Cited by 116Muscle Physiology and DisordersNutrition and Health in AgingMitochondrial Function and Pathology

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Update on mitochondria and muscle aging: all wrong roads lead to sarcopenia

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Picca, Anna, Calvani, Riccardo, Bossola, Maurizio, Allocca, Elena, Menghi, Amerigo, Pesce, Vito, Lezza, Angela Maria Serena, Bernabei, Roberto, Landi, Francesco, Marzetti, Emanuele·2018·Biological Chemistry

DOI 10.1515/hsz-2017-0331

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Abstract

Sarcopenia is a well-known geriatric syndrome that has been endorsed over the years as a biomarker allowing for the discrimination, at a clinical level, of biological from chronological age. Multiple candidate mechanisms have been linked to muscle degeneration during sarcopenia. Among them, there is wide consensus on the central role played by the loss of mitochondrial integrity in myocytes, secondary to dysfunctional quality control mechanisms. Indeed, mitochondria establish direct or indirect contacts with other cellular components (e.g. endoplasmic reticulum, peroxisomes, lysosomes/vacuoles) as well as the extracellular environment through the release of several biomolecules. The functional implications of these interactions in the context of muscle physiology and sarcopenia are not yet fully appreciated and represent a promising area of investigation. Here, we present an overview of recent findings concerning the interrelation between mitochondrial quality control processes, inflammation and the metabolic regulation of muscle mass in the pathogenesis of sarcopenia highlighting those pathways that may be exploited for developing preventive and therapeutic interventions against muscle aging.

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Authors: Picca, A., Calvani, R., Bossola, M., Allocca, E., Menghi, A., Pesce, V., Lezza, A. M. S., Bernabei, R., Landi, F., & Marzetti, E.
Affiliations: Università Cattolica del Sacro Cuore (IT)
University of Bari Aldo Moro (IT)
Corresponding author: Calvani, Riccardo
ORCID: Picca, Anna
Calvani, Riccardo
Bossola, Maurizio
Pesce, Vito
Lezza, Angela Maria Serena
Bernabei, Roberto
Landi, Francesco
Marzetti, Emanuele
Venue: Biological Chemistry
Publisher: Walter de Gruyter GmbH
Published: 2018-01-31
Volume: 399
Issue: 5
Pages: 421-436
ISSN: 1431-6730 (ISSN-L)
1437-4315
DOI: 10.1515/hsz-2017-0331
OpenAlex: W2896096385
Cited by: 116
References: 158
Citations by year: 2026: 3 · 2025: 14 · 2024: 17 · 2023: 21 · 2022: 15 · 2021: 10 · 2020: 15 · 2019: 10 · 2018: 11
FWCI: 1.13
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: Biological Chemistry (publishedVersion)
PubMed (publishedVersion)
PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, other-oa)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: sarcopenia, muscle aging, mitochondrial quality control, mitochondrial dysfunction, muscle cells, inflammation, muscle mass regulation, geriatric syndromes
MeSH terms: Aging, Animals, Humans, Mitochondria, Muscles, Sarcopenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

A second model labelled each claim on 2026-10-09 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Update on mitochondria and muscle aging: all wrong roads lead to sarcopenia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks