The DOI matches its Crossref record; 104 of the 105 references it cites were found in a registry or an index.
Towards organ printing: engineering an intra-organ branched vascular tree
Open accessAbstract
IMPORTANCE OF THE FIELD: Effective vascularization of thick three-dimensional engineered tissue constructs is a problem in tissue engineering. As in native organs, a tissue-engineered intra-organ vascular tree must be comprised of a network of hierarchically branched vascular segments. Despite this requirement, current tissue-engineering efforts are still focused predominantly on engineering either large-diameter macrovessels or microvascular networks. AREAS COVERED IN THIS REVIEW: We present the emerging concept of organ printing or robotic additive biofabrication of an intra-organ branched vascular tree, based on the ability of vascular tissue spheroids to undergo self-assembly. WHAT THE READER WILL GAIN: The feasibility and challenges of this robotic biofabrication approach to intra-organ vascularization for tissue engineering based on organ-printing technology using self-assembling vascular tissue spheroids including clinically relevantly vascular cell sources are analyzed. TAKE HOME MESSAGE: It is not possible to engineer 3D thick tissue or organ constructs without effective vascularization. An effective intra-organ vascular system cannot be built by the simple connection of large-diameter vessels and microvessels. Successful engineering of functional human organs suitable for surgical implantation will require concomitant engineering of a 'built in' intra-organ branched vascular system. Organ printing enables biofabrication of human organ constructs with a 'built in' intra-organ branched vascular tree.
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“This results in the easy isolation of autologous EPCs from peripheral blood, lipoaspirate tissue, and bone marrow in sufficient number, holding promising potential for reendothelization of decellularized livers for clinical application [239].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [239]
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1 retracted
RETRACTED: Clinical transplantation of a tissue-engineered airway
Macchiarini, P., Jungebluth, P., Go, T., Asnaghi, M. A., Rees, L., Cogan, T. A., Dodson, A., Martorell, J., Bellini, S., Parnigotto, P. P., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61598-6 · Cited by 1,431
RetractedLanger, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell, J. W., Katz, A. J., Benhaim, P., Lorenz, H. P., & Hedrick, M. H. (2001) · Tissue Engineering · doi:10.1089/107632701300062859 · Cited by 7,956
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
Mechanisms of angiogenesis and arteriogenesis
Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,235
Liao, J., Wei, Q., Zou, Y., Fan, J., Song, D., Cui, J., Zhang, W., Zhu, Y., Ma, C., Hu, X. Y., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471945 · Cited by 2,742
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650
Human induced pluripotent stem cells free of vector and transgene sequences
Yu, J., Hu, K., Smuga-Otto, K., Tian, S., Stewart, R., Slukvin, I. I., & Thomson, J. A. (2009) · Science · doi:10.1126/science.1172482 · Cited by 2,386
The Physiological Principle of Minimum Work
Murray, C. D. (1926) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.12.3.207 · Cited by 2,105
Tissue-engineered autologous bladders for patients needing cystoplasty
Atala, A., Bauer, S. B., Söker, S., Yoo, J. J., & Retik, A. B. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68438-9 · Cited by 1,857
Research works printed but not linked: 4
- Jakab K, 2004, Biorheology, 41, 371
- Jarrell BE, 1986, Surgery, 100, 392
- 10.1002/stem.20080922 · DOI
- Kostrominova TY, 2009, Histol Histopathol, 24, 541
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The Artificial Liver, in vivo Tissue Engineering, and Organ Printing
Sauer, I. M., Raschzok, N., & Neuhaus, P. (2014) · doi:10.1002/9781118873434.ch47 · Cited by 1
In vitro bioengineering applications of melt electrowritten and hydrogel composite scaffolds
Barnes, D. A. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.212352 · Cited by 1
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Mire, C. A. (2010) · Research Online (University of Wollongong)
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Yeon, J. H., Hu, Q. P., Ryu, H. R., Chung, M., & Jeon, N. L. (2011)
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Tao, G., & Martin, J. F. (2015) · KARGER eBooks · doi:10.1159/000375227
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Matz, P., Spitzhorn, L., Otte, J., Kawala, M.-A., Woestmann, J., Yigit, H., Wruck, W., & Adjaye, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12380-7
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Tse, C. (2015) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Biomaterials Based Strategies for Engineering Tumor Microenvironment
Arya, N., & Forget, A. (2017) · Advanced structured materials · doi:10.1007/978-981-10-3328-5_8
Mitchell, M. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805369-0.00004-3
CRISPR engineering cardiometabolic disease models using human iPSC
McKinney, C. E., & Baumgarner, K. M. (2018) · AIMS Cell and Tissue Engineering · doi:10.3934/celltissue.2018.3.185
Leonidakis, K. A., Soultan, A. H., Piluso, S., Kudva, A. K., den Broeck, L. V., Meiga, T. O., Gibney, R., & Patterson, J. (2017) · CRC Press eBooks · doi:10.1081/e-ebppc-140000002
Braig, J. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.213111
Faculty Opinions recommendation of Polymers for 3D printing and customized additive manufacturing.
Agis, H. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727857659.793561164
3D Printing and Bioprinting: Near Future Prospectives
Rosa, L. D. (2022) · Springer eBooks · doi:10.1007/978-3-031-10558-6_12
3D PRINTING TECHNOLOGY IMPLEMENTATION FOR PERSONALIZED MEDICATION
Kushwaha, S. K. S., Kushwaha, N., & Kumar, V. (2023) · Bulletin of Pharmaceutical Sciences Assiut · doi:10.21608/bfsa.2023.300942
Lagziel, T., Kawaji, Q., Ku, Y. C., Rostami, S., Martinez, S. L., Cox, C. A., Werthman, E., Caffrey, J. A., & Hultman, C. S. (2024) · Journal of Burn Care & Research · doi:10.1093/jbcr/irae132
In Vitro Assays Used to Analyse Vascular Cell Functions
Kirchhoff, A., Wechselberger, C., Bernhard, D., & Meßner, B. (2024) · Learning materials in biosciences · doi:10.1007/978-3-031-64591-4_16
In Vivo Bioreactor: New Type of Implantable Medical Devices
Tan, Q. (2013) · Springer eBooks · doi:10.1007/978-1-4614-1674-6_5
Regenerative Pharmacology of Implanted Materials and Tissue-Engineered Constructs
Ongstad, E. L., Yost, M. J., Goodwin, R. L., Friedman, H. I., Fann, S. A., Ghatnekar, G. S., & Gourdie, R. G. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139047357.018
Chaddad, H. (2019) · theses.fr (ABES) · doi:10.70675/e2786a5az288az46d4za2afz98cdafddfe5b
Engineering predictive human-relevant models: biomaterials at the interface of biology and function
Li, Z. A., Gentile, C., Romanyk, D. L., & Negrini, N. C. (2026) · Biomedical Materials Science · doi:10.1186/s44495-026-00012-3
Self-citation
Metadata
- Authors
- Visconti, R. P., Kasyanov, V., Gentile, C., Zhang, J., Markwald, R. R., & Mironov, V.
- Affiliations
- Medical University of South Carolina (US)
- Riga Stradiņš University (LV)
- Corresponding author
- Mironov, Vladimir
- Venue
- Expert Opinion on Biological Therapy
- Publisher
- Informa Healthcare
- Published
- 2010-02-04
- Volume
- 10
- Issue
- 3
- Pages
- 409-420
- ISSN
- 1471-2598 (ISSN-L)
- 1744-7682
- PMC
- PMC4580374
- OpenAlex
- W2052215721
- Cited by
- 224
- References
- 105
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 11 · 2022: 15 · 2021: 19 · 2020: 12 · 2019: 12 · 2018: 20 · 2017: 25 · 2016: 19 · 2015: 15 · 2014: 18 · 2013: 19 · 2012: 12
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Expert Opinion on Biological Therapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- publication.editionName
- Funders
- National Institutes of Health (5p20rr016461-11, 1c06rr015455-01a1, 1c06rr018823-01)
- National Center for Research Resources (RR16434-08, P20RR016434, P20RR021949, 2 P20 RR16461-05A1, C06 RR-015455, C06 RR-018823, P 20 RR-016461)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Industrial and Manufacturing Engineering › Additive Manufacturing and 3D Printing Technologies
- Keywords
- organ printing, self-assembly, 3D tissue constructs, organ engineering, microvascular networks
- MeSH terms
- Animals, Blood Vessels, Feasibility Studies, Humans, Robotics, Tissue Engineering
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