Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood

Abbott, David H.; Bacha, Fida

doi:10.1016/j.fertnstert.2013.05.023

Cited by 67Ovarian function and disordersGestational Diabetes Research and ManagementSexual Differentiation and Disorders

Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood

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Abbott, David H., Bacha, Fida·2013·Fertility and Sterility

DOI 10.1016/j.fertnstert.2013.05.023PMC PMC3732450

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Abstract

Polycystic ovary syndrome (PCOS) is a prevalent hyperandrogenic infertility and cardiometabolic disorder that increases a woman's lifetime risk of type 2 diabetes mellitus. It is heritable and intensely familial. Progress toward a cure has been delayed by absence of an etiology. Evidence is mounting, however, for in utero T excess, together with gestational hyperglycemia, contributing to either early differentiation of PCOS or phenotypic amplification of its genotypes. Abnormal endocrine, ovarian, and hyperinsulinemic traits are detectable as early as 2 months of age in daughters of women with PCOS, with adiposity enhancement of hyperinsulinemia during childhood potentially contributing to hyperandrogenism and LH excess by adolescence. These findings encourage increasing clinical focus on early childhood markers for adiposity and hyperinsulinemia accompanying ovarian and adrenal endocrine abnormalities that precede a diagnosable PCOS phenotype. They raise the possibility for lifestyle or therapeutic intervention before and during pregnancy or during childhood and adolescence alleviating the manifestations of a familial genetic predisposition to PCOS.

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Available data support the hypothesis that prenatal androgen exposure programs the neuroendocrine, metabolic, and reproductive manifestations of PCOS.
“Available data support the hypothesis that prenatal androgen exposure programs the neuroendocrine, metabolic, and reproductive manifestations of PCOS [103].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [103]

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Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563 · see citing works
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works
The thrifty phenotype hypothesis
Hales, C. N., & Barker, D. J. (2001) · British Medical Bulletin · doi:10.1093/bmb/60.1.5 · Cited by 2,749 · see citing works
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715 · see citing works
Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468 · see citing works
Polycystic Ovary Syndrome
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works
Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group
Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.024 · Cited by 1,976 · see citing works
Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
Goodarzi, M. O., Dumesic, D. A., Chazenbalk, G., & Azziz, R. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.217 · Cited by 1,488 · see citing works
The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen
Manning, J. T., Scutt, D., Wilson, J., & Lewis-Jones, D. I. (1998) · Human Reproduction · doi:10.1093/humrep/13.11.3000 · Cited by 1,470 · see citing works
Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: A study of discordant sibships
Dabelea, D., Hanson, R. L., Lindsay, R. S., Pettitt, D. J., Imperatore, G., Gabir, M. M., Roumain, J., Bennett, P. H., & Knowler, W. C. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2208 · Cited by 1,277 · see citing works
Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society
Wild, R. A., Carmina, E., Diamanti-Kandarakis, E., Dokras, A., Escobar-Morreale, H. F., Futterweit, W., Lobo, R., Norman, R. J., Talbott, E., & Dumesic, D. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2724 · Cited by 1,010 · see citing works
The Insulin-Related Ovarian Regulatory System in Health and Disease
Poretsky, L., Cataldo, N. A., Rosenwaks, Z., & Giudice, L. C. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0374 · Cited by 839 · see citing works
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
Chen, Z.-J., Zhao, H., He, L., Shi, Y., Qin, Y., Shi, Y., Li, Z., You, L., Zhao, J., Liu, J., et al. (2011) · Nature Genetics · doi:10.1038/ng.732 · Cited by 782 · see citing works
Earlier Onset of Puberty in Girls: Relation to Increased Body Mass Index and Race
Kaplowitz, P. B., Slora, E. J., Wasserman, R. C., Pedlow, S. E., & Herman‐Giddens, M. E. (2001) · PEDIATRICS · doi:10.1542/peds.108.2.347 · Cited by 750 · see citing works
Lifestyle changes in women with polycystic ovary syndrome
Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725 · see citing works
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study
The HAPO Study Cooperative Research Group (2009) · Diabetes · doi:10.2337/db08-1112 · Cited by 702 · see citing works
Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both?
Bavdekar, A., Yajnik, C. S., Fall, C. H. D., Bapat, S. A., Pandit, A. N., Deshpande, V., Bhave, S., Kellingray, S., & Joglekar, C. V. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2422 · Cited by 652 · see citing works
Heritability of polycystic ovary syndrome in a Dutch twin-family study
Vink, J. M., Sadrzadeh, S., Lambalk, C. B., & Boomsma, D. I. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1494 · Cited by 647 · see citing works
Impaired Glucose Tolerance in Adolescent Offspring of Diabetic Mothers: Relationship to fetal hyperinsulinism
Silverman, B. L., Metzger, B. E., Cho, N. H., & Loeb, C. A. (1995) · Diabetes Care · doi:10.2337/diacare.18.5.611 · Cited by 643 · see citing works
Insulin Stimulates Testosterone Biosynthesis by Human Thecal Cells from Women with Polycystic Ovary Syndrome by Activating Its Own Receptor and Using Inositolglycan Mediators as the Signal Transduction System<sup>1</sup>
Nestler, J. E., Jakubowicz, D. J., Falcon de Vargas, A., Brik, C., Quintero, N., & Medina, F. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4886 · Cited by 617 · see citing works
The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis
Lim, S. S., Norman, R. J., Davies, M. J., & Moran, L. J. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01053.x · Cited by 539 · see citing works
Precocious Pubarche, Hyperinsulinism, and Ovarian Hyperandrogenism in Girls: Relation to Reduced Fetal Growth
Ibáñez, L., Potau, N., François, I., & de Zegher, F. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5205 · Cited by 509 · see citing works
Developmental origin of polycystic ovary syndrome—a hypothesis
Abbott, D., Dumesic, D., & Franks, S. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1740001 · Cited by 504 · see citing works
Self-citation
Hyperglycemia and Adverse Pregnancy Outcomes
Metzger, B. E., Lowe, L. P., Dyer, A. R., Trimble, E. R., Chaovarindr, U., Coustan, D. R., Hadden, D. R., McCance, D. R., Hod, M., McIntyre, H. D., et al. (2009) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000344706.95925.dc · Cited by 479 · see citing works
Adolescent Girls with Polycystic Ovary Syndrome Have an Increased Risk of the Metabolic Syndrome Associated with Increasing Androgen Levels Independent of Obesity and Insulin Resistance
Coviello, A. D., Legro, R. S., & Dunaif, A. E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1666 · Cited by 446 · see citing works
Insulin Sensitivity and Secretion Are Related to Catch-Up Growth in Small-for-Gestational-Age Infants at Age 1 Year: Results from a Prospective Cohort
Néstor Soto, I., Bazaes, R. A., Peña, V., Salazar, T., Ávila, A., Íñiguez, G., Ong, K. K., Dunger, D. B., & Verónica Mericq, G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-030031 · Cited by 436 · see citing works
Catch-up Growth
Boersma, B., & Wit, J. M. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0313 · Cited by 434 · see citing works
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review
Palomba, S., Falbo, A., Zullo, F., & Orio, F. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0030 · Cited by 426 · see citing works
Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization
Sir‐Petermann, T. (2002) · Human Reproduction · doi:10.1093/humrep/17.10.2573 · Cited by 412 · see citing works
Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS
Kahsar-Miller, M. D., Nixon, C., Boots, L. R., Go, R. C., & Azziz, R. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01662-9 · Cited by 406 · see citing works
Untitled work
(1998) · PubMed · Cited by 404 · see citing works
Reduced final height and indications for insulin resistance in 20 year olds born small for gestational age: regional cohort study
Léger, J., Lévy‐Marchal, C., Bloch, J., Pinet, A., Chevenne, D., Porquet, D., Collin, D., & Czernichow, P. (1997) · BMJ · doi:10.1136/bmj.315.7104.341 · Cited by 389 · see citing works
Obesity, Regional Fat Distribution, and Syndrome X in Obese BlackVersusWhite Adolescents: Race Differential in Diabetogenic and Atherogenic Risk Factors
Bacha, F. F., Saad, R. J., Gungor, N., Janosky, J. E., & Arslanian, S. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021267 · Cited by 363 · see citing works
Screening for Abnormal Glucose Tolerance in Adolescents with Polycystic Ovary Syndrome
Palmert, M. R., Gordon, C. M., Kartashov, A. I., Legro, R. S., Emans, S. J., & Dunaif, A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8305 · Cited by 354 · see citing works
Longitudinal study of physiologic insulin resistance and metabolic changes of puberty
Hannon, T. S., Janosky, J., & Arslanian, S. A. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000246097.73031.27 · Cited by 353 · see citing works
The diagnosis of polycystic ovary syndrome in adolescents
Carmina, E., Oberfield, S. E., & Lobo, R. A. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.03.008 · Cited by 339 · see citing works
Rodent Models for Human Polycystic Ovary Syndrome1
Walters, K. A., Allan, C. M., & Handelsman, D. J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.097808 · Cited by 315 · see citing works
Development of polycystic ovary syndrome: involvement of genetic and environmental factors
Franks, S., McCarthy, M. I., & Hardy, K. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00623.x · Cited by 304 · see citing works
The use of digit ratios as markers for perinatal androgen action
McIntyre, M. H. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-10 · Cited by 299 · see citing works
Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome
Lewy, V. D., Danadian, K., Witchel, S. F., & Arslanian, S. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.109603 · Cited by 298 · see citing works
Lifestyle changes in women with polycystic ovary syndrome
Moran, L. J., Hutchison, S. K., Norman, R. J., & Teede, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub3 · Cited by 292 · see citing works
Identifying Children at Risk for Polycystic Ovary Syndrome
Rosenfield, R. L. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2012 · Cited by 288 · see citing works
Fetal Programming of Polycystic Ovary Syndrome by Androgen Excess: Evidence from Experimental, Clinical, and Genetic Association Studies
Xita, N. V., & Tsatsoulis, A. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2757 · Cited by 287 · see citing works
Anogenital Distance or Digit Length Ratio as Measures of Fetal Androgen Exposure: Relationship to Male Reproductive Development and Its Disorders
Dean, A., & Sharpe, R. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4057 · Cited by 286 · see citing works
Obesity and PCOS: Implications for Diagnosis and Treatment
Legro, R. S. (2012) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1328878 · Cited by 280 · see citing works
Glucose Intolerance, Insulin Resistance, and Hyperandrogenemia in First Degree Relatives of Women with Polycystic Ovary Syndrome
Yıldız, B. O., Yaralı́, H., Oğuz, H., & Bayraktar, M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021499 · Cited by 273 · see citing works
Metformin Therapy in Obese Adolescents with Polycystic Ovary Syndrome and Impaired Glucose Tolerance: Amelioration of Exaggerated Adrenal Response to Adrenocorticotropin with Reduction of Insulinemia/Insulin Resistance
Arslanian, S. A., Lewy, V., Danadian, K., & Saad, R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8398 · Cited by 272 · see citing works
Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels
Ong, K. K., Petry, C. J., Emmett, P. M., Sandhu, M. S., Kiess, W., Hales, C. N., Ness, A., the ALSPAC study team, & Dunger, D. B. (2004) · Diabetologia · doi:10.1007/s00125-004-1405-8 · Cited by 266 · see citing works
DENN Domain Proteins: Regulators of Rab GTPases
Marat, A. L., Dokainish, H., & McPherson, P. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.217067 · Cited by 265 · see citing works
Glucose Tolerance, Insulin Sensitivity, and Insulin Secretion in Children Born Small for Gestational Age
Veening, M. A., van Weissenbruch, M. M., & de Waal, H. A. D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-011940 · Cited by 261 · see citing works
Metabolic and Reproductive Features before and during Puberty in Daughters of Women with Polycystic Ovary Syndrome
Sir-Petermann, T., Codner, E., Pérez, V., Echiburú, B., Maliqueo, M., Ladrón de Guevara, A., Preisler, J., Crisosto, N., Sánchez, F., Cassorla, F., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2836 · Cited by 260 · see citing works
Opposing Influences of Prenatal and Postnatal Weight Gain on Adrenarche in Normal Boys and Girls
Ong, K. K., Potau, N., Petry, C. J., Jones, R. W., Ness, A., Honour, J. W., de Zegher, F., Ibáñez, L., & Dunger, D. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031848 · Cited by 255 · see citing works
Insulin sensitivity, lipids, and body composition in childhood: is "syndrome X" present?
Arslanian, S. A., & Suprasongsin, C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772576 · Cited by 254 · see citing works
Obesity and Sex Steroid Changes across Puberty: Evidence for Marked Hyperandrogenemia in Pre- and Early Pubertal Obese Girls
McCartney, C. R., Blank, S. K., Prendergast, K. A., Chhabra, S., Eagleson, C. A., Helm, K. D., Yoo, R. Y., Chang, R. J., Foster, C. M., Caprio, S., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2002 · Cited by 250 · see citing works
Fetal growth, length of gestation, and polycystic ovaries in adult life
Cresswell, J., Barker, D., Osmond, C., Egger, P., Phillips, D., & Fraser, R. (1997) · The Lancet · doi:10.1016/s0140-6736(97)06062-5 · Cited by 241 · see citing works
Low birthweight and adult insulin resistance: the “catch-up growth” hypothesis: Figure 1
Cianfarani, S., Germani, D., & Branca, F. (1999) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.81.1.f71 · Cited by 239 · see citing works
Insights into the Development of Polycystic Ovary Syndrome (PCOS) from Studies of Prenatally Androgenized Female Rhesus Monkeys
Abbott, D. H., Dumesic, D. A., Eisner, J. R., Colman, R. J., & Kemnitz, J. W. (1998) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00019-8 · Cited by 228 · see citing works
Placental steroidogenesis in pregnant women with polycystic ovary syndrome
Maliqueo, M. A., Lara, H. E., Sánchez, F., Echiburú, B., Crisosto, N., & Sir‐Petermann, T. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.10.015 · Cited by 223 · see citing works
Sheep models of polycystic ovary syndrome phenotype
Padmanabhan, V., & Veiga‐Lopez, A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.005 · Cited by 222 · see citing works
Birth weight in offspring of mothers with polycystic ovarian syndrome
Sir‐Petermann, T., Hitchsfeld, C., Maliqueo, M. A., Ethel Codner, D., Echiburú, B., Gazitúa, R., Recabarren, S. E., & CASSORLA, F. G. (2005) · Human Reproduction · doi:10.1093/humrep/dei009 · Cited by 211 · see citing works
Early Puberty: Rapid Progression and Reduced Final Height in Girls With Low Birth Weight
Ibáñez, L., Ferrer, A., Marcos, M. V., Hierro, F. R., & de Zegher, F. (2000) · PEDIATRICS · doi:10.1542/peds.106.5.e72 · Cited by 211 · see citing works
Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts
Goodarzi, M. O., Jones, M. R., Li, X., Chua, A. K., Garcia, O. A., Chen, Y. I., Krauss, R. M., Rotter, J. I., Ankener, W., Legro, R. S., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2011-100427 · Cited by 200 · see citing works
Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity
Moghetti, P., Castello, R., Negri, C., Tosi, F., Spiazzi, G., Brun, E., Balducci, R., Toscano, V., & Muggeo, M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772544 · Cited by 196 · see citing works
Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20‐year retrospective cohort study
Mani, H., Levy, M. J., Davies, M. J., Morris, D. H., Gray, L. J., Bankart, J., Blackledge, H., Khunti, K. K., & Howlett, T. A. (2012) · Clinical Endocrinology · doi:10.1111/cen.12068 · Cited by 192 · see citing works
Polycystic Ovary Syndrome
Nandi, A. A., Chen, Z., Patel, R., & Poretsky, L. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.10.003 · Cited by 189 · see citing works
Early Puberty-Menarche After Precocious Pubarche: Relation to Prenatal Growth
Ibáñez, L., Jiménez, R., & de Zegher, F. (2006) · PEDIATRICS · doi:10.1542/peds.2005-0664 · Cited by 183 · see citing works
Prodomains of Transforming Growth Factor β (TGFβ) Superfamily Members Specify Different Functions
Sengle, G., Ono, R. N., Sasaki, T., & Sakai, L. Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188615 · Cited by 182 · see citing works
INSULIN ACTION IN THE POLYCYSTIC OVARY SYNDROME
Dunaif, A. E. (1999) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70073-6 · Cited by 180 · see citing works
The Association of Obesity and Hyperandrogenemia during the Pubertal Transition in Girls: Obesity as a Potential Factor in the Genesis of Postpubertal Hyperandrogenism
McCartney, C. R., Prendergast, K. A., Chhabra, S., Eagleson, C. A., Yoo, R. Y., Chang, R. J., Foster, C. M., & Marshall, J. C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1852 · Cited by 176 · see citing works
Variants inDENND1AAre Associated with Polycystic Ovary Syndrome in Women of European Ancestry
Welt, C. K., Styrkársdóttir, U., Ehrmann, D. A., Þorleifsson, G., Arason, G., Guðmundsson, J. A., Ober, C., Rosenfield, R. L., Saxena, R., Þorsteinsdóttir, U., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3478 · Cited by 168 · see citing works
Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism
Apter, D. L., Bützow, T. L., Laughlin, G. A., & YEN, S. S. C. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.10.7559882 · Cited by 167 · see citing works
Assembly of fibrillin microfibrils governs extracellular deposition of latent TGFβ
Massam-Wu, T., Chiu, M., Choudhury, R., Chaudhry, S. S., Baldwin, A. K., McGovern, A., Baldock, C., Shuttleworth, C. A., & Kielty, C. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.073437 · Cited by 165 · see citing works
Effect of Lifestyle Intervention on Features of Polycystic Ovarian Syndrome, Metabolic Syndrome, and Intima-Media Thickness in Obese Adolescent Girls
Lass, N., Kleber, M., Winkel, K., Wunsch, R., & Reinehr, T. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1609 · Cited by 160 · see citing works
Genetics of the polycystic ovary syndrome
Kosova, G., & Urbanek, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.009 · Cited by 156 · see citing works
Epigenetic Mechanism Underlying the Development of Polycystic Ovary Syndrome (PCOS)-Like Phenotypes in Prenatally Androgenized Rhesus Monkeys
Xu, N., Kwon, S., Abbott, D. H., Geller, D. H., Dumesic, D. A., Azziz, R., Guo, X., & Goodarzi, M. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027286 · Cited by 155 · see citing works
Recognizing rare disorders: aromatase deficiency
Jones, M. E. E., Boon, W. C., McInnes, K. J., MAFFEI, L. E., Carani, C., & Simpson, E. R. (2007) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet0477 · Cited by 153 · see citing works
Early Metabolic Derangements in Daughters of Women with Polycystic Ovary Syndrome
Sir‐Petermann, T., Maliqueo, M. A., Ethel Codner, D., Echiburú, B., Crisosto, N., Pérez, V., Pérez‐Bravo, F., & CASSORLA, F. G. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1036 · Cited by 151 · see citing works
Phenotype and genotype in polycystic ovary syndrome
Legro, R. S. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545191.003 · Cited by 147 · see citing works
Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case–control study
Palomba, S., Marotta, R., Di Cello, A., Russo, T., Falbo, A., Orio, F., Tolino, A., Zullo, F., Esposito, R., & Sala, G. B. L. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04443.x · Cited by 144 · see citing works
The Relationship between Maternal and Umbilical Cord Androgen Levels and Polycystic Ovary Syndrome in Adolescence: A Prospective Cohort Study
Hickey, M., Sloboda, D. M., Atkinson, H. C., Doherty, D. A., Franks, S., Norman, R. J., Newnham, J. P., & Hart, R. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0544 · Cited by 143 · see citing works
Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity
Neville, K. A. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2004.053959 · Cited by 139 · see citing works
Maturation of Hypothalamic-Pituitary-Gonadal Function in Normal Human Fetuses: Circulating Levels of Gonadotropins, Their Common a-Subunit and Free Testosterone, and Discrepancy between Immunological and Biological Activities of Circulating Follicle-Stimulating Hormone*
Beck‐Peccoz, P., Padmanabhan, V., Baggiani, A., CORTELAZZI, D., Buscaglia, M., MEDRI, G., Marconi, A. M., Pardi, G., & Beitins, I. Z. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-3-525 · Cited by 139 · see citing works
Randomized comparison of the influence of dietary management and/or physical exercise on ovarian function and metabolic parameters in overweight women with polycystic ovary syndrome
Nybacka, Å., Carlström, K., Ståhle, A., Nyrén, S., Hellström, P. M., & Hirschberg, A. L. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.006 · Cited by 138 · see citing works
Hyperinsulinemia in postpubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism.
Ibanez, L., Potau, N., Zampolli, M., Prat, N., Virdis, R., Vicens-Calvet, E., & Carrascosa, A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772605 · Cited by 138 · see citing works
Animal models of polycystic ovary syndrome: a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk
Shi, D., & Vine, D. F. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.04.006 · Cited by 135 · see citing works
Anti-Mullerian hormone in the diagnosis of polycystic ovary syndrome: can morphologic description be replaced?
Eilertsen, T., Vanky, E., & Carlsen, S. M. (2012) · Human Reproduction · doi:10.1093/humrep/des213 · Cited by 134 · see citing works
Evidence for Chromosome 2p16.3 Polycystic Ovary Syndrome Susceptibility Locus in Affected Women of European Ancestry
Mutharasan, P., Galdones, E., Bernabé, B. P., Garcia, O. A., Jafari, N., Shea, L. D., Woodruff, T. K., Legro, R. S., Dunaif, A. E., & Urbanek, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2471 · Cited by 133 · see citing works
Individual serum levels of anti-Mullerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort study
Hagen, C. P., Aksglæde, L., Sørensen, K., Mouritsen, A., Andersson, A., Petersen, J. H., Main, K. M., & Juul, A. (2012) · Human Reproduction · doi:10.1093/humrep/der435 · Cited by 131 · see citing works
A 20-Year Follow-up of Young Women With Polycystic Ovary Syndrome
Carmina, E., Campagna, A. M., & Lobo, R. A. (2012) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31823f7135 · Cited by 128 · see citing works
Modulation of Gonadotropin-Releasing Hormone Pulse Generator Sensitivity to Progesterone Inhibition in Hyperandrogenic Adolescent Girls—Implications for Regulation of Pubertal Maturation
Blank, S. K., McCartney, C. R., Chhabra, S., Helm, K. D., Eagleson, C. A., Chang, R. J., & Marshall, J. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2606 · Cited by 128 · see citing works
Serum antimullerian hormone (AMH) levels are elevated in adolescent girls with polycystic ovaries and the polycystic ovarian syndrome (PCOS)
Hart, R. J., Doherty, D. A., Norman, R. J., Franks, S., Dickinson, J. E., Hickey, M., & Sloboda, D. M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.11.002 · Cited by 128 · see citing works
Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
Ibáñez, L. (2003) · Human Reproduction · doi:10.1093/humrep/deg351 · Cited by 128 · see citing works
Early Metformin Therapy (Age 8–12 Years) in Girls with Precocious Pubarche to Reduce Hirsutism, Androgen Excess, and Oligomenorrhea in Adolescence
Ibáñez, L., López-Bermejo, A., Díaz, M., Marcos, M. V., & de Zegher, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0555 · Cited by 123 · see citing works
Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels
Barry, J. A., Kay, A., Navaratnarajah, R., Iqbal, S., Bamfo, J. E. A. K., David, A. L., Hines, M., & Hardiman, P. J. (2010) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2010.485254 · Cited by 120 · see citing works
Aberrant Synthesis, Metabolism, and Plasma Accumulation of Circulating Estrogens and Estrogen Metabolites in Preeclampsia Implications for Vascular Dysfunction
Jobe, S. O., Tyler, C. T., & Magness, R. R. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.201624 · Cited by 118 · see citing works
Infants of Women with Polycystic Ovary Syndrome Have Lower Cord Blood Androstenedione and Estradiol Levels
Anderson, H., Fogel, N. R., Grebe, S. K. G., Singh, R. J., Taylor, R. L., & Dunaif, A. E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2651 · Cited by 118 · see citing works
Evaluating the twin testosterone transfer hypothesis: A review of the empirical evidence
Tapp, A. L., Maybery, M. T., & Whitehouse, A. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.011 · Cited by 116 · see citing works
Maturation of Luteinizing Hormone (Gonadotropin-Releasing Hormone) Secretion across Puberty: Evidence for Altered Regulation in Obese Peripubertal Girls
McCartney, C. R., Prendergast, K. A., Blank, S. K., Helm, K. D., Chhabra, S., & Marshall, J. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1252 · Cited by 116 · see citing works
Development of Steroid Signaling Pathways during Primordial Follicle Formation in the Human Fetal Ovary
Fowler, P., Anderson, R. A., Saunders, P. T. K., Kinnell, H. L., Mason, J. I., Evans, D. B., Bhattacharya, S., Flannigan, S., Franks, S., Monteiro, A., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2618 · Cited by 113 · see citing works
Identification of a Polycystic Ovary Syndrome Susceptibility Variant in Fibrillin-3 and Association with a Metabolic Phenotype
Urbanek, M., Sam, S., Legro, R. S., & Dunaif, A. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0761 · Cited by 111 · see citing works
Family-Based Analysis of Candidate Genes for Polycystic Ovary Syndrome
Ewens, K. G., Stewart, D. R., Ankener, W., Urbanek, M., McAllister, J. M., Chen, C., Baig, K. M., Parker, S. C. J., Margulies, E. H., Legro, R. S., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2703 · Cited by 110 · see citing works
Steroid profiling in preeclamptic women: evidence for aromatase deficiency
Hertig, A., Lière, P., Chabbert‐Buffet, N., Fort, J., Pianos, A., Eychenne, B., Cambourg, A., Schumacher, M., Berkane, N. B., Lefèvre, G., et al. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.06.011 · Cited by 108 · see citing works
Nonhuman primate models of polycystic ovary syndrome
Abbott, D. H., Nicol, L. E., Levine, J. E., Xu, N., Goodarzi, M. O., & Dumesic, D. A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.013 · Cited by 105 · see citing works
Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity
Rosenfield, R. L., & Bordini, B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.088 · Cited by 101 · see citing works
Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome
Sir‐Petermann, T., Bárbara Angel, B., Maliqueo, M. A., Carvajal, F., Santos, J. L., & Pérez-Bravo, F. (2002) · Diabetologia · doi:10.1007/s00125-002-0836-3 · Cited by 99 · see citing works
Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring
Abbott, D. H., Bruns, C. M., Barnett, D. K., Dunaif, A. E., Goodfriend, T. L., Dumesic, D. A., & Tarantal, A. F. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00058.2010 · Cited by 97 · see citing works
Fine Mapping of Genetic Susceptibility to Polycystic Ovary Syndrome on Chromosome 19p13.2 and Tests for Regulatory Activity
Stewart, D. R., Dombroski, B. A., Urbanek, M., Ankener, W., Ewens, K. G., Wood, J. R., Legro, R. S., Strauss, J. F., Dunaif, A. E., & Spielman, R. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0951 · Cited by 95 · see citing works
Linkage of regulators of TGF‐β activity in the fetal ovary to polycystic ovary syndrome
Hatzirodos, N., Bayne, R. A. L., Irving‐Rodgers, H. F., Hummitzsch, K., Sabatier, L., Lee, S. S., Bonner, W. M., Gibson, M. A., Rainey, W. E., Carr, B. R., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-181099 · Cited by 90 · see citing works
The Roles of Insulin Sensitivity, Insulin-Like Growth Factor I (IGF-I), and IGF-Binding Protein-1 and -3 in the Hyperandrogenism of African-American and Caribbean Hispanic Girls with Premature Adrenarche1
Vuguin, P. M., Linder, B. L., Rosenfeld, R. G., Saenger, P. H., & DiMartino-Nardi, J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5722 · Cited by 89 · see citing works
Ovarian Morphology Is a Marker of Heritable Biochemical Traits in Sisters with Polycystic Ovaries
Franks, S., Webber, L. J., Goh, M. J., Valentine, A., White, D. M., Conway, G. S., Wiltshire, S., & McCarthy, M. I. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0369 · Cited by 88 · see citing works
Anatomical evidence for in utero androgen exposure in women with polycystic ovary syndrome
Cattrall, F. R., Vollenhoven, B. J., & Weston, G. C. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.05.061 · Cited by 88 · see citing works
Hyperandrogenism and Hyperinsulinism in Children of Women with Polycystic Ovary Syndrome: A Controlled Study
Kent, S. C., Gnatuk, C. L., Kunselman, A. R., Demers, L. M., Lee, P. A., & Legro, R. S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1958 · Cited by 88 · see citing works
Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome
Moran, C., Arriaga, M., Rodriguez, G., & Moran, S. (2012) · International Journal of Endocrinology · doi:10.1155/2012/317241 · Cited by 86 · see citing works
Androgen Concentrations in Umbilical Cord Blood and Their Association with Maternal, Fetal and Obstetric Factors
Keelan, J. A., Mattes, E., Tan, H., Dinan, A., Newnham, J. P., Whitehouse, A., Jacoby, P. A., & Hickey, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042827 · Cited by 82 · see citing works
Polycystic ovary syndrome and insulin-resistant hyperinsulinemia
Rosenfield, R. L. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.117430 · Cited by 78 · see citing works
Combined Effects of Genetic and Environmental Factors on Insulin Resistance Associated With Reduced Fetal Growth
Jaquet, D., Trégouët, D., Godefroy, T., Nicaud, V., Chevenne, D., Tiret, L., Czernichow, P., & Lévy‐Marchal, C. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3473 · Cited by 78 · see citing works
Looking for Polycystic Ovary Syndrome Genes: Rational and Best Strategy
Goodarzi, M. O. (2008) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-992919 · Cited by 75 · see citing works
Fibrillin-3 expression in human development
Sabatier, L., Miosge, N., Hubmacher, D., Lin, G., Davis, E. C., & Reinhardt, D. P. (2010) · Matrix Biology · doi:10.1016/j.matbio.2010.10.003 · Cited by 75 · see citing works
Using the Androgen Excess–PCOS Society Criteria to Diagnose Polycystic Ovary Syndrome and the Risk of Metabolic Syndrome in Adolescents
Roe, A. H., Prochaska, E. C., Smith, M. E., Sammel, M. D., & Dokras, A. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.11.019 · Cited by 74 · see citing works
Adrenal Function during Childhood and Puberty in Daughters of Women with Polycystic Ovary Syndrome
Maliqueo, M. A., Sir‐Petermann, T., Pérez, V., Echiburú, B., de Guevara, A. L., Gálvez, C., Crisosto, N., & Azziz, R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0427 · Cited by 73 · see citing works
Brothers of women with polycystic ovary syndrome are characterised by impaired glucose tolerance, reduced insulin sensitivity and related metabolic defects
Baillargeon, J., & Carpentier, A. C. (2007) · Diabetologia · doi:10.1007/s00125-007-0831-9 · Cited by 72 · see citing works
A 20-Year Follow-up of Young Women With Polycystic Ovary Syndrome
Dungan, J. S. (2012) · Yearbook of Obstetrics Gynecology and Women s Health · doi:10.1016/j.yobg.2012.06.193 · Cited by 72 · see citing works
Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis: a possible component of polycystic ovary syndrome
McGee, W. K., Bishop, C. V., Bahar, A., Pohl, C. R., Chang, R. J., Marshall, J. C., Pau, F. K.-Y., Stouffer, R. L., & Cameron, J. L. (2011) · Human Reproduction · doi:10.1093/humrep/der393 · Cited by 71 · see citing works
Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
Abbott, A. D., Colman, R. J., Tiefenthaler, R., Dumesic, D. A., & Abbott, D. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042372 · Cited by 71 · see citing works
Endocrine consequences of premature pubarche in post‐pubertal Caucasian girls
Meas, T., Chevenne, D., Thibaud, E., Léger, J., Cabrol, S., Czernichow, P., & Lévy‐Marchal, C. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01579.x · Cited by 71 · see citing works
Plasma 17-ketosteroids and 17-beta hydroxysteroids in girls with premature development of sexual hair
Rosenfield, R. L. (1971) · The Journal of Pediatrics · doi:10.1016/s0022-3476(71)80111-7 · Cited by 66 · see citing works
Does PCOS have developmental origins?
Franks, S., & Berga, S. L. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.11.029 · Cited by 64 · see citing works
Intrauterine Growth Retardation Predisposes to Insulin Resistance But Not to Hyperandrogenism in Young Women
Jaquet, D., Léger, J., Chevenne, D., Czernichow, P., & Lévy‐Marchal, C. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6106 · Cited by 62 · see citing works
Animal Models and the Developmental Origins of Polycystic Ovary Syndrome: Increasing Evidence for the Role of Androgens in Programming Reproductive and Metabolic Dysfunction
Franks, S. (2012) · Endocrinology · doi:10.1210/en.2012-1366 · Cited by 62 · see citing works
Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters
Crisosto, N., Echiburú, B., Maliqueo, M. A., Pérez, V., de Guevara, A. L., Preisler, J., Sánchez, F., & Sir‐Petermann, T. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.10.002 · Cited by 62 · see citing works
Human Fetal Ovary Development Involves the Spatiotemporal Expression of P450c17 Protein
Cole, B., Hensinger, K., Maciel, G. A. R., Chang, R. J., & Erickson, G. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0641 · Cited by 61 · see citing works
Catch-up growth in girls born small for gestational age precedes childhood progression to high adiposity
Ibáñez, L., López‐Bermejo, A., Díaz, M., & de Zegher, F. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.03.107 · Cited by 61 · see citing works
Relationship Between Anti-Müllerian Hormone (AMH) and Insulin Levels During Different Tanner Stages in Daughters of Women With Polycystic Ovary Syndrome
Sir‐Petermann, T., de Guevara, A. L., Ethel Codner, D., Preisler, J., Crisosto, N., Echiburú, B., Maliqueo, M. A., Sánchez, F., Pérez‐Bravo, F., & CASSORLA, F. G. (2012) · Reproductive Sciences · doi:10.1177/1933719111424444 · Cited by 58 · see citing works
The 312 N variant of the luteinizing hormone/choriogonadotropin receptor gene ( LHCGR ) confers up to 2·7‐fold increased risk of polycystic ovary syndrome in a S ardinian population
Capalbo, A., Sagnella, F., Apa, R., Fulghesu, A. M., Lanzone, A., Morciano, A., Farcomeni, A., Gangalè, M. F., Moro, F., Martínez, D., et al. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04372.x · Cited by 58 · see citing works
Serum Dehydroepiandrosterone Sulfate Levels and Pubarche in Short Children Born Small for Gestational Age before and during Growth Hormone Treatment
Boonstra, V., Mulder, P. G. H., de Jong, F. H., & Hokken-Koelega, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031160 · Cited by 57 · see citing works
Hyperandrogenaemia in adolescent girls: origins of abnormal gonadotropin‐releasing hormone secretion
Solorzano, C. M. B., McCartney, C., Blank, S. K., Knudsen, K. L., & Jc, M. (2009) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2009.02383.x · Cited by 56 · see citing works
Intractable Early Childhood Obesity as the Initial Sign of Insulin Resistant Hyperinsulinism and Precursor of Polycystic Ovary Syndrome
Littlejohn, E. E., Weiss, R. E., Deplewski, D., Edidin, D. V., & Rosenfield, R. (2007) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2007.20.1.41 · Cited by 55 · see citing works
The Roles of Insulin Sensitivity, Insulin-Like Growth Factor I (IGF-I), and IGF-Binding Protein-1 and -3 in the Hyperandrogenism of African-American and Caribbean Hispanic Girls with Premature Adrenarche
Vuguin, P. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.2037 · Cited by 54 · see citing works
Hyperandrogenemia in Obese Peripubertal Girls: Correlates and Potential Etiological Determinants
Knudsen, K. L., Blank, S. K., Solorzano, C. M. B., Patrie, J. T., Chang, R. J., Caprio, S., Marshall, J. C., & McCartney, C. R. (2010) · Obesity · doi:10.1038/oby.2010.58 · Cited by 52 · see citing works
Comparison of Clinical, Ultrasonographic, and Biochemical Differences at the Beginning of Puberty in Healthy Girls Born Either Small for Gestational Age or Appropriate for Gestational Age: Preliminary Results
Hernández, M. I., Martínez, A., Capurro, T., Peña, V., Trejo, L., Avila, A., Salazar, T., Sylvia Asenjo, M., Iñiguez, G., & Verónica Mericq, G. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2368 · Cited by 52 · see citing works
Polycystic ovarian syndrome during puberty and adolescence
Williams, R. M., Ong, K. K., & Dunger, D. B. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.005 · Cited by 50 · see citing works
Digit ratios do not serve as anatomical evidence of prenatal androgen exposure in clinical phenotypes of polycystic ovary syndrome
Lujan, M. E., Bloski, T. G., Chizen, D. R., Lehotay, D. C., & Pierson, R. A. (2010) · Human Reproduction · doi:10.1093/humrep/dep363 · Cited by 49 · see citing works
Diagnosis and treatment of polycystic ovarian syndrome in adolescents
Nicandri, K. F., & Hoeger, K. M. (2012) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32835a1a03 · Cited by 47 · see citing works
Expression and enzymatic activity of the P450c17 gene in human adipose tissue
Puche, C., José, M., Cabero, A., & Meseguer, A. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460223 · Cited by 47 · see citing works
Birthweight and thinness at birth independently predict symptoms of polycystic ovary syndrome in adulthood
Davies, M. J., March, W. A., Willson, K. J., Giles, L. C., & Moore, V. (2012) · Human Reproduction · doi:10.1093/humrep/des027 · Cited by 46 · see citing works
Differential Expression and Functional Characterization of Luteinizing Hormone Receptor Splice Variants in Human Luteal Cells: Implications for Luteolysis
Dickinson, R. E., Stewart, A. J., Myers, M., Millar, R. P., & Duncan, W. C. (2009) · Endocrinology · doi:10.1210/en.2008-1382 · Cited by 44 · see citing works
Insulin Resistance, Premature Adrenarche, and a Risk of the Polycystic Ovary Syndrome (PCOS)
Ibáñez, L., Potau, N., & Carrascosa, A. (1998) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00014-9 · Cited by 41 · see citing works
Prevalence of Polycystic Ovary Syndrome in Women from Opposite-Sex Twin Pairs
Kuijper, E. A. M., Vink, J. M., Lambalk, C. B., & Boomsma, D. I. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0191 · Cited by 40 · see citing works
Comparison of the metabolic parameters and androgen level of umbilical cord blood in newborns of mothers with polycystic ovary syndrome and controls.
Mehrabian, F., & Kelishadi, R. (2012) · Europe PMC (PubMed Central) · Cited by 39 · see citing works
In vitro effects of chorionic gonadotropin hormone on human adipose development
Santos, E. D., Dieudonné, M., Leneveu, M.-C., Pecquery, R., Serazin-Leroy, V., & Giudicelli, Y. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0101 · Cited by 39 · see citing works
Effects of Birth Weight on Anti-Mullerian Hormone Serum Concentrations in Infant Girls
Sir‐Petermann, T., Márquez, L., Cárcamo, M., Hitschfeld, C., Ethel Codner, D., Maliqueo, M. A., Echiburú, B., Aranda, P., Crisosto, N., & CASSORLA, F. G. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1771 · Cited by 37 · see citing works
Early Origins of Polycystic Ovary Syndrome: Hypotheses May Change without Notice
de Zegher, F., & Ibáñez, L. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1608 · Cited by 35 · see citing works
Adipose tissue insulin resistance in peripubertal girls with first-degree family history of polycystic ovary syndrome
Trottier, A., Battista, M., Geller, D. H., Moreau, B., Carpentier, A. C., Simoneau‐Roy, J., & Baillargeon, J. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.025 · Cited by 34 · see citing works
Rab3B is essential for GnRH-induced gonadotrophin release from anterior pituitary cells
Tasaka, K., Masumoto, N., Mizuki, J., Ikebuchi, Y., Ohmichi, M., Kurachi, H., Miyake, A., & Murata, Y. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570267 · Cited by 32 · see citing works
Surgical management of metabolic dysfunction in PCOS
Escobar-Morreale, H. F. (2011) · Steroids · doi:10.1016/j.steroids.2011.12.004 · Cited by 26 · see citing works
Evaluating reported candidate gene associations with polycystic ovary syndrome
Pau, C. T., Saxena, R., & Welt, C. K. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.12.033 · Cited by 26 · see citing works
Recurrent severe hyperandrogenism during pregnancy: a case report
Holt, H., Medbak, S., Kirk, D., Guirgis, R. R., Hughes, I. A., Cummings, M. H., & Meeking, D. R. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.018382 · Cited by 26 · see citing works
Excess weight and precocious pubarche in children: alterations of the adrenocortical hormones.
Jabbar, M., Pugliese, M. T., Fort, P., Recker, B., & Lifshitz, F. (1991) · Journal of the American College of Nutrition · doi:10.1080/07315724.1991.10718155 · Cited by 25 · see citing works
Microsatellite polymorphism in the fibrillin 3 gene and susceptibility to PCOS: a case–control study and meta-analysis
Xie, G.-B., Xu, P., Che, Y., Xia, Y., Cao, Y., Wang, W., Qiao, D., Wu, X., Yi, L., Gao, Q., et al. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.10.014 · Cited by 24 · see citing works
Digit ratios by computer-assisted analysis confirm lack of anatomical evidence of prenatal androgen exposure in clinical phenotypes of polycystic ovary syndrome
Lujan, M. E., Podolski, A. J., Chizen, D. R., Lehotay, D. C., & Pierson, R. A. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-156 · Cited by 24 · see citing works
Anti-Mullerian hormone in short girls born small for gestational age and the effect of growth hormone treatment
Lem, A. J., Boonstra, V., Renes, J. S., Breukhoven, P. E., de Jong, F. H., Laven, J. S. E., & Hokken-Koelega, A. (2011) · Human Reproduction · doi:10.1093/humrep/deq391 · Cited by 17 · see citing works
Altered glucose disposition and insulin sensitivity in peri-pubertal first-degree relatives of women with polycystic ovary syndrome
Raissouni, N., Kolesnikov, A., Purushothaman, R., SINHA, S. K., Bhandari, S., Bhangoo, A., Malik, S., Mathew, R. P., Baillargeon, J., Hernández, M. I., et al. (2012) · International Journal of Pediatric Endocrinology · doi:10.1186/1687-9856-2012-14 · Cited by 16 · see citing works
The effect of in-utero undernutrition on the insulin resistance syndrome
Jaquet, D., Léger, J., Czernichow, P., & Lévy‐Marchal, C. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0062-x · Cited by 16 · see citing works
NIH Panel: Name Change, New Priorities Advised for Polycystic Ovary Syndrome
Hampton, T. (2013) · JAMA · doi:10.1001/jama.2013.1236 · Cited by 13 · see citing works
Thin newborns are more insulin resistant at 10 years of age
Larnkjær, A., Ingstrup, H. K., Schack‐Nielsen, L., Mølgaard, C., & Michaelsen, K. F. (2010) · Acta Paediatrica · doi:10.1111/j.1651-2227.2010.02087.x · Cited by 8 · see citing works

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The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113 · see citing works
The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited
Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603 · see citing works
Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works
Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment
Zhao, H., Zhang, J., Cheng, X., Nie, X., & He, B. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-022-01091-0 · Cited by 408 · see citing works
Sex, microbes, and polycystic ovary syndrome
Thackray, V. G. (2019) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.11.001 · Cited by 203 · see citing works
The gut microbiome is altered in a letrozole-induced mouse model of polycystic ovary syndrome
Kelley, S. T., Skarra, D. V., Rivera, A. J., & Thackray, V. G. (2016) · PLOS ONE · doi:10.1371/journal.pone.0146509 · Cited by 205 · see citing works
Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome
Roth, L. W., McCallie, B. R., Alvero, R. J., Schoolcraft, W. B., Minjarez, D. A., & Katz‐Jaffe, M. G. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-013-0161-4 · Cited by 195 · see citing works
Involvement of androgens in ovarian health and disease
Lebbe, M., & Woodruff, T. K. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat065 · Cited by 165 · see citing works
Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double‐blind placebo controlled clinical trial
Hajimonfarednejad, M., Nimrouzi, M., Heydari, M., Zarshenas, M. M., Raee, M. J., & Jahromi, B. N. (2017) · Phytotherapy Research · doi:10.1002/ptr.5970 · Cited by 114 · see citing works
Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model
Torres, P. J., Ho, B., Arroyo, P., Sau, L., Chen, A., Kelley, S. T., & Thackray, V. G. (2019) · Endocrinology · doi:10.1210/en.2019-00050 · Cited by 109 · see citing works
Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis
Yang, K., Zeng, L., Bao, T., & Ge, J. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0346-x · Cited by 103 · see citing works
Genome-wide screen of ovary-specific DNA methylation in polycystic ovary syndrome
Yu, Y.-Y., Sun, C.-X., Liu, Y., Li, Y., Wang, L., & Zhang, W. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.04.005 · Cited by 89 · see citing works
Insulin Resistance, Prediabetes, Metabolic Syndrome: What Should Every Pediatrician Know?
Ighbariya, A., & Weiss, R. (2018) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.2017.s005 · Cited by 78 · see citing works
Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms
Shpakov, A. O. (2021) · Pharmaceuticals · doi:10.3390/ph14010042 · Cited by 81 · see citing works
The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome
Hu, J., Tang, T., Zeng, Z., Wu, J., Tan, X., & Yan, J. (2020) · PeerJ · doi:10.7717/peerj.8640 · Cited by 72 · see citing works
Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome
Arroyo, P., Ho, B., Sau, L., Kelley, S. T., & Thackray, V. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223274 · Cited by 70 · see citing works
Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance
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Effects of bariatric surgery on obese polycystic ovary syndrome: a systematic review and meta-analysis
Li, Y., Han, Y., & He, B. (2019) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2019.03.032 · Cited by 64 · see citing works
Prenatal Exposure to Endocrine Disruptors: A Developmental Etiology for Polycystic Ovary Syndrome
Hewlett, M., Chow, E., Aschengrau, A., & Mahalingaiah, S. (2017) · Reproductive Sciences · doi:10.1177/1933719116654992 · Cited by 61 · see citing works
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Torres, P. J., Skarra, D. V., Ho, B., Sau, L., Anvar, A. R., Kelley, S. T., & Thackray, V. G. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1425-7 · Cited by 62 · see citing works
Intrauterine Reprogramming of the Polycystic Ovary Syndrome: Evidence from a Pilot Study of Cord Blood Global Methylation Analysis
Lambertini, L., Saul, S. R., Copperman, A. B., Hammerstad, S. S., Yi, Z., Zhang, W., Tomer, Y., & KASE, N. G. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00352 · Cited by 57 · see citing works
Hyperinsulinaemic androgen excess in adolescent girls
Ibáñez, L., Ong, K. K., López-Bermejo, A., Dunger, D. B., & de Zegher, F. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.58 · Cited by 56 · see citing works
Obesity and insulin resistance in children
Tagi, V. M., & Chiarelli, F. (2020) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000913 · Cited by 56 · see citing works
Effect of omega-3 fatty acids supplementation on insulin resistance in women with polycystic ovary syndrome: Meta-analysis of randomized controlled trials
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Androgens as double-edged swords: Induction and suppression of follicular development
Pan, J., Zhang, J., Ke, Z.-H., Wang, F., Barry, J. A., Hardiman, P. J., & Qu, F. (2015) · HORMONES · doi:10.14310/horm.2002.1580 · Cited by 41 · see citing works
The role of miRNAs in polycystic ovary syndrome with insulin resistance
Luo, Y., Cui, C., Han, X., Wang, Q., & Zhang, C. (2021) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-02019-7 · Cited by 41 · see citing works
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MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance
Zhang, C., Yu, C., Lin, Z., Pan, H., Li, K., & Ma, H. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05730-z · Cited by 37 · see citing works
Translational Insight Into Polycystic Ovary Syndrome (PCOS) From Female Monkeys with PCOS-like Traits
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Banaszewska, B., Pawelczyk, L. A., & Spaczyński, R. (2019) · Reproductive Biology · doi:10.1016/j.repbio.2019.09.006 · Cited by 33 · see citing works
Effects of bariatric surgery on patients with obesity and polycystic ovary syndrome: a meta-analysis
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RETRACTED: Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary
Rafiee, B., Karbalay‐Doust, S., Tabei, K., Azarpira, N., Alaee, S., Lohrasbi, P., & Bahmanpour, S. (2022) · European Journal of Translational Myology · doi:10.4081/ejtm.2022.10409 · Cited by 29 · see citing works
Retracted
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Adeyanju, O. A., Falodun, T. O., Michael, O. S., Soetan, O. A., Oyewole, A. L., & Agbana, R. D. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01809-1 · Cited by 25 · see citing works
Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report
ESHRE Capri Workshop Group (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0255-7 · Cited by 24 · see citing works
Polycystic ovary syndrome: Recent research and therapeutic advancements
Dilliyappan, S., Kumar, A. S., Venkatesalu, S., Palaniyandi, T., Baskar, G., Sivaji, A., Rab, S. O., Saeed, M., & Shivaranjani, K. S. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123221 · Cited by 24 · see citing works
Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model–Based Study
Wang, Y., Zeng, Z., Zhao, S., Tang, L., Yan, J., Li, N., Zou, L., Fan, X., Xu, C., Huang, J., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab056 · Cited by 22 · see citing works
Insulin Resistance in Polycystic Ovary Syndrome Improved by Chinese Medicine Dingkun Pill (定坤丹): A Randomized Controlled Clinical Trial
Deng, Y., Xue, W., Wang, Y., Liu, X., Zhu, S., Ma, X., Zuo, H., Jiang, J., Zheng, T.-P., & Sun, A. (2019) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-018-2947-1 · Cited by 19 · see citing works
Assessment of follicular fluid leptin levels and insulin resistance as outcome predictors in women undergoing in vitro fertilization–intracytoplasmic sperm injection
Llaneza-Suárez, D., Llaneza, P., González, C., de la Fuente, P. E., García-Ochoa, C., Garrido, P., Castañón, V., & Pérez-López, F. R. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.09.012 · Cited by 19 · see citing works
Female Offspring From Chronic Hyperandrogenemic Dams Exhibit Delayed Puberty and Impaired Ovarian Reserve
Wang, Z., Shen, M., Xue, P., DiVall, S. A., Segars, J. H., & Wu, S. (2018) · Endocrinology · doi:10.1210/en.2017-03078 · Cited by 19 · see citing works
Dehydroepiandrosterone with a high-fat diet treatment at inducing polycystic ovary syndrome in rat model
He, Y., Li, X., Li, Y., Kuai, D., Zhang, H., Wang, Y., & Tian, W. (2024) · Steroids · doi:10.1016/j.steroids.2024.109424 · Cited by 17 · see citing works
A Comparison of Anthropometric, Metabolic, and Reproductive Characteristics of Young Adult Women from Opposite-Sex and Same-Sex Twin Pairs
Korsoff, P., Bogl, L. H., Korhonen, P. E., Kangas, A. J., Soininen, P., Ala‐Korpela, M., Rose, R. J., Kaaja, R., & Kaprio, J. A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00028 · Cited by 16 · see citing works
Androgen and Anti-Mullerian Hormone Concentrations at Term in Newborns and Their Mothers with and without Polycystic Ovary Syndrome
Kollmann, M., Obermayer-Pietsch, B. M., Lerchbaum, E., Lang, U., Herzog, S. A., Trummer, C., Scheuchenegger, A., Ulrich, D., & Klaritsch, P. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111817 · Cited by 15 · see citing works
Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism and Polycystic Ovary Syndrome Risk: A Meta Analysis
Liu, Y., Sun, M.-G., Jiang, R., Ding, R., Che, Z., Chen, Y., Yao, C., Zhu, X., & Cao, J. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-013-0171-2 · Cited by 15 · see citing works
Elevated Anti-Müllerian Hormone Levels in Newborns of Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis Based on Observational Studies
Zhou, S., Lu, D., Wen, S., Sheng, Y., Kang, D., & Xu, L. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00652-w · Cited by 13 · see citing works
Molecular and genetic characterization of partial masculinization in embryonic ovaries grafted into male nude mice
Miura, K., Harikae, K., Nakaguchi, M., Imaimatsu, K., Hiramatsu, R., Tomita, A., Hirate, Y., Kanai-Azuma, M., Kurohmaru, M., Ogura, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212367 · Cited by 6 · see citing works
The Gonadal Axis: A Life Perspective
Huhtaniemi, I. T., Howard, S. R., Dunkel, L., & Anderson, R. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00066-3 · Cited by 9 · see citing works
The impact of androgen levels on serum metabolic profiles in patients with polycystic ovary syndrome
Zhao, T., Xinghua, T., Xiao, X., Lingchuan, L., Wu, X., & Yuan, T. (2024) · Gynecological Endocrinology · doi:10.1080/09513590.2024.2352136 · Cited by 8 · see citing works
Simple Method to Predict Insulin Resistance in Children Aged 6–12 Years by Using Machine Learning
Zhang, Q., & Wan, N. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s380772 · Cited by 8 · see citing works
Mitigating effect of metformin on polycystic ovarian syndrome and insulin resistance in rats, and the mechanisms involved
Hu, L., Wang, B., & Tao, Y. (2020) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v19i9.20 · Cited by 5 · see citing works
Low Frequency Electro-Acupuncture and Physical Exercise Induces Menstruation in A Young Woman with Amenorrhea Related to Polycystic Ovary Syndrome: A Case Report
Huang, D. (2014) · Alternative & Integrative Medicine · doi:10.4172/2327-5162.1000166 · Cited by 4 · see citing works
Mineralocorticoid receptor blockade attenuates hyperandrogenic metabolic dysregulation in letrozole-induced PCOS rat model
Uhunmwangho, E. G., Oniyide, A. A., Areloegbe, S. E. J., Soetan, O. A., Akintayo, C. O., Aturamu, A., & Olaniyi, K. S. (2022) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-022-01097-x · Cited by 3 · see citing works
Acupuncture for polycystic ovary syndrome
Liao, Z., Fan, H., Fan, H., & Chen, X. (2021) · Medicine · doi:10.1097/md.0000000000024218 · Cited by 3 · see citing works
Gestational Diabetes and Infertility
Turan, G. A., & Delibaşı, T. (2023) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2023.132016 · Cited by 2 · see citing works
Reproductive Disease Epigenetics
Oliva, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00021-1 · Cited by 2 · see citing works
Neuroendocrine Regulation of Puberty
Terasawa, E., & Levine, J. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00106-1 · Cited by 2 · see citing works
Research Progress of Hyperandrogen in Polycystic Ovary Syndrome
谭, 金. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.142475 · Cited by 1 · see citing works
The Impact of Down-Regulation on Obstetrics and Perinatal Outcomes in Singleton Pregnancies After In Vitro Fertilization
Jin, L., Ai, J., Zheng, Y., Chen, B., Wang, L., & Dong, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.622081 · Cited by 1 · see citing works
Postnatal Hypothalamic-Pituitary-Gonadal Axis Activation (i.e., Minipuberty) in Full-term and Preterm Infants
Kuiri‐Hänninen, T. (2015)
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Marina, P., & Beirut, L. (2016)
Peer Review #3 of "The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome (v0.1)"
(2020) · PeerJ · doi:10.7287/peerj.8640v0.1/reviews/3
Peer Review #1 of "The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome (v0.1)"
(2020) · PeerJ · doi:10.7287/peerj.8640v0.1/reviews/1
Peer Review #3 of "The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome (v0.2)"
(2020) · PeerJ · doi:10.7287/peerj.8640v0.2/reviews/3
Peer Review #2 of "The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome (v0.1)"
(2020) · PeerJ · doi:10.7287/peerj.8640v0.1/reviews/2
Uso de plantas medicinais no tratamento da Síndrome do Ovário Policístico (SOP): Uma revisão integrativa
Albuquerque, F. N. D. N., de Araujo, K. K. B., Silva, L. V. D. S., de Siqueira, A. B. A. P., Souza, A. T. M., Magalhães, C. D. S., & Randau, K. P. (2022) · Research Society and Development · doi:10.33448/rsd-v11i13.35916
The effect of letrozole treatment on the fertility and embryos parameters in female mice: Histological and hormonal study
AL-Rekabi, S. A., & Noori, N. (2023) · Journal of the Pakistan Medical Association · doi:10.47391/jpma.iq-31

Ontogeny of Polycystic Ovary Syndrome: A Creative Approach
Witchel, S. F. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0591
Adult polycystic ovary syndrome begins in childhood
Franks, S. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0203 · Cited by 142 · see citing works
Hyperandrogenism and Hyperinsulinism in Children of Women With Polycystic Ovary Syndrome: A Controlled Study
Kent, S. C., Gnatuk, C. L., Kunselman, A. R., Demers, L. M., Lee, P. A., & Legro, R. S. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000327779.35659.81 · Cited by 6 · see citing works
Early origins of polycystic ovary syndrome
Xu, X. (2013) · International journal of pediatrics · doi:10.3760/cma.j.issn.1673-4408.2013.01.010
The pediatric origins of polycystic ovary syndrome
Roldán, B., & Escobar-Morreale, H. F. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545191.015 · Cited by 2 · see citing works

Authors: Abbott, D. H., & Bacha, F.
Affiliations: University of Wisconsin–Madison (US)
Baylor College of Medicine (US)
Corresponding author: Abbott, David H.
ORCID: Abbott, David H.
Bacha, Fida
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2013-07
Volume: 100
Issue: 1
Pages: 2-11
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2013.05.023
PMC: PMC3732450
OpenAlex: W2085933036
Cited by: 67
References: 168
Citations by year: 2024: 4 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 4 · 2014: 7 · 2013: 1
FWCI: 1.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3252 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Agriculture (ARS 6250-5100-054)
National Institutes of Health (P50 HD044405, P51 RR000167, R03 HD059798)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords: polycystic ovary syndrome, insulin resistance, hyperinsulinemia, hyperglycemia in pregnancy, childhood adiposity, hyperandrogenism, type 2 diabetes risk, familial predisposition
MeSH terms: Animals, Child, Female, Humans, Hyperinsulinism, Insulin Resistance, Polycystic Ovary Syndrome, Pregnancy, Prenatal Exposure Delayed Effects, Testosterone

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Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood

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