Cited by 25Diabetes Treatment and ManagementDiabetes Management and ResearchPharmacology and Obesity Treatment

Pharmacological profile, efficacy and safety of lixisenatide in type 2 diabetes mellitus

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Forst, Thomas, Pfützner, Andreas·2013·Expert Opinion on Pharmacotherapy

Abstract

INTRODUCTION: The global prevalence of type 2 diabetes mellitus (T2DM) is rapidly increasing and is associated with a high risk of microvascular and macrovascular complications. Although some glucose-lowering therapies are associated with hypoglycemia and weight gain, glucagon-like peptide-1 (GLP-1) receptor agonists represent a significant advance in the treatment of T2DM, as they provide effective glycemic control with a low incidence of hypoglycemia and a beneficial effect on body weight, as well as potential improvements in cardiovascular outcomes. AREAS COVERED: This article evaluates the pharmacological and clinical profile of the once-daily prandial GLP-1 receptor agonist lixisenatide for the treatment of T2DM. EXPERT OPINION: Once-daily prandial lixisenatide has been evaluated in an extensive clinical trials program, in which it was shown to have a favorable safety and tolerability profile, and to effectively improve metabolic control. The unique pharmacological properties of lixisenatide clearly differentiate it from other GLP-1 receptor agonists. As a once-daily agonist with a high affinity for the GLP-1 receptor, lixisenatide improves overall glycemic control, with particularly strong effects on postprandial plasma glucose levels. These attributes encourage the application of lixisenatide in those patients with extensive postprandial glucose excursions, or in combination with other antidiabetic drugs that have prevailing effects on fasting glucose levels.

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Crossref · 10.1517/14656566.2013.838559

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  • LIXI has cardiovascular benefits, delays gastric emptying, protects pancreatic beta-cells, and increases insulin mRNA expression and hormone secretion.

    “Along with its role in lowering blood glucose levels, LIXI has many other functions, such as cardiovascular benefits, delaying gastric emptying, protective effect on pancreatic beta-cells, and increased insulin mRNA expression and hormone secretion (65).”

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Research works printed but not linked: 3

  1. Haschke G, Haag-Diergarten S, Werner U, et al. The GLP-1 receptor agonist AVE0010 preserves beta cell function and insulin secretion after a 6 week treatment in make obese Zucker diabetic fatty rats --an isolated perfusion pancreas study [abstract]. Diabetologia 2006;49:400-1
  2. Becker RH, Kapitza C, Stechl J, et al. Restitution of glucose disposition with lixisenatide in healthy subjects and patients with type 2 diabetes [abstract 813]. Diabetologia 2012;55:S1-S538
  3. '-adenosine monophosphate-dependent protein kinase A-and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 2003;144:1444-55

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Authors
Forst, T., & Pfützner, A.
Venue
Expert Opinion on Pharmacotherapy
Published
2013-10-03
Volume
14
Issue
16
Pages
2281-2296
ISSN
  • 1465-6566 (ISSN-L)
  • 1744-7666
OpenAlex
W2095994700
Cited by
25
References
87
Citations by year
2025: 2 · 2023: 2 · 2020: 4 · 2019: 4 · 2018: 3 · 2016: 1 · 2015: 3 · 2014: 6
FWCI
0.49
Type
journal article
Language
en
Open access
Locations
  • Expert Opinion on Pharmacotherapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
lixisenatide, type 2 diabetes, GLP-1 receptor agonists, postprandial hyperglycemia, glycemic control, drug safety and tolerability, pharmacological profile, combination antidiabetic therapy
MeSH terms
Glucagon-Like Peptide-1 Receptor, Glucagon-Like Peptide-2 Receptor, Animals, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Peptides, Treatment Outcome, Receptors, Glucagon

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