple candidate mechanisms have been linked to muscle degeneration during sarcopenia. Among them, there is wide consensus on the central role played by the loss of mitochondrial integrity in myocytes, secondary to dysfunctional quality control mechanisms. Indeed, mitochondria establish direct or indirect contacts with other cellular components (e.g. endoplasmic reticulum, peroxisomes, lysosomes/vacuoles) as well as the extracellular environment through the release of several biomolecules. The functional implications of these interactions in the context of muscle physiology and sarcopenia are not yet fully appreciated and represent a promising area of investigation. Here, we present an overview of recent findings concerning the interrelation between mitochondrial quality control processes, inflammation and the metabolic regulation of muscle mass in the pathogenesis of sarcopenia highlighting those pathways that may be exploited for developing preventive and therapeutic interventions against muscle aging.
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Sarcopenia: modern views of the problem
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“Ageing and clinically defined sarcopenia are associated with reduced mitochondrial content or function, impaired oxidative phosphorylation, altered mitochondrial dynamics, and increased oxidative stress, but the temporal and causal direction of these changes remains incompletely resolved [6,37].”
Topçuoğlu, M. A., Güler, A., Halil, M. G., Hanagasi, H., Midi, İ., Saka, B., & Saka, E. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1966218
Metadata
- Authors
- Picca, A., Calvani, R., Bossola, M., Allocca, E., Menghi, A., Pesce, V., Lezza, A. M. S., Bernabei, R., Landi, F., & Marzetti, E.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- University of Bari Aldo Moro (IT)
- Corresponding author
- Calvani, Riccardo
- ORCID
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018-01-31
- Volume
- 399
- Issue
- 5
- Pages
- 421-436
- ISSN
- 1431-6730 (ISSN-L)
- 1437-4315
- OpenAlex
- W2896096385
- Cited by
- 116
- References
- 158
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 17 · 2023: 21 · 2022: 15 · 2021: 10 · 2020: 15 · 2019: 10 · 2018: 11
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Biological Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, other-oa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- sarcopenia, muscle aging, mitochondrial quality control, mitochondrial dysfunction, muscle cells, inflammation, muscle mass regulation, geriatric syndromes
- MeSH terms
- Aging, Animals, Humans, Mitochondria, Muscles, Sarcopenia
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