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Cited by 72Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsExtracellular vesicles in disease

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Gliotransmitters and cytokines in the control of blood-brain barrier permeability

Osipova, Elena D., Semyachkina-Glushkovskaya, Oxana V., Morgun, Andrey V., Pisareva, Natalia V., Malinovskaya, Natalia A., Boitsova, Elizaveta B., Pozhilenkova, Elena A., Belova, Olga A., Salmin, Vladimir V., Taranushenko, Tatiana E., Noda, Mami, Salmina, Alla B.·2018·Reviews in the Neurosciences
DOI 10.1515/revneuro-2017-0092
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Abstract

The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.

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Metadata

Authors
Osipova, E. D., Semyachkina-Glushkovskaya, O. V., Morgun, A. V., Pisareva, N. V., Malinovskaya, N. A., Boitsova, E. B., Pozhilenkova, E. A., Belova, O. A., Salmin, V. V., Taranushenko, T. E., Noda, M., & Salmina, A. B.
Affiliations
  • Saratov State University (RU)
  • Krasnoyarsk State Medical University (RU)
  • Kyushu University (JP)
Corresponding author
Salmina, Alla B.
ORCID
Venue
Reviews in the Neurosciences
Publisher
Walter de Gruyter GmbH
Published
2018-07-26
Volume
29
Issue
5
Pages
567-591
ISSN
  • 0334-1763 (ISSN-L)
  • 2191-0200
DOI
10.1515/revneuro-2017-0092
OpenAlex
W2781614775
Cited by
72
References
15
Citations by year
2026: 6 · 2025: 9 · 2024: 13 · 2023: 7 · 2022: 12 · 2021: 13 · 2020: 5 · 2019: 5 · 2018: 2
FWCI
0.59
Type
journal article
Language
en
Open access
closed
Locations
  • Reviews in the Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (17K08276)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
gliotransmitters, cytokines, blood-brain barrier permeability, neurovascular unit, astrocytes, microglia, pericytes, glutamate transporters, connexin hemichannels, purinergic signaling, exocytosis, inflammasome, angiogenesis, neuroinflammation, cerebrovascular remodeling, intercellular communication
MeSH terms
Animals, Astrocytes, Blood-Brain Barrier, Brain, Humans, Permeability, Cytokines, Pericytes

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