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Cited by 55Ovarian function and disordersGrowth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and Treatments

Intractable Early Childhood Obesity as the Initial Sign of Insulin Resistant Hyperinsulinism and Precursor of Polycystic Ovary Syndrome

Littlejohn, E.E., Weiss, R.E., Deplewski, D., Edidin, D.V., Rosenfield, R.·2007·Journal of Pediatric Endocrinology and Metabolism
DOI 10.1515/jpem.2007.20.1.41
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Abstract

OBJECTIVE: We report that intractable early childhood obesity may be associated with severe insulin resistance syndromes (pseudo-Cushing's syndrome and pseudo-acromegaly) and precede polycystic ovary syndrome (PCOS). STUDY DESIGN/RESULTS: Patient 1 had prepubertal obesity followed by early puberty and was diagnosed with pseudo-Cushing's syndrome and insulin resistance at 10.3 years. Oligomenorrhea, androgen excess, and type 2 diabetes mellitus (DM2) emerged at 13.5 years. Patient 2 developed intractable prepubertal obesity followed by atypical true sexual precocity and pseudo-Cushing's syndrome in early childhood. By 11.3 years, oligomenorrhea, androgen excess, and DM2 had appeared. Patient 3 had prepubertal overgrowth in weight and height and was diagnosed with pseudo-acromegaly, menstrual irregularity, androgen excess, and impaired glucose tolerance at 14.3 years of age. Patient 4 had prepubertal overgrowth that evolved into pseudo-acromegaly, insulin resistance, secondary amenorrhea, and androgen excess at 15.6 years. CONCLUSIONS: Intractable prepubertal obesity was recognized to culminate in early childhood pseudo-Cushing's syndrome or pseudo-acromegaly, which are manifestations of insulin-resistant hyperinsulinism, and to herald adolescent PCOS.

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  • hCG-stimulated testosterone concentration was increased in the presence of insulin resistance or hyperinsulinism.

    “hCG-stimulated testosterone concentration was increased in the presence of insulin resistance/hyperinsulinism [132]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [132]

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Authors
Littlejohn, E. E., Weiss, R. E., Deplewski, D., Edidin, D. V., & Rosenfield, R.
Affiliations
University of Chicago (US)
ORCID
Venue
Journal of Pediatric Endocrinology and Metabolism
Publisher
Walter de Gruyter GmbH
Published
2007-01
Volume
20
Issue
1
Pages
41-51
ISSN
  • 0334-018X (ISSN-L)
  • 2191-0251
DOI
10.1515/jpem.2007.20.1.41
OpenAlex
W1980721664
Cited by
55
References
63
Citations by year
2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 1
FWCI
3.68
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
insulin resistance, hyperinsulinism, pseudo-Cushing's syndrome, polycystic ovary syndrome, precocious puberty, hyperandrogenism, oligomenorrhea, type 2 diabetes, secondary amenorrhea, impaired glucose tolerance
MeSH terms
Adolescent, Child, Cushing Syndrome, Female, Humans, Hyperinsulinism, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Puberty, Precocious, Time Factors

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