The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Microspheres for controlled release drug delivery
Abstract
Controlled release drug delivery employs drug-encapsulating devices from which therapeutic agents may be released at controlled rates for long periods of time, ranging from days to months. Such systems offer numerous advantages over traditional methods of drug delivery, including tailoring of drug release rates, protection of fragile drugs and increased patient comfort and compliance. Polymeric microspheres are ideal vehicles for many controlled delivery applications due to their ability to encapsulate a variety of drugs, biocompatibility, high bioavailability and sustained drug release characteristics. Research discussed in this review is focused on improving large-scale manufacturing, maintaining drug stability and enhancing control of drug release rates. This paper describes methods of microparticle fabrication and the major factors controlling the release rates of encapsulated drugs. Furthermore, recent advances in the use of polymer microsphere-based systems for delivery of single-shot vaccines, plasmid DNA and therapeutic proteins are discussed, as well as some future directions of microsphere research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Direct Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
Discher, D. E., & Eisenberg, A. (2002) · Science · doi:10.1126/science.1074972 · Cited by 3,551
Polymersomes: Tough Vesicles Made from Diblock Copolymers
Discher, B. M., Won, Y.-Y., Ege, D. S., Lee, J. C.-M., Bates, F. S., Discher, D. E., & Hammer, D. A. (1999) · Science · doi:10.1126/science.284.5417.1143 · Cited by 2,512
PEGylated nanoparticles for biological and pharmaceutical applications
Otsuka, H., Nagasaki, Y., & Kataoka, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00226-0 · Cited by 1,588
Why degradable polymers undergo surface erosion or bulk erosion
Burkersroda, F. V., Schedl, L., & Göpferich, A. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00170-9 · Cited by 1,146
Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles
Savić, R., Luo, L., Eisenberg, A., & Maysinger, D. (2003) · Science · doi:10.1126/science.1078192 · Cited by 1,113
Cationic liposome-mediated transfection
Felgner, P. L., & Ringold, G. M. (1989) · Nature · doi:10.1038/337387a0 · Cited by 987
Donnelly, J. J., Ulmer, J. B., Shiver, J. W., & Liu, M. A. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.617 · Cited by 987
Barouch, D. H., Santra, S., Schmitz, J. E., Kuroda, M. J., Fu, T.-M., Wagner, W., Bilska, M., Craiu, A., Zheng, X. X., Krivulka, G. R., et al. (2000) · Science · doi:10.1126/science.290.5491.486 · Cited by 881
Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres
Cohen, S., Yoshioka, T., Lucarelli, M., Hwang, L. H., & Langer, R. (1991) · Pharmaceutical Research · doi:10.1023/a:1015841715384 · Cited by 843
Cited by
Polycaprolactone: Synthesis, Properties, and Applications
Guarino, V., Gentile, G., Sorrentino, L., & Ambrosio, L. (2017) · Encyclopedia of Polymer Science and Technology · doi:10.1002/0471440264.pst658 · Cited by 163
Fabrication and characterization of polycaprolactone-based green materials for drug delivery
Kurakula, M., Rao, G. S. N. K., & Yadav, K. S. (2021) · Applications of Advanced Green Materials · doi:10.1016/b978-0-12-820484-9.00016-7 · Cited by 34
Metadata
- Authors
- Varde, N. K., & Pack, D. W.
- Venue
- Expert Opinion on Biological Therapy
- Publisher
- Informa UK Limited
- Published
- 2004-01
- Volume
- 4
- Issue
- 1
- Pages
- 35-51
- ISSN
- 1471-2598 (ISSN-L)
- 1744-7682
- OpenAlex
- W2029198995
- Cited by
- 448
- References
- 124
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Microspheres for controlled release drug delivery. https://app.cochat.ai/papers/10.1517/14712598.4.1.35
- The paper
- Varde, N. K., & Pack, D. W. (2004). Microspheres for controlled release drug delivery. Expert Opinion on Biological Therapy. https://doi.org/10.1517/14712598.4.1.35
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
