The DOI matches its Crossref record; 147 of the 158 references it cites were found in a registry or an index.
Update on mitochondria and muscle aging: all wrong roads lead to sarcopenia
Open accessAbstract
Sarcopenia is a well-known geriatric syndrome that has been endorsed over the years as a biomarker allowing for the discrimination, at a clinical level, of biological from chronological age. Multiple candidate mechanisms have been linked to muscle degeneration during sarcopenia. Among them, there is wide consensus on the central role played by the loss of mitochondrial integrity in myocytes, secondary to dysfunctional quality control mechanisms. Indeed, mitochondria establish direct or indirect contacts with other cellular components (e.g. endoplasmic reticulum, peroxisomes, lysosomes/vacuoles) as well as the extracellular environment through the release of several biomolecules. The functional implications of these interactions in the context of muscle physiology and sarcopenia are not yet fully appreciated and represent a promising area of investigation. Here, we present an overview of recent findings concerning the interrelation between mitochondrial quality control processes, inflammation and the metabolic regulation of muscle mass in the pathogenesis of sarcopenia highlighting those pathways that may be exploited for developing preventive and therapeutic interventions against muscle aging.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
1 retracted
Safdar, A., Bourgeois, J. M., Ogborn, D. I., Little, J. P., Hettinga, B. P., Akhtar, M., Thompson, J. E., Melov, S., Mocellin, N. J., Kujoth, G. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019581108 · Cited by 320
RetractedLópez-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Autophagosome formation: core machinery and adaptations
Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,237
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A
Züchner, S., Mersiyanova, I. V., Muglia, M., Bissar-Tadmouri, N., Rochelle, J., Dadali, E. L., Zappia, M., Nelis, E., Patitucci, A., Senderek, J., et al. (2004) · Nature Genetics · doi:10.1038/ng1341 · Cited by 1,572
Cited by
Sorted by citations
Cruz-Jentoft, A. J., & Sayer, A. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31138-9 · Cited by 3,905
Physical activity and exercise: Strategies to manage frailty
Angulo, J., El Assar, M., Álvarez-Bustos, A., & Rodríguez-Mañas, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101513 · Cited by 771
Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia
Ticinesi, A., Nouvenne, A., Cerundolo, N., Catania, P., Prati, B., Tana, C., & Meschi, T. (2019) · Nutrients · doi:10.3390/nu11071633 · Cited by 418
El Assar, M., Álvarez-Bustos, A., Sosa, P., Angulo, J., & Rodríguez-Mañas, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158713 · Cited by 371
“Mitochondrial quality control (MQC), which includes mitochondrial proteostasis, biogenesis, dynamics and autophagy, is crucial for the maintenance of homeostasis in muscle cells during aging [59,60] In aging muscle, mitochondrial alterations are associated with downregulation of peroxisome proliferator-activated recep…”
BackgroundThe role of mitochondria in aging
Jang, J. Y., Blum, A., Liu, J., & Finkel, T. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120842 · Cited by 358
“These mitochondrial deficits track closely with functional decline in muscle strength and are believed by most to be a causal factor for age-related sarcopenia (65).”
Role of Age-Related Mitochondrial Dysfunction in Sarcopenia
Ferri, E., Marzetti, E., Calvani, R., Picca, A., Cesari, M., & Arosio, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155236 · Cited by 224
“Hence, the preservation of well-functioning mitochondria is pivotal for maintaining cellular homeostasis [24].”
BackgroundSelf-citationPicca, A., Ponziani, F. R., Calvani, R., Marini, F., Biancolillo, A., Coelho‐Júnior, H. J., Gervasoni, J., Primiano, A., Putignani, L., CHIERICO, F. D., et al. (2019) · Nutrients · doi:10.3390/nu12010065 · Cited by 181
“Multisystem derangements contribute to muscle loss and may ultimately lead to the development of PF&S [9].”
BackgroundSelf-citationExercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors
Alizadeh Pahlavani, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.811751 · Cited by 145
Diet for the prevention and management of sarcopenia
Calvani, R., Picca, A., Coelho‐Júnior, H. J., Tosato, M., Marzetti, E., & Landi, F. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155637 · Cited by 164
Self-citationYeo, D., Kang, C., Gomez-Cabrera, M. C., Vina, J., & Ji, L. L. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.456 · Cited by 137
Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans
Byrne, J. J., Soh, M. S., Chandhok, G., Vijayaraghavan, T., Teoh, J.-S., Crawford, S., Cobham, A. E., Yapa, N. M. B., Mirth, C. K., & Neumann, B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03024-5 · Cited by 119
Calvani, R., Picca, A., Marini, F., Biancolillo, A., Gervasoni, J., Persichilli, S., Primiano, A., Coelho‐Júnior, H. J., Bossola, M., Urbani, A., et al. (2018) · Nutrients · doi:10.3390/nu10111691 · Cited by 117
“to be critically involved in age-related muscle degeneration [50].”
BackgroundSelf-citationOudbier, S. J., Goh, J., Looijaard, S. M. L. M., Reijnierse, E. M., Meskers, C. G. M., & Maier, A. B. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac121 · Cited by 125
“In addition, damaged mitochondria lead to metabolic abnormalities such as insulin resistance and the activation of the ubiquitin–proteasome system (UPS), which plays a major role in muscle degradation (17).”
BackgroundGranic, A., Suetterlin, K., Shavlakadze, T., Grounds, M. D., & Sayer, A. A. (2023) · Clinical Science · doi:10.1042/cs20230319 · Cited by 124
“Therefore, it is not clear if mitochondrial decline causes sarcopenia or is a result of sarcopenia [161].”
BackgroundMassimino, E., Izzo, A. C., Riccardi, G., & Pepa, G. D. (2021) · Cells · doi:10.3390/cells10081958 · Cited by 108
“The mechanisms underlying the age-related changes involved in sarcopenia are not completely understood and are related to several and interacting processes: decline in the synthesis of muscle proteins [21], post-prandial resistance to synthesize protein in response to various nutritional factors [22], alteration in ho…”
BackgroundUbiquitin-proteasome pathway in skeletal muscle atrophy
Pang, X., Zhang, P., Chen, X., & Liu, W. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1289537 · Cited by 120
The clinical impact and biological mechanisms of skeletal muscle aging
Aversa, Z., Zhang, X., Fielding, R. A., Lanza, I. R., & LeBrasseur, N. K. (2019) · Bone · doi:10.1016/j.bone.2019.05.021 · Cited by 113
“, sarcopenia, insulin resistance) is a topic that remains at the leading edge of aging research [191, 192].”
BackgroundRole of lncRNAs in aging and age‐related diseases
He, J., Tu, C., & Liu, Y. (2018) · Aging Medicine · doi:10.1002/agm2.12030 · Cited by 88
“level, and increased inflammation, loss of proteostasis, and mitochondrial dysfunction.(201) H19 is implicated in skeletal muscle differentiation by acting as a molecular sponge to bind the miRlet‐7.”
BackgroundPicca, A., Beli, R., Calvani, R., Coelho‐Júnior, H. J., Landi, F., Bernabei, R., Bucci, C., Guerra, F., & Marzetti, E. (2020) · Cells · doi:10.3390/cells9040973 · Cited by 89
“Among the factors involved in muscle degeneration associated with PF&S, mitochondrial dysfunction and the accrual of abnormal organelles have been indicated as relevant players [30].”
BackgroundSelf-citationContribution of muscle satellite cells to sarcopenia
Huo, F., Liu, Q., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892749 · Cited by 74
“Decreased numbers of mitochondria and mitochondrial dysfunction occurring with aging can lead to muscle reduction and functional decline (Chabi et al., 2008; Wawrzyniak et al., 2016; Picca et al., 2018).”
BackgroundMolecular Mechanism and Pathogenesis of Sarcopenia: An Overview
Picca, A., & Calvani, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063032 · Cited by 67
“, inflammation and amino acid dysmetabolism) have been pinpointed as candidate molecular markers of sarcopenia [5].”
BackgroundSelf-citationKim, M., Sinam, I. S., Zerwa, S., Jeon, J., & Lee, I. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0305 · Cited by 74
“Among muscle cell types, a myofiber is a postmitotic, highly differentiated cell containing mitochondria as the sole provider of energy for movement and metabolism [7].”
BackgroundFan, J., Fan, J., & Khanzada, Z. (2025) · Muscles · doi:10.3390/muscles4030026 · Cited by 65
“Among the cellular hallmarks of muscle aging and diseases, mitochondrial dysfunction has been extensively studied and recognized as a central contributor [7–14].”
Aging alters acetylation status in skeletal and cardiac muscles
Yeo, D., Kang, C., & Ji, L. L. (2020) · GeroScience · doi:10.1007/s11357-020-00171-7 · Cited by 63
“It is well-documented that deterioration of mitochondrial function plays a critical role in the process of muscle aging (Hepple 2014; Picca et al. 2018).”
BackgroundThe role and therapeutic potential of stem cells in skeletal muscle in sarcopenia
Cai, Z., Liu, D., Yang, Y., Xie, W., He, M., Yu, D., Wu, Y., Wang, X., Xiao, W., & Li, Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02706-5 · Cited by 58
“Mitochondrial dysfunction plays a key role in muscle atrophy, as well as changes in multiple pathways [8].”
BackgroundMitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions
Liu, D., Fan, Y., Tao, X., Pan, W., Wu, Y., Wang, X., He, Y., Xiao, W., & Li, Y. (2021) · Aging and Disease · doi:10.14336/ad.2021.0427 · Cited by 62
“The MQC includes mitochondrial proteostasis, biogenesis, dynamics and autophagy [17, 18].”
BackgroundFrom mitochondria to sarcopenia: role of 17β-estradiol and testosterone
Tian, X., Lou, S., & Shi, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1156583 · Cited by 54
“Aberrant mitochondrial quality control (MQC) leads to loss of mitochondrial integrity, which is thought to be a major factor in muscle degeneration (20).”
BackgroundMeasuring Exercise Capacity and Physical Function in Adult and Older Mice
Graber, T. G., Maroto, R., Fry, C. S., Brightwell, C. R., & Rasmussen, B. B. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa205 · Cited by 54
Redox Signaling and Sarcopenia: Searching for the Primary Suspect
Foreman, N. A., Hesse, A. S., & Ji, L. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169045 · Cited by 53
Post‐translational regulation of muscle growth, muscle aging and sarcopenia
Zhong, Q., Zheng, K., Li, W., An, K., Liu, Y., Xiao, X., Hai, S., Dong, B., Li, S., An, Z., et al. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13241 · Cited by 59
“Specifically, PGC-1α and PGC-1β reduce protein breakdown by inhibiting the transcriptional activities of FoxO3 and NF-κB.62 In addition, FoxO stimulates the expression of several inducers involved in autophagosome biogenesis, such as Bnip3, LC-3, ATG12 and Gabarabl1.”
BackgroundAdiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice
Balasubramanian, P., Schaar, A. E., Gustafson, G. E., Smith, A. B., Howell, P. R., Greenman, A., Baum, S., Colman, R. J., Lamming, D. W., Diffee, G., et al. (2022) · eLife · doi:10.7554/elife.71282 · Cited by 49
Searching for a mitochondrial root to the decline in muscle function with ageing
Gonzalez‐Freire, M., Adelnia, F., Moaddel, R., & Ferrucci, L. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12313 · Cited by 48
“reactive oxygen species, which oxidize and damagemacromolecules.(35) Normally, stressed/damaged mitochondria can be”
BackgroundMolecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia
Káňová, M., & Kohout, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158396 · Cited by 51
Marzetti, E., Guerra, F., Calvani, R., Marini, F., Biancolillo, A., Gervasoni, J., Primiano, A., Coelho-Júnior, H. J., Landi, F., Bernabei, R., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.564417 · Cited by 45
Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise
Picca, A., Calvani, R., Leeuwenburgh, C., Coelho‐Júnior, H. J., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1559827 · Cited by 43
“ity control (MQC) axis is altered at several levels, including proteostasis, biogenesis, dynamics, and autophagy [3,7].”
BackgroundSelf-citationTetra-linoleoyl cardiolipin depletion plays a major role in the pathogenesis of sarcopenia
Semba, R. D., Moaddel, R., Zhang, P., Ramsden, C. E., & Ferrucci, L. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.04.015 · Cited by 43
“acid and glucose metabolism [33], energy production [32], regulation of intracellular calcium homeostasis [34], reactive oxygen species (ROS) signaling [35], mitophagy [36,37], and apoptosis in skeletal muscle [32,38] and are a nexus in the pathway of some of these proposed pathways to sarcopenia.”
BackgroundNAD+ centric mechanisms and molecular determinants of skeletal muscle disease and aging
Wagner, S., Manickam, R., Brotto, M. A. P., & Tipparaju, S. M. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04408-1 · Cited by 39
“1 3 Mitochondrial dysfunction is thought to be involved in the muscle aging process [102, 103].”
BackgroundAugmented temperature fluctuation aggravates muscular atrophy through the gut microbiota
Liu, Y., Guo, Y., Liu, Z., Xu, F., Zhou, R., He, Y., Zhou, H., Peng, H., & Huang, Y. (2023) · Nature Communications · doi:10.1038/s41467-023-39171-4 · Cited by 40
Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases
Zhang, Q., Jiang, Y., Deng, C., & Wang, J. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1353624 · Cited by 40
“Mitochondrial dysfunction is a critical aspect of aging, characterized by changes in biogenesis, protein inhibition, mitochondrial autophagy, and kinetics (138, 139).”
BackgroundMitochondrial DNA variants in inclusion body myositis characterized by deep sequencing
Hedberg‐Oldfors, C., Lindgren, U., Basu, S., Visuttijai, K., Lindberg, C., Falkenberg, M., Larsson, E., & Oldfors, A. (2020) · Brain Pathology · doi:10.1111/bpa.12931 · Cited by 35
“Mitochondrial dysfunction is another hallmark of sarcopenia (26,36), and it has been proposed that dysfunctional mitochondria and damaged mtDNA are parts of the pathogenesis of sarcopenia (37).”
BackgroundPathophysiological changes of muscle after ischemic stroke: a secondary consequence of stroke injury
Hu, Q., Tian, D., Luan, F., Yang, R., & Zeng, N. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382221 · Cited by 35
“…have several functions, such as fuel supply, regulation of cell proliferation, regulation of apoptotic signals, and regulation of cell homeostasis (Picca et al., 2018), while changes in the number, morphology, and function of mitochondria in soleus are thought to be one of the main causes of…”
Marzetti, E., Lozanoska‐Ochser, B., Calvani, R., Landi, F., Coelho‐Júnior, H. J., & Picca, A. (2024) · Biomolecules · doi:10.3390/biom14040415 · Cited by 36
Self-citationDong, W.-X., Chen, W., Zou, H., Shen, Z.-L., Yu, D., Chen, W., Jiang, H., Yan, X., & Yu, Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9159101 · Cited by 31
“Oxidative Medicine and Cellular Longevity of quiescence, which may due to the increased systematic in fl ammation and extrinsic factors in circulation of old individuals [8, 9].”
Akkoç, İ., Toptaş, M., Yalçın, M., Demir, E., & Toptaş, Y. (2020) · BioMed Research International · doi:10.1155/2020/1586707 · Cited by 29
“Decline in skeletal muscle function and mass are consequences of age-related deterioration in the function of several physiological systems including endocrine, neurological, cardiovascular, and/or immunological dysfunctions [6, 7].”
BackgroundCefis, M., Marcangeli, V., Hammad, R., Granet, J., Leduc‐Gaudet, J., Gaudreau, P., Trumpff, C., Huang, Q., Picard, M. A., Aubertin‐Leheudre, M., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101968 · Cited by 26
Penell, J. C., Morgan, D. M., Watson, P., Carmichael, S., & Adams, V. J. (2019) · Acta Veterinaria Scandinavica · doi:10.1186/s13028-019-0477-x · Cited by 23
Wang, Y., Mu, D., & Wang, Y. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05035-9 · Cited by 24
“Sar-copenia is a pathological condition when there is an imbalance in the anabolic and catabolic pathways for muscle protein, myofatty degeneration [3], pathogenic interactions between adipose tissue and muscle [4], and disruption of mitochondrial integrity [5, 6].”
BackgroundIspoglou, T., Wilson, O. J., McCullough, D., Aldrich, L., Ferentinos, P. P., Lyall, G. K., Stavropoulos‐Kalinoglou, A., Duckworth, L. C., Brown, M. A., Sutton, L., et al. (2023) · Biology · doi:10.3390/biology12070892 · Cited by 24
“, fussion, fission and mitophagy) and apoptosis [25,26].”
BackgroundA view at sarcopenia by endocrinologist
Mokrysheva, N. G., Krupinova, J. A., Volodicheva, V. L., Mirnaya, S. S., & Mel'nichenko, G. A. (2018) · Obesity and metabolism · doi:10.14341/omet9792 · Cited by 21
Chen, J., Wei, L., Zhu, X., Xu, W., Zou, Y., Qi, X., Fang, J., Wang, X., Shi, X., Sheng, Y., et al. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s420558 · Cited by 20
Research Progress on the Effect and Mechanism of Exercise Intervention on Sarcopenia Obesity
Chen, J., Jia, S., Guo, C., Fan, Z., Yan, W., & Dong, K. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s473083 · Cited by 22
“41”
Emerging molecular mediators and targets for age-related skeletal muscle atrophy
Brown, L. A., Guzman, S. D., & Brooks, S. V. (2020) · Translational research · doi:10.1016/j.trsl.2020.03.001 · Cited by 22
Grosman, Y., & Kalichman, L. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22040547 · Cited by 23
“Alterations in insulin signaling [39] and mitochondrial function [40] contribute to this decline.”
Understanding and Addressing Muscle Strength, Mass, and Function in Older Persons
Sloane, P. D., Marzetti, E., Landi, F., & Zimmerman, S. I. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.11.020 · Cited by 20
Self-citationRamírez, P. C., Máximo, R. D. O., de Oliveira, D. C., de Souza, A. F., Luiz, M. M., Delinocente, M. L. B., Steptoe, A., de Oliveira, C. M., & Alexandre, T. D. S. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-2039-1 · Cited by 21
“With aging, there has been described an increase in adipose tissue and redistribution of fat deposits, which become more concentrated in the visceral region, triggering chronic mild inflammation known as “inflammaging” (47–49).”
Birkbeck, M. G., Blamire, A. M., Whittaker, R. G., Sayer, A. A., & Dodds, R. M. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12655 · Cited by 20
Mitochondria Transplantation from Stem Cells for Mitigating Sarcopenia
Tian, X., Pan, M., Zhou, M., Tang, Q., Chen, M., Hong, W., Zhao, F., & Liu, K. (2023) · Aging and Disease · doi:10.14336/ad.2023.0210 · Cited by 18
“cell homeostasis with aging and is crucial for maintaining cellular homeostasis [18].”
BackgroundInfluentialRocha, J. N. D. S., Pereira-Monteiro, M. R., Vasconcelos, A. B. S., Pantoja-Cardoso, A., Aragão-Santos, J. C., & Da Silva-Grigoletto, M. E. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105303 · Cited by 15
Lee, M. J.-C., Saner, N. J., Ferri, A., García-Domínguez, E., Broatch, J. R., & Bishop, D. J. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101272 · Cited by 18
Prehabilitation: metabolic considerations
Chabot, K., Gillis, C., & Carli, F. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000663 · Cited by 15
“Interestingly, mitochondrial dysfunction has been associated with functional decline in muscle strength and could be a leading cause for age-related sarcopenia [24].”
BackgroundLee, Y. J., Kim, G. H., Park, S. I., & Lim, J. H. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14799 · Cited by 15
Guo, K., Cai, W., Chen, Y., Shi, Y., Xu, Z., & Chen, C. (2021) · Heart & Lung · doi:10.1016/j.hrtlng.2021.11.013 · Cited by 15
Multi-Modal Prehabilitation in Thoracic Surgery: From Basic Concepts to Practical Modalities
Licker, M. J., Manser, D. E., Bonnardel, É., Massias, S., Soualhi, M. I., Saint-Leger, C., & Koeltz, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102765 · Cited by 14
“…of reactive oxygen species (ROS) and cytokines, such as TNF-α and IL-1, have been implicated in deregulation of mitochondrial function and degradation of striated muscle proteins through all four proteolytic systems (i.e., calpains, caspase-3, ubiquitin-proteasome system and autophagy) [21].”
BackgroundA view at sarcopenia by endocrinologist
Mokrysheva, N. G., Krupinova, J. A., Volodicheva, V. L., Mirnaya, S. S., & Mel'nichenko, G. A. (2020) · Osteoporosis and Bone Diseases · doi:10.14341/osteo12465 · Cited by 14
Colloca, G. F., Bellieni, A., Capua, B. D., Iervolino, M., Bracci, S., Fusco, D., Tagliaferri, L., Landi, F., & Valentini, V. (2023) · Cancers · doi:10.3390/cancers15184600 · Cited by 14
“Cellular changes in sarcopenic muscle include reduction of myofibers and quality with intramuscular and intermuscular fat infiltration [48–50].”
BackgroundSelf-citationBidirectional Relationships between Sarcopenia and Pelvic Floor Disorders
Grosman, Y., & Kalichman, L. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21070879 · Cited by 15
The role of mitochondria in cytokine and chemokine signalling during ageing
Kalykaki, M., Rubio‐Tomás, T., & Tavernarakis, N. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111993 · Cited by 14
Mitochondrial pathways and sarcopenia in the geroscience era
Marzetti, E., Calvani, R., Coelho‐Júnior, H. J., & Picca, A. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100397 · Cited by 14
“Numerous intrinsic and extrinsic mechanisms have been associated with sarcopenia, but mitochondrial function and associated signaling pathways have emerged as critical factors [2].”
Self-citationNishimura, T., Naito, H., Fujisaki, N., et al. (2020) · Surgery Today · doi:10.1007/s00595-020-01980-1 · Cited by 13
Biomarkers for Physical Frailty and Sarcopenia
Picca, A., Calvani, R., & Marzetti, E. (2021) · Wiley eBooks · doi:10.1002/9781119597896.ch20 · Cited by 13
Self-citationMolecular mechanism of skeletal muscle loss and its prevention by natural resources
Kim, J. T., Jeon, D. H., & Lee, H. J. (2024) · Food Science and Biotechnology · doi:10.1007/s10068-024-01678-x · Cited by 12
“AMPK was reported to enhance the translocation of PGC-1α from the cytoplasm to the nucleus and mitochondria and promote mitochondrial biogenesis in skeletal muscle (Chen et al., 2017; Jiao et al., 2020; Picca et al., 2018).”
Muscle metabolism in older adults
Иванникова, Е. В., Dudinskaya, Е. N., & Onuchina, Y. S. (2022) · Russian Journal of Geriatric Medicine · doi:10.37586/2686-8636-2-2022-96-102 · Cited by 10
Lin, S.-W., Tsai, Y., Chen, Y., Wang, M.-F., Chen, C., Lin, W., & Fang, T. J. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6692363 · Cited by 11
Guo, F., Fu, L., & Lu, Z. (2024) · PubMed · doi:10.22038/ijbms.2024.71345.15509 · Cited by 8
“Mitochondria are the main site of energy synthesis in skeletal muscles cells and their number is critical to skeletal muscles function (4).”
BackgroundLC/MS-Based Untargeted Lipidomics Reveals Lipid Signatures of Sarcopenia
Yang, Q.-W., Zhang, Z.-W., He, P.-P., Mao, X.-Q., Jing, X., Hu, Y., & Jing, L.-P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168793 · Cited by 8
“…leads to a decrease in mitochondrial numbers and increased production of reactive oxygen species, potentially compromising muscle function [7]; Specific fatty acids trigger the release of signaling molecules such as prostaglandins and leukotrienes, which induce skeletal muscle…”
BackgroundSarcopenia and sarcopenic obesity in cardiovascular disease: a comprehensive review
Tan, L. F., Sia, C., & Merchant, R. A. (2025) · Singapore Medical Journal · doi:10.4103/singaporemedj.smj-2024-233 · Cited by 10
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022
Zhang, Y., Zhao, Y., Rong, J., Liu, K., Zhan, Y., Chai, Y., Ning, J., & Yuan, W.-A. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112316 · Cited by 10
“They work together to research the biomarkers associated with the development of sarcopenia (Picca et al., 2020), and discuss the main pathogenetic pathways of sarcopenia (Picca et al., 2018).”
da Silva, E. M., Mesquita‐Ferrari, R. A., Rodrigues, M. F. S. D., Magalhães, E. M. R., Bussadori, S. K., Brito, A., Messias, F. D. M., Souza, N. H. C., Alves, A. N., & Fernandes, K. P. S. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz076 · Cited by 10
Guimarães, D. S. P. S. F., Barrios, N. M. F., de Oliveira, A. G., Rizo‐Roca, D., Jollet, M., Smith, J. A. B., Araújo, T. R., da Cruz, M. V., Marconato-Júnior, E., Hirabara, S. M., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13480 · Cited by 8
Kirk, B., Phu, S., Debruin, D. A., Hayes, A., & Duque, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11430-8 · Cited by 7
Yang, J., Jiang, T., Xu, G., Wang, S., & Liu, W. (2023) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2023.08.005 · Cited by 6
“Among the TFs, ATF3, NRF1 and EGR1 have already been shown to be involved in KOA and sarcopenia [91 – 94].”
BackgroundZhu, J., Gao, Y., Zhang, C., Wu, Y., Wang, Q., Chen, W., Lyu, X., Zhang, X., Liu, Z., & Pan, S. (2025) · BMC Cancer · doi:10.1186/s12885-025-13664-5 · Cited by 6
Jeong, Y., Seo, K., Hwang, S.-B., Park, Y., & Kim, H. (2025) · Journal of Dairy Science · doi:10.3168/jds.2024-26229 · Cited by 6
Li, W., Fang, W. J., Zhang, Y., Chen, Q., Shentu, W., Lai, Q., Cheng, L., Yan, S., Kong, Q., & Qiao, S. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1552905 · Cited by 5
What role do extracellular vesicles play in developing physical frailty and sarcopenia?
Wang, L.-X., Zhang, X., Guan, L.-J., & Pen, Y. (2022) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-022-02150-3 · Cited by 5
Rocha, J. N. D. S., Vasconcelos, A. B. S., Aragão-Santos, J. C., de Resende–Neto, A. G., Monteiro, M. R. P., Nogueira, A. C., Pantoja-Cardoso, A., Corrêa, C. B., de Moura, T. R., & Silva‐Grigoletto, M. E. D. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1054424 · Cited by 5
“Although aging is a natural process, it can be accompanied by some deleterious effects on functional fitness, with a reduction in physical capacities such as muscle power and cardiorespiratory capacity (Picca et al., 2018; Fragala et al., 2019).”
BackgroundShi, F., & Chen, J. (2025) · Aging and Disease · doi:10.14336/ad.2025.0670 · Cited by 5
“However, in individuals with T2DM, the PGC-1α– nuclear respiratory factor 1 (NRF1) – mitochondrial transcription factor A (TFAM) signaling pathway becomes impaired, leading to reduced mitochondrial function and quantity, which in turn promotes the onset and progression of sarcopenia [131].”
Postoperative Stress, Metabolism, and Catabolism
Calvani, R., Picca, A., Coelho‐Júnior, H. J., Tosato, M., & Marzetti, E. (2024) · Practical issues in geriatrics · doi:10.1007/978-3-031-77707-3_21 · Cited by 3
Self-citationWang, Z., Fang, L., Wang, L., & Zhang, J. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1673736 · Cited by 3
Healthy ageing and the science of longevity in dogs. Part II: a life course perspective
Adams, V. J., Morgan, D. M., & Watson, P. (2018) · Companion animal · doi:10.12968/coan.2018.23.9.514 · Cited by 5
Protein Acetylation and NAD+ Homeostasis in Aging Muscle
Ji, L. L. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_17 · Cited by 3
Cordeiro, L. D. S., Linhares, D. G., de Castro, J. B. P., dos Santos, A. O. B., dos Santos, L. L., da Silva, G. C. P. S. M., & Vale, R. G. D. S. (2025) · Journal of Physical Activity and Health · doi:10.1123/jpah.2024-0281 · Cited by 2
Ji, R., Zhang, L., Shen, Y., et al. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05288-8 · Cited by 2
“[25] found that increased levels of oxidative stress and damage of mitochondria induced the decrease of muscle mass, this may also be an important mechanism for muscular mass reduction without a decrease in muscle perfusion.”
BackgroundMarzetti, E., Picca, A., Tummolo, A. M., & Calvani, R. (2022) · Wiley eBooks · doi:10.1002/9781119484288.ch99 · Cited by 2
Self-citationCefis, M., Marcangeli, V., Hammad, R., Granet, J., Leduc‐Gaudet, J., Gaudreau, P., Trumpff, C., Huang, H., Picard, M. A., Aubertin‐Leheudre, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.09.602758 · Cited by 2
Yang, X., Tian, M., Jia, Z., & Lyu, W. (2025) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.70084 · Cited by 1
Clinical, laboratory and instrumental aspects of sarcopenia diagnostics
Станиславовна, Ж. А., Belaya, Z. E., Omelchenko, K. A., & Airapetov, G. A. (2026) · Osteoporosis and Bone Diseases · doi:10.14341/osteo13206 · Cited by 1
“Митохондриальная дисфункция с развитием оксидативного стресса, увеличения соотношения АМФ-АТФ через активацию катаболизма приводит к атрофии мышечной ткани и развитию саркопении [24].”
Prevalência de sarcopenia na Doença Pulmonar Obstrutiva Crônica: revisão sistemática
Caria, K. R. S. A., Camelier, F. W. R., Cordeiro, N., Moreira, A., dos Santos, B. S., & Camelier, A. A. (2018) · Revista Pesquisa em Fisioterapia · doi:10.17267/2238-2704rpf.v8i4.2105
Dietary Protein and Muscle in Aging People
Cesari, M., & Marzetti, E. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-458-1
Self-citationПОСТМЕНОПАУЗАЛЬНАЯ ОСТЕОСАРКОПЕНИЯ
Іgnatiev, О. М., Turchin, M. I., & Yermolenko, T. О. (2021) · Актуальні питання педіатрії акушерства та гінекології · doi:10.11603/24116-4944.2020.2.11845
Metadata
- Authors
- Picca, A., Calvani, R., Bossola, M., Allocca, E., Menghi, A., Pesce, V., Lezza, A. M. S., Bernabei, R., Landi, F., & Marzetti, E.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- University of Bari Aldo Moro (IT)
- Corresponding author
- Calvani, Riccardo
- ORCID
- Venue
- Biological Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018-01-31
- Volume
- 399
- Issue
- 5
- Pages
- 421-436
- ISSN
- 1431-6730 (ISSN-L)
- 1437-4315
- OpenAlex
- W2896096385
- Cited by
- 116
- References
- 158
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 17 · 2023: 21 · 2022: 15 · 2021: 10 · 2020: 15 · 2019: 10 · 2018: 11
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Biological Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, other-oa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- sarcopenia, muscle aging, mitochondrial quality control, mitochondrial dysfunction, muscle cells, inflammation, muscle mass regulation, geriatric syndromes
- MeSH terms
- Aging, Animals, Humans, Mitochondria, Muscles, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A second model labelled each claim on 2026-10-09 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
