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Cited by 206Autophagy in Disease and TherapyAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Autophagy in Alzheimer’s disease

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Zare-shahabadi, Ameneh, Masliah, Eliezer, Johnson, Gail V.W., Rezaei, Nima·2015·Reviews in the Neurosciences
DOI 10.1515/revneuro-2014-0076PMC PMC5039008
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Abstract

Autophagy is a vesicle and lysosome-mediated degradative pathway that is essential for protein homeostasis and cell health. In particular, compared to nonneuronal cells, neurons are dependent on high basal autophagy for survival. There is emerging agreement that defects in autophagy are likely to contribute to the neurodegenerative processes in numerous diseases, including Alzheimer’s disease (AD). Autophagy-lysosome defects occur early in the pathogenesis of AD and have been proposed to be a significant contributor to the disease process. Given the fact that autophagy deficits are likely major contributors to the etiology of AD, the focus of this review will be on recent studies that support a role for autophagy deficits in AD.

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Metadata

Authors
Zare-shahabadi, A., Masliah, E., Johnson, G. V. W., & Rezaei, N.
Affiliations
  • Tehran University of Medical Sciences (IR)
  • University of California San Diego (US)
  • University of Rochester Medicine (US)
  • Universal Scientific Education and Research Network (IR)
Corresponding author
Rezaei, Nima
ORCID
Venue
Reviews in the Neurosciences
Publisher
Walter de Gruyter GmbH
Published
2015-01-01
Volume
26
Issue
4
Pages
385-95
ISSN
  • 0334-1763 (ISSN-L)
  • 2191-0200
DOI
10.1515/revneuro-2014-0076
PMC
PMC5039008
OpenAlex
W1992935533
Cited by
204
References
119
Citations by year
2026: 2 · 2025: 10 · 2024: 10 · 2023: 21 · 2022: 27 · 2021: 25 · 2020: 38 · 2019: 27 · 2018: 21 · 2017: 19 · 2016: 3 · 2015: 1
FWCI
1.89
Type
journal article
Language
en
Open access
Locations
  • Reviews in the Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG018440)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
autophagy, Alzheimer's disease, autophagy-lysosome pathway, neurodegeneration, proteostasis, neuronal survival, lysosomal dysfunction
MeSH terms
Alzheimer Disease, Animals, Autophagy, Humans, Amyloid beta-Peptides, tau Proteins

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